The network for 'adenylate cyclase inhibiting serotonin receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

adenylate cyclase inhibiting serotonin receptor signaling pathway

The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).

NameDescriptionProbabilityFunc Analog Organism
MPDZmultiple PDZ domain protein1.000
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 21.000
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 31.000
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.997
PLEKHA1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 10.951
ARRDC3arrestin domain containing 30.897
OR2AG1olfactory receptor, family 2, subfamily AG, member 10.679
SSTR3somatostatin receptor 30.613
TBC1D10ATBC1 domain family, member 10A0.481
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.339
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.311
EZRezrin0.184
COPG2coatomer protein complex, subunit gamma 20.147
DRD1dopamine receptor D10.139
HTR1A5-hydroxytryptamine (serotonin) receptor 1A0.137
TSHRthyroid stimulating hormone receptor0.134
YAP1Yes-associated protein 10.131
PLEKHA2pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 20.099
GPR6G protein-coupled receptor 60.091
CCKcholecystokinin0.089
GRIA2glutamate receptor, ionotropic, AMPA 20.088
HTR2C5-hydroxytryptamine (serotonin) receptor 2C0.081
SLC6A11solute carrier family 6 (neurotransmitter transporter, GABA), member 110.069
AQP7aquaporin 70.064
GABRA1gamma-aminobutyric acid (GABA) A receptor, alpha 10.061
HTR3A5-hydroxytryptamine (serotonin) receptor 3A0.058
HTR1B5-hydroxytryptamine (serotonin) receptor 1B0.057
ADRB3adrenergic, beta-3-, receptor0.056
DLGAP3discs, large (Drosophila) homolog-associated protein 30.054
TRHthyrotropin-releasing hormone0.053
OR2H1olfactory receptor, family 2, subfamily H, member 10.049
GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)0.049
DLGAP2discs, large (Drosophila) homolog-associated protein 20.048
P2RY1purinergic receptor P2Y, G-protein coupled, 10.048
PTPRAprotein tyrosine phosphatase, receptor type, A0.047
GRM5glutamate receptor, metabotropic 50.045
CDH8cadherin 8, type 20.044
GHRHRgrowth hormone releasing hormone receptor0.044
KRT33Bkeratin 33B0.043
ZP2zona pellucida glycoprotein 2 (sperm receptor)0.043
KCNE1potassium voltage-gated channel, Isk-related family, member 10.041
CHRNB4cholinergic receptor, nicotinic, beta 40.041
CCR3chemokine (C-C motif) receptor 30.041
NTSR1neurotensin receptor 1 (high affinity)0.039
FRMPD4FERM and PDZ domain containing 40.036
GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 20.034
KCNJ1potassium inwardly-rectifying channel, subfamily J, member 10.033
PTGER3prostaglandin E receptor 3 (subtype EP3)0.032
CALCRcalcitonin receptor0.032
SLC6A1solute carrier family 6 (neurotransmitter transporter, GABA), member 10.031
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.031
ADRA2Badrenergic, alpha-2B-, receptor0.030
KCNJ6potassium inwardly-rectifying channel, subfamily J, member 60.030
RELNreelin0.030
CTNND2catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)0.030
NELL1NEL-like 1 (chicken)0.029
HTR45-hydroxytryptamine (serotonin) receptor 40.029
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.029
PADI1peptidyl arginine deiminase, type I0.028
HNF1BHNF1 homeobox B0.028
RHOrhodopsin0.028
OLIG2oligodendrocyte lineage transcription factor 20.028
SLC18A1solute carrier family 18 (vesicular monoamine), member 10.028
CHRNB2cholinergic receptor, nicotinic, beta 2 (neuronal)0.027
HTR1D5-hydroxytryptamine (serotonin) receptor 1D0.027
GRIA1glutamate receptor, ionotropic, AMPA 10.027
RASGRF1Ras protein-specific guanine nucleotide-releasing factor 10.027
VIPR2vasoactive intestinal peptide receptor 20.027
FGF6fibroblast growth factor 60.026
DSCAML1Down syndrome cell adhesion molecule like 10.026
THPOthrombopoietin0.026
ALX1ALX homeobox 10.025
PTPRRprotein tyrosine phosphatase, receptor type, R0.025
KRT9keratin 90.025
LEPleptin0.025
LGI1leucine-rich, glioma inactivated 10.025
NXPH3neurexophilin 30.025
AMOTangiomotin0.024
IL6Rinterleukin 6 receptor0.024
TFF2trefoil factor 20.024
RAPGEF2Rap guanine nucleotide exchange factor (GEF) 20.024
MUSKmuscle, skeletal, receptor tyrosine kinase0.024
INAinternexin neuronal intermediate filament protein, alpha0.024
SPTBspectrin, beta, erythrocytic0.024
TNP2transition protein 2 (during histone to protamine replacement)0.024
NPY1Rneuropeptide Y receptor Y10.023
ADAMTS8ADAM metallopeptidase with thrombospondin type 1 motif, 80.023
SRCIN1SRC kinase signaling inhibitor 10.023
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.023
GH2growth hormone 20.022
ATP10AATPase, class V, type 10A0.022
OPRK1opioid receptor, kappa 10.022
GABRA6gamma-aminobutyric acid (GABA) A receptor, alpha 60.022
ZNF280Azinc finger protein 280A0.022
SMCPsperm mitochondria-associated cysteine-rich protein0.022
CRPC-reactive protein, pentraxin-related0.021
LSAMPlimbic system-associated membrane protein0.021
APOC3apolipoprotein C-III0.021
PROL1proline rich, lacrimal 10.021
SLC4A1solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)0.021
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Olfr70olfactory receptor 700.145
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.112
SspoSCO-spondin0.100
Pou2f3POU domain, class 2, transcription factor 30.097
Kcnq2potassium voltage-gated channel, subfamily Q, member 20.094
Pax1paired box gene 10.090
Ghrhrgrowth hormone releasing hormone receptor0.084
Tacr1tachykinin receptor 10.074
Hoxb1homeobox B10.064
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.062
Wnt1wingless-related MMTV integration site 10.058
Pitx3paired-like homeodomain transcription factor 30.055
Foxl1forkhead box L10.050
Lhbluteinizing hormone beta0.048
Fshrfollicle stimulating hormone receptor0.048
Chrm1cholinergic receptor, muscarinic 1, CNS0.047
Foxn1forkhead box N10.046
Tacr2tachykinin receptor 20.046
Shbgsex hormone binding globulin0.045
Foxh1forkhead box H10.045
Nkx1-2NK1 transcription factor related, locus 2 (Drosophila)0.042
Drd2dopamine receptor D20.042
Klf17Kruppel-like factor 170.040
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.038
C78513EST C785130.038
Lalbalactalbumin, alpha0.036
Klk4kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)0.036
Dnajb8DnaJ (Hsp40) homolog, subfamily B, member 80.035
Tlx2T-cell leukemia, homeobox 20.031
Cox8ccytochrome c oxidase, subunit VIIIc0.030
Odf1outer dense fiber of sperm tails 10.030
Lmx1bLIM homeobox transcription factor 1 beta0.030
Olfr71olfactory receptor 710.030
A930012N16RikRIKEN cDNA A930012N16 gene0.028
Vax1ventral anterior homeobox containing gene 10.027
Prop1paired like homeodomain factor 10.027
Neurod2neurogenic differentiation 20.026
Krtap14keratin associated protein 140.026
Prss29protease, serine, 290.026
Oprm1opioid receptor, mu 10.026
Hils1histone H1-like protein in spermatids 10.026
Tcl1b1T-cell leukemia/lymphoma 1B, 10.025
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.024
Itgb2lintegrin beta 2-like0.024
Pspnpersephin0.024
Evx2even skipped homeotic gene 2 homolog0.024
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.024
Adra2cadrenergic receptor, alpha 2c0.023
Sox14SRY-box containing gene 140.023
Gsx1GS homeobox 10.023
AA511254expressed sequence AA5112540.023
Foxb1forkhead box B10.023
Gpr44G protein-coupled receptor 440.022
Hist1h1thistone cluster 1, H1t0.022
Olfr1264olfactory receptor 12640.021
Edaectodysplasin-A0.021
Gpr27G protein-coupled receptor 270.021
Ppyr1pancreatic polypeptide receptor 10.019
Epha8Eph receptor A80.019
Ifna9interferon alpha 90.019
Hmx1H6 homeobox 10.018
Znrf4zinc and ring finger 40.018
Brs3bombesin-like receptor 30.017
Pmfbp1polyamine modulated factor 1 binding protein 10.017
Nr5a1nuclear receptor subfamily 5, group A, member 10.017
Lcn3lipocalin 30.017
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.017
Ifnabinterferon alpha B0.017
Kcnh3potassium voltage-gated channel, subfamily H (eag-related), member 30.017
SeboxSEBOX homeobox0.016
Cckbrcholecystokinin B receptor0.016
AF067063cDNA sequence AF0670630.016
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.016
Lhx3LIM homeobox protein 30.015
Rbpjlrecombination signal binding protein for immunoglobulin kappa J region-like0.015
Syt2synaptotagmin II0.015
Foxd2forkhead box D20.015
Syngr4synaptogyrin 40.015
Srcin1SRC kinase signaling inhibitor 10.015
Figlafolliculogenesis specific basic helix-loop-helix0.014
Btn1a1butyrophilin, subfamily 1, member A10.014
Hoxd13homeobox D130.014
Galr3galanin receptor 30.013
Prss40protease, serine, 400.013
Sstr5somatostatin receptor 50.013
Mmp24matrix metallopeptidase 240.013
Gm2717predicted gene 27170.013
Dlx4distal-less homeobox 40.013
Amhanti-Mullerian hormone0.012
BC089491cDNA sequence BC0894910.012
Cfc1cripto, FRL-1, cryptic family 10.012
Wnt7awingless-related MMTV integration site 7A0.012
Rhorhodopsin0.012
Sstr3somatostatin receptor 30.012
Slc18a3solute carrier family 18 (vesicular monoamine), member 30.012
Nhlh1nescient helix loop helix 10.012
Slc22a12solute carrier family 22 (organic anion/cation transporter), member 120.012
Sncbsynuclein, beta0.011
Ear4eosinophil-associated, ribonuclease A family, member 40.011
Hoxb7homeobox B70.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.170
Col10a1collagen, type X, alpha 10.146
Fgf14fibroblast growth factor 140.132
Egr3early growth response 30.098
Csrnp2cysteine-serine-rich nuclear protein 20.098
Insrrinsulin receptor-related receptor0.092
Syt8synaptotagmin VIII0.082
RGD1560784similar to RIKEN cDNA B630019K060.074
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.072
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.070
Tacr2tachykinin receptor 20.068
Olr416olfactory receptor 4160.065
Htr2a5-hydroxytryptamine (serotonin) receptor 2A0.065
Synposynaptopodin0.064
Chrna6cholinergic receptor, nicotinic, alpha 60.063
Atp2b4ATPase, Ca++ transporting, plasma membrane 40.061
Kcnj10potassium inwardly-rectifying channel, subfamily J, member 100.059
Aqp2aquaporin 2 (collecting duct)0.059
Fgf7fibroblast growth factor 70.056
Akap4A kinase (PRKA) anchor protein 40.054
Grm6glutamate receptor, metabotropic 60.054
Svs1seminal vesicle secretory protein 10.053
Grik3glutamate receptor, ionotropic, kainate 30.053
Cmtm2aCKLF-like MARVEL transmembrane domain containing 2A0.052
Arandrogen receptor0.051
Mc5rmelanocortin 5 receptor0.051
Prl4a1prolactin family 4, subfamily a, member 10.051
Gja3gap junction protein, alpha 30.049
Hpcahippocalcin0.048
Il13interleukin 130.048
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.048
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.048
Hes2hairy and enhancer of split 2 (Drosophila)0.047
Hnmthistamine N-methyltransferase0.047
Fgf2fibroblast growth factor 20.046
Syt6synaptotagmin VI0.046
Hapln1hyaluronan and proteoglycan link protein 10.046
Slc7a2solute carrier family 7 (cationic amino acid transporter, y+ system), member 20.046
Plauplasminogen activator, urokinase0.045
Gna15guanine nucleotide binding protein, alpha 150.045
Muskmuscle, skeletal, receptor tyrosine kinase0.043
Npy5rneuropeptide Y receptor Y50.043
Trpc4transient receptor potential cation channel, subfamily C, member 40.042
Svs3aseminal vesicle secretory protein 3A0.042
Lsm6LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)0.042
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.041
Ucp1uncoupling protein 1 (mitochondrial, proton carrier)0.041
Olr1500olfactory receptor 15000.040
Mmp10matrix metallopeptidase 100.039
Myogmyogenin0.039
Lalbalactalbumin, alpha0.038
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.038
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.038
Kcnj15potassium inwardly-rectifying channel, subfamily J, member 150.037
Il2rainterleukin 2 receptor, alpha0.036
Akp3alkaline phosphatase 3, intestine, not Mn requiring0.036
Reg3aregenerating islet-derived 3 alpha0.036
Gria1glutamate receptor, ionotropic, AMPA 10.036
Grid2glutamate receptor, ionotropic, delta 20.035
RGD1565859RGD15658590.035
Phkg1phosphorylase kinase, gamma 10.034
Neurod2neurogenic differentiation 20.034
Ier5immediate early response 50.034
Il5interleukin 50.034
Prp15proline-rich protein 150.034
Mmp3matrix metallopeptidase 30.034
Ccbp2chemokine binding protein 20.034
Mdga1MAM domain containing glycosylphosphatidylinositol anchor 10.033
Kcnq2potassium voltage-gated channel, KQT-like subfamily, member 20.033
Oprd1opioid receptor, delta 10.032
Necab1N-terminal EF-hand calcium binding protein 10.032
Folh1folate hydrolase 10.032
Cd40lgCD40 ligand0.032
Vom2r44vomeronasal 2 receptor 440.032
Dccdeleted in colorectal carcinoma0.032
Pmfbp1polyamine modulated factor 1 binding protein 10.032
Srd5a2steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)0.031
Mcpt1mast cell protease 10.031
Myo9amyosin IXA0.031
Ncanneurocan0.031
Cd8bCD8b molecule0.031
Prrx1paired related homeobox 10.031
Csf3colony stimulating factor 3 (granulocyte)0.031
Aqp5aquaporin 50.030
Hpcal4hippocalcin-like 40.030
Ccr2chemokine (C-C motif) receptor 20.029
Cdh6cadherin 60.029
Robo2roundabout homolog 2 (Drosophila)0.029
Gpr6G protein-coupled receptor 60.029
Sfrp4secreted frizzled-related protein 40.029
Dlx5distal-less homeobox 50.029
Gabra3gamma-aminobutyric acid (GABA) A receptor, alpha 30.029
Pthparathyroid hormone0.028
Cxcr5chemokine (C-X-C motif) receptor 50.028
Ptgdrprostaglandin D receptor0.028
Gad2glutamate decarboxylase 20.028
Dusp4dual specificity phosphatase 40.028
Nlgn1neuroligin 10.028
Adora3adenosine A3 receptor0.028
Sprr1alsmall proline-rich protein 1A-like0.028
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism