The network for 'cell cycle dna replication' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell cycle dna replication

The DNA-dependent DNA replication that takes place as part of the cell cycle.

Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CDK2cyclin-dependent kinase 20.996
CDC6cell division cycle 6 homolog (S. cerevisiae)0.653
MCM6minichromosome maintenance complex component 60.599
MCM2minichromosome maintenance complex component 20.451
CCNE1cyclin E10.361
SKP2S-phase kinase-associated protein 2 (p45)0.355
RBBP8retinoblastoma binding protein 80.266
ORC1origin recognition complex, subunit 10.241
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.184
RBL2retinoblastoma-like 2 (p130)0.175
E2F7E2F transcription factor 70.171
MCM7minichromosome maintenance complex component 70.164
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.162
MCM3minichromosome maintenance complex component 30.157
MCM10minichromosome maintenance complex component 100.141
BRCA1breast cancer 1, early onset0.126
RAD21RAD21 homolog (S. pombe)0.116
UHRF2ubiquitin-like with PHD and ring finger domains 20.100
WAPALwings apart-like homolog (Drosophila)0.098
CCNA2cyclin A20.096
ORC2origin recognition complex, subunit 20.092
CDC25Acell division cycle 25 homolog A (S. pombe)0.087
RB1retinoblastoma 10.081
MCMBPminichromosome maintenance complex binding protein0.079
NBNnibrin0.079
CDT1chromatin licensing and DNA replication factor 10.076
MCM4minichromosome maintenance complex component 40.075
E2F8E2F transcription factor 80.059
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.056
TFDP2transcription factor Dp-2 (E2F dimerization partner 2)0.047
CCNB2cyclin B20.046
CDC7cell division cycle 7 homolog (S. cerevisiae)0.044
E2F1E2F transcription factor 10.040
CDC45cell division cycle 45 homolog (S. cerevisiae)0.039
DUSP1dual specificity phosphatase 10.036
E2F4E2F transcription factor 4, p107/p130-binding0.035
ORC3origin recognition complex, subunit 30.035
ARRB1arrestin, beta 10.033
TFDP1transcription factor Dp-10.031
ORC6origin recognition complex, subunit 60.031
SMC1Astructural maintenance of chromosomes 1A0.030
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.028
MDM2Mdm2 p53 binding protein homolog (mouse)0.027
RBL1retinoblastoma-like 1 (p107)0.026
ORC4origin recognition complex, subunit 40.026
CCNE2cyclin E20.025
DBF4DBF4 homolog (S. cerevisiae)0.025
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.024
STAG2stromal antigen 20.024
PELP1proline, glutamate and leucine rich protein 10.023
RAD50RAD50 homolog (S. cerevisiae)0.021
PDS5BPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.021
MAPK1mitogen-activated protein kinase 10.021
SSRP1structure specific recognition protein 10.019
MMS22LMMS22-like, DNA repair protein0.019
CHEK1CHK1 checkpoint homolog (S. pombe)0.019
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.018
YY1YY1 transcription factor0.018
BTRCbeta-transducin repeat containing0.018
IBTKinhibitor of Bruton agammaglobulinemia tyrosine kinase0.017
SSU72SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)0.016
BOP1block of proliferation 10.015
ATF3activating transcription factor 30.015
ORC5origin recognition complex, subunit 50.014
JUBjub, ajuba homolog (Xenopus laevis)0.014
E2F5E2F transcription factor 5, p130-binding0.013
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.013
CPNE6copine VI (neuronal)0.013
DDIT3DNA-damage-inducible transcript 30.013
POLD3polymerase (DNA-directed), delta 3, accessory subunit0.013
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.013
MCM5minichromosome maintenance complex component 50.012
POLA2polymerase (DNA directed), alpha 2 (70kD subunit)0.012
GMNNgeminin, DNA replication inhibitor0.012
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.011
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.011
SENP3SUMO1/sentrin/SMT3 specific peptidase 30.010
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
F55A3.3Protein F55A3.30.027
zyg-9Protein ZYG-90.024
F25B5.2Protein F25B5.20.023
npp-11Protein NPP-110.020
C48B6.3Protein C48B6.30.019
san-1Protein SAN-10.018
brc-1Protein BRC-10.018
mcm-5Protein MCM-50.016
spd-1Protein SPD-10.016
lin-9Protein LIN-90.015
cst-1Protein CST-10.015
scc-3Protein SCC-30.015
xpo-1Protein XPO-10.015
tag-232Protein TAG-2320.015
cyk-4Protein CYK-40.014
zen-4Protein ZEN-40.014
bub-1Protein BUB-10.014
fzy-1Protein FZY-10.014
plk-1Protein PLK-10.014
F39B2.1Protein F39B2.10.014
par-2Protein PAR-20.013
nst-1Protein NST-10.013
F55F8.9Protein F55F8.90.013
mes-4Protein MES-40.013
D1081.7Protein D1081.70.013
ndc-80Protein NDC-800.013
set-21Protein SET-210.013
lag-1Protein LAG-10.012
cec-6Protein CEC-60.012
chk-1Protein CHK-10.012
isw-1Protein ISW-10.012
crm-1Protein CRM-10.012
dcn-1Protein DCN-10.012
F11E6.7Protein F11E6.70.012
air-2Protein AIR-20.012
npp-6Protein NPP-60.012
D2085.4Protein D2085.40.012
duo-1Protein DUO-10.012
smo-1Protein SMO-10.012
hcp-3Protein HCP-30.012
emb-27Protein EMB-270.011
cin-4Protein CIN-40.011
mcm-7Protein MCM-70.011
F33H2.5Protein F33H2.50.011
dog-1Protein DOG-10.011
Y44E3A.6Protein Y44E3A.60.011
coh-3Protein COH-30.011
kup-1Protein KUP-10.011
cpt-1Protein CPT-10.011
klp-16Protein KLP-160.011
CELE_F53F4.11Protein F53F4.110.011
F58E10.3Protein F58E10.30.011
eya-1Protein EYA-10.010
R74.6Protein R74.60.010
cdt-1Protein CDT-10.010
mcm-4Protein MCM-40.010
mcm-2Protein MCM-20.010
Y55F3BR.8Protein Y55F3BR.80.010
ima-2Protein IMA-20.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Mcm2Minichromosome maintenance 20.974
Orc2Origin recognition complex subunit 20.965
CDC45LCG3658 gene product from transcript CG3658-RA0.955
Mcm6Minichromosome maintenance 60.954
CycACyclin A0.946
dupdouble parked0.937
jumujumeau0.876
mus209mutagen-sensitive 2090.868
slp1sloppy paired 10.850
dpadisc proliferation abnormal0.824
hephemipterous0.728
CG13350CG13350 gene product from transcript CG13350-RA0.696
hdhumpty dumpty0.685
mus101mutagen-sensitive 1010.659
RbfRetinoblastoma-family protein0.600
gtgiant0.568
Mcm5Minichromosome maintenance 50.551
Orc5Origin recognition complex subunit 50.531
CycBCyclin B0.522
dapdacapo0.486
E2f2E2F transcription factor 20.466
Mcm10Sensitized chromosome inheritance modifier 190.457
CG5524CG5524 gene product from transcript CG5524-RA0.456
Mcm7Minichromosome maintenance 70.453
Eip63EEcdysone-induced protein 63E0.428
slp2sloppy paired 20.411
cdc2cCG10498 gene product from transcript CG10498-RC0.405
Rbf2Retinoblastoma-family protein 20.399
barrbarren0.378
CG9772CG9772 gene product from transcript CG9772-RB0.370
gsbgooseberry0.360
DpDP transcription factor0.345
Ets97DEts at 97D0.312
CG3430CG3430 gene product from transcript CG3430-RA0.269
DNApol-alpha73DNA polymerase alpha 73kD0.264
CycECyclin E0.264
SlbpStem-loop binding protein0.263
piwiCG6122 gene product from transcript CG6122-RA0.245
Mcm3Minichromosome maintenance 30.218
Orc1Origin recognition complex subunit 10.215
Ndc80CG9938 gene product from transcript CG9938-RA0.214
Btk29ABtk family kinase at 29A0.206
mip120Myb-interacting protein 1200.195
runrunt0.191
Traf4TNF-receptor-associated factor 40.189
picpiccolo0.186
escextra sexcombs0.185
midmidline0.174
tostosca0.162
bynbrachyenteron0.160
hkbhuckebein0.160
CG7686CG7686 gene product from transcript CG7686-RA0.159
oddodd skipped0.158
pitaCG3941 gene product from transcript CG3941-RA0.158
btlbreathless0.149
nejnejire0.146
DNApol-alpha60DNA polymerase alpha 60kD0.132
tlltailless0.129
Wnt4Wnt oncogene analog 40.129
RnrLRibonucleoside diphosphate reductase large subunit0.125
Nop60BNucleolar protein at 60B0.125
nebnebbish0.124
cidcentromere identifier0.121
fzyfizzy0.118
DrefDNA replication-related element factor0.117
smidsmallminded0.115
RfC4Replication factor C subunit 40.110
fkhfork head0.109
mus301mutagen-sensitive 3010.106
chicoCG5686 gene product from transcript CG5686-RB0.105
osoutstretched0.105
scwscrew0.104
HmrHybrid male rescue0.100
RicRas which interacts with Calmodulin0.097
jubAjuba LIM protein0.096
tldtolloid0.095
prdpaired0.093
pavpavarotti0.093
pluplutonium0.088
Cdk4Cyclin-dependent kinase 40.086
SuURSuppressor of Under-Replication0.084
l(2)gllethal (2) giant larvae0.082
pdm2POU domain protein 20.081
HsfHeat shock factor0.080
Rab23CG2108 gene product from transcript CG2108-RA0.079
CG14869CG14869 gene product from transcript CG14869-RB0.078
HLH54FCG5005 gene product from transcript CG5005-RA0.077
Top1Topoisomerase 10.077
rad50CG6339 gene product from transcript CG6339-RD0.076
latlatheo0.074
skpACG16983 gene product from transcript CG16983-RD0.073
spn-Bspindle B0.070
RipalphaRPA-interacting protein alpha0.068
DNApol-epsilonDNA polymerase epsilon0.066
Nup107Nucleoporin 1070.065
CG11284CG11284 gene product from transcript CG11284-RA0.065
sspsunspot0.065
nkdnaked cuticle0.065
KrKruppel0.064
stgstring0.063
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Top2atopoisomerase (DNA) II alpha0.314
Ube2cubiquitin-conjugating enzyme E2C0.258
Cdkn3cyclin-dependent kinase inhibitor 30.221
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.155
Racgap1Rac GTPase-activating protein 10.118
Ccnb1cyclin B10.108
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.076
Pttg1pituitary tumor-transforming 10.075
Syt4synaptotagmin IV0.067
Ns5atp9NS5A (hepatitis C virus) transactivated protein 90.060
Mcm7minichromosome maintenance complex component 70.058
Rrm2ribonucleotide reductase M20.052
Cdca3cell division cycle associated 30.039
Cdk1cyclin-dependent kinase 10.039
Kifc1kinesin family member C10.039
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.035
Mcm6minichromosome maintenance complex component 60.030
Mcm3minichromosome maintenance complex component 30.024
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.023
Ccne1cyclin E10.023
Hmmrhyaluronan mediated motility receptor (RHAMM)0.019
LOC689399hypothetical protein LOC6893990.018
SnrkSNF related kinase0.018
Mcm5minichromosome maintenance complex component 50.018
Melkmaternal embryonic leucine zipper kinase0.018
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.017
Aldh6a1aldehyde dehydrogenase 6 family, member A10.017
Klhl24kelch-like 24 (Drosophila)0.017
Stmn1stathmin 10.017
Arhgap11aRho GTPase activating protein 11A0.017
Nusap1nucleolar and spindle associated protein 10.016
Fyco1FYVE and coiled-coil domain containing 10.016
Kif22kinesin family member 220.016
Hist1h1ahistone cluster 1, H1a0.016
Tk1thymidine kinase 1, soluble0.015
Lig3ligase III, DNA, ATP-dependent0.015
Tmpothymopoietin0.015
Dapk3death-associated protein kinase 30.015
JunJun oncogene0.015
Traf4af1TRAF4 associated factor 10.014
Aurkbaurora kinase B0.014
Prc1protein regulator of cytokinesis 10.014
Stxbp3syntaxin binding protein 30.014
Map2k4mitogen activated protein kinase kinase 40.013
Mki67antigen identified by monoclonal antibody Ki-670.013
Birc5baculoviral IAP repeat-containing 50.013
Rgs3regulator of G-protein signaling 30.013
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.013
Map6microtubule-associated protein 60.013
Mrpl37mitochondrial ribosomal protein L370.013
Kif1bkinesin family member 1B0.013
Kif4kinesin family member 40.012
Kif2ckinesin family member 2C0.012
Plk4polo-like kinase 4 (Drosophila)0.012
Cbln1cerebellin 1 precursor0.012
Trmt1TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae)0.011
Fen1flap structure-specific endonuclease 10.011
Spc25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.011
Foxm1forkhead box M10.011
Prkag3protein kinase, AMP-activated, gamma 3 non-catalytic subunit0.011
RGD1308448similar to RIKEN cDNA B130016O10 gene0.011
Ncf4neutrophil cytosolic factor 40.011
LOC363326hypothetical LOC3633260.011
Fut4fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)0.011
Cenpecentromere protein E0.011
Ccnb2cyclin B20.010
Timelesstimeless homolog (Drosophila)0.010
PbkPDZ binding kinase0.010
Nuf2NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.010
Akap1A kinase (PRKA) anchor protein 10.010
Rhohras homolog gene family, member H0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
ORC1Orc1p0.989
MCM2Mcm2p0.977
CLB5Clb5p0.970
MCM5Mcm5p0.961
CDC6Cdc6p0.928
ORC2Orc2p0.927
MCM4Mcm4p0.910
DBF4Dbf4p0.821
ORC6Orc6p0.808
MCM6Mcm6p0.808
CDC14Cdc14p0.781
ORC3Orc3p0.755
ORC5Orc5p0.601
MCM10Mcm10p0.589
DIA2Dia2p0.533
CKS1Cks1p0.522
SIC1Sic1p0.391
MCM7Mcm7p0.373
TOF1Tof1p0.361
CDC28Cdc28p0.358
MCM3Mcm3p0.350
RAD53Rad53p0.281
ORC4Orc4p0.270
MDN1Mdn1p0.263
RSC4Rsc4p0.244
NOG1Nog1p0.235
CDC5Cdc5p0.200
DPB2Dpb2p0.192
CLB1Clb1p0.187
HAT1Hat1p0.174
CLB3Clb3p0.156
CLB6Clb6p0.154
CDC34Cdc34p0.153
TAH11Tah11p0.140
CAK1Cak1p0.132
MRC1Mrc1p0.129
RFC1Rfc1p0.128
SLD3Sld3p0.118
SLD5Sld5p0.114
RSC58Rsc58p0.111
IPI3Ipi3p0.105
ARP9Arp9p0.102
RSC9Rsc9p0.089
POL12Pol12p0.088
CTF18Ctf18p0.084
IME4Ime4p0.071
RSC8Rsc8p0.069
PSF1Psf1p0.067
ARP4Arp4p0.066
PIL1Pil1p0.066
CDC45Cdc45p0.061
SLD2Sld2p0.060
HAT2Hat2p0.060
SCC2Scc2p0.058
RLP7Rlp7p0.058
CDC4Cdc4p0.055
SEC39Sec39p0.055
RIX1Rix1p0.054
NOC3Noc3p0.053
PDS1Pds1p0.049
DUN1Dun1p0.048
RHO5Rho5p0.044
NOP7Nop7p0.040
MYO1Myo1p0.040
IES1Ies1p0.040
RAD9Rad9p0.040
SLN1Sln1p0.038
CDC12Cdc12p0.037
YPL014Whypothetical protein0.037
BUB1Bub1p0.036
FKH1Fkh1p0.035
CLB4Clb4p0.035
SFG1Sfg1p0.034
BIT61Bit61p0.033
CHL1Chl1p0.031
RAD5Rad5p0.030
CLN1Cln1p0.030
SAE2Sae2p0.030
CDC7Cdc7p0.029
POL1Pol1p0.029
YLR264C-Ahypothetical protein0.028
SDA1Sda1p0.028
SRD1Srd1p0.028
RDH54Rdh54p0.028
ADH2Adh2p0.028
PRI1Pri1p0.027
GAL7Gal7p0.027
PRI2Pri2p0.027
DBF2Dbf2p0.027
YNR014Whypothetical protein0.027
SPT16Spt16p0.027
YLR162Whypothetical protein0.026
VPS13Vps13p0.026
SDS22Sds22p0.026
RSA4Rsa4p0.026
TIF6Tif6p0.025
SWE1Swe1p0.025
MSA1Msa1p0.025
RSC6Rsc6p0.025
CDC20Cdc20p0.025