The network for 'leukocyte activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

leukocyte activation

A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.

NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor1.000
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)1.000
SYKspleen tyrosine kinase1.000
LCKlymphocyte-specific protein tyrosine kinase1.000
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence1.000
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)1.000
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1.000
PTPN6protein tyrosine phosphatase, non-receptor type 60.999
SHC1SHC (Src homology 2 domain containing) transforming protein 10.999
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.998
GRB2growth factor receptor-bound protein 20.998
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.995
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.993
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.985
TNFAIP3tumor necrosis factor, alpha-induced protein 30.984
VAV1vav 1 guanine nucleotide exchange factor0.984
LATlinker for activation of T cells0.983
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.982
CD2CD2 molecule0.982
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.977
PLCG1phospholipase C, gamma 10.974
CCR7chemokine (C-C motif) receptor 70.970
IL2RBinterleukin 2 receptor, beta0.970
PTPRCprotein tyrosine phosphatase, receptor type, C0.964
CCL5chemokine (C-C motif) ligand 50.958
PTPN1protein tyrosine phosphatase, non-receptor type 10.939
TRAF1TNF receptor-associated factor 10.936
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.935
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.933
RUNX1runt-related transcription factor 10.928
IL2RGinterleukin 2 receptor, gamma0.926
SH2D1ASH2 domain containing 1A0.925
SOS1son of sevenless homolog 1 (Drosophila)0.917
RB1retinoblastoma 10.914
IRF4interferon regulatory factor 40.904
LAPTM5lysosomal protein transmembrane 50.898
SLAMF1signaling lymphocytic activation molecule family member 10.897
CCR5chemokine (C-C motif) receptor 50.896
IL10RAinterleukin 10 receptor, alpha0.895
ITKIL2-inducible T-cell kinase0.891
LTAlymphotoxin alpha (TNF superfamily, member 1)0.885
FGFR1fibroblast growth factor receptor 10.885
CXCL9chemokine (C-X-C motif) ligand 90.881
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.878
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.866
CCL22chemokine (C-C motif) ligand 220.862
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.861
BRCA1breast cancer 1, early onset0.860
CAV1caveolin 1, caveolae protein, 22kDa0.859
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.848
CD80CD80 molecule0.848
CCL4chemokine (C-C motif) ligand 40.833
JAG1jagged 10.828
FGFR2fibroblast growth factor receptor 20.828
NOTCH1notch 10.820
HCKhemopoietic cell kinase0.820
CD247CD247 molecule0.809
CCR1chemokine (C-C motif) receptor 10.779
JAK2Janus kinase 20.777
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.774
CXCL10chemokine (C-X-C motif) ligand 100.767
CD48CD48 molecule0.767
FHL2four and a half LIM domains 20.765
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.752
IFNGinterferon, gamma0.747
CD86CD86 molecule0.746
HLA-Emajor histocompatibility complex, class I, E0.740
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.735
CD3GCD3g molecule, gamma (CD3-TCR complex)0.727
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.716
HLA-Cmajor histocompatibility complex, class I, C0.709
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.709
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.707
BLNKB-cell linker0.704
FYBFYN binding protein0.700
ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)0.696
CD28CD28 molecule0.693
CARD11caspase recruitment domain family, member 110.693
IL4Rinterleukin 4 receptor0.693
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.691
INSRinsulin receptor0.687
NKG7natural killer cell group 7 sequence0.679
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.658
ICAM1intercellular adhesion molecule 10.651
PPARAperoxisome proliferator-activated receptor alpha0.650
AXLAXL receptor tyrosine kinase0.648
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.644
BCL10B-cell CLL/lymphoma 100.630
TFF1trefoil factor 10.622
CD6CD6 molecule0.614
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.613
IL1R1interleukin 1 receptor, type I0.613
APPamyloid beta (A4) precursor protein0.604
IRF8interferon regulatory factor 80.601
CD37CD37 molecule0.597
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.592
IL10interleukin 100.587
STAT4signal transducer and activator of transcription 40.585
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
capns1bcalpain, small subunit 1 b0.570
fgf3fibroblast growth factor 30.442
cmybtranscription factor cmyb0.365
cdx4caudal type homeo box transcription factor 40.353
lhx3LIM homeobox 30.291
bmp2bbone morphogenetic protein 2b0.274
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.240
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.239
mmp9matrix metalloproteinase 90.217
fgf8afibroblast growth factor 8 a0.154
lcp1lymphocyte cytosolic plastin 10.121
ikzf1IKAROS family zinc finger 1 (Ikaros)0.116
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.111
otx1borthodenticle homolog 1b0.104
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.099
satb2SATB homeobox 20.098
tbx1T-box 10.097
csf3rcolony stimulating factor 3 receptor (granulocyte)0.096
il6rinterleukin 6 receptor0.083
ccnd1cyclin D10.081
fzd7afrizzled homolog 7a0.077
dnmt4DNA (cytosine-5-)-methyltransferase 40.074
gata3GATA-binding protein 30.074
bocbrother of CDO0.073
mycamyelocytomatosis oncogene a0.073
pcdh18bprotocadherin 18b0.072
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.067
cxcr4bchemokine (C-X-C motif), receptor 4b0.065
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.063
fzd10frizzled homolog 100.061
nadl1.1neural adhesion molecule L1.10.059
edn1endothelin 10.058
fabp7afatty acid binding protein 7, brain, a0.056
rag1recombination activating gene 10.056
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.055
gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic0.051
crip2cysteine-rich protein 20.050
shhasonic hedgehog a0.049
egr2bearly growth response 2b0.047
tshbthyroid stimulating hormone, beta subunit0.047
axin2axin 2 (conductin, axil)0.045
efna2ephrin A20.045
il12bbinterleukin 12B, b0.044
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.043
fzd5frizzled homolog 50.042
runx2arunt-related transcription factor 2a0.041
kitakit receptor a0.041
il7rinterleukin 7 receptor0.039
tlr3toll-like receptor 30.038
pdcd2programmed cell death 20.037
wnt9bwingless-type MMTV integration site family, member 9B0.037
arrb2barrestin, beta 2b0.035
elk4ELK4, ETS-domain protein0.035
nrp2bneuropilin 2b0.033
eomesbeomesodermin homolog b0.032
ext2exostoses (multiple) 20.032
fesfeline sarcoma oncogene0.032
runx3runt-related transcription factor 30.031
crfa31.2IL-4RA-like protein 20.031
fn1fibronectin 10.031
wasaWiskott-Aldrich syndrome (eczema-thrombocytopenia) a0.030
terttelomerase reverse transcriptase0.030
rykreceptor-like tyrosine kinase0.029
tbx2bT-box 2b0.029
cd8aCD8 antigen, alpha polypeptide0.029
caspacaspase a0.029
jak3Janus kinase 3 (a protein tyrosine kinase, leukocyte)0.029
scdstearoyl-CoA desaturase (delta-9-desaturase)0.028
btkBruton agammaglobulinemia tyrosine kinase0.027
hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.027
LOC100003514protein kinase C alpha type-like0.026
gli1GLI-Kruppel family member 10.025
flhfloating head0.025
rad21RAD21 homolog (S. pombe)0.025
pglyrp6peptidoglycan recognition protein 60.025
ptger4aprostaglandin E receptor 4 (subtype EP4) a0.024
hlxb9lahomeo box HB9 like a0.024
cntn2contactin 20.024
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.024
grinaglutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)0.024
fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.024
ip6k2inositol hexaphosphate kinase 20.024
tp53tumor protein p530.024
lrrc33leucine rich repeat containing 330.024
tcf12transcription factor 120.023
tnfsf10l2tumor necrosis factor (ligand) superfamily, member 10 like 20.023
hirip3HIRA interacting protein 30.023
eya2eyes absent homolog 2 (Drosophila)0.023
notch3notch homolog 30.023
fcer1glFc receptor, IgE, high affinity I, gamma polypeptide like0.023
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cd2Cd2 molecule0.961
Ptprcprotein tyrosine phosphatase, receptor type, C0.937
Ccr5chemokine (C-C motif) receptor 50.935
RT1-BaRT1 class II, locus Ba0.929
Gzmkgranzyme K0.917
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.896
Casp1caspase 10.880
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.850
Cd247Cd247 molecule0.833
Anxa2annexin A20.750
Cd86CD86 molecule0.748
Ccl5chemokine (C-C motif) ligand 50.720
Hckhemopoietic cell kinase0.702
Csf1colony stimulating factor 1 (macrophage)0.700
Cd53Cd53 molecule0.682
Cd5Cd5 molecule0.674
Clec9aC-type lectin domain family 9, member a0.674
RT1-DaRT1 class II, locus Da0.671
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.659
Tgfbr2transforming growth factor, beta receptor II0.647
Cd4Cd4 molecule0.563
Il1binterleukin 1 beta0.552
RT1-Db1RT1 class II, locus Db10.516
Adora2aadenosine A2a receptor0.509
Ciitaclass II, major histocompatibility complex, transactivator0.504
Flt1FMS-related tyrosine kinase 10.502
Sellselectin L0.465
Cd38CD38 molecule0.421
Ptafrplatelet-activating factor receptor0.419
Il6interleukin 60.392
Xcl1chemokine (C motif) ligand 10.391
Il2rbinterleukin 2 receptor, beta0.388
Cd37CD37 molecule0.386
Lcp2lymphocyte cytosolic protein 20.375
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.345
Klrd1killer cell lectin-like receptor, subfamily D, member 10.337
Cxcr3chemokine (C-X-C motif) receptor 30.305
Arhgap4Rho GTPase activating protein 40.299
Igh-6immunoglobulin heavy chain 60.298
Metmet proto-oncogene0.279
Cd74Cd74 molecule, major histocompatibility complex, class II invariant chain0.279
Cd3gCD3 molecule, gamma0.277
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.274
FaslgFas ligand (TNF superfamily, member 6)0.271
Mmp12matrix metallopeptidase 120.266
Klrk1killer cell lectin-like receptor subfamily K, member 10.266
Cd3dCD3 molecule, delta0.262
Nkg7natural killer cell group 7 sequence0.261
Cd8aCD8a molecule0.259
Fgfr2fibroblast growth factor receptor 20.258
Pecam1platelet/endothelial cell adhesion molecule 10.257
Tfectranscription factor EC0.254
Calcrlcalcitonin receptor-like0.252
Lst1leukocyte specific transcript 10.251
TcrbT-cell receptor beta chain0.237
Ly86lymphocyte antigen 860.233
Fcgr3aFc fragment of IgG, low affinity IIIa, receptor0.233
Il1r1interleukin 1 receptor, type I0.232
Hdac7histone deacetylase 70.229
Vipvasoactive intestinal peptide0.227
Ccr2chemokine (C-C motif) receptor 20.225
Havcr1hepatitis A virus cellular receptor 10.223
Dock8dedicator of cytokinesis 80.223
Zbp1Z-DNA binding protein 10.221
Kcnq2potassium voltage-gated channel, KQT-like subfamily, member 20.217
Cybbcytochrome b-245, beta polypeptide0.214
Il4interleukin 40.213
Ctsecathepsin E0.212
Il7rinterleukin 7 receptor0.209
Bin2bridging integrator 20.208
Igsf6immunoglobulin superfamily, member 60.207
Plauplasminogen activator, urokinase0.204
Tlr4toll-like receptor 40.202
Scn11asodium channel, voltage-gated, type XI, alpha0.200
Klra5killer cell lectin-like receptor, subfamily A, member 50.199
Inpp5dinositol polyphosphate-5-phosphatase D0.197
Gja1gap junction protein, alpha 10.188
Zcwpw1zinc finger, CW-type with PWWP domain 10.187
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.186
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.184
Ptger4prostaglandin E receptor 4 (subtype EP4)0.183
Tnfrsf8tumor necrosis factor receptor superfamily, member 80.180
Iappislet amyloid polypeptide0.179
Lef1lymphoid enhancer binding factor 10.179
FasFas (TNF receptor superfamily, member 6)0.178
Gata6GATA binding protein 60.172
Btg2BTG family, member 20.171
Vcam1vascular cell adhesion molecule 10.170
Calm1calmodulin 10.169
Mcpt2mast cell protease 20.168
N5DNA binding protein N50.167
Itgadintegrin, alpha D0.166
Pgam1phosphoglycerate mutase 1 (brain)0.165
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.164
Jak1Janus kinase 10.164
Prm2protamine 20.162
Cd79bCd79b molecule, immunoglobulin-associated beta0.162
Gimap4GTPase, IMAP family member 40.161
Ctsjcathepsin J0.160
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism