The network for 'positive regulation of protein localization to nucleus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of protein localization to nucleus

Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.

NameDescriptionProbabilityFunc Analog Organism
SMAD3SMAD family member 30.989
SMAD7SMAD family member 70.968
SMAD4SMAD family member 40.957
SMAD2SMAD family member 20.942
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.885
EGFRepidermal growth factor receptor0.883
SH3KBP1SH3-domain kinase binding protein 10.869
BMPR1Abone morphogenetic protein receptor, type IA0.841
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.806
IQGAP1IQ motif containing GTPase activating protein 10.719
GRB2growth factor receptor-bound protein 20.711
IL8interleukin 80.676
ESR1estrogen receptor 10.630
FLNAfilamin A, alpha0.584
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.555
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.487
CCL4chemokine (C-C motif) ligand 40.486
CXCL2chemokine (C-X-C motif) ligand 20.465
FAF1Fas (TNFRSF6) associated factor 10.459
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.434
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.422
CXCL3chemokine (C-X-C motif) ligand 30.421
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.401
SH2D4ASH2 domain containing 4A0.394
SHC1SHC (Src homology 2 domain containing) transforming protein 10.386
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.381
CCR5chemokine (C-C motif) receptor 50.374
SF3A1splicing factor 3a, subunit 1, 120kDa0.361
NCOA1nuclear receptor coactivator 10.347
SGCDsarcoglycan, delta (35kDa dystrophin-associated glycoprotein)0.342
SMURF2SMAD specific E3 ubiquitin protein ligase 20.331
IL1R1interleukin 1 receptor, type I0.329
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.306
FKBP1AFK506 binding protein 1A, 12kDa0.298
KPNA2karyopherin alpha 2 (RAG cohort 1, importin alpha 1)0.273
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.269
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.257
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.253
BMP2bone morphogenetic protein 20.246
SRPK2SRSF protein kinase 20.240
SOCS3suppressor of cytokine signaling 30.233
MYH9myosin, heavy chain 9, non-muscle0.231
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.218
BMPR1Bbone morphogenetic protein receptor, type IB0.211
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.207
TGFB1transforming growth factor, beta 10.206
CCL8chemokine (C-C motif) ligand 80.203
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.200
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.198
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.193
YAP1Yes-associated protein 10.185
CXCL10chemokine (C-X-C motif) ligand 100.183
IL6interleukin 6 (interferon, beta 2)0.179
WWP2WW domain containing E3 ubiquitin protein ligase 20.178
RACGAP1Rac GTPase activating protein 10.176
TGFBR1transforming growth factor, beta receptor 10.175
FBXW11F-box and WD repeat domain containing 110.173
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.172
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.165
SF3A2splicing factor 3a, subunit 2, 66kDa0.162
PSEN1presenilin 10.158
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.154
MYD88myeloid differentiation primary response gene (88)0.146
LMNAlamin A/C0.139
IGF1Rinsulin-like growth factor 1 receptor0.134
RASA1RAS p21 protein activator (GTPase activating protein) 10.132
RNF31ring finger protein 310.130
IDEinsulin-degrading enzyme0.127
ZNF84zinc finger protein 840.125
CDK8cyclin-dependent kinase 80.124
BTRCbeta-transducin repeat containing0.123
FSTL1follistatin-like 10.119
KPNB1karyopherin (importin) beta 10.118
CUL1cullin 10.117
DSG2desmoglein 20.115
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.112
RIPK2receptor-interacting serine-threonine kinase 20.110
GDF5growth differentiation factor 50.106
CTNND1catenin (cadherin-associated protein), delta 10.106
SYKspleen tyrosine kinase0.103
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.101
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.097
ANGPT1angiopoietin 10.096
SNAI1snail homolog 1 (Drosophila)0.095
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.095
ANGPT2angiopoietin 20.093
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.092
HIPK3homeodomain interacting protein kinase 30.089
BAIAP2BAI1-associated protein 20.089
UBXN1UBX domain protein 10.089
CCR1chemokine (C-C motif) receptor 10.088
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.087
TGFB3transforming growth factor, beta 30.086
VCPvalosin containing protein0.084
DPP4dipeptidyl-peptidase 40.082
PLAURplasminogen activator, urokinase receptor0.082
SFNstratifin0.079
FOXD3forkhead box D30.079
ACTN4actinin, alpha 40.078
FYNFYN oncogene related to SRC, FGR, YES0.077
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
plc-3Protein PLC-30.016
lmn-1Protein LMN-10.012
cdc-48.2Protein CDC-48.20.012
imb-2Protein IMB-20.011
pqn-59Protein PQN-590.011
rpn-1Protein RPN-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
ovoCG6824 gene product from transcript CG6824-RE0.432
l(2)gllethal (2) giant larvae0.266
panpangolin0.260
DatDopamine N acetyltransferase0.247
wgwingless0.239
MadMothers against dpp0.232
hthhomothorax0.170
Gap1GTPase-activating protein 10.132
TolloCG6890 gene product from transcript CG6890-RA0.129
Toll-7CG8595 gene product from transcript CG8595-RA0.122
Act87EActin 87E0.118
Tak1TGF-beta activated kinase 10.114
coroCG9446 gene product from transcript CG9446-RC0.105
CG16885CG16885 gene product from transcript CG16885-RA0.104
Cul-3Cullin-30.103
AxnAxin0.102
Toll-6CG7250 gene product from transcript CG7250-RA0.101
cpbcapping protein beta0.089
tumtumbleweed0.079
Stat92ESignal-transducer and activator of transcription protein at 92E0.078
coscosta0.071
exexpanded0.070
myoglianinCG1838 gene product from transcript CG1838-RD0.065
sosine oculis0.063
enengrailed0.061
CadNCadherin-N0.060
Kap-alpha3karyopherin alpha30.059
Cul-2Cullin-20.057
comtcomatose0.056
highikaru genki0.056
mib1mind bomb 10.055
CanBCalcineurin B0.054
Nek2CG17256 gene product from transcript CG17256-RA0.053
TlToll0.052
Ca-P60ACalcium ATPase at 60A0.052
scnyscrawny0.051
perperiod0.050
dsdachsous0.049
crccryptocephal0.046
tutlturtle0.044
Su(H)Suppressor of Hairless0.044
ttvtout-velu0.044
ftfat0.044
armarmadillo0.043
spispitz0.040
CG32810CG32810 gene product from transcript CG32810-RB0.038
hhhedgehog0.037
Cpr62BcCuticular protein 62Bc0.037
bibbig brain0.035
ogreoptic ganglion reduced0.035
Tpr2Tetratricopeptide repeat protein 20.034
rho-5rhomboid-50.033
cicubitus interruptus0.032
Vap-33-1CG5014 gene product from transcript CG5014-RB0.032
Eip63F-1Ecdysone-induced protein 63F 10.032
PsnPresenilin0.030
CG31904CG31904 gene product from transcript CG31904-RD0.030
kibrakibra ortholog0.030
PaxPaxillin0.029
Ulp1CG12359 gene product from transcript CG12359-RA0.028
SaraSmad anchor for receptor activation0.027
BicDBicaudal D0.027
18w18 wheeler0.026
Act5CActin 5C0.026
ArgkArginine kinase0.026
osoutstretched0.026
srasarah0.025
forforaging0.025
Vps35Vacuolar protein sorting 350.025
LacLachesin0.025
amonamontillado0.025
Traf6TNF-receptor-associated factor 60.024
hipkhomeodomain interacting protein kinase0.024
klgklingon0.024
dnr1defense repressor 10.024
aopanterior open0.024
dhddeadhead0.022
arrarrow0.022
GLazGlial Lazarillo0.022
PGRP-LEPeptidoglycan recognition protein LE0.022
su(Hw)suppressor of Hairy wing0.022
stmAstambha A0.022
ChcClathrin heavy chain0.022
EcREcdysone receptor0.021
Ube3aUbiquitin protein ligase E3A0.021
Dcr-2Dicer-20.021
bnbbangles and beads0.021
MerMerlin0.021
NotumCG13076 gene product from transcript CG13076-RB0.020
GlyPGlycogen phosphorylase0.020
slmbsupernumerary limbs0.020
CG11347CG11347 gene product from transcript CG11347-RE0.020
sdscalloped0.020
Ras85DRas oncogene at 85D0.020
pr-set7CG3307 gene product from transcript CG3307-RC0.020
argosCG4531 gene product from transcript CG4531-RA0.020
CG4962CG4962 gene product from transcript CG4962-RA0.019
appapproximated0.019
bazbazooka0.019
CG3363CG3363 gene product from transcript CG3363-RB0.019
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor0.996
Gli3GLI-Kruppel family member GLI30.951
Ctnnb1catenin (cadherin associated protein), beta 10.904
Ptenphosphatase and tensin homolog0.852
Mapk14mitogen-activated protein kinase 140.794
Gli2GLI-Kruppel family member GLI20.781
CblCasitas B-lineage lymphoma0.731
Map3k7mitogen-activated protein kinase kinase kinase 70.645
Ptpn11protein tyrosine phosphatase, non-receptor type 110.601
Fgfr2fibroblast growth factor receptor 20.595
Cd19CD19 antigen0.584
Atf2activating transcription factor 20.552
Smad4MAD homolog 4 (Drosophila)0.516
Axin1axin 10.505
Il1r1interleukin 1 receptor, type I0.490
Casp1caspase 10.478
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.455
Apcadenomatosis polyposis coli0.449
Ptk2PTK2 protein tyrosine kinase 20.440
Htthuntingtin0.420
Smad1MAD homolog 1 (Drosophila)0.366
Ikbkginhibitor of kappaB kinase gamma0.324
Smad2MAD homolog 2 (Drosophila)0.320
Edaectodysplasin-A0.314
Nodalnodal0.312
Traf6TNF receptor-associated factor 60.306
Il6interleukin 60.295
Smad3MAD homolog 3 (Drosophila)0.278
Grb2growth factor receptor bound protein 20.262
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.255
Fgfr1fibroblast growth factor receptor 10.249
Sfrp2secreted frizzled-related protein 20.246
Mapk8mitogen-activated protein kinase 80.218
Nos2nitric oxide synthase 2, inducible0.209
Cd40CD40 antigen0.198
Ikbkbinhibitor of kappaB kinase beta0.197
EdaraddEDAR (ectodysplasin-A receptor)-associated death domain0.186
Ptprcprotein tyrosine phosphatase, receptor type, C0.182
Plcg2phospholipase C, gamma 20.178
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.173
Foxc1forkhead box C10.160
Bmpr1abone morphogenetic protein receptor, type 1A0.153
Myd88myeloid differentiation primary response gene 880.152
Ptch1patched homolog 10.144
Vangl2vang-like 2 (van gogh, Drosophila)0.141
Meox2mesenchyme homeobox 20.138
Nos3nitric oxide synthase 3, endothelial cell0.137
Ifnginterferon gamma0.136
Ppp3cbprotein phosphatase 3, catalytic subunit, beta isoform0.126
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)0.121
Nr3c1nuclear receptor subfamily 3, group C, member 10.119
Rac1RAS-related C3 botulinum substrate 10.119
Rnf111ring finger 1110.108
Gsk3bglycogen synthase kinase 3 beta0.108
Mapk1mitogen-activated protein kinase 10.107
Tgfatransforming growth factor alpha0.106
Cux1cut-like homeobox 10.106
Smad6MAD homolog 6 (Drosophila)0.106
Erbb2ipErbb2 interacting protein0.105
Sfrp1secreted frizzled-related protein 10.103
Pax6paired box gene 60.102
Wnt5awingless-related MMTV integration site 5A0.102
Il10interleukin 100.099
Tgfbr2transforming growth factor, beta receptor II0.099
Cxcl13chemokine (C-X-C motif) ligand 130.098
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.095
Pou2af1POU domain, class 2, associating factor 10.094
Usp9xubiquitin specific peptidase 9, X chromosome0.092
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.091
Kpnb1karyopherin (importin) beta 10.088
Stim2stromal interaction molecule 20.086
Tgfbr1transforming growth factor, beta receptor I0.084
Caprin1cell cycle associated protein 10.081
Il4interleukin 40.079
Sall1sal-like 1 (Drosophila)0.079
Cd44CD44 antigen0.078
Map3k14mitogen-activated protein kinase kinase kinase 140.076
Trp53transformation related protein 530.076
Zic2zinc finger protein of the cerebellum 20.076
Kpna1karyopherin (importin) alpha 10.073
Fstfollistatin0.072
Rpgrip1lRpgrip1-like0.072
Ikzf1IKAROS family zinc finger 10.070
Kpna3karyopherin (importin) alpha 30.068
Aurkbaurora kinase B0.068
Tlr4toll-like receptor 40.068
NanogNanog homeobox0.067
Mks1Meckel syndrome, type 10.067
Leprleptin receptor0.065
Gspt1G1 to S phase transition 10.064
Csf1rcolony stimulating factor 1 receptor0.064
Ccnb1cyclin B10.062
Inpp5dinositol polyphosphate-5-phosphatase D0.062
SharpinSHANK-associated RH domain interacting protein0.062
Bmp4bone morphogenetic protein 40.059
Mapk9mitogen-activated protein kinase 90.058
Tnfrsf19tumor necrosis factor receptor superfamily, member 190.058
Ipo5importin 50.057
Smad7MAD homolog 7 (Drosophila)0.056
Cd86CD86 antigen0.056
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Stip1stress-induced phosphoprotein 10.358
Hspa8heat shock protein 80.105
Jak1Janus kinase 10.091
Hist1h1ahistone cluster 1, H1a0.083
Adam10ADAM metallopeptidase domain 100.063
Mpripmyosin phosphatase Rho interacting protein0.062
Hsph1heat shock 105/110 protein 10.060
Fgfr1Fibroblast growth factor receptor 10.060
Eef2eukaryotic translation elongation factor 20.057
Nckap1NCK-associated protein 10.056
Galnt1UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)0.053
Nek9NIMA (never in mitosis gene a)- related kinase 90.049
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.047
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.045
Tnks2tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 20.043
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.039
Mapk1mitogen activated protein kinase 10.034
Casp2caspase 20.033
Pak2p21 protein (Cdc42/Rac)-activated kinase 20.033
Hspd1heat shock protein 1 (chaperonin)0.031
Gna12guanine nucleotide binding protein (G protein) alpha 120.030
Rbm25RNA binding motif protein 250.029
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.027
Gja1gap junction protein, alpha 10.026
Prkcbprotein kinase C, beta0.026
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.025
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.024
Smad7SMAD family member 70.023
Nr4a3nuclear receptor subfamily 4, group A, member 30.022
Ehmt2euchromatic histone lysine N-methyltransferase 20.021
Psmd2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.021
Cyth1cytohesin 10.020
Tcf12transcription factor 120.020
Synj1synaptojanin 10.020
Syngr2synaptogyrin 20.020
Tgfbr2transforming growth factor, beta receptor II0.019
Akt1v-akt murine thymoma viral oncogene homolog 10.018
Ppatphosphoribosyl pyrophosphate amidotransferase0.017
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.017
Stat3signal transducer and activator of transcription 30.017
Hckhemopoietic cell kinase0.016
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.016
Mapk9mitogen-activated protein kinase 90.016
Tgfbr1transforming growth factor, beta receptor 10.016
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.016
Ipo7importin 70.014
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.014
Castcalpastatin0.014
Ptbp1polypyrimidine tract binding protein 10.014
BtkBruton agammaglobulinemia tyrosine kinase0.013
Ireb2iron responsive element binding protein 20.013
Mstnmyostatin0.013
Ptger4prostaglandin E receptor 4 (subtype EP4)0.013
Icam1intercellular adhesion molecule 10.013
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.013
Edn1endothelin 10.013
Hk1hexokinase 10.013
Taok1TAO kinase 10.013
Igsf6immunoglobulin superfamily, member 60.013
Atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.013
Msnmoesin0.013
Garnl1GTPase activating Rap/RanGAP domain-like 10.013
Mib1mindbomb homolog 1 (Drosophila)0.013
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.012
Ubqln1ubiquilin 10.012
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.012
Apba3amyloid beta (A4) precursor protein-binding, family A, member 30.012
Ddr2discoidin domain receptor tyrosine kinase 20.012
Slit3slit homolog 3 (Drosophila)0.012
Arl5aADP-ribosylation factor-like 5A0.012
Phka1phosphorylase kinase, alpha 10.012
Myo1cmyosin IC0.012
Fgfr2fibroblast growth factor receptor 20.011
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.011
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.011
Lig3ligase III, DNA, ATP-dependent0.011
Myadmmyeloid-associated differentiation marker0.011
Msl1male-specific lethal 1 homolog (Drosophila)0.011
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.011
Hsp90b1heat shock protein 90, beta, member 10.011
Hspb1heat shock protein 10.011
Mdm2Mdm2 p53 binding protein homolog (mouse)0.011
Gucy1b3guanylate cyclase 1, soluble, beta 30.011
Nraddneurotrophin receptor associated death domain0.011
Pcmtd2protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 20.011
LOC687856similar to Myeloid cell surface antigen CD33 precursor (Siglec-3)0.011
Rcsd1RCSD domain containing 10.011
Rasgrp1RAS guanyl releasing protein 1 (calcium and DAG-regulated)0.010
Exoc5exocyst complex component 50.010
Ctbp1C-terminal binding protein 10.010
Akt2v-akt murine thymoma viral oncogene homolog 20.010
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.010
Raf1v-raf-leukemia viral oncogene 10.010
Eif4heukaryotic translation initiation factor 4H0.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
UFD1Ufd1p0.220
ARP4Arp4p0.152
CDC48Cdc48p0.137
CNA1Cna1p0.107
NPL4Npl4p0.100
NUP49Nup49p0.080
CNB1Cnb1p0.080
PBS2Pbs2p0.075
GCN2Gcn2p0.072
ATG13Atg13p0.065
CMD1Cmd1p0.043
TPD3Tpd3p0.038
YNL155Whypothetical protein0.033
STI1Sti1p0.028
RCN1Rcn1p0.027
EPL1Epl1p0.021
UBA1Uba1p0.020
OTU1Otu1p0.019
CMP2Cmp2p0.019
HMG2Hmg2p0.019
ARE2Are2p0.017
EAF1Eaf1p0.017
PPH22Pph22p0.017
NUP82Nup82p0.017
SRD1Srd1p0.017
LEU2Leu2p0.016
KSP1Ksp1p0.016
ATG29Atg29p0.015
UBP7Ubp7p0.015
CAK1Cak1p0.015
YOL038C-Ahypothetical protein0.015
ATG2Atg2p0.015
TAE2Tae2p0.014
YLR162Whypothetical protein0.014
BEM3Bem3p0.014
CUP1-1Cup1-1p0.014
MER1Mer1p0.014
SRO7Sro7p0.014
PTI1Pti1p0.013
PKH3Pkh3p0.013
YLR264C-Ahypothetical protein0.013
CDC55Cdc55p0.013
ARP10Arp10p0.013
MSL5Msl5p0.013
UBP1Ubp1p0.013
MTR10Mtr10p0.012
PPH21Pph21p0.012
GYL1Gyl1p0.012
RGC1Rgc1p0.012
PTR2Ptr2p0.012
RPN2Rpn2p0.012
MPS1Mps1p0.011
YOL098Chypothetical protein0.011
HOHop0.011
ERO1Ero1p0.011
ZDS1Zds1p0.011
PRS2Prs2p0.011
YLR042Chypothetical protein0.011
URA3Ura3p0.011
CKS1Cks1p0.010
CDC6Cdc6p0.010
HXT3Hxt3p0.010
ARO10Aro10p0.010