The network for 'positive regulation of bone resorption' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of bone resorption

Any process that activates or increases the frequency, rate or extent of bone resorption.

NameDescriptionProbabilityFunc Analog Organism
CASP8caspase 8, apoptosis-related cysteine peptidase0.971
CFLARCASP8 and FADD-like apoptosis regulator0.694
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.655
CASP10caspase 10, apoptosis-related cysteine peptidase0.613
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.543
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.345
FASFas (TNF receptor superfamily, member 6)0.290
FADDFas (TNFRSF6)-associated via death domain0.288
OS9osteosarcoma amplified 9, endoplasmic reticulum lectin0.085
SH3BP4SH3-domain binding protein 40.061
ATP6V0CATPase, H+ transporting, lysosomal 16kDa, V0 subunit c0.056
UBASH3Bubiquitin associated and SH3 domain containing B0.032
FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)0.028
PTPN6protein tyrosine phosphatase, non-receptor type 60.022
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.020
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.020
NEU1sialidase 1 (lysosomal sialidase)0.020
DKK1dickkopf homolog 1 (Xenopus laevis)0.020
GAAglucosidase, alpha; acid0.018
BBS10Bardet-Biedl syndrome 100.018
LRRK2leucine-rich repeat kinase 20.017
C1orf93chromosome 1 open reading frame 930.017
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.014
BLNKB-cell linker0.014
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.013
LMO4LIM domain only 40.012
IGFBP3insulin-like growth factor binding protein 30.012
MYO1Gmyosin IG0.011
ATP6V0D1ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d10.010
ESR2estrogen receptor 2 (ER beta)0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tgfb2transforming growth factor, beta 20.551
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.409
Hspg2perlecan (heparan sulfate proteoglycan 2)0.370
Itgb3integrin beta 30.301
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.198
Adam15a disintegrin and metallopeptidase domain 15 (metargidin)0.145
Adam12a disintegrin and metallopeptidase domain 12 (meltrin alpha)0.124
Prrx2paired related homeobox 20.114
Cxcr7chemokine (C-X-C motif) receptor 70.106
Mmp2matrix metallopeptidase 20.104
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.101
Gja1gap junction protein, alpha 10.099
Hey2hairy/enhancer-of-split related with YRPW motif 20.098
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.098
Loxlysyl oxidase0.097
Xcr1chemokine (C motif) receptor 10.094
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.089
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.088
Pdgfbplatelet derived growth factor, B polypeptide0.071
Bmp1bone morphogenetic protein 10.070
Foxc2forkhead box C20.068
C5ar1complement component 5a receptor 10.066
Twsg1twisted gastrulation homolog 1 (Drosophila)0.065
Egfrepidermal growth factor receptor0.064
Adam17a disintegrin and metallopeptidase domain 170.064
Jag1jagged 10.061
Ppargc1bperoxisome proliferative activated receptor, gamma, coactivator 1 beta0.060
Cd22CD22 antigen0.054
Apaf1apoptotic peptidase activating factor 10.051
Ntf3neurotrophin 30.051
Vangl2vang-like 2 (van gogh, Drosophila)0.051
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.047
Csf1colony stimulating factor 1 (macrophage)0.047
Fbn1fibrillin 10.045
Col1a1collagen, type I, alpha 10.045
Mrc2mannose receptor, C type 20.043
Lrp5low density lipoprotein receptor-related protein 50.043
Adam8a disintegrin and metallopeptidase domain 80.043
Jupjunction plakoglobin0.043
Slc11a2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 20.040
Prnpprion protein0.039
Iduaiduronidase, alpha-L-0.037
Nolc1nucleolar and coiled-body phosphoprotein 10.035
Fgfr2fibroblast growth factor receptor 20.035
Ngpneutrophilic granule protein0.035
Gp5glycoprotein 5 (platelet)0.034
Runx2runt related transcription factor 20.033
Lama5laminin, alpha 50.033
F2rl2coagulation factor II (thrombin) receptor-like 20.033
Creb3l1cAMP responsive element binding protein 3-like 10.033
Ddx21DEAD (Asp-Glu-Ala-Asp) box polypeptide 210.033
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.032
Pick1protein interacting with C kinase 10.032
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.032
Nid1nidogen 10.032
Lamc2laminin, gamma 20.031
Igkimmunoglobulin kappa chain complex0.031
Lrp1low density lipoprotein receptor-related protein 10.031
Mc5rmelanocortin 5 receptor0.031
Wwp1WW domain containing E3 ubiquitin protein ligase 10.030
Fn1fibronectin 10.030
Hbegfheparin-binding EGF-like growth factor0.030
Sirpasignal-regulatory protein alpha0.029
Col6a1collagen, type VI, alpha 10.029
Thbs2thrombospondin 20.029
Cx3cr1chemokine (C-X3-C) receptor 10.028
Epha6Eph receptor A60.028
Aebp1AE binding protein 10.027
Tnks1bp1tankyrase 1 binding protein 10.027
Ctskcathepsin K0.027
Col6a2collagen, type VI, alpha 20.027
Col16a1collagen, type XVI, alpha 10.027
Efnb2ephrin B20.026
Kiss1KiSS-1 metastasis-suppressor0.026
Tgfbr2transforming growth factor, beta receptor II0.026
Smosmoothened homolog (Drosophila)0.025
Itga4integrin alpha 40.025
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.025
Sorbs3sorbin and SH3 domain containing 30.025
Tenc1tensin like C1 domain-containing phosphatase0.025
Cd44CD44 antigen0.024
Starsteroidogenic acute regulatory protein0.024
Cd96CD96 antigen0.023
Prg3proteoglycan 30.023
Lef1lymphoid enhancer binding factor 10.023
Wnt5awingless-related MMTV integration site 5A0.023
Ptrfpolymerase I and transcript release factor0.022
Klra5killer cell lectin-like receptor, subfamily A, member 50.022
Axin1axin 10.022
Nfam1Nfat activating molecule with ITAM motif 10.022
Col8a1collagen, type VIII, alpha 10.022
Npr2natriuretic peptide receptor 20.021
Pax1paired box gene 10.021
Thbs1thrombospondin 10.021
Col5a1collagen, type V, alpha 10.020
Hic1hypermethylated in cancer 10.020
Lcp2lymphocyte cytosolic protein 20.020
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism