The network for 'negative regulation of protein modification by small protein conjugation or removal' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of protein modification by small protein conjugation or removal

Any process that stops, prevents or reduces the frequency, rate or extent of protein modification by small protein conjugation or removal.

NameDescriptionProbabilityFunc Analog Organism
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.965
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.758
DAXXdeath-domain associated protein0.550
SMAD4SMAD family member 40.548
SMAD7SMAD family member 70.477
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.420
HSPA8heat shock 70kDa protein 80.410
PMLpromyelocytic leukemia0.328
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.303
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.296
SMAD1SMAD family member 10.251
SMAD2SMAD family member 20.229
TP53tumor protein p530.208
CFL1cofilin 1 (non-muscle)0.182
ANAPC4anaphase promoting complex subunit 40.179
TRAF6TNF receptor-associated factor 60.165
DTX3Ldeltex 3-like (Drosophila)0.161
CAV1caveolin 1, caveolae protein, 22kDa0.157
SMAD3SMAD family member 30.136
SMURF2SMAD specific E3 ubiquitin protein ligase 20.133
CAPNS1calpain, small subunit 10.130
CTAG1Bcancer/testis antigen 1B0.127
ZNF496zinc finger protein 4960.116
TTNtitin0.115
IFIT1interferon-induced protein with tetratricopeptide repeats 10.115
TEKT4tektin 40.110
NAP1L5nucleosome assembly protein 1-like 50.106
PSEN1presenilin 10.105
MAGEA3melanoma antigen family A, 30.098
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.098
FBXW11F-box and WD repeat domain containing 110.095
POU3F2POU class 3 homeobox 20.093
NSMCE1non-SMC element 1 homolog (S. cerevisiae)0.079
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.075
CCNB1cyclin B10.074
MBD1methyl-CpG binding domain protein 10.071
HIPK2homeodomain interacting protein kinase 20.070
TNIP1TNFAIP3 interacting protein 10.069
SP110SP110 nuclear body protein0.069
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.069
BRAPBRCA1 associated protein0.066
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.066
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.059
EID2EP300 interacting inhibitor of differentiation 20.059
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.058
SFNstratifin0.058
ZNF263zinc finger protein 2630.056
CSNK2A1casein kinase 2, alpha 1 polypeptide0.052
PTENphosphatase and tensin homolog0.052
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.049
TRIM5tripartite motif containing 50.049
MED15mediator complex subunit 150.048
NOXA1NADPH oxidase activator 10.048
SPRY4sprouty homolog 4 (Drosophila)0.048
PJA1praja ring finger 10.046
RING1ring finger protein 10.046
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.045
PAX3paired box 30.045
FLNBfilamin B, beta0.045
CDK2cyclin-dependent kinase 20.043
HSPH1heat shock 105kDa/110kDa protein 10.043
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.042
EGFRepidermal growth factor receptor0.042
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.042
ANAPC1anaphase promoting complex subunit 10.041
SMAD5SMAD family member 50.041
GCLMglutamate-cysteine ligase, modifier subunit0.041
HSPA4heat shock 70kDa protein 40.041
BAG1BCL2-associated athanogene0.040
MAGEA1melanoma antigen family A, 1 (directs expression of antigen MZ2-E)0.040
PIAS1protein inhibitor of activated STAT, 10.040
NSMCE4Anon-SMC element 4 homolog A (S. cerevisiae)0.040
MAP3K5mitogen-activated protein kinase kinase kinase 50.040
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.039
PCGF2polycomb group ring finger 20.039
FASFas (TNF receptor superfamily, member 6)0.038
SMURF1SMAD specific E3 ubiquitin protein ligase 10.038
TADA3transcriptional adaptor 30.037
PRKCAprotein kinase C, alpha0.037
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.036
MAGEA2melanoma antigen family A, 20.036
UBQLN1ubiquilin 10.036
PSEN2presenilin 2 (Alzheimer disease 4)0.035
HDAC1histone deacetylase 10.035
SKP2S-phase kinase-associated protein 2 (p45)0.035
HERC2hect domain and RLD 20.034
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.033
ATG12ATG12 autophagy related 12 homolog (S. cerevisiae)0.033
RB1retinoblastoma 10.033
HSPB1heat shock 27kDa protein 10.032
SIN3ASIN3 homolog A, transcription regulator (yeast)0.032
CCNA2cyclin A20.032
ZRANB1zinc finger, RAN-binding domain containing 10.032
BTBD2BTB (POZ) domain containing 20.032
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.032
TRIM32tripartite motif containing 320.030
HSPA1Aheat shock 70kDa protein 1A0.030
RASSF1Ras association (RalGDS/AF-6) domain family member 10.030
ARIH1ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)0.030
MEOX2mesenchyme homeobox 20.029
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Cry2cryptochrome 2 (photolyase-like)0.972
Clockcircadian locomotor output cycles kaput0.710
Per2period homolog 2 (Drosophila)0.693
Arntlaryl hydrocarbon receptor nuclear translocator-like0.686
Psen1presenilin 10.385
Ncoa3nuclear receptor coactivator 30.381
Iigp1interferon inducible GTPase 10.251
SkilSKI-like0.165
Trp53transformation related protein 530.164
Gbp3guanylate binding protein 30.155
Arrb1arrestin, beta 10.155
Gli3GLI-Kruppel family member GLI30.149
Cry1cryptochrome 1 (photolyase-like)0.146
Rpgrip1lRpgrip1-like0.133
Shhsonic hedgehog0.125
Axin1axin 10.122
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.120
Usp18ubiquitin specific peptidase 180.108
Lrrk2leucine-rich repeat kinase 20.106
Iqcb1IQ calmodulin-binding motif containing 10.104
Notch1Notch gene homolog 1 (Drosophila)0.087
Gdnfglial cell line derived neurotrophic factor0.086
PycardPYD and CARD domain containing0.086
Irf9interferon regulatory factor 90.084
Gbp7guanylate binding protein 70.074
Hspa8heat shock protein 80.070
Per1period homolog 1 (Drosophila)0.059
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.058
Hsph1heat shock 105kDa/110kDa protein 10.057
Arrb2arrestin, beta 20.055
Ptrfpolymerase I and transcript release factor0.054
Stat1signal transducer and activator of transcription 10.054
Oasl22'-5' oligoadenylate synthetase-like 20.053
Dkk1dickkopf homolog 1 (Xenopus laevis)0.052
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.051
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.049
Ncstnnicastrin0.049
Notch2Notch gene homolog 2 (Drosophila)0.047
ND6NADH dehydrogenase subunit 60.045
Wnt3awingless-related MMTV integration site 3A0.045
Ctnnb1catenin (cadherin associated protein), beta 10.044
Ifit3interferon-induced protein with tetratricopeptide repeats 30.044
Ifih1interferon induced with helicase C domain 10.043
Tbrachyury0.042
Sox9SRY-box containing gene 90.041
Usp2ubiquitin specific peptidase 20.039
Parp9poly (ADP-ribose) polymerase family, member 90.039
Fgfr2fibroblast growth factor receptor 20.039
Irgm2immunity-related GTPase family M member 20.038
SrcRous sarcoma oncogene0.037
Igtpinterferon gamma induced GTPase0.037
Ifi47interferon gamma inducible protein 470.037
Zfp651zinc finger protein 6510.036
Cdk2cyclin-dependent kinase 20.036
Sap18Sin3-associated polypeptide 180.036
Aph1aanterior pharynx defective 1a homolog (C. elegans)0.035
Sgol2shugoshin-like 2 (S. pombe)0.034
Ptk2PTK2 protein tyrosine kinase 20.034
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.034
Retret proto-oncogene0.033
Trim30atripartite motif-containing 30A0.033
Kdm2blysine (K)-specific demethylase 2B0.033
Ror2receptor tyrosine kinase-like orphan receptor 20.033
Pou3f1POU domain, class 3, transcription factor 10.032
Mgea5meningioma expressed antigen 5 (hyaluronidase)0.032
Trp73transformation related protein 730.032
Pax8paired box gene 80.032
Efnb2ephrin B20.030
Ric8resistance to inhibitors of cholinesterase 8 homolog (C. elegans)0.029
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.029
Gbp6guanylate binding protein 60.027
Csnk1ecasein kinase 1, epsilon0.026
Irgm1immunity-related GTPase family M member 10.026
Rararetinoic acid receptor, alpha0.026
Ifit1interferon-induced protein with tetratricopeptide repeats 10.025
Atg12autophagy-related 12 (yeast)0.025
Col2a1collagen, type II, alpha 10.025
Casp4caspase 4, apoptosis-related cysteine peptidase0.025
Ptch1patched homolog 10.024
Trim21tripartite motif-containing 210.023
Uba7ubiquitin-like modifier activating enzyme 70.023
Setdb1SET domain, bifurcated 10.023
Gbp2guanylate binding protein 20.023
Amhanti-Mullerian hormone0.022
Ccne1cyclin E10.022
Trim25tripartite motif-containing 250.022
Chordc1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 10.022
Ifi35interferon-induced protein 350.021
Wnt10bwingless related MMTV integration site 10b0.021
Smad6MAD homolog 6 (Drosophila)0.021
Rabep1rabaptin, RAB GTPase binding effector protein 10.021
Fbxl3F-box and leucine-rich repeat protein 30.021
Pax2paired box gene 20.020
Traf6TNF receptor-associated factor 60.020
Porcnporcupine homolog (Drosophila)0.020
Aim2absent in melanoma 20.020
Gsk3bglycogen synthase kinase 3 beta0.020
Casp1caspase 10.020
Tbx2T-box 20.019
Per3period homolog 3 (Drosophila)0.019
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Rpl18aribosomal protein L18A0.045
Rps9ribosomal protein S90.043
Ppibpeptidylprolyl isomerase B0.037
Psmb1proteasome (prosome, macropain) subunit, beta type 10.034
Rplp0ribosomal protein, large, P00.033
Rpl34ribosomal protein L340.031
Rps4xribosomal protein S4, X-linked0.029
LOC100188932dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 40.029
Rpl11ribosomal protein L110.029
Mrps16mitochondrial ribosomal protein S160.027
Cox5bcytochrome c oxidase subunit Vb0.026
Ndufa11NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 110.026
Rpl7aribosomal protein L7a0.026
Atp5hATP synthase, H+ transporting, mitochondrial F0 complex, subunit d0.024
LOC688869similar to cytochrome c oxidase, subunit VIb polypeptide 10.024
Rpl15ribosomal protein L150.024
Rpl36alribosomal protein L36a-like0.023
Ndufa13NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 130.022
Timm13translocase of inner mitochondrial membrane 13 homolog (yeast)0.022
Atp5lATP synthase, H+ transporting, mitochondrial F0 complex, subunit G0.022
Ccdc56coiled-coil domain containing 560.022
Rps5ribosomal protein S50.022
Atp5jATP synthase, H+ transporting, mitochondrial F0 complex, subunit F60.021
Rps3ribosomal protein S30.021
Rps10ribosomal protein S100.021
Sdhbsuccinate dehydrogenase complex, subunit B, iron sulfur (Ip)0.020
RGD1564058similar to cDNA sequence BC0564740.020
Eif3meukaryotic translation initiation factor 3, subunit M0.020
Ndufa8NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 80.020
Rps7ribosomal protein S70.020
LOC100359498ribosomal protein L35a-like0.019
Rpl27ribosomal protein L270.019
Mrps21mitochondrial ribosomal protein S210.019
Uqcrqubiquinol-cytochrome c reductase, complex III subunit VII0.019
Nacanascent polypeptide-associated complex alpha subunit0.018
Ndufb10NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 100.018
Ndufa2NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 20.018
Ndufs3NADH dehydrogenase (ubiquinone) Fe-S protein 30.018
Eif5aeukaryotic translation initiation factor 5A0.017
Ndufb5NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 50.017
Rps25ribosomal protein s250.017
Rps20ribosomal protein S200.017
Gnb2l1guanine nucleotide binding protein (G protein), beta polypeptide 2 like 10.017
Ndufa4NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 40.017
Rps15ribosomal protein S150.017
Ssr4signal sequence receptor, delta0.017
Dnajc15DnaJ (Hsp40) homolog, subfamily C, member 150.016
Tmem126atransmembrane protein 126A0.016
LOC499782similar to 60S ribosomal protein L120.016
Atp5j2ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F20.016
Rpl4ribosomal protein L40.016
Chmp2achromatin modifying protein 2A0.016
Ndufa12NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 120.016
Rpl18ribosomal protein L180.016
Cox7ccytochrome c oxidase, subunit VIIc0.016
Eif3feukaryotic translation initiation factor 3, subunit F0.016
Ostcoligosaccharyltransferase complex subunit0.016
CutacutA divalent cation tolerance homolog (E. coli)0.015
Rpl17ribosomal protein L170.015
Tomm6translocase of outer mitochondrial membrane 6 homolog (yeast)0.015
Rps2ribosomal protein S20.015
Rpl29ribosomal protein L290.015
Npm1nucleophosmin (nucleolar phosphoprotein B23, numatrin)0.015
Sec61bSec61 beta subunit0.015
Ndufc1NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 10.015
LOC301124hypothetical LOC3011240.015
Ndufs8NADH dehydrogenase (ubiquinone) Fe-S protein 80.015
Rpl26ribosomal protein L260.015
Cox7a2cytochrome c oxidase subunit VIIa polypeptide 20.015
Rpl10aribosomal protein L10A0.015
Rpn2ribophorin II0.015
Rpl3ribosomal protein L30.015
Sec61gSEC61, gamma subunit0.015
Arpc1bactin related protein 2/3 complex, subunit 1B0.015
Rps17ribosomal protein S170.015
Hsd17b10hydroxysteroid (17-beta) dehydrogenase 100.015
Rps6ribosomal protein S60.015
Prdx2peroxiredoxin 20.014
Hnrnpa1heterogeneous nuclear ribonucleoprotein A10.014
Ndufb4NADH dehydrogenase (ubiquinone) 1 beta subcomplex 40.014
Churc1churchill domain containing 10.014
Polr2jpolymerase (RNA) II (DNA directed) polypeptide J0.014
Rpl36aribosomal protein L36a0.014
LOC685322similar to ubiquinol-cytochrome c reductase complex 7.2kDa protein isoform b0.014
Ndufs5NADH dehydrogenase (ubiquinone) Fe-S protein 50.014
Rps26ribosomal protein S260.014
Pnrc2proline-rich nuclear receptor coactivator 20.014
H2afzH2A histone family, member Z0.014
Syncripsynaptotagmin binding, cytoplasmic RNA interacting protein0.013
Hnrnpabheterogeneous nuclear ribonucleoprotein A/B0.013
RGD1560328similar to UPF0197 protein C11orf10 homolog0.013
Rpl21ribosomal protein L210.013
Uqcr11ubiquinol-cytochrome c reductase, complex III subunit XI0.013
Cox7bcytochrome c oxidase subunit VIIb0.013
Rpl6ribosomal protein L60.013
Nclnucleolin0.013
Ndufv2NADH dehydrogenase (ubiquinone) flavoprotein 20.013
Rps3aribosomal protein S3a0.013
Ndufb6NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 60.013
Ndufc2NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 20.013
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism