The network for 'negative regulation of immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of immune response

Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

NameDescriptionProbabilityFunc Analog Organism
C1Scomplement component 1, s subcomponent0.884
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.879
HLA-DRB5major histocompatibility complex, class II, DR beta 50.854
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.827
CD86CD86 molecule0.827
HLA-Amajor histocompatibility complex, class I, A0.821
PTPN1protein tyrosine phosphatase, non-receptor type 10.813
HLA-Cmajor histocompatibility complex, class I, C0.799
HLA-Gmajor histocompatibility complex, class I, G0.789
IL4Rinterleukin 4 receptor0.786
GHRgrowth hormone receptor0.726
HLA-Emajor histocompatibility complex, class I, E0.677
CD80CD80 molecule0.664
CCL4chemokine (C-C motif) ligand 40.649
CD14CD14 molecule0.645
SMAD4SMAD family member 40.641
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.613
CCR1chemokine (C-C motif) receptor 10.591
C1Rcomplement component 1, r subcomponent0.578
CCR5chemokine (C-C motif) receptor 50.562
NCOR2nuclear receptor corepressor 20.522
COL1A2collagen, type I, alpha 20.504
PTPN6protein tyrosine phosphatase, non-receptor type 60.500
CXCL9chemokine (C-X-C motif) ligand 90.491
IL2RGinterleukin 2 receptor, gamma0.489
COL1A1collagen, type I, alpha 10.487
IL2RBinterleukin 2 receptor, beta0.453
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.449
HLA-Bmajor histocompatibility complex, class I, B0.440
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.425
PSMB1proteasome (prosome, macropain) subunit, beta type, 10.411
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.399
COL3A1collagen, type III, alpha 10.384
THOC4THO complex 40.376
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.303
TFF1trefoil factor 10.283
PILRApaired immunoglobin-like type 2 receptor alpha0.279
CFHcomplement factor H0.276
SOCS3suppressor of cytokine signaling 30.271
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.270
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.266
THOC5THO complex 50.260
CCR7chemokine (C-C motif) receptor 70.247
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.237
CASP3caspase 3, apoptosis-related cysteine peptidase0.236
TAPBPTAP binding protein (tapasin)0.233
PMLpromyelocytic leukemia0.232
SHC1SHC (Src homology 2 domain containing) transforming protein 10.232
CCL22chemokine (C-C motif) ligand 220.231
C2complement component 20.228
SIGLEC7sialic acid binding Ig-like lectin 70.225
JAK2Janus kinase 20.224
HLA-Fmajor histocompatibility complex, class I, F0.220
MED15mediator complex subunit 150.217
TRAF1TNF receptor-associated factor 10.209
CALM1calmodulin 1 (phosphorylase kinase, delta)0.205
ARRB1arrestin, beta 10.204
HLA-DRB4major histocompatibility complex, class II, DR beta 40.204
CCL8chemokine (C-C motif) ligand 80.193
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.185
IL10RAinterleukin 10 receptor, alpha0.179
SP100SP100 nuclear antigen0.178
CCL5chemokine (C-C motif) ligand 50.176
IFNGinterferon, gamma0.173
ATF2activating transcription factor 20.164
MED10mediator complex subunit 100.164
CXCL10chemokine (C-X-C motif) ligand 100.162
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.161
SLAMF1signaling lymphocytic activation molecule family member 10.160
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.159
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.159
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.154
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.151
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.151
APOC1apolipoprotein C-I0.144
PSMB8proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)0.143
IL10interleukin 100.142
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.141
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.140
HLA-DMBmajor histocompatibility complex, class II, DM beta0.136
HK3hexokinase 3 (white cell)0.125
CCL2chemokine (C-C motif) ligand 20.125
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.123
PSMA7proteasome (prosome, macropain) subunit, alpha type, 70.123
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.123
IFITM2interferon induced transmembrane protein 2 (1-8D)0.123
TGFB1transforming growth factor, beta 10.120
TNFAIP3tumor necrosis factor, alpha-induced protein 30.119
TGFB3transforming growth factor, beta 30.117
DDR2discoidin domain receptor tyrosine kinase 20.116
IL22RA1interleukin 22 receptor, alpha 10.113
TIMM9translocase of inner mitochondrial membrane 9 homolog (yeast)0.113
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.112
BTN3A3butyrophilin, subfamily 3, member A30.111
CCL19chemokine (C-C motif) ligand 190.110
COL5A2collagen, type V, alpha 20.109
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
atf3activating transcription factor 30.199
junbjun B proto-oncogene0.190
lrrc33leucine rich repeat containing 330.107
adra2daadrenergic, alpha-2D-, receptor a0.097
mmp9matrix metalloproteinase 90.096
adra2badrenergic, alpha-2B-, receptor0.078
socs1suppressor of cytokine signaling 10.072
pglyrp5peptidoglycan recognition protein 50.059
vipr2vasoactive intestinal peptide receptor 20.056
cxcr3.2chemokine (C-X-C motif) receptor 3.20.051
skianuclear oncoprotein skia0.049
jak1Janus kinase 10.046
fn1bfibronectin 1b0.039
yrkYes-related kinase0.039
psmb2proteasome (prosome, macropain) subunit, beta type, 20.036
jhdm1dajumonji C domain containing histone demethylase 1 homolog Da (S. cerevisiae)0.034
ldb2aLIM-domain binding factor 2a0.033
pglyrp6peptidoglycan recognition protein 60.033
eya2eyes absent homolog 2 (Drosophila)0.033
ptpn21protein tyrosine phosphatase, non-receptor type 210.031
ptpn6protein tyrosine phosphatase, non-receptor type 60.030
lsrlipolysis stimulated lipoprotein receptor0.030
ca15acarbonic anhydrase XV a0.030
ptprcprotein tyrosine phosphatase, receptor type, C0.029
npy8brneuropeptide Y receptor Y8b0.029
csnk1a1casein kinase 1, alpha 10.029
fli1bfriend leukemia integration 1b0.028
tlr21toll-like receptor 210.028
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.028
sgk1serum/glucocorticoid regulated kinase 10.028
psmd4bproteasome (prosome, macropain) 26S subunit, non-ATPase, 4b0.028
llgl2lethal giant larvae homolog 2 (Drosophila)0.028
sox5SRY-box containing gene 50.028
tbx5bT-box 5b0.027
ccm2cerebral cavernous malformation 20.027
wacaWW domain containing adaptor with coiled-coil a0.027
gmfgglia maturation factor, gamma0.026
poldip2polymerase (DNA-directed), delta interacting protein 20.026
il7rinterleukin 7 receptor0.026
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.026
psmd12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.026
krit1KRIT1, ankyrin repeat containing0.026
ncf1neutrophil cytosolic factor 10.025
rhogbras homolog gene family, member Gb0.025
elk4ELK4, ETS-domain protein0.025
slc2a1asolute carrier family 2 (facilitated glucose transporter), member 1a0.025
wnt10awingless-type MMTV integration site family, member 10a0.025
atp1b1aATPase, Na+/K+ transporting, beta 1a polypeptide0.024
abcb3l1ATP-binding cassette, sub-family B (MDR/TAP), member 3 like 10.023
bmpr2bbone morphogenetic protein receptor, type II b (serine/threonine kinase)0.023
bmpr2abone morphogenetic protein receptor, type II a (serine/threonine kinase)0.023
myh11amyosin, heavy polypeptide 11, smooth muscle a0.022
lppLIM domain containing preferred translocation partner in lipoma0.022
igf2binsulin-like growth factor 2b0.022
npy7rneuropeptide Y receptor Y70.022
dkk3ldickkopf homolog 3 like (Xenopus laevis)0.022
rap1bRAS related protein 1b0.022
spint1aserine peptidase inhibitor, Kunitz type 1 a0.022
mst1rbmacrophage stimulating 1 receptor (c-met-related tyrosine kinase), b0.022
ednraendothelin receptor type A0.022
znf148zinc finger protein 1480.021
gdf11growth differentiation factor 110.021
pknox1.2pbx/knotted 1 homeobox 1.20.021
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.021
vdravitamin D receptor a0.021
cd8aCD8 antigen, alpha polypeptide0.021
dnm2dynamin 20.021
cebpdCCAAT/enhancer binding protein (C/EBP), delta0.021
taf3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto0.021
lhx6LIM homeobox 60.020
mmrn2amultimerin 2a0.020
lipclipase, hepatic0.020
tgfb2transforming growth factor, beta 20.020
vdrbvitamin D receptor b0.020
pyyapeptide YYa0.020
bmp10bone morphogenetic protein 100.020
timp2btissue inhibitor of metalloproteinase 2b0.020
aidaaxin interaction partner and dorsalization antagonist0.020
tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.020
tagln2transgelin 20.020
adra2dbadrenergic, alpha-2D-, receptor b0.019
junbljun B proto-oncogene, like0.019
wnt5awingless-type MMTV integration site family, member 5a0.019
rhcgbRhesus blood group, C glycoprotein b0.019
phexphosphate regulating gene with homologues to endopeptidases on the X chromosome0.019
nr5a5nuclear receptor subfamily 5, group A, member 50.019
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Stat92ESignal-transducer and activator of transcription protein at 92E0.285
MadMothers against dpp0.227
foxoforkhead box, sub-group O0.156
p38bCG7393 gene product from transcript CG7393-RA0.114
Ras85DRas oncogene at 85D0.109
PGRP-LCPeptidoglycan recognition protein LC0.108
CG9014CG9014 gene product from transcript CG9014-RA0.099
Spn27ASerpin 27A0.095
grassGram-positive Specific Serine protease0.076
PGRP-LBPeptidoglycan recognition protein LB0.075
Sp7Serine protease 70.073
PGRP-SC1bCG8577 gene product from transcript CG8577-RA0.072
ird1immune response deficient 10.054
chicoCG5686 gene product from transcript CG5686-RB0.053
PGRP-SC1aCG14746 gene product from transcript CG14746-RA0.052
RagACG11968 gene product from transcript CG11968-RA0.052
Socs36ESuppressor of cytokine signaling at 36E0.052
CG42863CG42863 gene product from transcript CG42863-RB0.051
LysCLysozyme C0.049
Nrx-IVNeurexin IV0.047
Ntf-2Nuclear transport factor-20.043
CG18594CG18594 gene product from transcript CG18594-RA0.042
upd3unpaired 30.041
modSPmodular serine protease0.040
Mekk1CG7717 gene product from transcript CG7717-RB0.040
Sod2Superoxide dismutase 2 (Mn)0.040
CG8709CG8709 gene product from transcript CG8709-RK0.040
fhfrataxin homolog0.039
polyCG9829 gene product from transcript CG9829-RB0.033
drkdownstream of receptor kinase0.032
PtenCG5671 gene product from transcript CG5671-RB0.031
Pi3K92ECG4141 gene product from transcript CG4141-RB0.029
dcodiscs overgrown0.029
UnrUpstream of N-ras0.027
pirkpoor Imd response upon knock-in0.027
CG15917CG15917 gene product from transcript CG15917-RA0.026
Pvf1PDGF- and VEGF-related factor 10.026
CG13060CG13060 gene product from transcript CG13060-RA0.025
CaMKIICalcium/calmodulin-dependent protein kinase II0.025
unc-104CG8566 gene product from transcript CG8566-RB0.025
eaterCG6124 gene product from transcript CG6124-RB0.024
coroCG9446 gene product from transcript CG9446-RC0.024
CG5325CG5325 gene product from transcript CG5325-RB0.024
Cdc42CG12530 gene product from transcript CG12530-RA0.023
Patr-1Protein associated with topo II related - 10.023
ird5immune response deficient 50.022
CG9238CG9238 gene product from transcript CG9238-RA0.022
PGRP-LFPeptidoglycan recognition protein LF0.022
Pk61CProtein kinase 61C0.021
PGRP-SC2CG14745 gene product from transcript CG14745-RA0.021
imdimmune deficiency0.021
upd2unpaired 20.020
Myo31DFMyosin 31DF0.020
SPESpatzle-Processing Enzyme0.019
LaspCG3849 gene product from transcript CG3849-RB0.019
Cyp12c1CG4120 gene product from transcript CG4120-RA0.019
gclgerm cell-less0.019
psidinphagocyte signaling impaired0.019
CG17633CG17633 gene product from transcript CG17633-RA0.019
PGRP-SAPeptidoglycan recognition protein SA0.019
l(3)mbnlethal (3) malignant blood neoplasm0.018
CG7607CG7607 gene product from transcript CG7607-RA0.018
Mmp1Matrix metalloproteinase 10.018
CG34424CG34424 gene product from transcript CG34424-RA0.018
CG18135CG18135 gene product from transcript CG18135-RC0.018
spheroideCG9675 gene product from transcript CG9675-RA0.018
CG11286CG11286 gene product from transcript CG11286-RA0.018
Spn1Serine protease inhibitor 10.017
CG13641CG13641 gene product from transcript CG13641-RA0.017
CG9139CG9139 gene product from transcript CG9139-RA0.017
fs(1)Nfemale sterile (1) Nasrat0.017
CG33138CG33138 gene product from transcript CG33138-RA0.017
CG30031CG30031 gene product from transcript CG30031-RA0.017
GNBP1Gram-negative bacteria binding protein 10.017
CG7017CG7017 gene product from transcript CG7017-RA0.017
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gzmkgranzyme K0.080
Ccr2chemokine (C-C motif) receptor 20.067
Mmp12matrix metallopeptidase 120.067
RT1-EC2RT1 class Ib, locus EC20.059
Aebp1AE binding protein 10.046
Arhgap4Rho GTPase activating protein 40.039
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.038
Icam1intercellular adhesion molecule 10.034
Cd247Cd247 molecule0.033
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.033
Aif1allograft inflammatory factor 10.031
Sult2a1sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.029
Igsf6immunoglobulin superfamily, member 60.026
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.024
C1rcomplement component 1, r subcomponent0.024
C3complement component 30.023
Fggfibrinogen gamma chain0.023
Cd2Cd2 molecule0.022
Psmb3proteasome (prosome, macropain) subunit, beta type 30.021
Timp2TIMP metallopeptidase inhibitor 20.021
Cd37CD37 molecule0.020
Ccl5chemokine (C-C motif) ligand 50.020
Kcna3potassium voltage-gated channel, shaker-related subfamily, member 30.019
Il1binterleukin 1 beta0.019
Ctsl1cathepsin L10.019
Col1a1collagen, type I, alpha 10.018
Gzmbgranzyme B0.018
Ppp3r2protein phosphatase 3, regulatory subunit B, beta isoform0.017
Klrd1killer cell lectin-like receptor, subfamily D, member 10.017
Il2rbinterleukin 2 receptor, beta0.017
Ifnginterferon gamma0.017
Ptp4a2protein tyrosine phosphatase 4a20.016
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.016
Lyz2lysozyme 20.016
Xcl1chemokine (C motif) ligand 10.016
Smcpsperm mitochondria-associated cysteine-rich protein0.016
Arhgap25Rho GTPase activating protein 250.015
Grpel1GrpE-like 1, mitochondrial0.015
Klrc1killer cell lectin-like receptor subfamily C, member 10.015
Lilrb4leukocyte immunoglobulin-like receptor, subfamily B, member 40.015
Il7rinterleukin 7 receptor0.015
Sellselectin L0.015
Nop58nucleolar protein NOP580.015
Csn1s1casein alpha s10.015
Gzmmgranzyme M (lymphocyte met-ase 1)0.015
Irf2interferon regulatory factor 20.014
Uba7ubiquitin-like modifier activating enzyme 70.014
Ceacam11carcinoembryonic antigen-related cell adhesion molecule 110.014
C1scomplement component 1, s subcomponent0.014
Map4k1mitogen activated protein kinase kinase kinase kinase 10.013
RT1-A3RT1 class I, locus A30.013
Hes2hairy and enhancer of split 2 (Drosophila)0.013
Klrk1killer cell lectin-like receptor subfamily K, member 10.013
Il17rainterleukin 17 receptor A0.013
Oas1a2'-5' oligoadenylate synthetase 1A0.013
Cfbcomplement factor B0.013
Rt1.aaMHC class I RT1.Aa alpha-chain0.013
Klra5killer cell lectin-like receptor, subfamily A, member 50.013
Psma7proteasome (prosome, macropain) subunit, alpha type 70.013
Gucy2eguanylate cyclase 2E0.013
Fgf16fibroblast growth factor 160.013
Ifit3interferon-induced protein with tetratricopeptide repeats 30.012
Lcn5lipocalin 50.012
Tcp11t-complex protein 110.012
Klrb1akiller cell lectin-like receptor subfamily B, member 1A0.012
Olr1697olfactory receptor 16970.012
Pcolceprocollagen C-endopeptidase enhancer0.012
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.012
Psma2proteasome (prosome, macropain) subunit, alpha type 20.012
Tfectranscription factor EC0.012
Tnftumor necrosis factor (TNF superfamily, member 2)0.011
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.011
Vom1r93vomeronasal 1 receptor 930.011
Acppacid phosphatase, prostate0.011
Abcc6ATP-binding cassette, subfamily C (CFTR/MRP), member 60.011
Fcnbficolin B0.011
Mmp8matrix metallopeptidase 80.011
Il1rninterleukin 1 receptor antagonist0.010
Col3a1collagen, type III, alpha 10.010
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.010
Gcgrglucagon receptor0.010
Pdx1pancreatic and duodenal homeobox 10.010
Pim1pim-1 oncogene0.010
Prf1perforin 1 (pore forming protein)0.010
Cxcl10chemokine (C-X-C motif) ligand 100.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism