The network for 'positive regulation of immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

NameDescriptionProbabilityFunc Analog Organism
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma1.000
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)1.000
TNFAIP3tumor necrosis factor, alpha-induced protein 31.000
BIRC3baculoviral IAP repeat containing 30.999
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.999
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.999
LCKlymphocyte-specific protein tyrosine kinase0.998
IRAK1interleukin-1 receptor-associated kinase 10.998
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.998
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.993
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.992
TNIP2TNFAIP3 interacting protein 20.989
SHC1SHC (Src homology 2 domain containing) transforming protein 10.985
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.984
GRB2growth factor receptor-bound protein 20.982
MAPK14mitogen-activated protein kinase 140.972
TRAF6TNF receptor-associated factor 60.968
MYD88myeloid differentiation primary response gene (88)0.966
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.962
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.951
SYKspleen tyrosine kinase0.945
PTK2PTK2 protein tyrosine kinase 20.943
LATlinker for activation of T cells0.942
BIRC2baculoviral IAP repeat containing 20.932
CD80CD80 molecule0.926
ESR1estrogen receptor 10.907
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.904
PTPN6protein tyrosine phosphatase, non-receptor type 60.901
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.901
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.893
CARD11caspase recruitment domain family, member 110.888
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.882
CCR1chemokine (C-C motif) receptor 10.878
SQSTM1sequestosome 10.841
HLA-Emajor histocompatibility complex, class I, E0.833
PTPN1protein tyrosine phosphatase, non-receptor type 10.831
UBCubiquitin C0.830
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.826
HLA-Cmajor histocompatibility complex, class I, C0.807
BTN3A1butyrophilin, subfamily 3, member A10.801
CD86CD86 molecule0.799
IRAK2interleukin-1 receptor-associated kinase 20.797
BTKBruton agammaglobulinemia tyrosine kinase0.793
IL4Rinterleukin 4 receptor0.792
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.791
FYBFYN binding protein0.791
BTN3A3butyrophilin, subfamily 3, member A30.789
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.781
LAIR1leukocyte-associated immunoglobulin-like receptor 10.760
CD163CD163 molecule0.752
LRRK2leucine-rich repeat kinase 20.748
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.744
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.740
MAP3K14mitogen-activated protein kinase kinase kinase 140.739
CD40CD40 molecule, TNF receptor superfamily member 50.734
C1Scomplement component 1, s subcomponent0.733
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.730
FGF1fibroblast growth factor 1 (acidic)0.725
PMLpromyelocytic leukemia0.724
HLA-DMBmajor histocompatibility complex, class II, DM beta0.721
SIGLEC7sialic acid binding Ig-like lectin 70.715
CD84CD84 molecule0.714
CCR5chemokine (C-C motif) receptor 50.712
CREBBPCREB binding protein0.703
NCOA3nuclear receptor coactivator 30.701
GRB10growth factor receptor-bound protein 100.697
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.692
MAP3K7mitogen-activated protein kinase kinase kinase 70.684
CXCL10chemokine (C-X-C motif) ligand 100.676
CCL4chemokine (C-C motif) ligand 40.662
CD247CD247 molecule0.658
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.645
MAPK3mitogen-activated protein kinase 30.644
GAB1GRB2-associated binding protein 10.643
BCL2L1BCL2-like 10.642
UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.641
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.639
FASFas (TNF receptor superfamily, member 6)0.629
NLRC4NLR family, CARD domain containing 40.628
HLA-Gmajor histocompatibility complex, class I, G0.622
CXCL9chemokine (C-X-C motif) ligand 90.620
NCF1neutrophil cytosolic factor 10.617
KRT17keratin 170.615
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.615
TNIP1TNFAIP3 interacting protein 10.597
ARandrogen receptor0.588
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.586
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.579
CASP8caspase 8, apoptosis-related cysteine peptidase0.576
TRAF1TNF receptor-associated factor 10.568
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.565
VAV1vav 1 guanine nucleotide exchange factor0.564
CD79ACD79a molecule, immunoglobulin-associated alpha0.562
BCL2L11BCL2-like 11 (apoptosis facilitator)0.562
HLA-Amajor histocompatibility complex, class I, A0.557
C1Rcomplement component 1, r subcomponent0.556
NCOR1nuclear receptor corepressor 10.551
EP300E1A binding protein p3000.551
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
F09A5.4Protein F09A5.40.108
sek-1Protein SEK-10.099
egl-27Protein EGL-270.059
drh-1Protein DRH-10.055
vps-11Protein VPS-110.041
unc-116Protein UNC-1160.040
eya-1Protein EYA-10.039
R05F9.11Protein R05F9.110.030
lin-25Protein LIN-250.026
flh-2Protein FLH-20.022
C35C5.6Protein C35C5.60.022
itr-1Protein ITR-10.020
fos-1Protein FOS-10.020
pmk-1Protein PMK-10.019
tat-4Protein TAT-40.018
pek-1Protein PEK-10.018
egl-8Protein EGL-80.018
unc-94Protein UNC-940.018
cgef-1Protein CGEF-10.017
cyn-7Protein CYN-70.017
sec-10Protein SEC-100.017
tre-1Protein TRE-10.017
C34F6.10Protein C34F6.100.017
C52E12.4Protein C52E12.40.017
unc-32Protein UNC-320.016
unc-43Protein UNC-430.016
Y22D7AL.10Protein Y22D7AL.100.016
K06A5.1Protein K06A5.10.015
unc-26Protein UNC-260.015
CELE_R02D3.3Protein R02D3.30.014
hum-5Protein HUM-50.014
ndk-1Protein NDK-10.014
glh-1Protein GLH-10.013
sax-3Protein SAX-30.013
pqm-1Protein PQM-10.013
afd-1Protein AFD-10.013
tax-6Protein TAX-60.012
F54D8.6Protein F54D8.60.012
nhr-34Protein NHR-340.012
CELE_C14A11.9Protein C14A11.90.012
M02E1.1Protein M02E1.10.012
drh-3Protein DRH-30.012
F32B5.7Protein F32B5.70.012
Y42H9AR.4Protein Y42H9AR.40.011
best-3Protein BEST-30.011
akt-2Protein AKT-20.011
oga-1Protein OGA-10.011
sym-4Protein SYM-40.011
C18B12.4Protein C18B12.40.010
K11G12.6Protein K11G12.60.010
dpy-23Protein DPY-230.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
grnagranulin a0.523
meis1myeloid ecotropic viral integration 10.500
LOC566708FL cytokine receptor-like0.491
c3bcomplement component c3b0.401
pcdh18bprotocadherin 18b0.393
dnmt4DNA (cytosine-5-)-methyltransferase 40.337
ef1aelongation factor 1-alpha0.305
egr2bearly growth response 2b0.296
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.290
stc1lstanniocalcin 1, like0.284
eomesaeomesodermin homolog a0.252
card9caspase recruitment domain family, member 90.221
tlr9toll-like receptor 90.203
nod1nucleotide-binding oligomerization domain containing 10.202
tlr21toll-like receptor 210.197
ripk2receptor-interacting serine-threonine kinase 20.193
tnfbtumor necrosis factor b (TNF superfamily, member 2)0.157
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.153
coro1acoronin, actin binding protein, 1A0.147
mpxmyeloid-specific peroxidase0.146
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.133
LOC100000934hypothetical protein LOC1000009340.119
sh3gl1bSH3-domain GRB2-like 1b0.110
irak4interleukin-1 receptor-associated kinase 40.103
pdcd2programmed cell death 20.092
tlr2toll-like receptor 20.092
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.087
gata1aGATA binding protein 1a0.086
LOC557072caspase recruitment domain-containing protein 11-like0.084
jak1Janus kinase 10.080
caspacaspase a0.073
tgfb3transforming growth factor, beta 30.070
sdcbpsyndecan binding protein (syntenin)0.069
ptenaphosphatase and tensin homolog A0.069
vasavasa homolog0.068
arl4abADP-ribosylation factor-like 4ab0.066
slc30a7solute carrier family 30 (zinc transporter), member 70.062
stat1bsignal transducer and activator of transcription 1b0.062
sema3fbsemaphorin 3fb0.060
epas1bendothelial PAS domain protein 1b0.059
rnasel1ribonuclease like 10.059
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.058
tp53tumor protein p530.057
fxr2fragile X mental retardation, autosomal homolog 20.055
ikzf1IKAROS family zinc finger 1 (Ikaros)0.053
c1qccomplement component 1, q subcomponent, C chain0.053
copacoatomer protein complex, subunit alpha0.053
klf2bKruppel-like factor 2b0.052
defbl3defensin, beta-like 30.047
rhagRhesus blood group-associated glycoprotein0.046
eporerythropoietin receptor0.045
nos2anitric oxide synthase 2a, inducible0.042
LOC100151531zinc finger protein Gfi-1b-like0.042
isg15ISG15 ubiquitin-like modifier0.041
fgfr2fibroblast growth factor receptor 20.040
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.040
runx1runt-related transcription factor 10.039
ip6k2inositol hexaphosphate kinase 20.038
LOC100332505hypothetical protein LOC1003325050.038
pax7apaired box gene 7a0.037
ifnphi1interferon phi 10.037
LOC100535037leukotriene B4 receptor 1-like0.037
procprotein C (inactivator of coagulation factors Va and VIIIa)0.036
cry1acryptochrome 1a0.035
dnmt6DNA (cytosine-5-)-methyltransferase 60.033
itgb1aintegrin, beta 1a0.032
serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.031
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.031
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.031
col12a1collagen, type XII, alpha 10.030
vwfvon Willebrand factor0.029
lcp1lymphocyte cytosolic plastin 10.029
ptpn11aprotein tyrosine phosphatase, non-receptor type 11, a0.029
xrcc5X-ray repair complementing defective repair in Chinese hamster cells 50.029
c1qbcomplement component 1, q subcomponent, B chain0.028
pax5paired box gene 50.028
acvr2aactivin receptor IIa0.028
wnt8awingless-type MMTV integration site family, member 8a0.028
entpd1ectonucleoside triphosphate diphosphohydrolase 10.027
ca15acarbonic anhydrase XV a0.027
ahr1aaryl hydrocarbon receptor 1a0.026
nos2bnitric oxide synthase 2b, inducible0.025
foxl1forkhead box L10.025
pycardPYD and CARD domain containing0.025
pcsk2proprotein convertase subtilisin/kexin type 20.024
tlr4bbtoll-like receptor 4b, duplicate b0.024
kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.024
LOC100534776toll-like receptor 7-like0.024
mitfamicrophthalmia-associated transcription factor a0.024
trim25tripartite motif-containing 250.023
rorcaRAR-related orphan receptor C a0.022
pth1aparathyroid hormone 1a0.022
fstafollistatin a0.022
tmem144btransmembrane protein 144b0.022
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.022
zp3bzona pellucida glycoprotein 3b0.021
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
PGRP-LCPeptidoglycan recognition protein LC0.958
DptBDiptericin B0.909
PGRP-SAPeptidoglycan recognition protein SA0.619
Spn27ASerpin 27A0.569
Mpk2CG5475 gene product from transcript CG5475-RB0.561
Pp1-87BProtein phosphatase 1 at 87B0.518
SPESpatzle-Processing Enzyme0.505
PGRP-SDCG7496 gene product from transcript CG7496-RA0.462
Mekk1CG7717 gene product from transcript CG7717-RB0.394
imdimmune deficiency0.380
grassGram-positive Specific Serine protease0.331
Nrx-IVNeurexin IV0.321
p38bCG7393 gene product from transcript CG7393-RA0.321
Tak1TGF-beta activated kinase 10.292
DreddDeath related ced-3/Nedd2-like protein0.287
BG4CG12297 gene product from transcript CG12297-RA0.267
lunaCG33473 gene product from transcript CG33473-RB0.245
JIL-1CG6297 gene product from transcript CG6297-RA0.241
ird5immune response deficient 50.228
CG8155CG8155 gene product from transcript CG8155-RA0.222
l(2)k16918lethal (2) k169180.215
modSPmodular serine protease0.208
GNBP3Gram-negative bacteria binding protein 30.201
drkdownstream of receptor kinase0.187
PGRP-SB1CG9681 gene product from transcript CG9681-RA0.186
HsfHeat shock factor0.164
IrcImmune-regulated catalase0.152
DuoxDual oxidase0.149
Pp2B-14DProtein phosphatase 2B at 14D0.147
Spn28DSerpin 28D0.146
Toll-7CG8595 gene product from transcript CG8595-RA0.145
Atf-2Activating transcription factor-20.139
mbcmyoblast city0.138
CG18067CG18067 gene product from transcript CG18067-RA0.138
stumpsCG31317 gene product from transcript CG31317-RC0.130
Hip14Huntingtin-interacting protein 140.128
Sema-1bCG6446 gene product from transcript CG6446-RA0.127
Sp7Serine protease 70.127
TimpTissue inhibitor of metalloproteases0.127
Toll-6CG7250 gene product from transcript CG7250-RA0.127
Mmp1Matrix metalloproteinase 10.126
Jafrac1thioredoxin peroxidase 10.126
fs(1)Nfemale sterile (1) Nasrat0.125
CecCCecropin C0.123
IM18Immune induced molecule 180.119
Gap1GTPase-activating protein 10.118
CG16718CG16718 gene product from transcript CG16718-RA0.115
Pk92BProtein kinase at 92B0.114
Spn1Serine protease inhibitor 10.109
CG10743CG10743 gene product from transcript CG10743-RB0.108
Hs6stHeparan sulfate 6-O-sulfotransferase0.108
Myd88CG2078 gene product from transcript CG2078-RA0.105
CG5794CG5794 gene product from transcript CG5794-RB0.101
NijANinjurin A0.100
Traf6TNF-receptor-associated factor 60.100
ovoCG6824 gene product from transcript CG6824-RE0.100
CG18666CG18666 gene product from transcript CG18666-RA0.100
Sir2CG5216 gene product from transcript CG5216-RA0.098
p120ctnAdherens junction protein p1200.087
ImpIGF-II mRNA-binding protein0.082
debcldeath executioner Bcl-2 homologue0.082
Traf4TNF-receptor-associated factor 40.081
Dcp-1Death caspase-10.078
rev7CG2948 gene product from transcript CG2948-RA0.077
StamSignal transducing adaptor molecule0.075
GNBP1Gram-negative bacteria binding protein 10.075
HcfHost cell factor0.075
Dsp1Dorsal switch protein 10.073
lolallola like0.072
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cfbcomplement factor B0.319
Cd86CD86 molecule0.312
Casp1caspase 10.297
RT1-BaRT1 class II, locus Ba0.273
Il2rginterleukin 2 receptor, gamma0.246
Tmem176btransmembrane protein 176B0.199
Ccr5chemokine (C-C motif) receptor 50.166
C2complement component 20.165
RT1-DaRT1 class II, locus Da0.163
Cybbcytochrome b-245, beta polypeptide0.163
Phkg1phosphorylase kinase, gamma 10.145
Sirpasignal-regulatory protein alpha0.132
DbpD site of albumin promoter (albumin D-box) binding protein0.132
Cd4Cd4 molecule0.130
Sellselectin L0.127
Clec4a1C-type lectin domain family 4, member a10.124
Ctsecathepsin E0.119
Cd3gCD3 molecule, gamma0.116
Hsph1heat shock 105/110 protein 10.109
Emr1EGF-like module containing, mucin-like, hormone receptor-like 10.107
Ncr1natural cytotoxicity triggering receptor 10.105
Csf1colony stimulating factor 1 (macrophage)0.102
Unc93b1unc-93 homolog B1 (C. elegans)0.097
Ifnginterferon gamma0.094
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.092
Arhgap25Rho GTPase activating protein 250.088
Myo1fmyosin IF0.087
Tpt1tumor protein, translationally-controlled 10.085
Inpp5dinositol polyphosphate-5-phosphatase D0.082
Folr2folate receptor 2 (fetal)0.079
RT1-EC2RT1 class Ib, locus EC20.072
Hsd17b1hydroxysteroid (17-beta) dehydrogenase 10.072
Ctla2acytotoxic T lymphocyte-associated protein 2 alpha0.071
Ly86lymphocyte antigen 860.071
Cd5Cd5 molecule0.070
Batf3basic leucine zipper transcription factor, ATF-like 30.069
Cd38CD38 molecule0.068
Hspb1heat shock protein 10.067
Slasrc-like adaptor0.065
Slc15a3solute carrier family 15, member 30.063
Cd8aCD8a molecule0.061
Dchs1dachsous 1 (Drosophila)0.060
Calcrlcalcitonin receptor-like0.059
Tgfbr2transforming growth factor, beta receptor II0.059
S1pr2sphingosine-1-phosphate receptor 20.059
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.057
Reg3aregenerating islet-derived 3 alpha0.056
Alox5aparachidonate 5-lipoxygenase activating protein0.056
P2ry14purinergic receptor P2Y, G-protein coupled, 140.056
Dnase1l3deoxyribonuclease 1-like 30.056
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.056
Tlr4toll-like receptor 40.055
Vav1vav 1 guanine nucleotide exchange factor0.054
Ctsccathepsin C0.053
Arl11ADP-ribosylation factor-like 110.053
Ptprcprotein tyrosine phosphatase, receptor type, C0.053
Adam17ADAM metallopeptidase domain 170.052
RGD1559588similar to cell surface receptor FDFACT0.052
TcrbT-cell receptor beta chain0.051
Klrd1killer cell lectin-like receptor, subfamily D, member 10.050
Irf5interferon regulatory factor 50.049
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.048
Mobpmyelin-associated oligodendrocyte basic protein0.048
Gbp2guanylate binding protein 20.047
Cficomplement factor I0.047
Dok2docking protein 20.047
Pzppregnancy-zone protein0.047
Prf1perforin 1 (pore forming protein)0.047
Cxcr4chemokine (C-X-C motif) receptor 40.046
Gimap4GTPase, IMAP family member 40.046
Rab20RAB20, member RAS oncogene family0.045
Cd2Cd2 molecule0.044
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.044
Cd247Cd247 molecule0.044
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.044
RT1-Db1RT1 class II, locus Db10.044
Il2rbinterleukin 2 receptor, beta0.043
Fam115cfamily with sequence similarity 115, member C0.043
Itgamintegrin, alpha M0.043
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.042
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.041
Alox5arachidonate 5-lipoxygenase0.041
Lcn2lipocalin 20.041
Nek9NIMA (never in mitosis gene a)- related kinase 90.040
Gipgastric inhibitory polypeptide0.040
Ltalymphotoxin alpha (TNF superfamily, member 1)0.039
Anxa3annexin A30.039
Fgafibrinogen alpha chain0.039
C7complement component 70.038
BtkBruton agammaglobulinemia tyrosine kinase0.038
Adcy10adenylate cyclase 10 (soluble)0.038
Arhgap9Rho GTPase activating protein 90.038
Ccl5chemokine (C-C motif) ligand 50.037
Apol3apolipoprotein L, 30.037
Trim47tripartite motif-containing 470.037
Cishcytokine inducible SH2-containing protein0.037
Fgd2FYVE, RhoGEF and PH domain containing 20.037
Cd22CD22 molecule0.037
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism