The network for 'rac protein signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

rac protein signal transduction

A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state.

NameDescriptionProbabilityFunc Analog Organism
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.999
NCK1NCK adaptor protein 10.973
GAS7growth arrest-specific 70.964
NCKAP1NCK-associated protein 10.868
ABI1abl-interactor 10.854
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.690
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.669
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.630
EGFRepidermal growth factor receptor0.619
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.578
PFDN1prefoldin subunit 10.459
WASF1WAS protein family, member 10.391
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.330
ARFIP2ADP-ribosylation factor interacting protein 20.325
FMR1fragile X mental retardation 10.315
ZNF746zinc finger protein 7460.302
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.294
RAB1ARAB1A, member RAS oncogene family0.293
SH3KBP1SH3-domain kinase binding protein 10.287
PRR5proline rich 5 (renal)0.284
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.268
CYFIP2cytoplasmic FMR1 interacting protein 20.255
PRDX1peroxiredoxin 10.254
CTNND1catenin (cadherin-associated protein), delta 10.212
BCRbreakpoint cluster region0.201
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.198
RICTORRPTOR independent companion of MTOR, complex 20.197
ABI2abl-interactor 20.197
EFNA1ephrin-A10.186
ADAM19ADAM metallopeptidase domain 190.178
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.175
DSG2desmoglein 20.171
NCK2NCK adaptor protein 20.164
DOCK1dedicator of cytokinesis 10.158
RPTORregulatory associated protein of MTOR, complex 10.154
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.146
PRKCAprotein kinase C, alpha0.144
NLRC4NLR family, CARD domain containing 40.140
SPAG9sperm associated antigen 90.139
ATN1atrophin 10.138
SPRR2Asmall proline-rich protein 2A0.135
MTORmechanistic target of rapamycin (serine/threonine kinase)0.134
AKT1S1AKT1 substrate 1 (proline-rich)0.130
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.127
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.122
HIPK2homeodomain interacting protein kinase 20.122
NCF4neutrophil cytosolic factor 4, 40kDa0.121
BAIAP2BAI1-associated protein 20.116
PLCG1phospholipase C, gamma 10.114
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.113
MAP3K1mitogen-activated protein kinase kinase kinase 10.113
JUPjunction plakoglobin0.109
TXNthioredoxin0.106
NCF1neutrophil cytosolic factor 10.099
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.093
SORBS3sorbin and SH3 domain containing 30.089
WASF2WAS protein family, member 20.087
PDE4DIPphosphodiesterase 4D interacting protein0.086
EPHA7EPH receptor A70.081
LST1leukocyte specific transcript 10.080
SOS1son of sevenless homolog 1 (Drosophila)0.076
RAB6ARAB6A, member RAS oncogene family0.075
DSPdesmoplakin0.075
EPS8epidermal growth factor receptor pathway substrate 80.073
SH2D4ASH2 domain containing 4A0.073
HCLS1hematopoietic cell-specific Lyn substrate 10.072
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.071
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.071
DNM2dynamin 20.070
EFHD2EF-hand domain family, member D20.070
MEFVMediterranean fever0.069
PREX1phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 10.069
PVRL2poliovirus receptor-related 2 (herpesvirus entry mediator B)0.066
PRKAA1protein kinase, AMP-activated, alpha 1 catalytic subunit0.063
DEPTORDEP domain containing MTOR-interacting protein0.060
NTF4neurotrophin 40.060
FKBP1AFK506 binding protein 1A, 12kDa0.058
ADRBK1adrenergic, beta, receptor kinase 10.056
NCKIPSDNCK interacting protein with SH3 domain0.056
PTK2PTK2 protein tyrosine kinase 20.055
HCKhemopoietic cell kinase0.053
SKP1S-phase kinase-associated protein 10.052
CYFIP1cytoplasmic FMR1 interacting protein 10.052
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.051
PRR5Lproline rich 5 like0.051
UBE2R2ubiquitin-conjugating enzyme E2R 20.050
MAPKAP1mitogen-activated protein kinase associated protein 10.049
MSH5mutS homolog 5 (E. coli)0.049
EZRezrin0.047
PIK3AP1phosphoinositide-3-kinase adaptor protein 10.046
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 10.045
FGFR1fibroblast growth factor receptor 10.045
CYTH2cytohesin 20.044
LATlinker for activation of T cells0.043
LZTS2leucine zipper, putative tumor suppressor 20.043
CALM1calmodulin 1 (phosphorylase kinase, delta)0.042
RHOCras homolog gene family, member C0.042
PVRL3poliovirus receptor-related 30.042
PVRL1poliovirus receptor-related 1 (herpesvirus entry mediator C)0.040
GRB10growth factor receptor-bound protein 100.040
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
unc5bunc-5 homolog B (C. elegans)0.029
rc3rabconnectin 30.015
ext2exostoses (multiple) 20.013
lama2laminin, alpha 20.013
pink1PTEN induced putative kinase 10.012
foxp2forkhead box P20.011
ap2a1adaptor-related protein complex 2, alpha 1 subunit0.011
lhx2bLIM homeobox 2b0.011
extl3exostoses (multiple)-like 30.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
mbcmyoblast city0.512
roboroundabout0.396
AbiAbelson interacting protein0.156
Pi3K92ECG4141 gene product from transcript CG4141-RB0.136
CG5794CG5794 gene product from transcript CG5794-RB0.094
Sra-1specifically Rac1-associated protein 10.080
liglingerer0.075
HemHEM-protein0.074
Arf79FADP ribosylation factor 79F0.069
frafrazzled0.064
miminus0.060
numbCG3779 gene product from transcript CG3779-RB0.058
CG2219CG2219 gene product from transcript CG2219-RA0.058
EphrinCG1862 gene product from transcript CG1862-RA0.057
Rac1CG2248 gene product from transcript CG2248-RA0.054
commcommissureless0.054
drkdownstream of receptor kinase0.050
enaenabled0.049
SosSon of sevenless0.049
wtswarts0.048
rapretina aberrant in pattern0.048
RhoGAP93BCG3421 gene product from transcript CG3421-RA0.048
vimarvisceral mesodermal armadillo-repeats0.047
Sh3betaCG8582 gene product from transcript CG8582-RD0.047
p120ctnAdherens junction protein p1200.045
CG7222CG7222 gene product from transcript CG7222-RA0.045
RalaRas-related protein0.044
phlpole hole0.042
dxdeltex0.039
unc-5CG8166 gene product from transcript CG8166-RA0.039
dockdreadlocks0.035
slislit0.035
pod1CG4532 gene product from transcript CG4532-RF0.035
AlkCG8250 gene product from transcript CG8250-RA0.034
trioCG18214 gene product from transcript CG18214-RA0.034
Eip63EEcdysone-induced protein 63E0.034
phopleiohomeotic0.034
bchsblue cheese0.033
rlrolled0.032
Fak56DFocal Adhesion Kinase0.032
InRInsulin-like receptor0.030
MTF-1Metal response element-binding Transcription Factor-10.030
sunstunted0.030
Pk61CProtein kinase 61C0.029
alpha-Catalpha Catenin0.029
CG11178CG11178 gene product from transcript CG11178-RA0.028
putpunt0.028
fogfolded gastrulation0.028
CG8668CG8668 gene product from transcript CG8668-RA0.027
brubrunelleschi0.027
CG31224CG31224 gene product from transcript CG31224-RA0.026
chicoCG5686 gene product from transcript CG5686-RB0.025
CG12024CG12024 gene product from transcript CG12024-RA0.025
RhoGAPp190CG32555 gene product from transcript CG32555-RB0.025
RanBPMRan-binding protein M0.025
plexBplexin B0.024
slikSterile20-like kinase0.024
hppyhappyhour0.024
GitCG16728 gene product from transcript CG16728-RA0.024
alpha-AdaptinCG4260 gene product from transcript CG4260-RA0.023
cdicenter divider0.023
Rab11Rab-protein 110.022
mip130Myb-interacting protein 1300.021
synjsynaptojanin0.021
PtenCG5671 gene product from transcript CG5671-RB0.021
ApcAPC-like0.020
Pi3K21BCG2699 gene product from transcript CG2699-RA0.020
didumdilute class unconventional myosin0.020
reporeversed polarity0.020
Axud1CG4272 gene product from transcript CG4272-RA0.020
Atg1Autophagy-specific gene 10.019
S6kRPS6-p70-protein kinase0.019
CG17184CG17184 gene product from transcript CG17184-RB0.019
CG10641CG10641 gene product from transcript CG10641-RA0.019
sxcsuper sex combs0.018
vavCG7893 gene product from transcript CG7893-RB0.018
smosmoothened0.018
jebjelly belly0.018
RhebCG1081 gene product from transcript CG1081-RA0.018
sqzsqueeze0.018
wbwing blister0.017
savsalvador0.017
Hsc70-5Heat shock protein cognate 50.017
CG4511CG4511 gene product from transcript CG4511-RA0.017
Eps-15Epidermal growth factor receptor pathway substrate clone 150.017
grogroucho0.017
tutlturtle0.016
LnkCG17367 gene product from transcript CG17367-RC0.016
CG8578CG8578 gene product from transcript CG8578-RA0.016
CatCatalase0.016
MAPk-Ak2MAP kinase activated protein-kinase-20.016
CG10960CG10960 gene product from transcript CG10960-RC0.016
CG9063CG9063 gene product from transcript CG9063-RA0.016
l(2)k16918lethal (2) k169180.016
AP-1sigmaCG5864 gene product from transcript CG5864-RA0.016
rnorhinoceros0.016
htlheartless0.015
Sema-1aCG18405 gene product from transcript CG18405-RD0.015
CG12424CG12424 gene product from transcript CG12424-RC0.015
Trim9CG31721 gene product from transcript CG31721-RB0.015
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Efnb2ephrin B21.000
Efnb1ephrin B10.992
Epha4Eph receptor A40.991
Ntf3neurotrophin 30.991
Ptpn11protein tyrosine phosphatase, non-receptor type 110.983
Hey2hairy/enhancer-of-split related with YRPW motif 20.979
Tgfb2transforming growth factor, beta 20.968
Dock1dedicator of cytokinesis 10.947
Abi1abl-interactor 10.941
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.882
Adam17a disintegrin and metallopeptidase domain 170.881
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.862
Egfrepidermal growth factor receptor0.851
Ephb2Eph receptor B20.814
Mapkap1mitogen-activated protein kinase associated protein 10.787
Fgd1FYVE, RhoGEF and PH domain containing 10.767
Jag1jagged 10.737
Gata4GATA binding protein 40.706
Efna4ephrin A40.704
Gli3GLI-Kruppel family member GLI30.681
Klf3Kruppel-like factor 3 (basic)0.680
BrafBraf transforming gene0.675
Grb2growth factor receptor bound protein 20.675
Casp1caspase 10.613
Hif1ahypoxia inducible factor 1, alpha subunit0.579
Dll4delta-like 4 (Drosophila)0.574
Zfpm2zinc finger protein, multitype 20.560
Flt4FMS-like tyrosine kinase 40.557
Mlst8MTOR associated protein, LST8 homolog (S. cerevisiae)0.555
Mtormechanistic target of rapamycin (serine/threonine kinase)0.532
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.522
Retret proto-oncogene0.517
Nck2non-catalytic region of tyrosine kinase adaptor protein 20.482
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.468
Hoxa1homeobox A10.462
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.455
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.437
Gbp5guanylate binding protein 50.436
Wnt5awingless-related MMTV integration site 5A0.415
Hspg2perlecan (heparan sulfate proteoglycan 2)0.403
Ephb4Eph receptor B40.388
Bmp1bone morphogenetic protein 10.387
Gata5GATA binding protein 50.375
Etv1ets variant gene 10.372
Bdnfbrain derived neurotrophic factor0.365
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.360
Arhgef15Rho guanine nucleotide exchange factor (GEF) 150.356
Hey1hairy/enhancer-of-split related with YRPW motif 10.330
Pik3cbphosphatidylinositol 3-kinase, catalytic, beta polypeptide0.324
Sema3fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F0.310
Aim2absent in melanoma 20.310
Tjap1tight junction associated protein 10.298
Rptorregulatory associated protein of MTOR, complex 10.297
Shc1src homology 2 domain-containing transforming protein C10.293
Grip1glutamate receptor interacting protein 10.287
Arpc4actin related protein 2/3 complex, subunit 40.279
Pcdhgb1protocadherin gamma subfamily B, 10.269
Pvrl2poliovirus receptor-related 20.260
Sox9SRY-box containing gene 90.252
Itgb1integrin beta 1 (fibronectin receptor beta)0.250
Hbegfheparin-binding EGF-like growth factor0.245
Mtpnmyotrophin0.243
Vaspvasodilator-stimulated phosphoprotein0.240
Sox18SRY-box containing gene 180.237
Plxna3plexin A30.235
FybFYN binding protein0.234
Sh3rf1SH3 domain containing ring finger 10.231
Jupjunction plakoglobin0.225
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.224
Gli2GLI-Kruppel family member GLI20.223
Col2a1collagen, type II, alpha 10.223
Fgf9fibroblast growth factor 90.222
Fzd2frizzled homolog 2 (Drosophila)0.220
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.216
Casp4caspase 4, apoptosis-related cysteine peptidase0.215
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.204
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.203
Dag1dystroglycan 10.202
Grik2glutamate receptor, ionotropic, kainate 2 (beta 2)0.199
Itga6integrin alpha 60.199
Pfn2profilin 20.198
CblCasitas B-lineage lymphoma0.197
Smad6MAD homolog 6 (Drosophila)0.196
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.191
Fgfr3fibroblast growth factor receptor 30.187
Adcy4adenylate cyclase 40.187
Ptch1patched homolog 10.184
Bcar1breast cancer anti-estrogen resistance 10.183
Arhgef40Rho guanine nucleotide exchange factor (GEF) 400.182
Cdc42ep1CDC42 effector protein (Rho GTPase binding) 10.176
Mybl1myeloblastosis oncogene-like 10.175
Sez6lseizure related 6 homolog like0.174
Egfl7EGF-like domain 70.171
Plcg1phospholipase C, gamma 10.171
Sox4SRY-box containing gene 40.171
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.170
Phldb1pleckstrin homology-like domain, family B, member 10.170
Dckdeoxycytidine kinase0.169
Spag9sperm associated antigen 90.168
Ddx17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.166
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism