The network for 'response to tumor necrosis factor' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to tumor necrosis factor

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.

NameDescriptionProbabilityFunc Analog Organism
TRAF2TNF receptor-associated factor 20.997
BIRC3baculoviral IAP repeat containing 30.995
CASP8caspase 8, apoptosis-related cysteine peptidase0.989
TRAF1TNF receptor-associated factor 10.986
PTPN1protein tyrosine phosphatase, non-receptor type 10.975
ZNF43zinc finger protein 430.948
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.945
FASFas (TNF receptor superfamily, member 6)0.942
TRADDTNFRSF1A-associated via death domain0.864
C1QAcomplement component 1, q subcomponent, A chain0.856
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.813
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.809
MAP3K5mitogen-activated protein kinase kinase kinase 50.805
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.801
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.793
RIPK2receptor-interacting serine-threonine kinase 20.780
BCAR1breast cancer anti-estrogen resistance 10.766
TANKTRAF family member-associated NFKB activator0.724
ZNF253zinc finger protein 2530.659
BIRC2baculoviral IAP repeat containing 20.657
ZNF273zinc finger protein 2730.656
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.647
CXCL9chemokine (C-X-C motif) ligand 90.642
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.636
CXCL10chemokine (C-X-C motif) ligand 100.632
CASP3caspase 3, apoptosis-related cysteine peptidase0.624
TRAF3TNF receptor-associated factor 30.608
IFNGR1interferon gamma receptor 10.606
CD40CD40 molecule, TNF receptor superfamily member 50.562
CXCL3chemokine (C-X-C motif) ligand 30.547
IL8interleukin 80.541
XIAPX-linked inhibitor of apoptosis0.522
INSRinsulin receptor0.498
ZNF675zinc finger protein 6750.496
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.488
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.469
IL4Rinterleukin 4 receptor0.442
TRAF5TNF receptor-associated factor 50.436
MAP3K14mitogen-activated protein kinase kinase kinase 140.418
NMIN-myc (and STAT) interactor0.417
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.406
EGFRepidermal growth factor receptor0.393
ZNF260zinc finger protein 2600.391
CCL2chemokine (C-C motif) ligand 20.386
CCR5chemokine (C-C motif) receptor 50.381
MAP2K4mitogen-activated protein kinase kinase 40.377
MAP3K7mitogen-activated protein kinase kinase kinase 70.376
CASP7caspase 7, apoptosis-related cysteine peptidase0.375
CXCL2chemokine (C-X-C motif) ligand 20.371
CCL8chemokine (C-C motif) ligand 80.369
JAK2Janus kinase 20.368
ICAM1intercellular adhesion molecule 10.368
SOCS3suppressor of cytokine signaling 30.357
MAP3K1mitogen-activated protein kinase kinase kinase 10.354
MAPK8mitogen-activated protein kinase 80.349
CFLARCASP8 and FADD-like apoptosis regulator0.343
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.338
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.313
TNFtumor necrosis factor0.310
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.278
ZNF91zinc finger protein 910.275
NLRC4NLR family, CARD domain containing 40.274
IFNAR2interferon (alpha, beta and omega) receptor 20.272
MAFGv-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)0.271
CXCL5chemokine (C-X-C motif) ligand 50.267
CAV1caveolin 1, caveolae protein, 22kDa0.259
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.250
KEAP1kelch-like ECH-associated protein 10.248
CCL4chemokine (C-C motif) ligand 40.246
APAF1apoptotic peptidase activating factor 10.244
ZNF85zinc finger protein 850.239
SOD2superoxide dismutase 2, mitochondrial0.231
TAL1T-cell acute lymphocytic leukemia 10.231
CCL5chemokine (C-C motif) ligand 50.228
NOSTRINnitric oxide synthase trafficker0.227
MMP12matrix metallopeptidase 12 (macrophage elastase)0.222
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.221
IL2RBinterleukin 2 receptor, beta0.220
IL1Binterleukin 1, beta0.216
IRAK1interleukin-1 receptor-associated kinase 10.216
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.207
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.207
ABI2abl-interactor 20.207
APOC1apolipoprotein C-I0.205
INADLInaD-like (Drosophila)0.203
CXCL11chemokine (C-X-C motif) ligand 110.201
MAPK1mitogen-activated protein kinase 10.198
C1QCcomplement component 1, q subcomponent, C chain0.194
ZNF708zinc finger protein 7080.193
ZNF430zinc finger protein 4300.192
ZNF93zinc finger protein 930.192
MAP3K11mitogen-activated protein kinase kinase kinase 110.191
DPP4dipeptidyl-peptidase 40.190
CASP9caspase 9, apoptosis-related cysteine peptidase0.189
TNFAIP3tumor necrosis factor, alpha-induced protein 30.188
PTPN11protein tyrosine phosphatase, non-receptor type 110.173
IRF1interferon regulatory factor 10.172
SLAMF8SLAM family member 80.170
MDM4Mdm4 p53 binding protein homolog (mouse)0.169
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.166
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor1.000
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.998
Ccl2chemokine (C-C motif) ligand 20.973
Ltalymphotoxin A0.860
Ikbkginhibitor of kappaB kinase gamma0.819
Il1r1interleukin 1 receptor, type I0.775
Map3k14mitogen-activated protein kinase kinase kinase 140.716
Krt5keratin 50.642
Tnfaip3tumor necrosis factor, alpha-induced protein 30.617
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.615
Cxcl13chemokine (C-X-C motif) ligand 130.598
Apoeapolipoprotein E0.592
Casp4caspase 4, apoptosis-related cysteine peptidase0.570
Socs1suppressor of cytokine signaling 10.553
Ppargperoxisome proliferator activated receptor gamma0.527
Csf1colony stimulating factor 1 (macrophage)0.517
Stat3signal transducer and activator of transcription 30.498
Tlr4toll-like receptor 40.489
Nos1nitric oxide synthase 1, neuronal0.482
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.482
Mdm2transformed mouse 3T3 cell double minute 20.476
Trp53transformation related protein 530.467
Cd44CD44 antigen0.440
Myd88myeloid differentiation primary response gene 880.421
Map3k7mitogen-activated protein kinase kinase kinase 70.413
Arandrogen receptor0.399
Ptenphosphatase and tensin homolog0.397
Ccr1chemokine (C-C motif) receptor 10.393
Krt17keratin 170.372
Ccl7chemokine (C-C motif) ligand 70.360
Lyz2lysozyme 20.360
Il6interleukin 60.358
Traf2TNF receptor-associated factor 20.356
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.345
Leprleptin receptor0.334
Ighimmunoglobulin heavy chain complex0.315
Ifnginterferon gamma0.293
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.287
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.283
Ptgs2prostaglandin-endoperoxide synthase 20.269
Tnfrsf18tumor necrosis factor receptor superfamily, member 180.254
Krtap8-1keratin associated protein 8-10.236
Ltblymphotoxin B0.233
Ccl4chemokine (C-C motif) ligand 40.232
Rnf31ring finger protein 310.221
Pkp1plakophilin 10.212
Cd40CD40 antigen0.203
Traf6TNF receptor-associated factor 60.200
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.187
Krt33bkeratin 33B0.187
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.186
Casp1caspase 10.182
Icam1intercellular adhesion molecule 10.176
Ch25hcholesterol 25-hydroxylase0.165
Il1binterleukin 1 beta0.162
Sprr1asmall proline-rich protein 1A0.159
Saa3serum amyloid A 30.158
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.157
Krt6akeratin 6A0.153
Il1rninterleukin 1 receptor antagonist0.149
Irf1interferon regulatory factor 10.147
C3complement component 30.146
Thbs1thrombospondin 10.146
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.144
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.140
Ccl8chemokine (C-C motif) ligand 80.138
Ikbkbinhibitor of kappaB kinase beta0.137
Ccr2chemokine (C-C motif) receptor 20.135
Ccl12chemokine (C-C motif) ligand 120.133
Socs3suppressor of cytokine signaling 30.133
Selpselectin, platelet0.133
Cxcl2chemokine (C-X-C motif) ligand 20.128
Clec4dC-type lectin domain family 4, member d0.119
Krt14keratin 140.118
Nlrp3NLR family, pyrin domain containing 30.114
Krt35keratin 350.113
Has1hyaluronan synthase10.110
Bcl3B-cell leukemia/lymphoma 30.109
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.107
Mef2dmyocyte enhancer factor 2D0.107
Ncoa3nuclear receptor coactivator 30.103
Krtap3-1keratin associated protein 3-10.102
Ccl3chemokine (C-C motif) ligand 30.101
SharpinSHANK-associated RH domain interacting protein0.099
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.097
Irg1immunoresponsive gene 10.096
Tlr2toll-like receptor 20.094
Ccl17chemokine (C-C motif) ligand 170.086
Birc3baculoviral IAP repeat-containing 30.086
S100a8S100 calcium binding protein A8 (calgranulin A)0.085
Krt86keratin 860.085
Cxcr5chemokine (C-X-C motif) receptor 50.081
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.081
Ptpn11protein tyrosine phosphatase, non-receptor type 110.080
Hif1ahypoxia inducible factor 1, alpha subunit0.078
Il10interleukin 100.072
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.071
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Col1a1collagen, type I, alpha 10.906
Cxcl10chemokine (C-X-C motif) ligand 100.902
Ccl2chemokine (C-C motif) ligand 20.882
Cxcl2chemokine (C-X-C motif) ligand 20.868
Mmp12matrix metallopeptidase 120.808
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.806
Il6interleukin 60.621
Il1binterleukin 1 beta0.619
Col3a1collagen, type III, alpha 10.560
Mobpmyelin-associated oligodendrocyte basic protein0.529
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.522
Tnftumor necrosis factor (TNF superfamily, member 2)0.462
Ccl4chemokine (C-C motif) ligand 40.450
Tgm1transglutaminase 1, K polypeptide0.445
Col1a2collagen, type I, alpha 20.444
Mmp3matrix metallopeptidase 30.430
Ccl7chemokine (C-C motif) ligand 70.381
Col5a1collagen, type V, alpha 10.360
Cd14CD14 molecule0.354
Orm1orosomucoid 10.338
Krt18keratin 180.325
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.324
Col5a2collagen, type V, alpha 20.317
Hckhemopoietic cell kinase0.308
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.300
Calcbcalcitonin-related polypeptide, beta0.285
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.276
Postnperiostin, osteoblast specific factor0.255
Ggt1gamma-glutamyltransferase 10.248
Il4rainterleukin 4 receptor, alpha0.240
Neurl3neuralized homolog 3 (Drosophila)0.233
Ccl3chemokine (C-C motif) ligand 30.214
Gpx2glutathione peroxidase 20.214
Crhr1corticotropin releasing hormone receptor 10.205
Clec9aC-type lectin domain family 9, member a0.200
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.197
Ptpn11protein tyrosine phosphatase, non-receptor type 110.182
Slc13a1solute carrier family 13 (sodium/sulfate symporters), member 10.169
Cd86CD86 molecule0.169
Anxa1annexin A10.167
Col14a1collagen, type XIV, alpha 10.166
Stc1stanniocalcin 10.152
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.149
Birc3baculoviral IAP repeat-containing 30.149
Myd88myeloid differentiation primary response gene 880.146
Rhojras homolog gene family, member J0.145
Gja4gap junction protein, alpha 40.143
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.143
Pspparotid secretory protein0.140
Fosl1fos-like antigen 10.140
Stat3signal transducer and activator of transcription 30.136
Ifnginterferon gamma0.135
Stat6signal transducer and activator of transcription 60.128
Nkx6-1NK6 homeobox 10.126
Ripk3receptor-interacting serine-threonine kinase 30.125
P2ry2purinergic receptor P2Y, G-protein coupled, 20.124
Lilrb4leukocyte immunoglobulin-like receptor, subfamily B, member 40.123
Reg3gregenerating islet-derived 3 gamma0.118
Syt6synaptotagmin VI0.116
Litaflipopolysaccharide-induced TNF factor0.115
Bcl2B-cell CLL/lymphoma 20.115
Ece1endothelin converting enzyme 10.110
Il1rninterleukin 1 receptor antagonist0.110
Nfkbienuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.107
Ppardperoxisome proliferator-activated receptor delta0.105
Hmox1heme oxygenase (decycling) 10.105
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.103
Gja3gap junction protein, alpha 30.102
Selpselectin P0.101
Ier3immediate early response 30.101
Ltbrlymphotoxin beta receptor (TNFR superfamily, member 3)0.100
Ctskcathepsin K0.096
Prss22protease, serine, 220.096
Dab2disabled homolog 2 (Drosophila)0.094
Inhbainhibin beta-A0.093
Arl5cADP-ribosylation factor-like 5C0.091
Mmp2matrix metallopeptidase 20.089
Rhox5reproductive homeobox 50.089
Col12a1collagen, type XII, alpha 10.088
Chrnb3cholinergic receptor, nicotinic, beta 30.088
Flt1FMS-related tyrosine kinase 10.088
Mmp13matrix metallopeptidase 130.088
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.087
Sbno2strawberry notch homolog 2 (Drosophila)0.087
MosMoloney sarcoma oncogene0.085
Col4a2collagen, type IV, alpha 20.085
Gssglutathione synthetase0.085
Cd8aCD8a molecule0.083
Cnp2',3'-cyclic nucleotide 3' phosphodiesterase0.083
Bdkrb2bradykinin receptor B20.082
RT1-BaRT1 class II, locus Ba0.082
Nrg1neuregulin 10.082
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.081
Steap1six transmembrane epithelial antigen of the prostate 10.081
Mvpmajor vault protein0.080
Runx1runt-related transcription factor 10.080
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism