The network for 'disruption by host of symbiont cells' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

disruption by host of symbiont cells

Any process in which an organism has a negative effect on the functioning of the symbiont's cells. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.

NameDescriptionProbabilityFunc Analog Organism
CXCL3chemokine (C-X-C motif) ligand 31.000
IL8interleukin 81.000
CXCL2chemokine (C-X-C motif) ligand 20.992
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.971
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.953
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.770
IL6interleukin 6 (interferon, beta 2)0.720
CCL20chemokine (C-C motif) ligand 200.527
IL1Binterleukin 1, beta0.379
NCF2neutrophil cytosolic factor 20.225
CYBAcytochrome b-245, alpha polypeptide0.187
INADLInaD-like (Drosophila)0.112
NCF4neutrophil cytosolic factor 4, 40kDa0.099
IER3immediate early response 30.092
SETD7SET domain containing (lysine methyltransferase) 70.075
CXCL5chemokine (C-X-C motif) ligand 50.072
TRIM9tripartite motif containing 90.066
LIFleukemia inhibitory factor (cholinergic differentiation factor)0.061
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.059
PI3peptidase inhibitor 3, skin-derived0.056
SOD2superoxide dismutase 2, mitochondrial0.054
RNASE3ribonuclease, RNase A family, 30.049
MMP10matrix metallopeptidase 10 (stromelysin 2)0.041
BPIbactericidal/permeability-increasing protein0.039
ELANEelastase, neutrophil expressed0.038
DEFA4defensin, alpha 4, corticostatin0.038
MMP1matrix metallopeptidase 1 (interstitial collagenase)0.038
TNFAIP6tumor necrosis factor, alpha-induced protein 60.037
AZU1azurocidin 10.036
LCN2lipocalin 20.032
CCL7chemokine (C-C motif) ligand 70.030
FPR1formyl peptide receptor 10.030
PRKCBprotein kinase C, beta0.029
PRKCDprotein kinase C, delta0.028
PGLYRP1peptidoglycan recognition protein 10.028
CDCP1CUB domain containing protein 10.027
PASKPAS domain containing serine/threonine kinase0.027
CCL2chemokine (C-C motif) ligand 20.026
SERPINB2serpin peptidase inhibitor, clade B (ovalbumin), member 20.026
PRTN3proteinase 30.025
GPR97G protein-coupled receptor 970.025
MMP8matrix metallopeptidase 8 (neutrophil collagenase)0.025
CAMPcathelicidin antimicrobial peptide0.024
TFPI2tissue factor pathway inhibitor 20.024
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.023
DPP4dipeptidyl-peptidase 40.023
PROCRprotein C receptor, endothelial0.022
CEACAM4carcinoembryonic antigen-related cell adhesion molecule 40.021
MPZL2myelin protein zero-like 20.021
CXCR2chemokine (C-X-C motif) receptor 20.021
ORM1orosomucoid 10.021
CAV2caveolin 20.021
CSF3colony stimulating factor 3 (granulocyte)0.020
NFE2nuclear factor (erythroid-derived 2), 45kDa0.019
SELEselectin E0.019
S100A12S100 calcium binding protein A120.018
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.018
PF4platelet factor 40.017
LRP1low density lipoprotein receptor-related protein 10.017
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 30.016
PPBPpro-platelet basic protein (chemokine (C-X-C motif) ligand 7)0.016
ACTG1actin, gamma 10.016
CFL2cofilin 2 (muscle)0.016
LAMB3laminin, beta 30.015
IL1R2interleukin 1 receptor, type II0.015
SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.015
MAP3K8mitogen-activated protein kinase kinase kinase 80.015
ZC3H12Azinc finger CCCH-type containing 12A0.014
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)0.014
PTX3pentraxin 3, long0.014
G0S2G0/G1switch 20.013
TFPItissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)0.013
GFI1growth factor independent 1 transcription repressor0.013
HBDhemoglobin, delta0.013
INHBAinhibin, beta A0.013
VNN1vanin 10.013
CMA1chymase 1, mast cell0.013
MASP2mannan-binding lectin serine peptidase 20.013
IL1RAPinterleukin 1 receptor accessory protein0.013
EPHA2EPH receptor A20.013
IL18R1interleukin 18 receptor 10.013
IL13RA2interleukin 13 receptor, alpha 20.012
CEACAM8carcinoembryonic antigen-related cell adhesion molecule 80.012
CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)0.012
MYL4myosin, light chain 4, alkali; atrial, embryonic0.012
PHLDA1pleckstrin homology-like domain, family A, member 10.012
MMP12matrix metallopeptidase 12 (macrophage elastase)0.012
SERPINA1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.012
FFAR2free fatty acid receptor 20.011
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.011
LAMC2laminin, gamma 20.011
F3coagulation factor III (thromboplastin, tissue factor)0.011
LTC4Sleukotriene C4 synthase0.011
DEFA1Bdefensin, alpha 1B0.011
IL1RNinterleukin 1 receptor antagonist0.011
ITGA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)0.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctsgcathepsin G0.933
S100a9S100 calcium binding protein A9 (calgranulin B)0.858
Ngpneutrophilic granule protein0.764
S100a8S100 calcium binding protein A8 (calgranulin A)0.708
Mmp8matrix metallopeptidase 80.663
Cxcl2chemokine (C-X-C motif) ligand 20.557
Ccl4chemokine (C-C motif) ligand 40.557
Il1rninterleukin 1 receptor antagonist0.532
Saa3serum amyloid A 30.400
Cma1chymase 1, mast cell0.390
Gzmbgranzyme B0.379
Elaneelastase, neutrophil expressed0.347
Klrk1killer cell lectin-like receptor subfamily K, member 10.341
Irg1immunoresponsive gene 10.319
Clec4dC-type lectin domain family 4, member d0.302
Slfn4schlafen 40.291
Il18rapinterleukin 18 receptor accessory protein0.279
Campcathelicidin antimicrobial peptide0.278
Mcpt4mast cell protease 40.265
Il1r2interleukin 1 receptor, type II0.222
Ccl7chemokine (C-C motif) ligand 70.220
Cpa3carboxypeptidase A3, mast cell0.209
Gzmcgranzyme C0.205
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.202
C5ar1complement component 5a receptor 10.191
Clec4eC-type lectin domain family 4, member e0.160
FaslFas ligand (TNF superfamily, member 6)0.159
Il1binterleukin 1 beta0.156
Ccl8chemokine (C-C motif) ligand 80.144
Klrg1killer cell lectin-like receptor subfamily G, member 10.143
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.142
Batfbasic leucine zipper transcription factor, ATF-like0.138
Prg2proteoglycan 2, bone marrow0.136
Ccl3chemokine (C-C motif) ligand 30.126
Fpr1formyl peptide receptor 10.119
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.111
Gbp1guanylate binding protein 10.108
Ccl12chemokine (C-C motif) ligand 120.105
Cxcr2chemokine (C-X-C motif) receptor 20.104
Mcpt2mast cell protease 20.103
Chi3l3chitinase 3-like 30.102
Ltc4sleukotriene C4 synthase0.101
Il1rl1interleukin 1 receptor-like 10.101
Xcl1chemokine (C motif) ligand 10.096
Fcgr1Fc receptor, IgG, high affinity I0.096
Ifitm6interferon induced transmembrane protein 60.094
Ccl22chemokine (C-C motif) ligand 220.091
Fpr2formyl peptide receptor 20.088
Il2rbinterleukin 2 receptor, beta chain0.087
Gzmfgranzyme F0.086
Niacr1niacin receptor 10.083
Gfi1bgrowth factor independent 1B0.080
Cma2chymase 2, mast cell0.073
Fcer1aFc receptor, IgE, high affinity I, alpha polypeptide0.067
Mmp10matrix metallopeptidase 100.067
Slpisecretory leukocyte peptidase inhibitor0.062
Mmp13matrix metallopeptidase 130.060
Rsad2radical S-adenosyl methionine domain containing 20.058
Ccl11chemokine (C-C motif) ligand 110.057
Klra2killer cell lectin-like receptor, subfamily A, member 20.057
Aoahacyloxyacyl hydrolase0.056
Ubdubiquitin D0.055
Serpina3gserine (or cysteine) peptidase inhibitor, clade A, member 3G0.053
Mcpt8mast cell protease 80.053
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.053
Folr2folate receptor 2 (fetal)0.052
Prtn3proteinase 30.051
1100001G20RikRIKEN cDNA 1100001G20 gene0.050
Cst7cystatin F (leukocystatin)0.049
LOC100504404h-2 class II histocompatibility antigen, E-K alpha chain-like0.049
Pgk2phosphoglycerate kinase 20.048
Fosl1fos-like antigen 10.047
Plaurplasminogen activator, urokinase receptor0.047
Gdf15growth differentiation factor 150.047
Maffv-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)0.044
RhagRhesus blood group-associated A glycoprotein0.044
Gp1baglycoprotein 1b, alpha polypeptide0.043
C2complement component 2 (within H-2S)0.042
Il1ainterleukin 1 alpha0.042
Fcnaficolin A0.042
Prl2b1prolactin family 2, subfamily b, member 10.040
H2-M9histocompatibility 2, M region locus 90.039
Ccl5chemokine (C-C motif) ligand 50.036
Klrc1killer cell lectin-like receptor subfamily C, member 10.036
Cideccell death-inducing DFFA-like effector c0.035
Tnfaip2tumor necrosis factor, alpha-induced protein 20.035
Cd300lfCD300 antigen like family member F0.034
Adipoqadiponectin, C1Q and collagen domain containing0.033
Ms4a3membrane-spanning 4-domains, subfamily A, member 30.033
Cxcl1chemokine (C-X-C motif) ligand 10.033
Trim10tripartite motif-containing 100.032
Prol1proline rich, lacrimal 10.032
Il6interleukin 60.031
Ctswcathepsin W0.031
Sh2d2aSH2 domain protein 2A0.031
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism