The network for 'musculoskeletal movement' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

musculoskeletal movement

The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system.

NameDescriptionProbabilityFunc Analog Organism
TNNC1troponin C type 1 (slow)1.000
TNNI1troponin I type 1 (skeletal, slow)0.999
LIN7Blin-7 homolog B (C. elegans)0.940
TRIM63tripartite motif containing 630.931
ATP2A1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.914
TNNI2troponin I type 2 (skeletal, fast)0.910
TNNT2troponin T type 2 (cardiac)0.900
CKMcreatine kinase, muscle0.880
TNNT3troponin T type 3 (skeletal, fast)0.863
SMYD1SET and MYND domain containing 10.862
COX6A2cytochrome c oxidase subunit VIa polypeptide 20.742
LDB3LIM domain binding 30.731
TTNtitin0.692
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.681
MYH7myosin, heavy chain 7, cardiac muscle, beta0.615
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.593
MYLPFmyosin light chain, phosphorylatable, fast skeletal muscle0.511
GFI1Bgrowth factor independent 1B transcription repressor0.481
MYL1myosin, light chain 1, alkali; skeletal, fast0.473
MYBPC2myosin binding protein C, fast type0.471
ACTA1actin, alpha 1, skeletal muscle0.439
TNNC2troponin C type 2 (fast)0.389
MYL4myosin, light chain 4, alkali; atrial, embryonic0.365
MYH2myosin, heavy chain 2, skeletal muscle, adult0.354
MYH6myosin, heavy chain 6, cardiac muscle, alpha0.325
ACTN2actinin, alpha 20.315
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.302
MYL2myosin, light chain 2, regulatory, cardiac, slow0.300
MYOZ1myozenin 10.299
ACTN3actinin, alpha 30.289
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.244
ANKRD2ankyrin repeat domain 2 (stretch responsive muscle)0.226
MYBPHmyosin binding protein H0.225
MYL3myosin, light chain 3, alkali; ventricular, skeletal, slow0.211
MYH1myosin, heavy chain 1, skeletal muscle, adult0.190
SYNMsynemin, intermediate filament protein0.179
MYH8myosin, heavy chain 8, skeletal muscle, perinatal0.164
CACNA1Scalcium channel, voltage-dependent, L type, alpha 1S subunit0.162
SGCAsarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)0.158
DTNAdystrobrevin, alpha0.157
CHUKconserved helix-loop-helix ubiquitous kinase0.135
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.133
PINK1PTEN induced putative kinase 10.132
MYBPC1myosin binding protein C, slow type0.103
MAPK8mitogen-activated protein kinase 80.099
ACTC1actin, alpha, cardiac muscle 10.093
MYOZ2myozenin 20.092
SRPK3SRSF protein kinase 30.088
CHRNDcholinergic receptor, nicotinic, delta0.087
MYOGmyogenin (myogenic factor 4)0.085
LTBP4latent transforming growth factor beta binding protein 40.082
CAV3caveolin 30.082
HAP1huntingtin-associated protein 10.077
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.075
TCAPtitin-cap (telethonin)0.070
EP300E1A binding protein p3000.068
ARRDC3arrestin domain containing 30.064
TUBB2Btubulin, beta 2B0.062
MBmyoglobin0.061
CHRNA1cholinergic receptor, nicotinic, alpha 1 (muscle)0.060
SLNsarcolipin0.056
PGAM2phosphoglycerate mutase 2 (muscle)0.054
MTORmechanistic target of rapamycin (serine/threonine kinase)0.052
DESdesmin0.051
TNNI3troponin I type 3 (cardiac)0.047
TICAM2toll-like receptor adaptor molecule 20.046
SYNPO2Lsynaptopodin 2-like0.046
CHRNGcholinergic receptor, nicotinic, gamma0.043
ACTA2actin, alpha 2, smooth muscle, aorta0.043
MYH4myosin, heavy chain 4, skeletal muscle0.042
SNTB1syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)0.041
CASQ1calsequestrin 1 (fast-twitch, skeletal muscle)0.041
ARHGAP22Rho GTPase activating protein 220.040
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.036
DTNBdystrobrevin, beta0.035
APOBEC2apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 20.035
FLNAfilamin A, alpha0.034
HRChistidine rich calcium binding protein0.034
CASQ2calsequestrin 2 (cardiac muscle)0.033
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.033
RAPSNreceptor-associated protein of the synapse0.032
TAL1T-cell acute lymphocytic leukemia 10.032
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.032
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.030
MYOM1myomesin 1, 185kDa0.030
PYGMphosphorylase, glycogen, muscle0.030
TRPM7transient receptor potential cation channel, subfamily M, member 70.029
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta0.028
TCF4transcription factor 40.028
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.027
UCP3uncoupling protein 3 (mitochondrial, proton carrier)0.027
RPL3Lribosomal protein L3-like0.027
MYF6myogenic factor 6 (herculin)0.025
MEGF8multiple EGF-like-domains 80.024
MEGF6multiple EGF-like-domains 60.023
HSPG2heparan sulfate proteoglycan 20.023
CACNG1calcium channel, voltage-dependent, gamma subunit 10.023
SMPXsmall muscle protein, X-linked0.023
TRPM6transient receptor potential cation channel, subfamily M, member 60.022
HSPB3heat shock 27kDa protein 30.022
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
myhz2myosin, heavy polypeptide 2, fast muscle specific0.964
lama2laminin, alpha 20.938
tnni1altroponin I, skeletal, slow like0.911
hsp90a.1heat shock protein 90-alpha 10.896
ryr1bryanodine receptor 1b (skeletal)0.883
lamb2laminin, beta 2 (laminin S)0.734
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.701
smyhc2slow myosin heavy chain 20.690
tnnt3btroponin T3b, skeletal, fast0.680
smyd1bSET and MYND domain containing 1b0.630
myogmyogenin0.460
muskmuscle, skeletal, receptor tyrosine kinase0.438
mylz2myosin, light polypeptide 2, skeletal muscle0.415
myhz1.2myosin, heavy polypeptide 1.2, skeletal muscle0.357
smyhc1slow myosin heavy chain 10.302
unc45bunc-45 homolog B (C. elegans)0.272
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.171
tnnc1btroponin C type 1b (slow)0.167
myhc4myosin heavy chain 40.159
tpmaalpha-tropomyosin0.157
zgc:66286zgc:662860.132
tnnc2troponin C type 2 (fast)0.118
LOC100149148novel protein similar to myosin heavy chain 4 (myhc4)0.098
actn3bactinin alpha 3b0.087
tnni1btroponin I, skeletal, slow b0.085
nebnebulin0.083
smyhc3slow myosin heavy chain 30.075
stac3SH3 and cysteine rich domain 30.063
actn3aactinin alpha 3a0.050
ryr3ryanodine receptor 30.048
ampd1adenosine monophosphate deaminase 1 (isoform M)0.047
flncbfilamin C, gamma b (actin binding protein 280)0.036
hspb8heat shock protein, alpha-crystallin-related, b80.033
dmddystrophin0.033
acta1aactin, alpha 1a, skeletal muscle0.031
vgll2bvestigial like 2b0.031
ryr1aryanodine receptor 1a (skeletal)0.029
zgc:114164zgc:1141640.028
kbtbd10bkelch repeat and BTB (POZ) domain containing 10b0.028
pvalb4parvalbumin 40.027
zgc:66156zgc:661560.026
acheacetylcholinesterase0.025
cacnb1calcium channel, voltage-dependent, beta 1 subunit0.024
sox6SRY-box containing gene 60.023
cacna1abcalcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b0.022
hcrthypocretin (orexin) neuropeptide precursor0.022
ckmt2creatine kinase, mitochondrial 2 (sarcomeric)0.021
chrndcholinergic receptor, nicotinic, delta polypeptide0.020
LOC100000934hypothetical protein LOC1000009340.019
zgc:101050zgc:1010500.019
im:6896270im:68962700.018
il1binterleukin 1, beta and interleukin 1, beta0.018
cav3caveolin 30.016
si:dkey-260j18.3si:dkey-260j18.30.015
me2malic enzyme 2, NAD(+)-dependent, mitochondrial0.014
si:ch211-142k18.1si:ch211-142k18.10.014
qkquaking0.014
rtn3reticulon 30.014
pvalb1parvalbumin 10.014
il6stinterleukin 6 signal transducer0.013
pvalb2parvalbumin 20.012
dnaja1lDnaJ (Hsp40) homolog, subfamily A, member 1, like0.012
im:6801444im:68014440.012
im:7154736im:71547360.012
hsp70lheat shock cognate 70-kd protein, like0.011
im:7137300im:71373000.011
im:7151827im:71518270.011
hprt1hypoxanthine phosphoribosyltransferase 10.011
scube2signal peptide, CUB domain, EGF-like 20.010
cdh23cadherin-like 230.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Act88FActin 88F0.070
Irk3Inwardly rectifying potassium channel 30.049
CrebACyclic-AMP response element binding protein A0.044
HLHmgammaE(spl) region transcript mgamma0.039
caupcaupolican0.028
PoxnPox neuro0.025
cv-2crossveinless 20.025
egreiger0.025
fngfringe0.023
OptixCG18455 gene product from transcript CG18455-RA0.022
bdgbedraggled0.021
Mlc2Myosin light chain 20.020
tshteashirt0.019
toytwin of eyeless0.018
BG4CG12297 gene product from transcript CG12297-RA0.018
Atg9Autophagy-specific gene 90.018
Gad1Glutamic acid decarboxylase 10.018
Gpo-1Glycerophosphate oxidase-10.017
scscute0.017
norpAno receptor potential A0.017
Gr28bGustatory receptor 28b0.016
bip2CG2009 gene product from transcript CG2009-RA0.016
HLHm5E(spl) region transcript m50.015
Zasp52Z band alternatively spliced PDZ-motif protein 520.014
AceAcetylcholine esterase0.014
pdm2POU domain protein 20.013
araaraucan0.013
NotumCG13076 gene product from transcript CG13076-RB0.012
ird1immune response deficient 10.012
swsswiss cheese0.012
Pink1PTEN-induced putative kinase 10.011
CG10200CG10200 gene product from transcript CG10200-RB0.011
TpnC4Troponin C isoform 40.011
CG32792CG32792 gene product from transcript CG32792-RF0.011
SmrSmrter0.011
CG13897CG13897 gene product from transcript CG13897-RA0.011
GABA-B-R2metabotropic GABA-B receptor subtype 20.011
Ilp2Insulin-like peptide 20.011
shfshifted0.011
Letm1CG4589 gene product from transcript CG4589-RB0.011
bab2CG9102 gene product from transcript CG9102-RA0.010
netCG11450 gene product from transcript CG11450-RB0.010
CG8486CG8486 gene product from transcript CG8486-RE0.010
mttmangetout0.010
RelRelish0.010
GM130CG11061 gene product from transcript CG11061-RB0.010
DllDistal-less0.010
CG33289CG33289 gene product from transcript CG33289-RA0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hrchistidine rich calcium binding protein0.042
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.041
Actn2actinin alpha 20.039
Mybphmyosin binding protein H0.038
Ldb3LIM domain binding 30.032
Tnnt3troponin T3, skeletal, fast0.029
Jarid2jumonji, AT rich interactive domain 20.027
Tnni2troponin I, skeletal, fast 20.027
Tnnc2troponin C2, fast0.025
Nos1nitric oxide synthase 1, neuronal0.023
Myl3myosin, light polypeptide 30.022
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.021
Ikbkginhibitor of kappaB kinase gamma0.020
Mdm2transformed mouse 3T3 cell double minute 20.020
Nrapnebulin-related anchoring protein0.019
Cox6a2cytochrome c oxidase, subunit VI a, polypeptide 20.018
Myom2myomesin 20.017
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.016
Myogmyogenin0.016
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.016
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.015
Tnni1troponin I, skeletal, slow 10.014
Csrp3cysteine and glycine-rich protein 30.014
Ankrd2ankyrin repeat domain 2 (stretch responsive muscle)0.014
Ryr1ryanodine receptor 1, skeletal muscle0.014
Myh8myosin, heavy polypeptide 8, skeletal muscle, perinatal0.014
Ckmt2creatine kinase, mitochondrial 20.013
Tcaptitin-cap0.013
Srpk3serine/arginine-rich protein specific kinase 30.013
Myf6myogenic factor 60.013
Mylpfmyosin light chain, phosphorylatable, fast skeletal muscle0.012
Cacng1calcium channel, voltage-dependent, gamma subunit 10.012
Art5ADP-ribosyltransferase 50.012
Sgcgsarcoglycan, gamma (dystrophin-associated glycoprotein)0.012
Myh1myosin, heavy polypeptide 1, skeletal muscle, adult0.012
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.011
Cav3caveolin 30.011
Tnnt2troponin T2, cardiac0.011
Cacnb2calcium channel, voltage-dependent, beta 2 subunit0.011
Myh3myosin, heavy polypeptide 3, skeletal muscle, embryonic0.011
Cnga3cyclic nucleotide gated channel alpha 30.011
Rhorhodopsin0.010
Acta1actin, alpha 1, skeletal muscle0.010
Homer1homer homolog 1 (Drosophila)0.010
Ttntitin0.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Actc1actin, alpha, cardiac muscle 10.258
Hsph1heat shock 105/110 protein 10.252
Ckmcreatine kinase, muscle0.211
Mylpfmyosin light chain, phosphorylatable, fast skeletal muscle0.202
Hspa8heat shock protein 80.202
Hspd1heat shock protein 1 (chaperonin)0.199
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.157
Svs3aseminal vesicle secretory protein 3A0.148
Chrnecholinergic receptor, nicotinic, epsilon0.072
Muskmuscle, skeletal, receptor tyrosine kinase0.069
Myh3myosin, heavy chain 3, skeletal muscle, embryonic0.062
Scn5asodium channel, voltage-gated, type V, alpha subunit0.051
Casq2calsequestrin 2 (cardiac muscle)0.051
Csrp3cysteine and glycine-rich protein 30.050
Myogmyogenin0.049
Prm2protamine 20.048
Cntn2contactin 2 (axonal)0.043
Cd79bCd79b molecule, immunoglobulin-associated beta0.039
Grik3glutamate receptor, ionotropic, kainate 30.038
Myh1myosin, heavy polypeptide 1, skeletal muscle, adult0.035
Pthparathyroid hormone0.034
Arl11ADP-ribosylation factor-like 110.034
Akp3alkaline phosphatase 3, intestine, not Mn requiring0.034
Stip1stress-induced phosphoprotein 10.032
Chrnb2cholinergic receptor, nicotinic, beta 2 (neuronal)0.032
Chordc1cysteine and histidine-rich domain (CHORD)-containing 10.028
Actn2actinin alpha 20.028
Chrna6cholinergic receptor, nicotinic, alpha 60.028
Galnt5UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)0.027
RGD1565859RGD15658590.027
Myh6myosin, heavy chain 6, cardiac muscle, alpha0.026
Gja3gap junction protein, alpha 30.024
Synposynaptopodin0.023
Olr857olfactory receptor 8570.022
Edn2endothelin 20.021
Tnni2troponin I type 2 (skeletal, fast)0.021
Olr1078olfactory receptor 10780.021
Svs1seminal vesicle secretory protein 10.021
Vom1r93vomeronasal 1 receptor 930.021
Clcn1chloride channel 10.020
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.020
Myh7myosin, heavy chain 7, cardiac muscle, beta0.020
Myl1myosin, light chain 10.020
Fgf7fibroblast growth factor 70.019
Scn4asodium channel, voltage-gated, type IV, alpha subunit0.019
Myl3myosin, light chain 3, alkali; ventricular, skeletal, slow0.019
RGD1565493similar to DKFZP434I092 protein0.018
Csf3colony stimulating factor 3 (granulocyte)0.018
Npy5rneuropeptide Y receptor Y50.018
Chrna1cholinergic receptor, nicotinic, alpha 1 (muscle)0.018
Gfra2GDNF family receptor alpha 20.017
Trim54tripartite motif-containing 540.017
Esr1estrogen receptor 10.017
Cmtm2aCKLF-like MARVEL transmembrane domain containing 2A0.017
Gabra3gamma-aminobutyric acid (GABA) A receptor, alpha 30.017
Ldb3LIM domain binding 30.017
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.017
Canxcalnexin0.017
Lrrc15leucine rich repeat containing 150.016
Ppp4r2protein phosphatase 4, regulatory subunit 20.016
Insrrinsulin receptor-related receptor0.016
Pitx2paired-like homeodomain 20.016
Toretrispanning orphan0.016
Eif5eukaryotic translation initiation factor 50.016
Htr75-hydroxytryptamine (serotonin) receptor 70.016
Ptafrplatelet-activating factor receptor0.015
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.015
Vom2r27vomeronasal 2 receptor, 270.015
Ivlinvolucrin0.015
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.015
Mylk2myosin light chain kinase 20.014
Cryba1crystallin, beta A10.014
Oprl1opiate receptor-like 10.014
Rhorhodopsin0.014
Avpr1barginine vasopressin receptor 1B0.014
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.014
Olr1082olfactory receptor 10820.013
Isl2ISL LIM homeobox 20.013
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.013
Gpr176G protein-coupled receptor 1760.013
Kcnq2potassium voltage-gated channel, KQT-like subfamily, member 20.013
Il2rainterleukin 2 receptor, alpha0.013
LOC60591calcium-activated potassium channel beta subunit0.013
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.013
Vgll2vestigial like 2 (Drosophila)0.013
Myoz2myozenin 20.013
Cacnb1calcium channel, voltage-dependent, beta 1 subunit0.013
Ifnb1interferon beta 1, fibroblast0.012
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.012
Mybpc1myosin binding protein C, slow type0.012
Ptgfrprostaglandin F receptor0.012
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.012
Ampd1adenosine monophosphate deaminase 1 (isoform M)0.012
Olr287olfactory receptor 2870.012
Chrngcholinergic receptor, nicotinic, gamma0.012
RorbRAR-related orphan receptor B0.012
Mybphmyosin binding protein H0.012
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.012
Npy1rneuropeptide Y receptor Y10.012
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism