The network for 'regulation of histone h3 k27 methylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of histone h3 k27 methylation

Any process that modulates the rate, frequency, or extent of histone H3-K27 methylation. Histone H3-K27 methylation is the modification of histone H3 by addition of a methyl group to lysine at position 27 of the histone.

Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EZH2enhancer of zeste homolog 2 (Drosophila)0.998
SUZ12suppressor of zeste 12 homolog (Drosophila)0.989
DNMT1DNA (cytosine-5-)-methyltransferase 10.772
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.622
CBX5chromobox homolog 50.256
UHRF1ubiquitin-like with PHD and ring finger domains 10.240
SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila)0.210
CTCFCCCTC-binding factor (zinc finger protein)0.113
TCERG1transcription elongation regulator 10.103
SUV39H2suppressor of variegation 3-9 homolog 2 (Drosophila)0.094
MGEA5meningioma expressed antigen 5 (hyaluronidase)0.094
RBM39RNA binding motif protein 390.073
SRSF5serine/arginine-rich splicing factor 50.051
BMI1BMI1 polycomb ring finger oncogene0.044
GOLGA8Bgolgin A8 family, member B0.044
DNMT3ADNA (cytosine-5-)-methyltransferase 3 alpha0.043
HDAC2histone deacetylase 20.039
EEDembryonic ectoderm development0.037
SUPT5Hsuppressor of Ty 5 homolog (S. cerevisiae)0.037
CPSF6cleavage and polyadenylation specific factor 6, 68kDa0.033
CREBZFCREB/ATF bZIP transcription factor0.030
DEKDEK oncogene0.028
XPO1exportin 1 (CRM1 homolog, yeast)0.026
HDAC1histone deacetylase 10.025
ASXL1additional sex combs like 1 (Drosophila)0.025
POLA2polymerase (DNA directed), alpha 2 (70kD subunit)0.023
KLHDC4kelch domain containing 40.023
LUC7L3LUC7-like 3 (S. cerevisiae)0.023
SRSF7serine/arginine-rich splicing factor 70.022
C5orf54chromosome 5 open reading frame 540.021
HMGB2high mobility group box 20.020
BCL11BB-cell CLL/lymphoma 11B (zinc finger protein)0.018
RBBP4retinoblastoma binding protein 40.018
ADNPactivity-dependent neuroprotector homeobox0.018
LBRlamin B receptor0.016
GSTCDglutathione S-transferase, C-terminal domain containing0.015
VAMP2vesicle-associated membrane protein 2 (synaptobrevin 2)0.015
RBPMSRNA binding protein with multiple splicing0.014
SRSF4serine/arginine-rich splicing factor 40.013
RBM15RNA binding motif protein 150.013
C8orf74chromosome 8 open reading frame 740.013
KIAA0907KIAA09070.013
RNF2ring finger protein 20.012
SF3B1splicing factor 3b, subunit 1, 155kDa0.012
PNNpinin, desmosome associated protein0.012
WSB1WD repeat and SOCS box containing 10.012
MIS18BP1MIS18 binding protein 10.011
RBM25RNA binding motif protein 250.011
DUSP23dual specificity phosphatase 230.011
CHD8chromodomain helicase DNA binding protein 80.011
PRKD2protein kinase D20.011
SNF8SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)0.011
CELF1CUGBP, Elav-like family member 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
PcPolycomb0.201
cgcombgap0.071
gtgiant0.039
osaCG7467 gene product from transcript CG7467-RD0.027
ScmSex comb on midleg0.023
dvedefective proventriculus0.016
CTCFCG8591 gene product from transcript CG8591-RA0.016
polybromoCG11375 gene product from transcript CG11375-RA0.015
Su(z)12CG8013 gene product from transcript CG8013-RA0.012
ttvtout-velu0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Jarid2jumonji, AT rich interactive domain 20.993
Ezh2enhancer of zeste homolog 2 (Drosophila)0.921
Ezh1enhancer of zeste homolog 1 (Drosophila)0.838
Stk38serine/threonine kinase 380.789
Suz12suppressor of zeste 12 homolog (Drosophila)0.707
Gata6GATA binding protein 60.693
Eedembryonic ectoderm development0.481
Rxraretinoid X receptor alpha0.285
Clk4CDC like kinase 40.239
Tal1T-cell acute lymphocytic leukemia 10.174
Rbbp4retinoblastoma binding protein 40.164
Mtf2metal response element binding transcription factor 20.136
Aebp2AE binding protein 20.128
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.109
Setxsenataxin0.088
Ttc14tetratricopeptide repeat domain 140.081
HgsHGF-regulated tyrosine kinase substrate0.047
Zfp187zinc finger protein 1870.040
Klf3Kruppel-like factor 3 (basic)0.035
Notch1Notch gene homolog 1 (Drosophila)0.028
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.028
Gata4GATA binding protein 40.025
Smad6MAD homolog 6 (Drosophila)0.025
Slamf1signaling lymphocytic activation molecule family member 10.024
Rnf2ring finger protein 20.024
Zfpm2zinc finger protein, multitype 20.023
Klf1Kruppel-like factor 1 (erythroid)0.021
Hoxa1homeobox A10.018
Ellelongation factor RNA polymerase II0.018
S1pr2sphingosine-1-phosphate receptor 20.015
Myo6myosin VI0.014
Snai1snail homolog 1 (Drosophila)0.014
Fgf8fibroblast growth factor 80.014
Mybmyeloblastosis oncogene0.013
Runx1runt related transcription factor 10.012
Jag1jagged 10.012
Gfi1bgrowth factor independent 1B0.012
Pparaperoxisome proliferator activated receptor alpha0.012
P2rx1purinergic receptor P2X, ligand-gated ion channel, 10.011
CrebzfCREB/ATF bZIP transcription factor0.011
Elf4E74-like factor 4 (ets domain transcription factor)0.011
Chd7chromodomain helicase DNA binding protein 70.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism