The network for 'positive regulation of myeloid leukocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of myeloid leukocyte differentiation

Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.

NameDescriptionProbabilityFunc Analog Organism
CASP8caspase 8, apoptosis-related cysteine peptidase1.000
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.999
BIRC3baculoviral IAP repeat containing 30.998
CASP3caspase 3, apoptosis-related cysteine peptidase0.998
RIPK2receptor-interacting serine-threonine kinase 20.997
XIAPX-linked inhibitor of apoptosis0.996
BIRC2baculoviral IAP repeat containing 20.995
CASP10caspase 10, apoptosis-related cysteine peptidase0.992
CFLARCASP8 and FADD-like apoptosis regulator0.972
TRAF1TNF receptor-associated factor 10.960
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.922
FASFas (TNF receptor superfamily, member 6)0.903
CCR5chemokine (C-C motif) receptor 50.867
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.835
TRAF3TNF receptor-associated factor 30.762
SH2D4ASH2 domain containing 4A0.757
CCR2chemokine (C-C motif) receptor 20.705
FASLGFas ligand (TNF superfamily, member 6)0.693
CASP9caspase 9, apoptosis-related cysteine peptidase0.676
EP300E1A binding protein p3000.663
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.592
CCL4chemokine (C-C motif) ligand 40.529
IFNGinterferon, gamma0.515
CXCL10chemokine (C-X-C motif) ligand 100.464
CCL5chemokine (C-C motif) ligand 50.439
NOTCH1notch 10.425
IL2RBinterleukin 2 receptor, beta0.417
APAF1apoptotic peptidase activating factor 10.399
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.369
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.363
CXCL9chemokine (C-X-C motif) ligand 90.360
IL8interleukin 80.359
CXCL2chemokine (C-X-C motif) ligand 20.358
SMURF1SMAD specific E3 ubiquitin protein ligase 10.354
IL10interleukin 100.338
CXCR3chemokine (C-X-C motif) receptor 30.336
CXCL11chemokine (C-X-C motif) ligand 110.332
IL23Ainterleukin 23, alpha subunit p190.324
CASP7caspase 7, apoptosis-related cysteine peptidase0.309
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.284
MDM2Mdm2 p53 binding protein homolog (mouse)0.274
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.266
CXCL5chemokine (C-X-C motif) ligand 50.264
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.236
TNFAIP3tumor necrosis factor, alpha-induced protein 30.223
CCR7chemokine (C-C motif) receptor 70.220
HDAC6histone deacetylase 60.205
IL1Binterleukin 1, beta0.182
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.177
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.159
CCL8chemokine (C-C motif) ligand 80.158
IRF4interferon regulatory factor 40.155
CTBP1C-terminal binding protein 10.155
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.154
RBL1retinoblastoma-like 1 (p107)0.145
BBS10Bardet-Biedl syndrome 100.133
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.132
CASP4caspase 4, apoptosis-related cysteine peptidase0.131
RIPK3receptor-interacting serine-threonine kinase 30.126
ZMYND11zinc finger, MYND-type containing 110.124
CXCL13chemokine (C-X-C motif) ligand 130.124
CCR4chemokine (C-C motif) receptor 40.121
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.121
ATF2activating transcription factor 20.120
JUNDjun D proto-oncogene0.116
NLRC4NLR family, CARD domain containing 40.113
NUMBLnumb homolog (Drosophila)-like0.111
IDEinsulin-degrading enzyme0.097
LRDDleucine-rich repeats and death domain containing0.093
CXCR6chemokine (C-X-C motif) receptor 60.089
CCL20chemokine (C-C motif) ligand 200.086
CCL7chemokine (C-C motif) ligand 70.083
CCR1chemokine (C-C motif) receptor 10.081
IL16interleukin 16 (lymphocyte chemoattractant factor)0.081
WIPF1WAS/WASL interacting protein family, member 10.080
JAG1jagged 10.079
CYBBcytochrome b-245, beta polypeptide0.077
RUNX3runt-related transcription factor 30.075
ING2inhibitor of growth family, member 20.074
CCL3chemokine (C-C motif) ligand 30.070
CCL22chemokine (C-C motif) ligand 220.068
FADDFas (TNFRSF6)-associated via death domain0.067
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.066
RAI1retinoic acid induced 10.064
TNFRSF9tumor necrosis factor receptor superfamily, member 90.064
ZNRD1zinc ribbon domain containing 10.064
IL6interleukin 6 (interferon, beta 2)0.063
DIABLOdiablo, IAP-binding mitochondrial protein0.062
CD40CD40 molecule, TNF receptor superfamily member 50.061
HIPK2homeodomain interacting protein kinase 20.061
LTAlymphotoxin alpha (TNF superfamily, member 1)0.060
MGEA5meningioma expressed antigen 5 (hyaluronidase)0.059
ELF4E74-like factor 4 (ets domain transcription factor)0.059
TNFSF8tumor necrosis factor (ligand) superfamily, member 80.057
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.057
CCL2chemokine (C-C motif) ligand 20.056
TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)0.054
CXCL3chemokine (C-X-C motif) ligand 30.052
TNFtumor necrosis factor0.050
TCF4transcription factor 40.050
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
junbljun B proto-oncogene, like0.176
mpxmyeloid-specific peroxidase0.066
ltkleukocyte tyrosine kinase0.048
mitfamicrophthalmia-associated transcription factor a0.043
cmybtranscription factor cmyb0.041
socs3asuppressor of cytokine signaling 3a0.035
LOC100331484hypothetical protein LOC1003314840.034
atp6v0d1ATPase, H+ transporting, V0 subunit D isoform 10.029
tal1T-cell acute lymphocytic leukemia 10.028
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.028
cx43connexin 430.025
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.024
junbjun B proto-oncogene0.024
wu:fv91b12wu:fv91b120.023
atf3activating transcription factor 30.020
csf1racolony stimulating factor 1 receptor, a0.017
tgfbitransforming growth factor, beta-induced0.016
si:dkey-181m9.9si:dkey-181m9.90.016
zgc:63523zgc:635230.016
coro1acoronin, actin binding protein, 1A0.015
clic2chloride intracellular channel 20.015
pnp4apurine nucleoside phosphorylase 4a0.014
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.014
hhiphedgehog interacting protein0.014
phlda2pleckstrin homology-like domain, family A, member 20.013
kitakit receptor a0.013
zgc:92851zgc:928510.013
atp6v0caATPase, H+ transporting, lysosomal, V0 subunit c, a0.013
ldhalactate dehydrogenase A40.013
slc4a1asolute carrier family 4, anion exchanger, member 1a0.012
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.012
safbscaffold attachment factor B0.012
sltmSAFB-like, transcription modulator0.011
LOC100000332e3 ubiquitin-protein ligase RNF182-like0.011
mmrn2amultimerin 2a0.011
igf1insulin-like growth factor 10.011
sf3b1splicing factor 3b, subunit 10.010
snai1asnail homolog 1a (Drosophila)0.010
rargaretinoic acid receptor gamma a0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Notch1Notch gene homolog 1 (Drosophila)0.981
Tnftumor necrosis factor0.955
JunJun oncogene0.912
Tgfb1transforming growth factor, beta 10.818
Ptgs2prostaglandin-endoperoxide synthase 20.810
Leprleptin receptor0.793
Id1inhibitor of DNA binding 10.770
Map3k14mitogen-activated protein kinase kinase kinase 140.765
FosFBJ osteosarcoma oncogene0.759
Ikzf1IKAROS family zinc finger 10.745
Ctnnb1catenin (cadherin associated protein), beta 10.730
Stat3signal transducer and activator of transcription 30.728
Trp53transformation related protein 530.689
Id3inhibitor of DNA binding 30.677
Psen1presenilin 10.665
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.662
Tnfaip3tumor necrosis factor, alpha-induced protein 30.648
Egr1early growth response 10.631
Stat5asignal transducer and activator of transcription 5A0.603
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.593
Smad3MAD homolog 3 (Drosophila)0.559
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.554
Dll1delta-like 1 (Drosophila)0.538
Itgb1integrin beta 1 (fibronectin receptor beta)0.528
BtkBruton agammaglobulinemia tyrosine kinase0.522
Csf1colony stimulating factor 1 (macrophage)0.485
Ptenphosphatase and tensin homolog0.403
Col1a1collagen, type I, alpha 10.391
Ighimmunoglobulin heavy chain complex0.390
Cav1caveolin 1, caveolae protein0.371
Notch2Notch gene homolog 2 (Drosophila)0.366
Hif1ahypoxia inducible factor 1, alpha subunit0.331
Gata1GATA binding protein 10.329
Zfp36zinc finger protein 360.314
Ncoa3nuclear receptor coactivator 30.311
Cyldcylindromatosis (turban tumor syndrome)0.308
Map3k7mitogen-activated protein kinase kinase kinase 70.287
Tcf4transcription factor 40.277
Irf9interferon regulatory factor 90.277
Ldb3LIM domain binding 30.263
Hes1hairy and enhancer of split 1 (Drosophila)0.256
Kitkit oncogene0.253
Tcf3transcription factor 30.249
Ptpn6protein tyrosine phosphatase, non-receptor type 60.246
Id2inhibitor of DNA binding 20.246
FasFas (TNF receptor superfamily member 6)0.245
Casp8caspase 80.243
JunbJun-B oncogene0.215
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.208
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.197
Nckap1lNCK associated protein 1 like0.194
Klf4Kruppel-like factor 4 (gut)0.193
Cd44CD44 antigen0.193
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.192
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.191
Rbl2retinoblastoma-like 20.180
Gata3GATA binding protein 30.179
Ppargperoxisome proliferator activated receptor gamma0.169
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.169
Itgb3integrin beta 30.156
Dusp1dual specificity phosphatase 10.154
Fgfr2fibroblast growth factor receptor 20.151
Ltblymphotoxin B0.151
Klf6Kruppel-like factor 60.150
Atf3activating transcription factor 30.149
Mcl1myeloid cell leukemia sequence 10.143
Nfil3nuclear factor, interleukin 3, regulated0.139
Fgd1FYVE, RhoGEF and PH domain containing 10.138
Ccl4chemokine (C-C motif) ligand 40.136
Cd40CD40 antigen0.135
SkilSKI-like0.134
Il6stinterleukin 6 signal transducer0.129
Ets1E26 avian leukemia oncogene 1, 5' domain0.128
Btg2B-cell translocation gene 2, anti-proliferative0.122
Msx2homeobox, msh-like 20.121
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.121
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.119
Stat5bsignal transducer and activator of transcription 5B0.117
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.117
Il10interleukin 100.116
Ikbkbinhibitor of kappaB kinase beta0.115
Smad1MAD homolog 1 (Drosophila)0.110
Jak3Janus kinase 30.110
Psen2presenilin 20.108
Myd88myeloid differentiation primary response gene 880.106
SrcRous sarcoma oncogene0.105
Nr3c1nuclear receptor subfamily 3, group C, member 10.105
FaddFas (TNFRSF6)-associated via death domain0.104
Apaf1apoptotic peptidase activating factor 10.103
Nos2nitric oxide synthase 2, inducible0.103
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.101
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.099
Egr2early growth response 20.098
Smad4MAD homolog 4 (Drosophila)0.095
Ahraryl-hydrocarbon receptor0.093
Grap2GRB2-related adaptor protein 20.093
Il12binterleukin 12b0.092
Runx2runt related transcription factor 20.091
Twsg1twisted gastrulation homolog 1 (Drosophila)0.089
Tcirg1T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A30.089
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Dusp1dual specificity phosphatase 10.830
Klf4Kruppel-like factor 4 (gut)0.512
Fcn1ficolin (collagen/fibrinogen domain containing) 10.379
Egr1early growth response 10.352
Prf1perforin 1 (pore forming protein)0.197
Ier2immediate early response 20.171
Ddx17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.125
Cd247Cd247 molecule0.104
Il2rbinterleukin 2 receptor, beta0.096
Casp2caspase 20.091
FosFBJ osteosarcoma oncogene0.090
Btg2BTG family, member 20.087
Magmyelin-associated glycoprotein0.081
Klrd1killer cell lectin-like receptor, subfamily D, member 10.076
Il1binterleukin 1 beta0.063
Junbjun B proto-oncogene0.062
Cd2Cd2 molecule0.057
Cd3eCD3 molecule, epsilon0.053
Gfra2GDNF family receptor alpha 20.051
Nr4a3nuclear receptor subfamily 4, group A, member 30.048
Ccl4chemokine (C-C motif) ligand 40.047
Atf3activating transcription factor 30.046
Xcl1chemokine (C motif) ligand 10.043
AxlAxl receptor tyrosine kinase0.041
Nr4a1nuclear receptor subfamily 4, group A, member 10.038
Plekpleckstrin0.037
Cd8aCD8a molecule0.036
RGD1359529similar to chromosome 1 open reading frame 630.036
Egr2early growth response 20.035
C4bcomplement component 4B (Chido blood group)0.032
Myd88myeloid differentiation primary response gene 880.031
Errfi1ERBB receptor feedback inhibitor 10.031
Mmp3matrix metallopeptidase 30.030
Cfpcomplement factor properdin0.030
Reg3bregenerating islet-derived 3 beta0.030
Acacbacetyl-Coenzyme A carboxylase beta0.029
Cela1chymotrypsin-like elastase family, member 10.028
Zfp36zinc finger protein 360.027
Mrc1mannose receptor, C type 10.027
Cst7cystatin F (leukocystatin)0.027
Fgfr2fibroblast growth factor receptor 20.026
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.026
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.026
Stx11syntaxin 110.024
Ccl19chemokine (C-C motif) ligand 190.023
Il1ainterleukin 1 alpha0.023
Ivlinvolucrin0.023
Gzmkgranzyme K0.022
Guca2aguanylate cyclase activator 2a (guanylin)0.021
JunJun oncogene0.021
Inmtindolethylamine N-methyltransferase0.020
Dnase1l3deoxyribonuclease 1-like 30.020
Tnftumor necrosis factor (TNF superfamily, member 2)0.019
Calcrlcalcitonin receptor-like0.019
Kdrkinase insert domain receptor0.019
Adora2aadenosine A2a receptor0.018
Erp27endoplasmic reticulum protein 270.018
Ccl7chemokine (C-C motif) ligand 70.018
TcrbT-cell receptor beta chain0.018
Ccl3chemokine (C-C motif) ligand 30.017
F13a1coagulation factor XIII, A1 polypeptide0.016
Dusp6dual specificity phosphatase 60.016
Ctswcathepsin W0.016
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.016
Cd86CD86 molecule0.016
Ccl6chemokine (C-C motif) ligand 60.016
Lst1leukocyte specific transcript 10.016
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.015
Nos3nitric oxide synthase 3, endothelial cell0.015
Cd40CD40 molecule, TNF receptor superfamily member 50.015
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.015
Il8rbinterleukin 8 receptor, beta0.014
Klk6kallikrein related-peptidase 60.014
Clphcasein-like phosphoprotein0.014
Nkd1naked cuticle homolog 1 (Drosophila)0.014
Nkg7natural killer cell group 7 sequence0.014
Mycbp2MYC binding protein 20.014
Notch2Notch homolog 2 (Drosophila)0.014
Cyp2f4cytochrome P450, family 2, subfamily f, polypeptide 40.013
Icam2intercellular adhesion molecule 20.013
Tfectranscription factor EC0.013
S100a8S100 calcium binding protein A80.013
Gfi1growth factor independent 1 transcription repressor0.013
Tgm1transglutaminase 1, K polypeptide0.013
Gm2aGM2 ganglioside activator0.012
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.012
Fut2fucosyltransferase 2 (secretor status included)0.011
Rassf1Ras association (RalGDS/AF-6) domain family member 10.011
Gp5glycoprotein V (platelet)0.011
Ces1dcarboxylesterase 1D0.011
P2ry14purinergic receptor P2Y, G-protein coupled, 140.011
Mobpmyelin-associated oligodendrocyte basic protein0.011
Gzmagranzyme A0.011
Tcf12transcription factor 120.011
Nfibnuclear factor I/B0.011
Smad1SMAD family member 10.010
Psgb1pregnancy-specific beta 1-glycoprotein0.010
Igsf6immunoglobulin superfamily, member 60.010
Trem2triggering receptor expressed on myeloid cells 20.010
RT1-A3RT1 class I, locus A30.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism