The network for 'glycosaminoglycan metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

glycosaminoglycan metabolic process

The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties.

NameDescriptionProbabilityFunc Analog Organism
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.923
FGFR2fibroblast growth factor receptor 20.777
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.761
TEKTEK tyrosine kinase, endothelial0.634
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.579
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.575
IL1R1interleukin 1 receptor, type I0.542
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.479
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.396
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.365
BCL3B-cell CLL/lymphoma 30.263
HIP1huntingtin interacting protein 10.223
FGF1fibroblast growth factor 1 (acidic)0.215
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.179
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.162
NUMBnumb homolog (Drosophila)0.127
FGAfibrinogen alpha chain0.123
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.106
NRP1neuropilin 10.095
PLAURplasminogen activator, urokinase receptor0.085
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.081
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.066
THBS1thrombospondin 10.065
MAP3K8mitogen-activated protein kinase kinase kinase 80.061
COL6A1collagen, type VI, alpha 10.061
FGF10fibroblast growth factor 100.054
METmet proto-oncogene (hepatocyte growth factor receptor)0.047
APPamyloid beta (A4) precursor protein0.043
IL8interleukin 80.040
TOM1L1target of myb1 (chicken)-like 10.039
SHC1SHC (Src homology 2 domain containing) transforming protein 10.039
FGF7fibroblast growth factor 70.038
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.036
FGFR1fibroblast growth factor receptor 10.036
EGFRepidermal growth factor receptor0.034
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.033
CAV1caveolin 1, caveolae protein, 22kDa0.031
PTPRJprotein tyrosine phosphatase, receptor type, J0.030
COL6A2collagen, type VI, alpha 20.027
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.026
HSPG2heparan sulfate proteoglycan 20.026
DKK1dickkopf homolog 1 (Xenopus laevis)0.026
TGFBR1transforming growth factor, beta receptor 10.025
FGF2fibroblast growth factor 2 (basic)0.022
COL2A1collagen, type II, alpha 10.022
INHBAinhibin, beta A0.022
MMP14matrix metallopeptidase 14 (membrane-inserted)0.022
OCRLoculocerebrorenal syndrome of Lowe0.021
STC1stanniocalcin 10.021
TGFB1transforming growth factor, beta 10.021
COL4A2collagen, type IV, alpha 20.021
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)0.020
DDR2discoidin domain receptor tyrosine kinase 20.019
PLCG1phospholipase C, gamma 10.019
FNDC3Bfibronectin type III domain containing 3B0.019
PLAUplasminogen activator, urokinase0.019
IGFBP5insulin-like growth factor binding protein 50.019
FSTL1follistatin-like 10.019
CNTFciliary neurotrophic factor0.019
COL5A1collagen, type V, alpha 10.018
PTPN1protein tyrosine phosphatase, non-receptor type 10.018
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.018
CAPRIN2caprin family member 20.018
FRS2fibroblast growth factor receptor substrate 20.018
BMP1bone morphogenetic protein 10.017
TGFB3transforming growth factor, beta 30.017
ACSL4acyl-CoA synthetase long-chain family member 40.017
ICAM1intercellular adhesion molecule 10.017
MRC2mannose receptor, C type 20.017
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.017
FBN1fibrillin 10.016
MBL2mannose-binding lectin (protein C) 2, soluble0.016
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.016
TGFB2transforming growth factor, beta 20.016
B3GAT3beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)0.016
COL4A1collagen, type IV, alpha 10.016
IL1R2interleukin 1 receptor, type II0.015
ZNF431zinc finger protein 4310.015
MAN1B1mannosidase, alpha, class 1B, member 10.015
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.015
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.015
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.015
VEGFCvascular endothelial growth factor C0.014
VEGFAvascular endothelial growth factor A0.014
PCOLCEprocollagen C-endopeptidase enhancer0.014
LAMA2laminin, alpha 20.014
CHPFchondroitin polymerizing factor0.014
TIMP3TIMP metallopeptidase inhibitor 30.013
DOCK7dedicator of cytokinesis 70.013
PIP5K1Cphosphatidylinositol-4-phosphate 5-kinase, type I, gamma0.013
BMP2bone morphogenetic protein 20.013
TNFAIP6tumor necrosis factor, alpha-induced protein 60.013
CTSBcathepsin B0.013
CD81CD81 molecule0.013
CSPG4chondroitin sulfate proteoglycan 40.013
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
sqv-8Protein SQV-80.432
imp-3Protein IMP-30.094
sqv-1Protein SQV-10.089
F25H2.7Protein F25H2.70.054
CELE_C34D4.4Protein C34D4.40.047
grld-1Protein GRLD-10.047
F59A3.4Protein F59A3.40.046
nhr-20Protein NHR-200.025
sqv-2Protein SQV-20.024
pal-1Protein PAL-10.022
tac-1Protein TAC-10.021
C18A3.2Protein C18A3.20.020
csnk-1Protein CSNK-10.020
ZK652.6Protein ZK652.60.019
cup-5Protein CUP-50.018
F29G9.2Protein F29G9.20.017
F25H2.6Protein F25H2.60.016
rab-5Protein RAB-50.015
unc-69Protein UNC-690.015
rpn-1Protein RPN-10.014
F37D6.2Protein F37D6.20.014
CELE_Y52B11A.2Protein Y52B11A.20.014
sec-10Protein SEC-100.013
vps-54Protein VPS-540.012
K02A6.2Protein K02A6.20.012
rap-1Protein RAP-10.010
tat-1Protein TAT-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
sec24dSEC24 family, member D (S. cerevisiae)0.955
uxs1UDP-glucuronic acid decarboxylase 10.522
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.356
sulf1sulfatase 10.356
slc35b2solute carrier family 35, member B20.239
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.174
gle1GLE1 RNA export mediator homolog (yeast)0.146
ext2exostoses (multiple) 20.121
extl3exostoses (multiple)-like 30.092
xylt1xylosyltransferase 10.092
lmo4aLIM domain only 4a0.075
col11a1acollagen, type XI, alpha 1a0.073
LOC100000687signal peptide, CUB and EGF-like domain-containing protein 3-like0.068
cfl2lcofilin 2, like0.067
ptpraprotein tyrosine phosphatase, receptor type, A0.066
sulf2lsulfatase 2, like0.063
ecrg4aesophageal cancer related gene 4a0.062
dlx5adistal-less homeobox gene 5a0.055
igfbp3insulin-like growth factor binding protein 30.050
matn4matrilin 40.048
fam20bfamily with sequence similarity 20, member B (H. sapiens)0.045
esrraestrogen-related receptor alpha0.042
sufusuppressor of fused homolog (Drosophila)0.042
col10a1collagen, type X, alpha 10.034
hspg2heparan sulfate proteoglycan 20.031
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.031
prdm5PR domain containing 50.029
sept6septin 60.028
lhx2bLIM homeobox 2b0.028
loxlysyl oxidase0.025
wnt9awingless-type MMTV integration site family, member 9A0.024
wif1wnt inhibitory factor 10.023
col12a1collagen, type XII, alpha 10.023
col5a2lcollagen, type V, alpha 2-like0.022
ptprjaprotein tyrosine phosphatase, receptor type, J a0.021
glceaglucuronyl C5-epimerase a0.019
grifingalectin related inter-fiber protein0.019
lass2LAG1 homolog, ceramide synthase 2 (S. cerevisiae)0.018
col1a1acollagen, type I, alpha 1a0.018
sec13SEC13 homolog (S. cerevisiae)0.018
acanaaggrecan a0.017
ptprjbprotein tyrosine phosphatase, receptor type, J b0.016
msxdmuscle segment homeobox D0.016
sox9aSRY-box containing gene 9a0.016
ugdhUDP-glucose dehydrogenase0.016
disp1dispatched homolog 1 (Drosophila)0.015
col2a1acollagen type II, alpha-1a0.014
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.013
phf21aPHD finger protein 21A0.013
actn1actinin, alpha 10.013
wnt9bwingless-type MMTV integration site family, member 9B0.013
fn1fibronectin 10.013
cap1Cap1 CAP, adenylate cyclase-associated protein 10.013
thbs1thrombospondin 10.012
ldlrap1alow density lipoprotein receptor adaptor protein 1a0.012
LOC556849ectonucleoside triphosphate diphosphohydrolase 5-like0.012
stab1lstabilin 1-like0.012
olig4oligodendrocyte transcription factor 40.012
spon2aspondin 2a, extracellular matrix protein0.012
arl4caADP-ribosylation factor-like 4Ca0.012
pid1phosphotyrosine interaction domain containing 10.012
bmp16bone morphogenetic protein 160.012
ptprkprotein tyrosine phosphatase, receptor type, K0.012
zp3zona pellucida glycoprotein 30.012
ecm2extracellular matrix protein 2, female organ and adipocyte specific0.012
nkd1naked cuticle homolog 1 (Drosophila)0.011
pcsk5bproprotein convertase subtilisin/kexin type 5b0.011
sparcsecreted acidic cysteine rich glycoprotein0.011
sox11bSRY-box containing gene 11b0.011
pmp22aperipheral myelin protein 22a0.011
st3gal2lST3 beta-galactoside alpha-2,3-sialyltransferase 2, like0.011
pold1polymerase (DNA directed), delta 1, catalytic subunit0.011
prdm16PR domain containing 160.011
scxascleraxis homolog A (mouse)0.011
ihhaIndian hedgehog homolog a0.011
hs6st2heparan sulfate 6-O-sulfotransferase 20.010
rab7RAB7, member RAS oncogene family0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Ext2CG8433 gene product from transcript CG8433-RA0.730
PGRP-SAPeptidoglycan recognition protein SA0.650
SPESpatzle-Processing Enzyme0.618
PGRP-SDCG7496 gene product from transcript CG7496-RA0.425
GNBP3Gram-negative bacteria binding protein 30.264
grassGram-positive Specific Serine protease0.232
modSPmodular serine protease0.220
botvbrother of tout-velu0.110
GNBP1Gram-negative bacteria binding protein 10.087
PGRP-SC1bCG8577 gene product from transcript CG8577-RA0.081
IM1Immune induced molecule 10.076
jingCG9397 gene product from transcript CG9397-RI0.072
Sp7Serine protease 70.055
PGRP-SC1aCG14746 gene product from transcript CG14746-RA0.051
CG42863CG42863 gene product from transcript CG42863-RB0.049
pirkpoor Imd response upon knock-in0.045
PGRP-LBPeptidoglycan recognition protein LB0.034
CG9184CG9184 gene product from transcript CG9184-RB0.033
Bre1CG10542 gene product from transcript CG10542-RA0.032
Hs6stHeparan sulfate 6-O-sulfotransferase0.031
PvrPDGF- and VEGF-receptor related0.027
raspCG11495 gene product from transcript CG11495-RA0.026
DuoxDual oxidase0.024
eaterCG6124 gene product from transcript CG6124-RB0.022
CG15917CG15917 gene product from transcript CG15917-RA0.022
Spn1Serine protease inhibitor 10.021
Spn27ASerpin 27A0.021
imdimmune deficiency0.017
CG5390CG5390 gene product from transcript CG5390-RA0.016
IrcImmune-regulated catalase0.015
upd2unpaired 20.015
EloAElongin A0.014
Reg-5Rhythmically expressed gene 50.013
PGRP-LFPeptidoglycan recognition protein LF0.013
CG5880CG5880 gene product from transcript CG5880-RA0.013
bbgbig bang0.013
cbscentrosomin's beautiful sister0.013
CG18594CG18594 gene product from transcript CG18594-RA0.012
Gadd45CG11086 gene product from transcript CG11086-RA0.011
DreddDeath related ced-3/Nedd2-like protein0.011
CG3505CG3505 gene product from transcript CG3505-RA0.011
CG9870CG9870 gene product from transcript CG9870-RA0.010
TepIIIThiolester containing protein III0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tgfb2transforming growth factor, beta 20.886
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.690
Gli3GLI-Kruppel family member GLI30.639
Eya1eyes absent 1 homolog (Drosophila)0.630
Hexahexosaminidase A0.396
Foxc1forkhead box C10.360
Egfrepidermal growth factor receptor0.308
Hexbhexosaminidase B0.300
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.287
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.217
H2-Aahistocompatibility 2, class II antigen A, alpha0.195
Pthlhparathyroid hormone-like peptide0.185
Meox2mesenchyme homeobox 20.138
Nos3nitric oxide synthase 3, endothelial cell0.102
Vdrvitamin D receptor0.095
Lyz2lysozyme 20.092
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.087
Rxraretinoid X receptor alpha0.085
Myd88myeloid differentiation primary response gene 880.083
Lmx1bLIM homeobox transcription factor 1 beta0.082
Leprleptin receptor0.079
Nkx2-1NK2 homeobox 10.078
Islrimmunoglobulin superfamily containing leucine-rich repeat0.077
H2-Ab1histocompatibility 2, class II antigen A, beta 10.074
Tgfatransforming growth factor alpha0.070
Adam17a disintegrin and metallopeptidase domain 170.069
Amhr2anti-Mullerian hormone type 2 receptor0.065
Otx2orthodenticle homolog 2 (Drosophila)0.065
Pitx2paired-like homeodomain transcription factor 20.064
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.061
Pax8paired box gene 80.057
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.057
Foxh1forkhead box H10.056
Bmp4bone morphogenetic protein 40.055
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.054
Foxf2forkhead box F20.052
Celcarboxyl ester lipase0.052
Csf1colony stimulating factor 1 (macrophage)0.050
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.049
Gbx2gastrulation brain homeobox 20.049
Ptenphosphatase and tensin homolog0.048
Postnperiostin, osteoblast specific factor0.048
1700080E11RikRIKEN cDNA 1700080E11 gene0.047
Col1a2collagen, type I, alpha 20.047
Ghrgrowth hormone receptor0.046
Ctrb1chymotrypsinogen B10.046
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.043
Grb10growth factor receptor bound protein 100.043
Tgfbr2transforming growth factor, beta receptor II0.042
Timp2tissue inhibitor of metalloproteinase 20.042
Ptpn11protein tyrosine phosphatase, non-receptor type 110.041
Igf1rinsulin-like growth factor I receptor0.041
H2-DMahistocompatibility 2, class II, locus DMa0.039
Lrp1low density lipoprotein receptor-related protein 10.039
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.038
Adra2aadrenergic receptor, alpha 2a0.038
Ins1insulin I0.038
Ptf1apancreas specific transcription factor, 1a0.037
Otx1orthodenticle homolog 1 (Drosophila)0.037
Agap3ArfGAP with GTPase domain, ankyrin repeat and PH domain 30.036
Socs1suppressor of cytokine signaling 10.035
Aebp1AE binding protein 10.034
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.033
Apoeapolipoprotein E0.033
Galnt2UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 20.033
Col8a2collagen, type VIII, alpha 20.033
Mmp9matrix metallopeptidase 90.032
Lamp2lysosomal-associated membrane protein 20.031
Colec12collectin sub-family member 120.030
Impdh1inosine 5'-phosphate dehydrogenase 10.030
Fgfrl1fibroblast growth factor receptor-like 10.030
Reg3bregenerating islet-derived 3 beta0.029
Abi3bpABI gene family, member 3 (NESH) binding protein0.029
Cdkn1ccyclin-dependent kinase inhibitor 1C (P57)0.029
Flt4FMS-like tyrosine kinase 40.028
Treml1triggering receptor expressed on myeloid cells-like 10.028
Jag1jagged 10.028
Cacna1fcalcium channel, voltage-dependent, alpha 1F subunit0.028
Notch2Notch gene homolog 2 (Drosophila)0.027
Ins2insulin II0.027
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.027
Pax6paired box gene 60.027
Npc1Niemann Pick type C10.027
H2-Eb1histocompatibility 2, class II antigen E beta0.026
Pax2paired box gene 20.026
Fgf8fibroblast growth factor 80.026
Itm2cintegral membrane protein 2C0.026
Fgfr3fibroblast growth factor receptor 30.026
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.026
Lamp1lysosomal-associated membrane protein 10.025
Pkd1polycystic kidney disease 1 homolog0.025
Arap3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 30.025
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism