The network for 'regulation of immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

NameDescriptionProbabilityFunc Analog Organism
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)1.000
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma1.000
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)1.000
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)1.000
SHC1SHC (Src homology 2 domain containing) transforming protein 10.999
IRAK1interleukin-1 receptor-associated kinase 10.998
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.996
LATlinker for activation of T cells0.993
TRAF6TNF receptor-associated factor 60.993
TNIP2TNFAIP3 interacting protein 20.991
TNFAIP3tumor necrosis factor, alpha-induced protein 30.988
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.987
GRB2growth factor receptor-bound protein 20.986
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.984
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.983
SYKspleen tyrosine kinase0.981
EGFRepidermal growth factor receptor0.977
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.964
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.962
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.961
AKT1v-akt murine thymoma viral oncogene homolog 10.960
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.956
RARAretinoic acid receptor, alpha0.951
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.950
IRAK2interleukin-1 receptor-associated kinase 20.949
ARandrogen receptor0.948
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.944
ESR1estrogen receptor 10.942
PTPN6protein tyrosine phosphatase, non-receptor type 60.937
BIRC3baculoviral IAP repeat containing 30.935
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.931
C1QAcomplement component 1, q subcomponent, A chain0.924
TRAF1TNF receptor-associated factor 10.920
GHRgrowth hormone receptor0.904
RXRAretinoid X receptor, alpha0.874
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.871
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.871
PTPN1protein tyrosine phosphatase, non-receptor type 10.870
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.867
HLA-Cmajor histocompatibility complex, class I, C0.863
STAT1signal transducer and activator of transcription 1, 91kDa0.842
SQSTM1sequestosome 10.834
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.829
MED28mediator complex subunit 280.826
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.825
BCL2L11BCL2-like 11 (apoptosis facilitator)0.823
PTK2PTK2 protein tyrosine kinase 20.820
CAV1caveolin 1, caveolae protein, 22kDa0.818
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.813
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.812
VAV1vav 1 guanine nucleotide exchange factor0.812
CD86CD86 molecule0.806
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.802
EP300E1A binding protein p3000.801
BTN3A3butyrophilin, subfamily 3, member A30.798
CARD11caspase recruitment domain family, member 110.798
CCL5chemokine (C-C motif) ligand 50.797
APOEapolipoprotein E0.792
NCOA3nuclear receptor coactivator 30.788
IL2RBinterleukin 2 receptor, beta0.786
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.768
CD80CD80 molecule0.767
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.761
IL2RGinterleukin 2 receptor, gamma0.755
BTKBruton agammaglobulinemia tyrosine kinase0.745
JUNjun proto-oncogene0.743
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.740
CCR5chemokine (C-C motif) receptor 50.723
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.718
MAP3K7mitogen-activated protein kinase kinase kinase 70.716
HLA-DMBmajor histocompatibility complex, class II, DM beta0.708
TGFB1transforming growth factor, beta 10.700
MAPK14mitogen-activated protein kinase 140.700
CXCL9chemokine (C-X-C motif) ligand 90.698
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.698
FGAfibrinogen alpha chain0.693
CCR1chemokine (C-C motif) receptor 10.693
MAPK1mitogen-activated protein kinase 10.687
MYD88myeloid differentiation primary response gene (88)0.687
FASFas (TNF receptor superfamily, member 6)0.686
FYBFYN binding protein0.680
SMN1survival of motor neuron 1, telomeric0.676
SLAMF1signaling lymphocytic activation molecule family member 10.672
TLR2toll-like receptor 20.671
PMLpromyelocytic leukemia0.662
RIPK2receptor-interacting serine-threonine kinase 20.660
HLA-Emajor histocompatibility complex, class I, E0.660
IL10interleukin 100.659
CXCL10chemokine (C-X-C motif) ligand 100.656
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.652
BCL3B-cell CLL/lymphoma 30.641
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.638
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.638
BTN3A1butyrophilin, subfamily 3, member A10.633
LCKlymphocyte-specific protein tyrosine kinase0.627
CD163CD163 molecule0.627
NCOR2nuclear receptor corepressor 20.623
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.610
IL10RAinterleukin 10 receptor, alpha0.607
NCOA1nuclear receptor coactivator 10.607
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
nhr-67Protein NHR-670.034
rpn-10Protein RPN-100.031
egl-27Protein EGL-270.028
pmk-1Protein PMK-10.028
C09F5.1Protein C09F5.10.027
C52E12.4Protein C52E12.40.025
rde-1Protein RDE-10.022
C27A12.7Protein C27A12.70.022
par-5Protein PAR-50.021
unc-9Protein UNC-90.020
daf-14Protein DAF-140.020
madd-4Protein MADD-40.017
ser-3Protein SER-30.017
dao-5Protein DAO-50.017
ada-2Protein ADA-20.017
cam-1Protein CAM-10.017
daf-4Protein DAF-40.017
CELE_C27D8.2Protein C27D8.20.016
drh-3Protein DRH-30.016
ZK792.5Protein ZK792.50.015
lgc-39Protein LGC-390.015
ZK622.1Protein ZK622.10.015
sma-6Protein SMA-60.015
daf-5Protein DAF-50.015
ceh-44Protein CEH-440.014
exoc-7Protein EXOC-70.014
bec-1Protein BEC-10.014
gpb-2Protein GPB-20.014
sek-1Protein SEK-10.013
ser-1Protein SER-10.013
zyg-8Protein ZYG-80.013
flh-2Protein FLH-20.012
cka-2Protein CKA-20.012
pbs-3Protein PBS-30.011
akt-2Protein AKT-20.011
lin-25Protein LIN-250.011
B0336.3Protein B0336.30.011
Y106G6A.1Protein Y106G6A.10.010
aak-2Protein AAK-20.010
egl-1Protein EGL-10.010
csk-1Protein CSK-10.010
ctl-3Protein CTL-30.010
CELE_Y69A2AR.8Protein Y69A2AR.80.010
unc-43Protein UNC-430.010
unc-86Protein UNC-860.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
grnagranulin a0.843
wnt8awingless-type MMTV integration site family, member 8a0.449
gata6GATA-binding protein 60.352
LOC566708FL cytokine receptor-like0.330
tlr21toll-like receptor 210.330
tlr3toll-like receptor 30.289
ripk2receptor-interacting serine-threonine kinase 20.266
stc1lstanniocalcin 1, like0.201
cdh1cadherin 1, epithelial0.195
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.182
LOC100151531zinc finger protein Gfi-1b-like0.176
ef1aelongation factor 1-alpha0.173
nod1nucleotide-binding oligomerization domain containing 10.151
bmp2bbone morphogenetic protein 2b0.144
c3bcomplement component c3b0.138
atf3activating transcription factor 30.135
tlr9toll-like receptor 90.127
fabp11afatty acid binding protein 11a0.106
epas1bendothelial PAS domain protein 1b0.105
shbgsex hormone binding globulin0.100
irf11interferon regulatory factor 110.096
LOC557072caspase recruitment domain-containing protein 11-like0.094
eporerythropoietin receptor0.086
rargaretinoic acid receptor gamma a0.081
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.080
hbbe1.1hemoglobin beta embryonic-1.10.080
si:ch211-212m21.5si:ch211-212m21.50.079
LOC100000934hypothetical protein LOC1000009340.079
bocbrother of CDO0.079
desmadesmin a0.078
stat1bsignal transducer and activator of transcription 1b0.076
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.075
dharmadharma0.072
col12a1collagen, type XII, alpha 10.067
tbx5bT-box 5b0.065
si:dkey-27i16.2si:dkey-27i16.20.065
sh3gl1bSH3-domain GRB2-like 1b0.064
pglyrp5peptidoglycan recognition protein 50.061
wu:fi38e01wu:fi38e010.060
fesfeline sarcoma oncogene0.060
mmp9matrix metalloproteinase 90.058
rorcaRAR-related orphan receptor C a0.058
sh3gl1aSH3-domain GRB2-like 1a0.057
fstafollistatin a0.056
efnb3bephrin B3b0.055
pth1aparathyroid hormone 1a0.055
tlr2toll-like receptor 20.055
lsm14bLSM14B, SCD6 homolog B (S. cerevisiae)0.054
foxi3aforkhead box I3a0.054
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.054
irak4interleukin-1 receptor-associated kinase 40.053
adipoqladiponectin, C1Q and collagen domain containing, like0.051
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.051
calcrlacalcitonin receptor-like a0.048
rhagRhesus blood group-associated glycoprotein0.048
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.048
nos2anitric oxide synthase 2a, inducible0.046
lndc1ly6/neurotoxin domain containing 10.045
caspacaspase a0.044
vwfvon Willebrand factor0.044
ifnphi1interferon phi 10.044
jak1Janus kinase 10.044
nipblbnovel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila)0.043
dnmt4DNA (cytosine-5-)-methyltransferase 40.042
cpceruloplasmin0.041
tnfbtumor necrosis factor b (TNF superfamily, member 2)0.041
wu:fj82b07wu:fj82b070.040
pou3f3bPOU class 3 homeobox 3b0.039
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.038
tnfsf10l2tumor necrosis factor (ligand) superfamily, member 10 like 20.037
shhasonic hedgehog a0.037
foxi2forkhead box I20.036
slc4a4bsolute carrier family 4, sodium bicarbonate cotransporter, member 4b0.036
zgc:161979zgc:1619790.034
znf148zinc finger protein 1480.033
ezrezrin0.033
c1qccomplement component 1, q subcomponent, C chain0.032
tlr18toll-like receptor 180.032
perpPERP, TP53 apoptosis effector0.032
mitfamicrophthalmia-associated transcription factor a0.032
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.032
copacoatomer protein complex, subunit alpha0.031
tp63tumor protein p630.031
c1qbcomplement component 1, q subcomponent, B chain0.031
zgc:66455zgc:664550.030
ythdf1YTH domain family, member 10.030
hs6st3heparan sulfate 6-O-sulfotransferase 30.030
si:dkeyp-110g5.2si:dkeyp-110g5.20.029
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.029
hspa4bheat shock protein 4b0.029
mpxmyeloid-specific peroxidase0.029
frzbfrizzled-related protein0.029
ptpn11aprotein tyrosine phosphatase, non-receptor type 11, a0.028
pax5paired box gene 50.028
rag2recombination activating gene 20.027
LOC100330224fatty acid binding protein 1b-like0.027
gclcglutamate-cysteine ligase, catalytic subunit0.027
cd40lgCD40 ligand0.027
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.026
rhcgl1Rhesus blood group, C glycoprotein, like 10.026
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
RelRelish0.996
rlrolled0.937
Spn27ASerpin 27A0.930
DptBDiptericin B0.915
TlToll0.904
grassGram-positive Specific Serine protease0.858
PGRP-LCPeptidoglycan recognition protein LC0.850
keykenny0.844
drkdownstream of receptor kinase0.838
babobaboon0.837
MadMothers against dpp0.828
krzkurtz0.816
SPESpatzle-Processing Enzyme0.780
Mpk2CG5475 gene product from transcript CG5475-RB0.749
Atg1Autophagy-specific gene 10.744
PGRP-SAPeptidoglycan recognition protein SA0.728
dapdacapo0.720
cactcactus0.699
fonfondue0.678
MtkMetchnikowin0.668
ird5immune response deficient 50.600
oskoskar0.574
AttAAttacin-A0.557
EgfrEpidermal growth factor receptor0.557
Nrx-IVNeurexin IV0.548
PvrPDGF- and VEGF-receptor related0.536
Mmp1Matrix metalloproteinase 10.531
stcksteamer duck0.526
slmbsupernumerary limbs0.509
Sp7Serine protease 70.499
mbcmyoblast city0.462
PGRP-SDCG7496 gene product from transcript CG7496-RA0.462
panpangolin0.461
Trx-2thioredoxin-20.457
CG7048CG7048 gene product from transcript CG7048-RB0.457
Tak1TGF-beta activated kinase 10.454
Pp2B-14DProtein phosphatase 2B at 14D0.452
CG15065CG15065 gene product from transcript CG15065-RA0.435
psqpipsqueak0.435
crolcrooked legs0.421
polyCG9829 gene product from transcript CG9829-RB0.406
ykiyorkie0.406
bowlbrother of odd with entrails limited0.397
Myo31DFMyosin 31DF0.392
LanALaminin A0.386
Myd88CG2078 gene product from transcript CG2078-RA0.368
wunwunen0.363
kiskismet0.361
imdimmune deficiency0.356
dcodiscs overgrown0.355
scbscab0.353
JIL-1CG6297 gene product from transcript CG6297-RA0.351
KrnKeren0.349
lbklambik0.342
DuoxDual oxidase0.332
Gap1GTPase-activating protein 10.325
ird1immune response deficient 10.324
pntpointed0.318
modSPmodular serine protease0.317
Vps25Vacuolar protein sorting 250.317
GNBP3Gram-negative bacteria binding protein 30.309
InRInsulin-like receptor0.308
liclicorne0.308
DreddDeath related ced-3/Nedd2-like protein0.306
sdscalloped0.301
PGRP-SB1CG9681 gene product from transcript CG9681-RA0.297
tamoCG4057 gene product from transcript CG4057-RA0.296
Lis-1Lissencephaly-10.291
TimpTissue inhibitor of metalloproteases0.282
saxsaxophone0.277
CG5794CG5794 gene product from transcript CG5794-RB0.273
SnooSno oncogene0.273
Mekk1CG7717 gene product from transcript CG7717-RB0.268
IrcImmune-regulated catalase0.266
p38bCG7393 gene product from transcript CG7393-RA0.265
rev7CG2948 gene product from transcript CG2948-RA0.257
rutrutabaga0.255
osoutstretched0.251
rprreaper0.250
lwrlesswright0.249
PGRP-SC1aCG14746 gene product from transcript CG14746-RA0.246
crmcramped0.245
Pp1-87BProtein phosphatase 1 at 87B0.238
CG18666CG18666 gene product from transcript CG18666-RA0.235
ovoCG6824 gene product from transcript CG6824-RE0.234
bazbazooka0.234
hpohippo0.232
cnncentrosomin0.227
fhfrataxin homolog0.226
CG6361CG6361 gene product from transcript CG6361-RA0.222
Ndae1Na[+]-driven anion exchanger 10.207
hthhomothorax0.204
CycDCyclin D0.201
Stat92ESignal-transducer and activator of transcription protein at 92E0.196
CecCCecropin C0.195
Pvf1PDGF- and VEGF-related factor 10.194
Akt1CG4006 gene product from transcript CG4006-RA0.194
shnschnurri0.193
HsfHeat shock factor0.193
Rac2CG8556 gene product from transcript CG8556-RA0.192
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cd37CD37 molecule0.756
Cpceruloplasmin0.693
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.452
Hckhemopoietic cell kinase0.414
Il2rginterleukin 2 receptor, gamma0.356
Ptprcprotein tyrosine phosphatase, receptor type, C0.347
Igsf6immunoglobulin superfamily, member 60.318
Cfbcomplement factor B0.318
Ccr5chemokine (C-C motif) receptor 50.247
Tlr4toll-like receptor 40.238
Mmp12matrix metallopeptidase 120.218
Hspb1heat shock protein 10.211
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.207
Arhgap4Rho GTPase activating protein 40.203
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.200
Inpp5dinositol polyphosphate-5-phosphatase D0.199
Arhgap25Rho GTPase activating protein 250.196
Csf1colony stimulating factor 1 (macrophage)0.178
DbpD site of albumin promoter (albumin D-box) binding protein0.173
Ncr1natural cytotoxicity triggering receptor 10.168
Arl11ADP-ribosylation factor-like 110.166
Il1binterleukin 1 beta0.154
Hsph1heat shock 105/110 protein 10.146
C3complement component 30.137
Cxcr5chemokine (C-X-C motif) receptor 50.117
Phkg1phosphorylase kinase, gamma 10.117
Pzppregnancy-zone protein0.115
Ctla2acytotoxic T lymphocyte-associated protein 2 alpha0.113
RGD1559588similar to cell surface receptor FDFACT0.106
Bak1BCL2-antagonist/killer 10.102
Dnase1l3deoxyribonuclease 1-like 30.100
Cd4Cd4 molecule0.097
Reg3aregenerating islet-derived 3 alpha0.096
Cybbcytochrome b-245, beta polypeptide0.093
Anpepalanyl (membrane) aminopeptidase0.092
Mca32mast cell antigen 320.089
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.088
Actg1actin, gamma 10.086
Cficomplement factor I0.084
Dock8dedicator of cytokinesis 80.084
Cd38CD38 molecule0.082
Cd5Cd5 molecule0.082
C2complement component 20.081
Casp1caspase 10.080
Tgfb1transforming growth factor, beta 10.078
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.077
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.076
Tmem176btransmembrane protein 176B0.076
Cd53Cd53 molecule0.076
Batf3basic leucine zipper transcription factor, ATF-like 30.072
Fabp2fatty acid binding protein 2, intestinal0.071
Mrgprx3MAS-related GPR, member X30.070
S1pr2sphingosine-1-phosphate receptor 20.069
Myo1fmyosin IF0.068
Arrb2arrestin, beta 20.068
Cd86CD86 molecule0.066
Map4k1mitogen activated protein kinase kinase kinase kinase 10.065
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.065
Lcp1lymphocyte cytosolic protein 10.065
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.065
Mpeg1macrophage expressed 10.063
Hmha1histocompatibility (minor) HA-10.063
Scn11asodium channel, voltage-gated, type XI, alpha0.063
Ctsecathepsin E0.063
Map2k2mitogen activated protein kinase kinase 20.062
C4bcomplement component 4B (Chido blood group)0.062
Cd247Cd247 molecule0.061
Cmtm6CKLF-like MARVEL transmembrane domain containing 60.060
Rhohras homolog gene family, member H0.059
Jak1Janus kinase 10.059
Dapp1dual adaptor of phosphotyrosine and 3-phosphoinositides0.058
F9coagulation factor IX0.058
Klf6Kruppel-like factor 60.058
Vav1vav 1 guanine nucleotide exchange factor0.058
Slc15a3solute carrier family 15, member 30.058
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.058
Klrd1killer cell lectin-like receptor, subfamily D, member 10.055
Gckrglucokinase (hexokinase 4) regulator0.054
Hoxa2homeo box A20.054
Ifi27interferon, alpha-inducible protein 270.054
Tfectranscription factor EC0.054
Rnase4ribonuclease, RNase A family 40.054
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.054
Reg3gregenerating islet-derived 3 gamma0.053
Il7rinterleukin 7 receptor0.052
Ctsjcathepsin J0.052
Cd8aCD8a molecule0.052
Ciitaclass II, major histocompatibility complex, transactivator0.051
Slc22a7solute carrier family 22 (organic anion transporter), member 70.051
Calhm2calcium homeostasis modulator 20.051
Plcg2phospholipase C, gamma 20.050
Npr1natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)0.050
Rcsd1RCSD domain containing 10.050
Chrnecholinergic receptor, nicotinic, epsilon0.050
Slc6a12solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 120.049
Kcna3potassium voltage-gated channel, shaker-related subfamily, member 30.048
Nrasneuroblastoma ras oncogene0.047
Ccl3chemokine (C-C motif) ligand 30.047
Prss21protease, serine, 210.047
Dusp1dual specificity phosphatase 10.047
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism