The network for 'hematopoietic stem cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

hematopoietic stem cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.

NameDescriptionProbabilityFunc Analog Organism
HDAC2histone deacetylase 21.000
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.968
HOXB7homeobox B70.931
HOXB5homeobox B50.890
CCND1cyclin D10.856
VAC14Vac14 homolog (S. cerevisiae)0.846
SF3A1splicing factor 3a, subunit 1, 120kDa0.842
HOXA10homeobox A100.804
SIN3ASIN3 homolog A, transcription regulator (yeast)0.726
RPS27ribosomal protein S270.696
RBBP4retinoblastoma binding protein 40.684
MKL1megakaryoblastic leukemia (translocation) 10.678
HOXA4homeobox A40.635
RUNX1runt-related transcription factor 10.568
HOXB9homeobox B90.488
HOXA7homeobox A70.463
HOXB3homeobox B30.430
HOXA5homeobox A50.416
RBBP7retinoblastoma binding protein 70.406
GATA2GATA binding protein 20.382
WBP11WW domain binding protein 110.375
PARP1poly (ADP-ribose) polymerase 10.355
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.347
MYOD1myogenic differentiation 10.330
PAX1paired box 10.326
HOXB6homeobox B60.314
CSNK2A1casein kinase 2, alpha 1 polypeptide0.309
RPS10ribosomal protein S100.303
HOXC10homeobox C100.242
HOXA6homeobox A60.240
RPL37Aribosomal protein L37a0.231
WHSC1L1Wolf-Hirschhorn syndrome candidate 1-like 10.220
APLFaprataxin and PNKP like factor0.212
ARFIP2ADP-ribosylation factor interacting protein 20.209
NOTCH1notch 10.167
UHRF2ubiquitin-like with PHD and ring finger domains 20.166
HOXA2homeobox A20.153
RPL39ribosomal protein L390.150
HOXA11homeobox A110.144
CCND2cyclin D20.141
CYTH2cytohesin 20.112
CCND3cyclin D30.112
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.112
RPS28ribosomal protein S280.112
HOXA1homeobox A10.095
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.093
HOXC5homeobox C50.086
HOXA3homeobox A30.084
CDK6cyclin-dependent kinase 60.083
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.083
NR2E3nuclear receptor subfamily 2, group E, member 30.083
HOXB2homeobox B20.078
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.076
WRNWerner syndrome, RecQ helicase-like0.075
HOXC8homeobox C80.074
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.073
HOXC6homeobox C60.069
EIF2S2eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa0.069
HDAC1histone deacetylase 10.068
DMTF1cyclin D binding myb-like transcription factor 10.067
RPA1replication protein A1, 70kDa0.066
TOP1topoisomerase (DNA) I0.065
HOXC11homeobox C110.065
CD2BP2CD2 (cytoplasmic tail) binding protein 20.065
HDGFhepatoma-derived growth factor0.062
DDIT3DNA-damage-inducible transcript 30.061
TNS1tensin 10.061
NOTCH3notch 30.060
TAL1T-cell acute lymphocytic leukemia 10.060
FKBP1AFK506 binding protein 1A, 12kDa0.060
KRT15keratin 150.056
MOV10Mov10, Moloney leukemia virus 10, homolog (mouse)0.054
RPL27ribosomal protein L270.051
CDK9cyclin-dependent kinase 90.046
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.046
RPL38ribosomal protein L380.044
CAV2caveolin 20.044
RAB5CRAB5C, member RAS oncogene family0.044
RBM5RNA binding motif protein 50.044
BCL11BB-cell CLL/lymphoma 11B (zinc finger protein)0.043
NCOR2nuclear receptor corepressor 20.043
RPA2replication protein A2, 32kDa0.042
MKL2MKL/myocardin-like 20.042
BCL6B-cell CLL/lymphoma 60.041
RPL41ribosomal protein L410.039
MTA2metastasis associated 1 family, member 20.038
SMAD6SMAD family member 60.038
POU2F1POU class 2 homeobox 10.038
PDX1pancreatic and duodenal homeobox 10.038
C4orf14chromosome 4 open reading frame 140.037
DHX58DEXH (Asp-Glu-X-His) box polypeptide 580.037
IER5immediate early response 50.037
SF3A2splicing factor 3a, subunit 2, 66kDa0.037
HOXB8homeobox B80.036
JAG1jagged 10.036
HOXC4homeobox C40.035
GATA1GATA binding protein 1 (globin transcription factor 1)0.035
HOXB4homeobox B40.034
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
kdrlkinase insert domain receptor like0.997
tbx16T-box gene 160.987
atoh1batonal homolog 1b0.919
etv2ets variant gene 20.882
tbx2aT-box gene 2a0.836
runx1runt-related transcription factor 10.774
ascl1aachaete-scute complex-like 1a (Drosophila)0.738
tbx5aT-box 5a0.737
mibmind bomb0.693
hand2heart and neural crest derivatives expressed transcript 20.634
ptf1apancreas specific transcription factor, 1a0.631
hoxd4ahomeo box D4a0.612
pax2apaired box gene 2a0.585
hnf1baHNF1 homeobox Ba0.536
myf5myogenic factor 50.534
her1hairy-related 10.533
tcf21transcription factor 210.518
notch1anotch homolog 1a0.495
fgf10afibroblast growth factor 10a0.457
cdh5cadherin 50.430
fn1fibronectin 10.419
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.406
gfi1.1growth factor independent 1.10.359
wnt9awingless-type MMTV integration site family, member 9A0.341
LOC566708FL cytokine receptor-like0.326
tbx15T-box 150.299
wnt2bbwingless-type MMTV integration site family, member 2Bb0.277
tbx1T-box 10.256
myod1myogenic differentiation 10.247
spns2spinster homolog 2 (Drosophila)0.240
ptch1patched 10.239
jag2jagged 20.227
sarsseryl-tRNA synthetase0.223
fgf8afibroblast growth factor 8 a0.222
neurog1neurogenin 10.215
unc45aunc-45 homolog A (C. elegans)0.215
ccm2cerebral cavernous malformation 20.198
tnnt3atroponin T3a, skeletal, fast0.184
metap2methionyl aminopeptidase 20.182
foxa3forkhead box A30.170
LOC799612prolactin 20.167
foxi1forkhead box I10.166
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.159
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.157
krit1KRIT1, ankyrin repeat containing0.155
nos2bnitric oxide synthase 2b, inducible0.154
tbx24T-box 240.144
smyhc1lslow myosin heavy chain 1, like0.144
wnt11wingless-type MMTV integration site family, member 110.140
atoh1aatonal homolog 1a0.138
her7hairy and enhancer of split related-70.127
lama1laminin, alpha 10.122
gja3gap junction protein, alpha 30.120
hoxc4ahomeo box C4a0.118
cdx4caudal type homeo box transcription factor 40.115
vcanaversican a0.115
snrnp70small nuclear ribonucleoprotein 70 (U1)0.111
lhx1aLIM homeobox 1a0.110
tfr1atransferrin receptor 1a0.107
dll4delta-like 4 (Drosophila)0.106
nkx2.3NK2 transcription factor related 30.099
nos2anitric oxide synthase 2a, inducible0.099
vhlvon Hippel-Lindau tumor suppressor0.098
tbx18T-box 180.098
sf3a3splicing factor 3a, subunit 30.097
notch1bnotch homolog 1b0.095
st14asuppression of tumorigenicity 14 (colon carcinoma) a0.093
hbbe3hemoglobin beta embryonic-30.090
wnt8awingless-type MMTV integration site family, member 8a0.088
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.088
neurod4neurogenic differentiation 40.087
six2asine oculis-related homeobox 2a0.083
fzd10frizzled homolog 100.080
tmem2transmembrane protein 20.078
barx1BarH-like homeobox 10.077
wnt3awingless-type MMTV integration site family, member 3A0.077
vegfcvascular endothelial growth factor c0.076
pvalb2parvalbumin 20.076
gcm2glial cells missing homolog 2 (Drosophila)0.075
jam2bjunctional adhesion molecule 2b0.072
otpborthopedia homolog b0.072
neurod6bneurogenic differentiation 6b0.070
hoxd11ahomeo box D11a0.070
six4asine oculis homeobox homolog 4a0.070
dlx6adistal-less homeobox gene 6a0.068
btkBruton agammaglobulinemia tyrosine kinase0.068
dmrt2adoublesex and mab-3 related transcription factor 2a0.068
cmybtranscription factor cmyb0.067
fbln1fibulin 10.067
grem2gremlin 2, cysteine knot superfamily0.066
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.062
metmet proto-oncogene (hepatocyte growth factor receptor)0.062
plcg1phospholipase C, gamma 10.061
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MED22Mediator complex subunit 220.091
RPA2Replication protein A20.050
Rcd5Reduction in Cnn dots 50.050
eIF-4EEukaryotic initiation factor 4E0.049
SMC2CG10212 gene product from transcript CG10212-RA0.041
CG11266CG11266 gene product from transcript CG11266-RD0.036
RpL34bRibosomal protein L34b0.035
Klp61FKinesin-like protein at 61F0.034
eIF3-S10CG9805 gene product from transcript CG9805-RA0.030
mRpL49mitochondrial ribosomal protein L490.027
Saf-BScaffold attachment factor B0.026
CG9740CG9740 gene product from transcript CG9740-RA0.025
MED14Mediator complex subunit 140.025
RpL31Ribosomal protein L310.024
TctpTranslationally controlled tumor protein0.024
Int6Int6 homologue0.023
CG5548CG5548 gene product from transcript CG5548-RA0.023
CG4364CG4364 gene product from transcript CG4364-RA0.022
CG9172CG9172 gene product from transcript CG9172-RA0.022
CG7181CG7181 gene product from transcript CG7181-RA0.021
CG7006CG7006 gene product from transcript CG7006-RA0.020
Spt6CG12225 gene product from transcript CG12225-RA0.020
CG9715CG9715 gene product from transcript CG9715-RA0.019
zf30CZinc finger protein 30C0.019
mRpL9mitochondrial ribosomal protein L90.018
CG14482CG14482 gene product from transcript CG14482-RA0.018
Rpb10CG13628 gene product from transcript CG13628-RA0.018
CG7757CG7757 gene product from transcript CG7757-RA0.018
lolalongitudinals lacking0.017
CG11015CG11015 gene product from transcript CG11015-RA0.017
mtacp1mitochondrial acyl carrier protein 10.017
CG5703CG5703 gene product from transcript CG5703-RA0.017
Rae1CG9862 gene product from transcript CG9862-RA0.017
Aos1CG12276 gene product from transcript CG12276-RA0.017
CG3909CG3909 gene product from transcript CG3909-RA0.016
CG3621CG3621 gene product from transcript CG3621-RA0.016
CG8485CG8485 gene product from transcript CG8485-RA0.016
rad50CG6339 gene product from transcript CG6339-RD0.016
Rpb5CG11979 gene product from transcript CG11979-RA0.016
Prx5Peroxiredoxin 50.016
CG9350CG9350 gene product from transcript CG9350-RA0.016
CG12079CG12079 gene product from transcript CG12079-RA0.015
CG5859CG5859 gene product from transcript CG5859-RA0.014
CG14235CG14235 gene product from transcript CG14235-RA0.014
CoVaCytochrome c oxidase subunit Va0.014
CG3560CG3560 gene product from transcript CG3560-RA0.013
CG8386CG8386 gene product from transcript CG8386-RA0.013
CG12259CG12259 gene product from transcript CG12259-RA0.013
CG2862CG2862 gene product from transcript CG2862-RA0.013
SelGSelenoprotein G0.013
PdswCG8844 gene product from transcript CG8844-RA0.013
CG4646CG4646 gene product from transcript CG4646-RA0.013
CG10664CG10664 gene product from transcript CG10664-RB0.013
RpL18ARibosomal protein L18A0.013
EcREcdysone receptor0.012
MBD-R2CG10042 gene product from transcript CG10042-RB0.012
CG10267CG10267 gene product from transcript CG10267-RB0.012
cidcentromere identifier0.012
CG12400CG12400 gene product from transcript CG12400-RA0.012
RpL37aRibosomal protein L37a0.011
SmESmall ribonucleoprotein particle protein SmE0.011
mspsmini spindles0.011
Ssb-c31aSingle stranded-binding protein c31A0.011
Neb-cGPCG15304 gene product from transcript CG15304-RA0.011
CG6422CG6422 gene product from transcript CG6422-RA0.011
CG3192CG3192 gene product from transcript CG3192-RA0.011
Ef1betaElongation factor 1 beta0.011
OscpOligomycin sensitivity-conferring protein0.011
CG2021CG2021 gene product from transcript CG2021-RA0.011
LSm7CG13277 gene product from transcript CG13277-RA0.011
CG14671CG14671 gene product from transcript CG14671-RA0.010
CG8460CG8460 gene product from transcript CG8460-RA0.010
CG3214CG3214 gene product from transcript CG3214-RB0.010
CG7630CG7630 gene product from transcript CG7630-RA0.010
CG9667CG9667 gene product from transcript CG9667-RA0.010
ND23NADH:ubiquinone reductase 23kD subunit precursor0.010
CG5362CG5362 gene product from transcript CG5362-RA0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Neurod1neurogenic differentiation 10.923
Ascl1achaete-scute complex homolog 1 (Drosophila)0.694
Notch1Notch gene homolog 1 (Drosophila)0.663
Ccnd1cyclin D10.651
Kiss1KiSS-1 metastasis-suppressor0.578
Ccnd2cyclin D20.350
Sfrp2secreted frizzled-related protein 20.339
Otx2orthodenticle homolog 2 (Drosophila)0.310
Ptf1apancreas specific transcription factor, 1a0.309
UncxUNC homeobox0.292
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.274
Tcf15transcription factor 150.227
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.213
Dsg4desmoglein 40.202
Gata1GATA binding protein 10.190
Tal1T-cell acute lymphocytic leukemia 10.188
Pdx1pancreatic and duodenal homeobox 10.187
Pax6paired box gene 60.172
Gfra3glial cell line derived neurotrophic factor family receptor alpha 30.117
Hand2heart and neural crest derivatives expressed transcript 20.113
Dkk1dickkopf homolog 1 (Xenopus laevis)0.101
Neurog2neurogenin 20.097
Onecut1one cut domain, family member 10.093
Shhsonic hedgehog0.092
Gata4GATA binding protein 40.090
MecomMDS1 and EVI1 complex locus0.088
Hoxc5homeobox C50.087
Efna2ephrin A20.086
Socs1suppressor of cytokine signaling 10.085
Isl1ISL1 transcription factor, LIM/homeodomain0.080
Gscgoosecoid homeobox0.080
Srebf2sterol regulatory element binding factor 20.078
Notch2Notch gene homolog 2 (Drosophila)0.069
Hoxb5homeobox B50.066
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.065
En1engrailed 10.064
Dlx2distal-less homeobox 20.062
Crb2crumbs homolog 2 (Drosophila)0.062
Insm1insulinoma-associated 10.059
Pax3paired box gene 30.056
Cbfa2t3core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)0.052
Hes1hairy and enhancer of split 1 (Drosophila)0.051
Foxf1aforkhead box F1a0.047
Nkx3-2NK3 homeobox 20.047
Tlx3T-cell leukemia, homeobox 30.046
Smu1smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)0.045
Tcfap2atranscription factor AP-2, alpha0.045
Hoxc6homeobox C60.045
Six5sine oculis-related homeobox 5 homolog (Drosophila)0.045
Anapc4anaphase promoting complex subunit 40.045
Hoxd13homeobox D130.043
Hba-xhemoglobin X, alpha-like embryonic chain in Hba complex0.042
Hand1heart and neural crest derivatives expressed transcript 10.041
Smn1survival motor neuron 10.041
Nhlh1nescient helix loop helix 10.041
Rim4recombination induced mutation 40.040
Sin3atranscriptional regulator, SIN3A (yeast)0.038
Nkx6-1NK6 homeobox 10.038
Tbx5T-box 50.037
Has2hyaluronan synthase 20.037
Cpsf3cleavage and polyadenylation specificity factor 30.036
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.036
Foxd3forkhead box D30.035
Hoxa11homeobox A110.035
Shox2short stature homeobox 20.034
LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.034
Nkx2-9NK2 transcription factor related, locus 9 (Drosophila)0.034
Foxd2forkhead box D20.033
Gpr50G-protein-coupled receptor 500.032
Myh7myosin, heavy polypeptide 7, cardiac muscle, beta0.031
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.031
Il21rinterleukin 21 receptor0.031
Meox2mesenchyme homeobox 20.031
Hoxb1homeobox B10.031
Nkx1-2NK1 transcription factor related, locus 2 (Drosophila)0.031
Eporerythropoietin receptor0.031
NrarpNotch-regulated ankyrin repeat protein0.031
Phldb2pleckstrin homology-like domain, family B, member 20.031
Dok1docking protein 10.030
Fgf15fibroblast growth factor 150.030
Lhx5LIM homeobox protein 50.029
Tcf3transcription factor 30.029
Pafah1b2platelet-activating factor acetylhydrolase, isoform 1b, subunit 20.029
Mab21l2mab-21-like 2 (C. elegans)0.028
Pitx1paired-like homeodomain transcription factor 10.028
Pou4f2POU domain, class 4, transcription factor 20.028
Hoxa5homeobox A50.028
Mybpc3myosin binding protein C, cardiac0.028
Lhx6LIM homeobox protein 60.028
Col22a1collagen, type XXII, alpha 10.027
Madcam1mucosal vascular addressin cell adhesion molecule 10.027
Isl2insulin related protein 2 (islet 2)0.027
Ccl4chemokine (C-C motif) ligand 40.027
Dab1disabled homolog 1 (Drosophila)0.026
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism