The network for 'immune response regulating cell surface receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

immune response regulating cell surface receptor signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response.

NameDescriptionProbabilityFunc Analog Organism
LCKlymphocyte-specific protein tyrosine kinase1.000
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.999
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.997
LATlinker for activation of T cells0.997
FYBFYN binding protein0.994
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.990
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.990
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.978
PTK2PTK2 protein tyrosine kinase 20.967
EGFRepidermal growth factor receptor0.948
B2Mbeta-2-microglobulin0.946
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.933
SH2D1ASH2 domain containing 1A0.915
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.912
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.882
SHC1SHC (Src homology 2 domain containing) transforming protein 10.862
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.860
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.860
CD80CD80 molecule0.852
CD2CD2 molecule0.848
HCKhemopoietic cell kinase0.841
HLA-Amajor histocompatibility complex, class I, A0.824
NCK1NCK adaptor protein 10.815
HLA-Gmajor histocompatibility complex, class I, G0.805
GHRgrowth hormone receptor0.790
PTPN6protein tyrosine phosphatase, non-receptor type 60.789
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.774
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.720
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.716
BTN3A2butyrophilin, subfamily 3, member A20.712
BCL2L1BCL2-like 10.667
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.661
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.654
PTPRCprotein tyrosine phosphatase, receptor type, C0.644
SYKspleen tyrosine kinase0.621
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.604
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.599
PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.596
BTN3A1butyrophilin, subfamily 3, member A10.582
BCL2L11BCL2-like 11 (apoptosis facilitator)0.569
BTN3A3butyrophilin, subfamily 3, member A30.537
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.535
HLA-Fmajor histocompatibility complex, class I, F0.534
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.523
HLA-Bmajor histocompatibility complex, class I, B0.513
CD247CD247 molecule0.502
MPDZmultiple PDZ domain protein0.483
SH3BP2SH3-domain binding protein 20.475
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.463
MAPK1mitogen-activated protein kinase 10.462
TFF1trefoil factor 10.459
GAB1GRB2-associated binding protein 10.458
CTLA4cytotoxic T-lymphocyte-associated protein 40.454
SOS1son of sevenless homolog 1 (Drosophila)0.444
GRB2growth factor receptor-bound protein 20.433
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.395
RNF31ring finger protein 310.367
FHL2four and a half LIM domains 20.355
PRKCQprotein kinase C, theta0.352
CD86CD86 molecule0.331
SLASrc-like-adaptor0.329
CD79ACD79a molecule, immunoglobulin-associated alpha0.328
CCR1chemokine (C-C motif) receptor 10.325
VAV1vav 1 guanine nucleotide exchange factor0.322
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.318
FCGR3BFc fragment of IgG, low affinity IIIb, receptor (CD16b)0.316
CARD11caspase recruitment domain family, member 110.307
SLAMF1signaling lymphocytic activation molecule family member 10.306
PXNpaxillin0.294
CD84CD84 molecule0.291
SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.276
BIRC3baculoviral IAP repeat containing 30.266
FASLGFas ligand (TNF superfamily, member 6)0.264
CD79BCD79b molecule, immunoglobulin-associated beta0.262
SIGLEC7sialic acid binding Ig-like lectin 70.256
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.253
HLA-Emajor histocompatibility complex, class I, E0.252
HK3hexokinase 3 (white cell)0.242
TRAF1TNF receptor-associated factor 10.232
SMURF1SMAD specific E3 ubiquitin protein ligase 10.232
NCK2NCK adaptor protein 20.231
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.227
LILRA2leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 20.220
PTPRJprotein tyrosine phosphatase, receptor type, J0.214
HDAC7histone deacetylase 70.211
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.200
PLCG1phospholipase C, gamma 10.199
HLA-Cmajor histocompatibility complex, class I, C0.198
BCL2B-cell CLL/lymphoma 20.198
CD40CD40 molecule, TNF receptor superfamily member 50.191
AQP9aquaporin 90.188
BADBCL2-associated agonist of cell death0.178
FYNFYN oncogene related to SRC, FGR, YES0.178
PTK2BPTK2B protein tyrosine kinase 2 beta0.169
BAXBCL2-associated X protein0.169
BIDBH3 interacting domain death agonist0.168
CD22CD22 molecule0.167
CD163CD163 molecule0.163
SPRR2Asmall proline-rich protein 2A0.162
LPXNleupaxin0.161
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Inpp5dinositol polyphosphate-5-phosphatase D1.000
Slamf1signaling lymphocytic activation molecule family member 10.999
Cd19CD19 antigen0.997
Grb2growth factor receptor bound protein 20.989
FynFyn proto-oncogene0.986
Ccr2chemokine (C-C motif) receptor 20.985
Tlr4toll-like receptor 40.975
Icosinducible T-cell co-stimulator0.974
Myd88myeloid differentiation primary response gene 880.968
Ptprcprotein tyrosine phosphatase, receptor type, C0.966
Tnftumor necrosis factor0.965
Cd22CD22 antigen0.962
Cd5CD5 antigen0.960
Dok1docking protein 10.954
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.952
FaslFas ligand (TNF superfamily, member 6)0.950
Ptk2PTK2 protein tyrosine kinase 20.941
CblCasitas B-lineage lymphoma0.933
Vav1vav 1 oncogene0.931
Il2rbinterleukin 2 receptor, beta chain0.930
Stat3signal transducer and activator of transcription 30.928
Ptenphosphatase and tensin homolog0.926
Sykbspleen tyrosine kinase0.926
Ikzf1IKAROS family zinc finger 10.899
FasFas (TNF receptor superfamily member 6)0.898
FcrlaFc receptor-like A0.879
Klrd1killer cell lectin-like receptor, subfamily D, member 10.865
BlkB lymphoid kinase0.851
Cdh5cadherin 50.847
Cd40CD40 antigen0.837
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.834
Sfpi1SFFV proviral integration 10.814
Klra9killer cell lectin-like receptor subfamily A, member 90.802
Cd2CD2 antigen0.801
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.797
ItkIL2-inducible T-cell kinase0.796
Ccr7chemokine (C-C motif) receptor 70.794
Zap70zeta-chain (TCR) associated protein kinase0.769
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.766
Latlinker for activation of T cells0.766
Ccr1chemokine (C-C motif) receptor 10.757
Gimap7GTPase, IMAP family member 70.750
Slamf6SLAM family member 60.748
Cd180CD180 antigen0.742
Cd6CD6 antigen0.727
Ncr1natural cytotoxicity triggering receptor 10.727
Tlr2toll-like receptor 20.712
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.700
Pyhin1pyrin and HIN domain family, member 10.698
Sh2d1aSH2 domain protein 1A0.689
Cd7CD7 antigen0.683
Cr2complement receptor 20.677
WasWiskott-Aldrich syndrome homolog (human)0.657
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.652
Sellselectin, lymphocyte0.646
Jak2Janus kinase 20.634
Il10interleukin 100.628
Igkimmunoglobulin kappa chain complex0.627
Vav2vav 2 oncogene0.606
Pou2af1POU domain, class 2, associating factor 10.602
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.598
Fcer2aFc receptor, IgE, low affinity II, alpha polypeptide0.594
Lyz2lysozyme 20.591
Nkg7natural killer cell group 7 sequence0.584
Ccr6chemokine (C-C motif) receptor 60.584
Il18rapinterleukin 18 receptor accessory protein0.581
Itgalintegrin alpha L0.579
Rasgrp1RAS guanyl releasing protein 10.576
Flt1FMS-like tyrosine kinase 10.575
Cd44CD44 antigen0.575
Cd4CD4 antigen0.567
BtkBruton agammaglobulinemia tyrosine kinase0.548
Gzmagranzyme A0.540
Fcgr1Fc receptor, IgG, high affinity I0.538
Ifnginterferon gamma0.527
Il10rainterleukin 10 receptor, alpha0.521
Cd80CD80 antigen0.516
Ptpn6protein tyrosine phosphatase, non-receptor type 60.514
Cd96CD96 antigen0.507
Rhohras homolog gene family, member H0.506
Cd3eCD3 antigen, epsilon polypeptide0.503
Tnfrsf13ctumor necrosis factor receptor superfamily, member 13c0.500
Dok2docking protein 20.494
Aoahacyloxyacyl hydrolase0.488
Tnfrsf13btumor necrosis factor receptor superfamily, member 13b0.485
Xcr1chemokine (C motif) receptor 10.477
Casp8caspase 80.473
Itgaxintegrin alpha X0.472
Cd8b1CD8 antigen, beta chain 10.467
Il4interleukin 40.443
SrcRous sarcoma oncogene0.443
Klrk1killer cell lectin-like receptor subfamily K, member 10.442
Map3k7mitogen-activated protein kinase kinase kinase 70.441
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.440
Gzmbgranzyme B0.434
Ms4a4cmembrane-spanning 4-domains, subfamily A, member 4C0.434
Ccr5chemokine (C-C motif) receptor 50.431
Msr1macrophage scavenger receptor 10.427
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.426
Plcg1phospholipase C, gamma 10.420
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ptprcprotein tyrosine phosphatase, receptor type, C0.645
Il2rginterleukin 2 receptor, gamma0.409
Igsf6immunoglobulin superfamily, member 60.291
Inpp5dinositol polyphosphate-5-phosphatase D0.246
Cybbcytochrome b-245, beta polypeptide0.236
Ctsecathepsin E0.221
Vav1vav 1 guanine nucleotide exchange factor0.220
Cd86CD86 molecule0.160
Ccr5chemokine (C-C motif) receptor 50.154
Lcp2lymphocyte cytosolic protein 20.132
Dock8dedicator of cytokinesis 80.104
Sykspleen tyrosine kinase0.091
Ptpn18protein tyrosine phosphatase, non-receptor type 180.089
Cd37CD37 molecule0.083
Ncf4neutrophil cytosolic factor 40.077
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.074
Slasrc-like adaptor0.069
Ptpn6protein tyrosine phosphatase, non-receptor type 60.064
Bin2bridging integrator 20.060
Casp1caspase 10.054
Arhgap25Rho GTPase activating protein 250.054
Hckhemopoietic cell kinase0.053
Prf1perforin 1 (pore forming protein)0.052
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.048
Rac2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.047
Cd3gCD3 molecule, gamma0.046
Il1binterleukin 1 beta0.040
Ciitaclass II, major histocompatibility complex, transactivator0.038
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.035
Arhgap9Rho GTPase activating protein 90.033
Ptafrplatelet-activating factor receptor0.033
Hcls1hematopoietic cell specific Lyn substrate 10.032
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.032
Plcg2phospholipase C, gamma 20.031
Serpinb1aserine (or cysteine) proteinase inhibitor, clade B, member 1a0.030
LOC100361706lambda-chain C1-region-like0.030
Ms4a11membrane-spanning 4-domains, subfamily A, member 110.029
Mobkl2aMOB1, Mps One Binder kinase activator-like 2A (yeast)0.029
Mca32mast cell antigen 320.027
Sellselectin L0.026
Aif1allograft inflammatory factor 10.026
Myo1fmyosin IF0.025
Clec4a3C-type lectin domain family 4, member a30.024
Folr2folate receptor 2 (fetal)0.024
Slfn2schlafen 20.024
Sirpasignal-regulatory protein alpha0.024
Arrb2arrestin, beta 20.023
Fgl2fibrinogen-like 20.023
Lcp1lymphocyte cytosolic protein 10.022
Arhgap4Rho GTPase activating protein 40.022
Ly86lymphocyte antigen 860.022
Cd53Cd53 molecule0.021
LOC100364854similar to RIKEN cDNA A430107P09 gene-like0.021
Cd22CD22 molecule0.021
Csf1rcolony stimulating factor 1 receptor0.021
Cd2Cd2 molecule0.021
Cd68Cd68 molecule0.020
Arl11ADP-ribosylation factor-like 110.020
Slc15a3solute carrier family 15, member 30.019
Phemxpan hematopoietic expression0.019
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.018
Lcklymphocyte-specific protein tyrosine kinase0.018
TyrobpTyro protein tyrosine kinase binding protein0.018
Itgb7integrin, beta 70.017
LOC308990hypothetical protein LOC3089900.017
Psd4pleckstrin and Sec7 domain containing 40.017
Cd4Cd4 molecule0.016
Tnfaip8l2tumor necrosis factor, alpha-induced protein 8-like 20.016
Tbxas1thromboxane A synthase 1, platelet0.016
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.016
Sit1signaling threshold regulating transmembrane adaptor 10.016
Cd8aCD8a molecule0.016
Stap1signal transducing adaptor family member 10.016
Cd38CD38 molecule0.016
BtkBruton agammaglobulinemia tyrosine kinase0.015
Cxcr3chemokine (C-X-C motif) receptor 30.015
Cfpcomplement factor properdin0.014
Igh-6immunoglobulin heavy chain 60.014
Clec4a1C-type lectin domain family 4, member a10.014
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.013
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.013
Rhohras homolog gene family, member H0.012
Sash3SAM and SH3 domain containing 30.012
Arl5cADP-ribosylation factor-like 5C0.012
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.012
LOC687856similar to Myeloid cell surface antigen CD33 precursor (Siglec-3)0.012
Slamf9SLAM family member 90.012
CebpeCCAAT/enhancer binding protein (C/EBP), epsilon0.012
Klhl6kelch-like 6 (Drosophila)0.012
Adfpadipose differentiation related protein0.012
Dok2docking protein 20.011
Map4k1mitogen activated protein kinase kinase kinase kinase 10.011
Cmtm6CKLF-like MARVEL transmembrane domain containing 60.011
Cd8bCD8b molecule0.011
RGD1561143similar to cell surface receptor FDFACT0.011
Cd83CD83 molecule0.011
Fermt3fermitin family homolog 3 (Drosophila)0.011
Mov10Moloney leukemia virus 100.011
Icosinducible T-cell co-stimulator0.011
Soat1sterol O-acyltransferase 10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism