The network for 'digestion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms


The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.

NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 20.996
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.770
KCNE1potassium voltage-gated channel, Isk-related family, member 10.734
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.615
NCOA1nuclear receptor coactivator 10.548
ABCG5ATP-binding cassette, sub-family G (WHITE), member 50.546
CAND1cullin-associated and neddylation-dissociated 10.537
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.508
ABCG8ATP-binding cassette, sub-family G (WHITE), member 80.504
FGF10fibroblast growth factor 100.444
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.427
PRKAB2protein kinase, AMP-activated, beta 2 non-catalytic subunit0.388
FGF1fibroblast growth factor 1 (acidic)0.315
RXRAretinoid X receptor, alpha0.309
CRHR1corticotropin releasing hormone receptor 10.284
S100A10S100 calcium binding protein A100.272
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.260
CD300LDCD300 molecule-like family member d0.224
TICAM2toll-like receptor adaptor molecule 20.211
COPEcoatomer protein complex, subunit epsilon0.202
HNRNPKheterogeneous nuclear ribonucleoprotein K0.194
H2AFXH2A histone family, member X0.181
KLHL3kelch-like 3 (Drosophila)0.159
LY96lymphocyte antigen 960.117
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.110
CLNS1Achloride channel, nucleotide-sensitive, 1A0.109
FGFR1fibroblast growth factor receptor 10.101
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.080
OXSR1oxidative-stress responsive 10.062
RUNX1runt-related transcription factor 10.061
CUL5cullin 50.052
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.046
SEC61GSec61 gamma subunit0.044
PCSK9proprotein convertase subtilisin/kexin type 90.044
CUL2cullin 20.042
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.042
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.038
ZHX1zinc fingers and homeoboxes 10.038
PRMT2protein arginine methyltransferase 20.038
HRhairless homolog (mouse)0.036
OPA1optic atrophy 1 (autosomal dominant)0.033
GLIS2GLIS family zinc finger 20.033
HMGA1high mobility group AT-hook 10.033
CAV2caveolin 20.032
APOC3apolipoprotein C-III0.031
RARAretinoic acid receptor, alpha0.031
MDFIMyoD family inhibitor0.031
DMC1DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)0.031
FCRL4Fc receptor-like 40.030
UBXN6UBX domain protein 60.030
LCATlecithin-cholesterol acyltransferase0.029
SLC34A1solute carrier family 34 (sodium phosphate), member 10.029
PRKAG1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.028
MSTO1misato homolog 1 (Drosophila)0.028
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.028
HIC1hypermethylated in cancer 10.027
PRODH2proline dehydrogenase (oxidase) 20.026
RIPK2receptor-interacting serine-threonine kinase 20.025
PKD2polycystic kidney disease 2 (autosomal dominant)0.024
SLC28A1solute carrier family 28 (sodium-coupled nucleoside transporter), member 10.024
EDF1endothelial differentiation-related factor 10.024
PYDC2pyrin domain containing 20.023
CUL4Acullin 4A0.023
S100A6S100 calcium binding protein A60.022
TXNDC2thioredoxin domain containing 2 (spermatozoa)0.022
SNRPFsmall nuclear ribonucleoprotein polypeptide F0.021
FGAfibrinogen alpha chain0.021
SPOPspeckle-type POZ protein0.021
ADAMTSL4ADAMTS-like 40.020
FUT6fucosyltransferase 6 (alpha (1,3) fucosyltransferase)0.020
SLC22A7solute carrier family 22 (organic anion transporter), member 70.019
PIGRpolymeric immunoglobulin receptor0.019
TMSB10thymosin beta 100.019
KBTBD7kelch repeat and BTB (POZ) domain containing 70.019
PSEN1presenilin 10.019
ALPIalkaline phosphatase, intestinal0.019
EMP1epithelial membrane protein 10.018
TFF3trefoil factor 3 (intestinal)0.018
FABP1fatty acid binding protein 1, liver0.018
ALDOBaldolase B, fructose-bisphosphate0.018
COPB2coatomer protein complex, subunit beta 2 (beta prime)0.018
VPS52vacuolar protein sorting 52 homolog (S. cerevisiae)0.018
FGF7fibroblast growth factor 70.018
MUC2mucin 2, oligomeric mucus/gel-forming0.017
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.016
MUC5Bmucin 5B, oligomeric mucus/gel-forming0.016
SLC17A1solute carrier family 17 (sodium phosphate), member 10.016
ANGangiogenin, ribonuclease, RNase A family, 50.016
TFF2trefoil factor 20.016
FGF8fibroblast growth factor 8 (androgen-induced)0.016
LGALS4lectin, galactoside-binding, soluble, 40.016
TNFRSF10Ctumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain0.015
SLC13A2solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 20.015
DRD2dopamine receptor D20.015
PDX1pancreatic and duodenal homeobox 10.015
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
anxa1bannexin A1b0.219
adrb2aadrenergic receptor, beta 2a0.082
fabp2fatty acid binding protein 2, intestinal0.067
neurog1neurogenin 10.066
sox9bSRY-box containing gene 9b0.061
fabp1b.1fatty acid binding protein 1b, tandem duplicate 10.051
ireb2iron-responsive element binding protein 20.043
copb1coatomer protein complex, subunit beta 10.031
hbaa1hemoglobin alpha adult-10.031
st8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.027
oprd1bopioid receptor, delta 1b0.025
trpv6transient receptor potential cation channel, subfamily V, member 60.022
aco1aconitase 1, soluble0.021
hoxc8ahomeo box C8a0.021
hnf4ahepatocyte nuclear factor 4, alpha0.021
apoblapolipoprotein B, like0.020
mogat2monoacylglycerol O-acyltransferase 20.020
cpa4carboxypeptidase A40.019
krt4keratin 40.018
cyp2y3cytochrome P450, family 2, subfamily Y, polypeptide 30.018
sgpl1sphingosine-1-phosphate lyase 10.018
wlswntless homolog (Drosophila)0.017
LOC100332193growth hormone secretagogue receptor type 1-like0.016
ptch1patched 10.015
apcadenomatosis polyposis coli0.015
krt5keratin 50.014
pi4kbphosphatidylinositol 4-kinase, catalytic, beta0.014
gata5GATA-binding protein 50.013
ak3adenylate kinase 30.013
acsl5acyl-CoA synthetase long-chain family member 50.013
myh11amyosin, heavy polypeptide 11, smooth muscle a0.012
c6ast3six-cysteine containing astacin protease 30.012
apoa1apolipoprotein A-I0.012
klf4aKruppel-like transcription factor 4a0.012
fgf10afibroblast growth factor 10a0.012
anxa1aannexin A1a0.012
stat3signal transduction and activation of transcription 30.012
cx30.3connexin 30.30.012
tax1bp3Tax1 (human T-cell leukemia virus type I) binding protein 30.011
sec31asec31 homolog A (S. cerevisiae)0.011
abcc5ATP-binding cassette, sub-family C (CFTR/MRP), member 50.011
atp1a1a.4ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide0.011
stk38lserine/threonine kinase 38 like0.010
pdzk1PDZ domain containing 10.010
sult1st3sulfotransferase family 1, cytosolic sulfotransferase 30.010
sucla2succinate-CoA ligase, ADP-forming, beta subunit0.010
htr1aa5-hydroxytryptamine (serotonin) receptor 1A a0.010
ompbolfactory marker protein b0.010
cahzcarbonic anhydrase0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG12171CG12171 gene product from transcript CG12171-RA0.018
Toll-6CG7250 gene product from transcript CG7250-RA0.011
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Neurod1neurogenic differentiation 10.930
Hand1heart and neural crest derivatives expressed transcript 10.904
Ascl1achaete-scute complex homolog 1 (Drosophila)0.859
Nos3nitric oxide synthase 3, endothelial cell0.828
Drd2dopamine receptor D20.761
Adrb1adrenergic receptor, beta 10.703
Ppargperoxisome proliferator activated receptor gamma0.679
Nos1nitric oxide synthase 1, neuronal0.657
Oprm1opioid receptor, mu 10.583
Celcarboxyl ester lipase0.544
Kcnj1potassium inwardly-rectifying channel, subfamily J, member 10.542
Npy2rneuropeptide Y receptor Y20.521
Hoxd13homeobox D130.517
Shhsonic hedgehog0.508
Pax6paired box gene 60.497
Apoa1apolipoprotein A-I0.497
Nr1i3nuclear receptor subfamily 1, group I, member 30.380
Hnf4ahepatic nuclear factor 4, alpha0.374
Alx3aristaless-like homeobox 30.373
Leprleptin receptor0.368
Tgfb1transforming growth factor, beta 10.352
Chrm1cholinergic receptor, muscarinic 1, CNS0.338
Thrbthyroid hormone receptor beta0.337
Isl1ISL1 transcription factor, LIM/homeodomain0.334
Pnpla2patatin-like phospholipase domain containing 20.333
Ptf1apancreas specific transcription factor, 1a0.325
Gata4GATA binding protein 40.318
Mogat2monoacylglycerol O-acyltransferase 20.315
Lhx3LIM homeobox protein 30.299
Foxd2forkhead box D20.298
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.296
Abcg8ATP-binding cassette, sub-family G (WHITE), member 80.288
Alx4aristaless-like homeobox 40.283
Kcnk4potassium channel, subfamily K, member 40.278
Rxrgretinoid X receptor gamma0.275
Adra2aadrenergic receptor, alpha 2a0.259
Slc12a1solute carrier family 12, member 10.247
Oprk1opioid receptor, kappa 10.238
Cckbrcholecystokinin B receptor0.225
Tbx15T-box 150.211
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.208
Abcc6ATP-binding cassette, sub-family C (CFTR/MRP), member 60.208
Sox7SRY-box containing gene 70.203
Pparaperoxisome proliferator activated receptor alpha0.199
Runx2runt related transcription factor 20.196
Vdrvitamin D receptor0.188
Alx1ALX homeobox 10.187
Sstr1somatostatin receptor 10.181
Trhthyrotropin releasing hormone0.177
Fgf4fibroblast growth factor 40.173
Onecut1one cut domain, family member 10.172
Slc4a4solute carrier family 4 (anion exchanger), member 40.167
Col1a1collagen, type I, alpha 10.166
Raver2ribonucleoprotein, PTB-binding 20.166
Kcnn1potassium intermediate/small conductance calcium-activated channel, subfamily N, member 10.164
Lhx9LIM homeobox protein 90.162
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.160
2210010C04RikRIKEN cDNA 2210010C04 gene0.159
Oprd1opioid receptor, delta 10.159
Pdx1pancreatic and duodenal homeobox 10.158
MecomMDS1 and EVI1 complex locus0.156
Neurog3neurogenin 30.152
Abcg5ATP-binding cassette, sub-family G (WHITE), member 50.150
Sstr5somatostatin receptor 50.150
Kcnq2potassium voltage-gated channel, subfamily Q, member 20.148
Fgf3fibroblast growth factor 30.147
Agtr2angiotensin II receptor, type 20.147
Prph2peripherin 20.146
Slc5a11solute carrier family 5 (sodium/glucose cotransporter), member 110.146
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.143
Clcnkachloride channel Ka0.142
Fshrfollicle stimulating hormone receptor0.139
Apoeapolipoprotein E0.139
Eporerythropoietin receptor0.138
Pax3paired box gene 30.138
Six6sine oculis-related homeobox 6 homolog (Drosophila)0.138
Npy1rneuropeptide Y receptor Y10.137
Tcfap2atranscription factor AP-2, alpha0.136
Apomapolipoprotein M0.136
Kcnd1potassium voltage-gated channel, Shal-related family, member 10.134
Iappislet amyloid polypeptide0.130
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.130
Zp1zona pellucida glycoprotein 10.129
Slc13a1solute carrier family 13 (sodium/sulfate symporters), member 10.128
Htr45 hydroxytryptamine (serotonin) receptor 40.125
Lhx6LIM homeobox protein 60.125
Gata6GATA binding protein 60.122
Glra1glycine receptor, alpha 1 subunit0.121
Ncoa3nuclear receptor coactivator 30.120
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.120
Atoh7atonal homolog 7 (Drosophila)0.120
Matn1matrilin 1, cartilage matrix protein0.119
Degs2degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase0.118
Gabra2gamma-aminobutyric acid (GABA) A receptor, subunit alpha 20.117
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Chrna7cholinergic receptor, nicotinic, alpha 70.353
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.148
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.080
Htr65-hydroxytryptamine (serotonin) receptor 60.064
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.057
Chst3carbohydrate (chondroitin 6) sulfotransferase 30.054
Olr1078olfactory receptor 10780.052
Cacng4calcium channel, voltage-dependent, gamma subunit 40.052
Grifingalectin-related inter-fiber protein0.052
Insrrinsulin receptor-related receptor0.051
Magmyelin-associated glycoprotein0.048
Fam65afamily with sequence similarity 65, member A0.047
Mamdc4MAM domain containing 40.047
Ctsjcathepsin J0.047
Kif6kinesin family member 60.047
P2rx3purinergic receptor P2X, ligand-gated ion channel, 30.046
Mep1ameprin 1 alpha0.045
Teddm1transmembrane epididymal protein 10.044
Ppypancreatic polypeptide0.043
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.043
Nlrp6NLR family, pyrin domain containing 60.043
Ccbp2chemokine binding protein 20.039
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.038
Cgaglycoprotein hormones, alpha polypeptide0.034
Hrh2histamine receptor H 20.034
Tmem79transmembrane protein 790.034
Klk8kallikrein related-peptidase 80.033
Zg16zymogen granule protein 160.033
Il13interleukin 130.032
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.032
CartptCART prepropeptide0.032
Olr1082olfactory receptor 10820.032
Cysscystatin S0.032
Nmbrneuromedin B receptor0.031
Olr287olfactory receptor 2870.031
Hnmthistamine N-methyltransferase0.030
Gucy2dguanylate cyclase 2d0.030
Aqp5aquaporin 50.029
Gria4glutamate receptor, ionotrophic, AMPA 40.029
Svs1seminal vesicle secretory protein 10.029
Slc14a2solute carrier family 14 (urea transporter), member 20.029
Slc6a2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 20.028
Prm3protamine 30.028
Avparginine vasopressin0.028
Prss3protease, serine, 30.027
Epha8Eph receptor A80.027
C3ar1complement component 3a receptor 10.026
Pax6paired box 60.026
Prlrprolactin receptor0.026
Ucp1uncoupling protein 1 (mitochondrial, proton carrier)0.026
Wfdc6aWAP four-disulfide core domain 6A0.025
Ifna1interferon-alpha 10.025
Pnlippancreatic lipase0.025
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.024
Scn10asodium channel, voltage-gated, type X, alpha subunit0.024
Starsteroidogenic acute regulatory protein0.024
Cnga1cyclic nucleotide gated channel alpha 10.024
Fgfbp1fibroblast growth factor binding protein 10.024
Accn2amiloride-sensitive cation channel 2, neuronal0.023
Kcnmb1potassium large conductance calcium-activated channel, subfamily M, beta member 10.023
Slc30a2solute carrier family 30 (zinc transporter), member 20.022
Ednraendothelin receptor type A0.022
Fgf7fibroblast growth factor 70.022
Npy5rneuropeptide Y receptor Y50.021
Csn2casein beta0.021
Cx3cr1chemokine (C-X3-C motif) receptor 10.021
Upk3bluroplakin 3B-like0.021
Tff3trefoil factor 3, intestinal0.021
Slco1a1solute carrier organic anion transporter family, member 1a10.021
Pspparotid secretory protein0.021
Olr1493olfactory receptor gene Olr14930.020
Grm6glutamate receptor, metabotropic 60.020
Trib1tribbles homolog 1 (Drosophila)0.020
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.020
Kcnj15potassium inwardly-rectifying channel, subfamily J, member 150.019
Prdx1peroxiredoxin 10.019
Npffr1neuropeptide FF receptor 10.019
Slc22a25solute carrier family 22, member 250.019
Tpbpatrophoblast specific protein alpha0.019
Cyp2a1cytochrome P450, family 2, subfamily a, polypeptide 10.019
Pmfbp1polyamine modulated factor 1 binding protein 10.019
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.019
Il12ainterleukin 12A0.019
Smgbneonatal submandibular gland protein B0.018
Cntn5contactin 50.018
Hsd3b5hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 50.018
Barhl1BarH-like homeobox 10.018
Gabra5gamma-aminobutyric acid (GABA) A receptor, alpha 50.018
Agtr1aangiotensin II receptor, type 1a0.018
Mc5rmelanocortin 5 receptor0.018
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.018
Add2adducin 2 (beta)0.018
Spink1serine peptidase inhibitor, Kazal type 10.018
Kcnj16potassium inwardly-rectifying channel, subfamily J, member 160.017
Slc28a1solute carrier family 28 (sodium-coupled nucleoside transporter), member 10.017
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism