The network for 'muscle cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

muscle cell proliferation

The expansion of a muscle cell population by cell division.

NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor1.000
FGFR2fibroblast growth factor receptor 21.000
ESR1estrogen receptor 10.999
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.999
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.998
TEKTEK tyrosine kinase, endothelial0.998
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.998
RARAretinoic acid receptor, alpha0.997
IL6interleukin 6 (interferon, beta 2)0.996
RXRAretinoid X receptor, alpha0.986
CDK2cyclin-dependent kinase 20.979
TBX5T-box 50.974
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.970
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.970
FGF1fibroblast growth factor 1 (acidic)0.965
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.963
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.960
EP300E1A binding protein p3000.954
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.945
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.942
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.941
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.934
CCL2chemokine (C-C motif) ligand 20.932
C1QAcomplement component 1, q subcomponent, A chain0.929
NRP1neuropilin 10.913
JAG1jagged 10.901
CCL4chemokine (C-C motif) ligand 40.898
ARandrogen receptor0.864
IGF2insulin-like growth factor 2 (somatomedin A)0.833
FGFR1fibroblast growth factor receptor 10.825
CXCL2chemokine (C-X-C motif) ligand 20.823
GRB7growth factor receptor-bound protein 70.803
IL8interleukin 80.798
CCR5chemokine (C-C motif) receptor 50.778
SHC1SHC (Src homology 2 domain containing) transforming protein 10.763
NOSTRINnitric oxide synthase trafficker0.723
TRAF6TNF receptor-associated factor 60.719
NCOA1nuclear receptor coactivator 10.696
TGFB3transforming growth factor, beta 30.673
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.659
CDH5cadherin 5, type 2 (vascular endothelium)0.657
THBS1thrombospondin 10.651
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.645
PPARGperoxisome proliferator-activated receptor gamma0.634
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.622
NEDD9neural precursor cell expressed, developmentally down-regulated 90.583
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.566
UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)0.539
TBXA2Rthromboxane A2 receptor0.525
DCNdecorin0.523
ENGendoglin0.514
EPAS1endothelial PAS domain protein 10.512
C3complement component 30.501
CXCL9chemokine (C-X-C motif) ligand 90.500
TNFAIP3tumor necrosis factor, alpha-induced protein 30.488
FSTL1follistatin-like 10.481
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.471
BMP2bone morphogenetic protein 20.459
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.454
ANGangiogenin, ribonuclease, RNase A family, 50.425
CCL5chemokine (C-C motif) ligand 50.421
C1QCcomplement component 1, q subcomponent, C chain0.409
CXCL3chemokine (C-X-C motif) ligand 30.398
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.396
CREBBPCREB binding protein0.394
SIRT1sirtuin 10.389
RNASE4ribonuclease, RNase A family, 40.384
DSG2desmoglein 20.358
HNF4Ahepatocyte nuclear factor 4, alpha0.350
NCOA3nuclear receptor coactivator 30.347
FGF10fibroblast growth factor 100.344
DDR2discoidin domain receptor tyrosine kinase 20.343
NR4A1nuclear receptor subfamily 4, group A, member 10.342
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.336
YAP1Yes-associated protein 10.327
NCOR2nuclear receptor corepressor 20.319
BMPR1Abone morphogenetic protein receptor, type IA0.298
CXCL12chemokine (C-X-C motif) ligand 120.297
CCL8chemokine (C-C motif) ligand 80.295
SPOPspeckle-type POZ protein0.291
FBLN1fibulin 10.287
PGFplacental growth factor0.278
PDGFAplatelet-derived growth factor alpha polypeptide0.266
FGF7fibroblast growth factor 70.263
FBXW11F-box and WD repeat domain containing 110.258
CD34CD34 molecule0.256
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.256
TCF4transcription factor 40.254
PTGIRprostaglandin I2 (prostacyclin) receptor (IP)0.253
INSRinsulin receptor0.241
IGFBP5insulin-like growth factor binding protein 50.240
IL1Binterleukin 1, beta0.229
PELI3pellino homolog 3 (Drosophila)0.224
HDAC1histone deacetylase 10.218
PSEN1presenilin 10.218
PLCG1phospholipase C, gamma 10.217
IL23Ainterleukin 23, alpha subunit p190.214
IL2RBinterleukin 2 receptor, beta0.210
CXCL10chemokine (C-X-C motif) ligand 100.200
MED25mediator complex subunit 250.198
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.092
nkx3.2NK3 homeobox 20.092
myod1myogenic differentiation 10.048
hey2hairy/enhancer-of-split related with YRPW motif 20.040
gli1GLI-Kruppel family member 10.032
nkx2.2bNK2 transcription factor related 2b0.025
cdh2cadherin 2, neuronal0.021
nkx2.2aNK2 transcription factor related 2a0.020
fabp11afatty acid binding protein 11a0.020
unc5bunc-5 homolog B (C. elegans)0.019
flt4fms-related tyrosine kinase 40.016
nkx2.5NK2 transcription factor related 50.015
fgf4fibroblast growth factor 40.014
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.013
hey1hairy/enhancer-of-split related with YRPW motif 10.013
twist1atwist1a0.012
hoxa13bhomeo box A13b0.012
tbx20T-box 200.012
pax6apaired box gene 6a0.011
six4bsine oculis homeobox homolog 4b0.011
shhbsonic hedgehog b0.011
fgf8afibroblast growth factor 8 a0.011
nog2noggin 20.011
rbpms2RNA binding protein with multiple splicing 20.010
flot1flotillin 10.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog0.998
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.992
Ptpn11protein tyrosine phosphatase, non-receptor type 110.987
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.983
Ctnnb1catenin (cadherin associated protein), beta 10.982
Prrx1paired related homeobox 10.977
Leprleptin receptor0.977
Fgfr2fibroblast growth factor receptor 20.973
Hand2heart and neural crest derivatives expressed transcript 20.969
Fgf8fibroblast growth factor 80.968
Gata4GATA binding protein 40.967
Foxc1forkhead box C10.966
Gli2GLI-Kruppel family member GLI20.965
Sox9SRY-box containing gene 90.953
Smad3MAD homolog 3 (Drosophila)0.952
Itgb1integrin beta 1 (fibronectin receptor beta)0.945
Foxc2forkhead box C20.940
Nos3nitric oxide synthase 3, endothelial cell0.934
Nognoggin0.909
Eya1eyes absent 1 homolog (Drosophila)0.908
Gli3GLI-Kruppel family member GLI30.881
Pthlhparathyroid hormone-like peptide0.878
Fgfr3fibroblast growth factor receptor 30.872
Fgfr1fibroblast growth factor receptor 10.872
Hoxa1homeobox A10.830
Pax3paired box gene 30.828
Tgfb2transforming growth factor, beta 20.825
Ptenphosphatase and tensin homolog0.810
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.798
Tbx3T-box 30.793
Chrdchordin0.791
Csf1colony stimulating factor 1 (macrophage)0.755
Pax2paired box gene 20.754
Foxa2forkhead box A20.748
Ror2receptor tyrosine kinase-like orphan receptor 20.747
Ntf3neurotrophin 30.730
Zfpm2zinc finger protein, multitype 20.709
Hand1heart and neural crest derivatives expressed transcript 10.708
Wnt10bwingless related MMTV integration site 10b0.678
Bmp2bone morphogenetic protein 20.670
Amhr2anti-Mullerian hormone type 2 receptor0.664
Bmp4bone morphogenetic protein 40.657
Bcl2B-cell leukemia/lymphoma 20.652
Tbx2T-box 20.642
Pax8paired box gene 80.636
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.635
Efnb2ephrin B20.628
Gscgoosecoid homeobox0.609
Apcadenomatosis polyposis coli0.594
Jag1jagged 10.588
Acvr1activin A receptor, type 10.587
Arandrogen receptor0.586
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.584
Bdnfbrain derived neurotrophic factor0.580
Esr2estrogen receptor 2 (beta)0.557
Gdnfglial cell line derived neurotrophic factor0.555
Flt4FMS-like tyrosine kinase 40.553
Tgfbr2transforming growth factor, beta receptor II0.548
Tcf4transcription factor 40.543
Tbx5T-box 50.520
Runx2runt related transcription factor 20.520
Notch1Notch gene homolog 1 (Drosophila)0.516
Gdf5growth differentiation factor 50.511
Hoxa13homeobox A130.503
Wnt3awingless-related MMTV integration site 3A0.501
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.499
Smosmoothened homolog (Drosophila)0.485
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.484
Gata6GATA binding protein 60.475
Nr3c1nuclear receptor subfamily 3, group C, member 10.471
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.466
Ptgs2prostaglandin-endoperoxide synthase 20.457
Zeb1zinc finger E-box binding homeobox 10.449
Fgf10fibroblast growth factor 100.446
Wnt2bwingless related MMTV integration site 2b0.443
Smad1MAD homolog 1 (Drosophila)0.440
Dll4delta-like 4 (Drosophila)0.413
Smad4MAD homolog 4 (Drosophila)0.398
Pou3f3POU domain, class 3, transcription factor 30.397
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.397
Msx1homeobox, msh-like 10.396
Hmx3H6 homeobox 30.395
Dlx5distal-less homeobox 50.361
Tbx1T-box 10.359
Nr2f2nuclear receptor subfamily 2, group F, member 20.350
Lmx1aLIM homeobox transcription factor 1 alpha0.350
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.350
Col1a1collagen, type I, alpha 10.341
Nr5a1nuclear receptor subfamily 5, group A, member 10.340
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.334
Kdrkinase insert domain protein receptor0.332
Notch2Notch gene homolog 2 (Drosophila)0.321
Pdx1pancreatic and duodenal homeobox 10.320
Il10interleukin 100.312
Phexphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)0.310
Pitx2paired-like homeodomain transcription factor 20.306
Traf6TNF receptor-associated factor 60.305
Smad6MAD homolog 6 (Drosophila)0.303
Rspo2R-spondin 2 homolog (Xenopus laevis)0.294
Twist2twist homolog 2 (Drosophila)0.292
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Flt1FMS-related tyrosine kinase 10.614
Phkg1phosphorylase kinase, gamma 10.438
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.281
Dnajb9DnaJ (Hsp40) homolog, subfamily B, member 90.264
Tgfbr2transforming growth factor, beta receptor II0.244
Ednraendothelin receptor type A0.227
Clic4chloride intracellular channel 40.223
Nrg1neuregulin 10.217
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.216
Car5acarbonic anhydrase 5a, mitochondrial0.205
Smad7SMAD family member 70.203
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.196
Itga6integrin, alpha 60.195
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.183
Smad1SMAD family member 10.181
Lims1LIM and senescent cell antigen-like domains 10.176
Cmklr1chemokine-like receptor 10.176
Abcc6ATP-binding cassette, subfamily C (CFTR/MRP), member 60.176
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.172
Apoa5apolipoprotein A-V0.169
A2malpha-2-macroglobulin0.168
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.155
Gpr116G protein-coupled receptor 1160.155
Timp3TIMP metallopeptidase inhibitor 30.153
Icam2intercellular adhesion molecule 20.143
Ahsgalpha-2-HS-glycoprotein0.139
Trib1tribbles homolog 1 (Drosophila)0.138
GperG protein-coupled estrogen receptor 10.134
Albalbumin0.134
Ucnurocortin0.132
Akr1d1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)0.131
Dmddystrophin0.128
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.126
Hist1h1ahistone cluster 1, H1a0.122
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.121
Cpxm2carboxypeptidase X (M14 family), member 20.120
Socs3suppressor of cytokine signaling 30.118
Itgamintegrin, alpha M0.116
Slco2a1solute carrier organic anion transporter family, member 2a10.116
Stat6signal transducer and activator of transcription 60.113
Ednrbendothelin receptor type B0.111
Robo1roundabout homolog 1 (Drosophila)0.111
Myo1cmyosin IC0.111
Elovl5ELOVL family member 5, elongation of long chain fatty acids (yeast)0.109
Pak2p21 protein (Cdc42/Rac)-activated kinase 20.109
KitlgKIT ligand0.108
Irs1insulin receptor substrate 10.107
Ptgfrprostaglandin F receptor0.107
Testintestin gene0.106
Megf6multiple EGF-like-domains 60.106
Slc7a12solute carrier family 7 (cationic amino acid transporter, y+ system), member 120.106
Gna12guanine nucleotide binding protein (G protein) alpha 120.103
Tgfbr3transforming growth factor, beta receptor III0.103
Ctsjcathepsin J0.103
Podxlpodocalyxin-like0.098
Nos1nitric oxide synthase 1, neuronal0.098
Thbdthrombomodulin0.098
Rxraretinoid X receptor alpha0.097
Ncr1natural cytotoxicity triggering receptor 10.097
LOC100362824caveolin 2-like0.095
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.094
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.093
Egfrepidermal growth factor receptor0.093
Jak1Janus kinase 10.092
Gja5gap junction protein, alpha 50.091
Bcl2B-cell CLL/lymphoma 20.089
Sirpasignal-regulatory protein alpha0.088
Rararetinoic acid receptor, alpha0.087
LOC100360403ATP-binding cassette, sub-family C, member 9-like0.086
Smad3SMAD family member 30.084
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.083
Aspnasporin0.082
RT1-BaRT1 class II, locus Ba0.082
Rgs14regulator of G-protein signaling 140.082
Dchs1dachsous 1 (Drosophila)0.080
Notch3Notch homolog 3 (Drosophila)0.080
Adrb1adrenergic, beta-1-, receptor0.078
RT1-M5RT1 class Ib, locus M50.077
Utrnutrophin0.075
Gas7growth arrest specific 70.074
Olr837olfactory receptor 8370.074
Elf1E74-like factor 10.073
Agtr1aangiotensin II receptor, type 1a0.073
Ncf1neutrophil cytosolic factor 10.072
Itpr2inositol 1,4,5-triphosphate receptor, type 20.071
Nos3nitric oxide synthase 3, endothelial cell0.071
Slc1a1solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 10.071
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.070
Hsd17b1hydroxysteroid (17-beta) dehydrogenase 10.070
St3gal3ST3 beta-galactoside alpha-2,3-sialyltransferase 30.069
RGD1561143similar to cell surface receptor FDFACT0.069
Ccnd3cyclin D30.068
Grb2growth factor receptor bound protein 20.068
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.068
Il9rinterleukin 9 receptor0.068
Fgf1fibroblast growth factor 10.067
Cdkn3cyclin-dependent kinase inhibitor 30.066
Adam9ADAM metallopeptidase domain 9 (meltrin gamma)0.066
Hrghistidine-rich glycoprotein0.064
Foxd3forkhead box D30.064
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism