The network for 'positive regulation of protein modification by small protein conjugation or removal' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of protein modification by small protein conjugation or removal

Any process that activates or increases the frequency, rate or extent of protein modification by small protein conjugation or removal.

NameDescriptionProbabilityFunc Analog Organism
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.998
RNF11ring finger protein 110.978
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.961
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.960
BIRC3baculoviral IAP repeat containing 30.956
DAXXdeath-domain associated protein0.938
SKP1S-phase kinase-associated protein 10.906
UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.891
TEKTEK tyrosine kinase, endothelial0.888
SMAD7SMAD family member 70.884
RNF2ring finger protein 20.868
UBE2D2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)0.803
UBE2Nubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)0.775
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.773
RASSF5Ras association (RalGDS/AF-6) domain family member 50.712
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.654
SMAD1SMAD family member 10.646
BIRC2baculoviral IAP repeat containing 20.608
ARIH2ariadne homolog 2 (Drosophila)0.605
GSK3Bglycogen synthase kinase 3 beta0.569
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.544
HSPA8heat shock 70kDa protein 80.534
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.527
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.520
CTAG1Bcancer/testis antigen 1B0.513
TRIM28tripartite motif containing 280.511
SNIP1Smad nuclear interacting protein 10.510
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.504
ZNRF1zinc and ring finger 10.503
HDAC4histone deacetylase 40.483
RBX1ring-box 1, E3 ubiquitin protein ligase0.472
MAP3K3mitogen-activated protein kinase kinase kinase 30.471
TRIM39tripartite motif containing 390.469
ESR1estrogen receptor 10.431
CBX7chromobox homolog 70.420
UBA1ubiquitin-like modifier activating enzyme 10.403
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.398
RNF111ring finger protein 1110.368
CUL1cullin 10.364
MTA3metastasis associated 1 family, member 30.363
CBX8chromobox homolog 80.361
LNX1ligand of numb-protein X 10.338
MAGEA3melanoma antigen family A, 30.328
NCOR1nuclear receptor corepressor 10.324
RANGAP1Ran GTPase activating protein 10.320
TRAF1TNF receptor-associated factor 10.319
OTUB1OTU domain, ubiquitin aldehyde binding 10.301
RNF144Bring finger protein 144B0.300
PIAS4protein inhibitor of activated STAT, 40.292
NAP1L5nucleosome assembly protein 1-like 50.267
TP53tumor protein p530.264
CHD3chromodomain helicase DNA binding protein 30.261
FGAfibrinogen alpha chain0.258
TUBA1Ctubulin, alpha 1c0.250
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.249
ZNF496zinc finger protein 4960.244
MAGEA6melanoma antigen family A, 60.243
ADRB2adrenergic, beta-2-, receptor, surface0.235
STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase0.229
NEDD4neural precursor cell expressed, developmentally down-regulated 40.228
SMURF2SMAD specific E3 ubiquitin protein ligase 20.228
SP1Sp1 transcription factor0.228
STK4serine/threonine kinase 40.224
PRMT6protein arginine methyltransferase 60.212
RING1ring finger protein 10.208
TRAF3TNF receptor-associated factor 30.206
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.206
SEPT11septin 110.200
TEKT4tektin 40.197
SKP2S-phase kinase-associated protein 2 (p45)0.194
EID2EP300 interacting inhibitor of differentiation 20.192
TUBA1Btubulin, alpha 1b0.185
SIRT2sirtuin 20.184
HDAC3histone deacetylase 30.179
UBE3Aubiquitin protein ligase E3A0.178
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.176
PSMC4proteasome (prosome, macropain) 26S subunit, ATPase, 40.176
XIAPX-linked inhibitor of apoptosis0.162
ANAPC4anaphase promoting complex subunit 40.160
ACVR1Bactivin A receptor, type IB0.156
CUL2cullin 20.151
PJA1praja ring finger 10.150
NEDD8neural precursor cell expressed, developmentally down-regulated 80.144
HDAC1histone deacetylase 10.142
TADA3transcriptional adaptor 30.134
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.134
RIPK2receptor-interacting serine-threonine kinase 20.128
BMI1BMI1 polycomb ring finger oncogene0.127
ELK1ELK1, member of ETS oncogene family0.127
MEF2Cmyocyte enhancer factor 2C0.126
DVL2dishevelled, dsh homolog 2 (Drosophila)0.120
MBD3methyl-CpG binding domain protein 30.120
BAG1BCL2-associated athanogene0.120
ZNF746zinc finger protein 7460.118
MOAP1modulator of apoptosis 10.116
TRIM27tripartite motif containing 270.113
ATF5activating transcription factor 50.113
TSC2tuberous sclerosis 20.110
RASSF2Ras association (RalGDS/AF-6) domain family member 20.110
KDM1Alysine (K)-specific demethylase 1A0.105
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 10.996
Gsk3bglycogen synthase kinase 3 beta0.936
Axin1axin 10.933
Trp53transformation related protein 530.806
Apcadenomatosis polyposis coli0.687
Mdm2transformed mouse 3T3 cell double minute 20.687
Ptenphosphatase and tensin homolog0.638
Tlr4toll-like receptor 40.503
Ncoa3nuclear receptor coactivator 30.464
Arrb1arrestin, beta 10.447
Arrb2arrestin, beta 20.377
Mef2dmyocyte enhancer factor 2D0.373
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.364
Cry1cryptochrome 1 (photolyase-like)0.327
Ahraryl-hydrocarbon receptor0.288
Rnf111ring finger 1110.261
Map3k7mitogen-activated protein kinase kinase kinase 70.258
Atf4activating transcription factor 40.247
Clockcircadian locomotor output cycles kaput0.235
Hsp90b1heat shock protein 90, beta (Grp94), member 10.219
Traf6TNF receptor-associated factor 60.206
Myd88myeloid differentiation primary response gene 880.203
Mbd3methyl-CpG binding domain protein 30.183
Fgfr1fibroblast growth factor receptor 10.165
Smad2MAD homolog 2 (Drosophila)0.155
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.145
Pick1protein interacting with C kinase 10.134
Cd44CD44 antigen0.131
Mdm4transformed mouse 3T3 cell double minute 40.120
Ooepoocyte expressed protein homolog (dog)0.119
SrcRous sarcoma oncogene0.114
Pkd1polycystic kidney disease 1 homolog0.100
Arntaryl hydrocarbon receptor nuclear translocator0.099
Sufusuppressor of fused homolog (Drosophila)0.099
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.093
Bcar1breast cancer anti-estrogen resistance 10.089
Smad3MAD homolog 3 (Drosophila)0.086
Htthuntingtin0.086
Tbx3T-box 30.085
Hipk1homeodomain interacting protein kinase 10.084
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.082
Cdkn1bcyclin-dependent kinase inhibitor 1B0.079
Apoeapolipoprotein E0.079
Smad7MAD homolog 7 (Drosophila)0.078
Lrp6low density lipoprotein receptor-related protein 60.075
Pax2paired box gene 20.075
Lrp5low density lipoprotein receptor-related protein 50.074
Axin2axin20.073
Lyz2lysozyme 20.071
Pdpk13-phosphoinositide dependent protein kinase 10.071
Ptk2PTK2 protein tyrosine kinase 20.065
Casp1caspase 10.064
Abca1ATP-binding cassette, sub-family A (ABC1), member 10.063
Eif2c1eukaryotic translation initiation factor 2C, 10.062
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.062
Tgfbr1transforming growth factor, beta receptor I0.062
DaxxFas death domain-associated protein0.057
Ppargperoxisome proliferator activated receptor gamma0.057
Rbbp7retinoblastoma binding protein 70.056
Erhenhancer of rudimentary homolog (Drosophila)0.054
Pbx1pre B-cell leukemia transcription factor 10.054
Prmt1protein arginine N-methyltransferase 10.054
Hccsholocytochrome c synthetase0.054
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.053
Foxm1forkhead box M10.052
Hdac5histone deacetylase 50.052
Aurkaaurora kinase A0.052
Traf3TNF receptor-associated factor 30.051
Ccnb1cyclin B10.051
Nbnnibrin0.051
Prkcbprotein kinase C, beta0.049
Hspa8heat shock protein 80.049
Smad4MAD homolog 4 (Drosophila)0.049
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.048
Rnf19aring finger protein 19A0.047
Sertad2SERTA domain containing 20.046
Rb1retinoblastoma 10.046
Trem3triggering receptor expressed on myeloid cells 30.046
Bmpr1abone morphogenetic protein receptor, type 1A0.045
Kif20akinesin family member 20A0.045
Fgfr3fibroblast growth factor receptor 30.044
Phf1PHD finger protein 10.043
Prnpprion protein0.043
Hcsthematopoietic cell signal transducer0.041
Nsfl1cNSFL1 (p97) cofactor (p47)0.039
MefvMediterranean fever0.039
E2f1E2F transcription factor 10.039
Siglecesialic acid binding Ig-like lectin E0.038
Prkceprotein kinase C, epsilon0.038
Zfp281zinc finger protein 2810.038
Sh3gl3SH3-domain GRB2-like 30.038
Smad6MAD homolog 6 (Drosophila)0.038
Stk4serine/threonine kinase 40.037
Sdf2l1stromal cell-derived factor 2-like 10.037
Atp4aATPase, H+/K+ exchanging, gastric, alpha polypeptide0.037
Asap1ArfGAP with SH# domain, ankyrin repeat and PH domain10.036
Nedd4neural precursor cell expressed, developmentally down-regulated 40.036
Cd14CD14 antigen0.036
Setdb1SET domain, bifurcated 10.036
Fbxo11F-box protein 110.035
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CDC6Cdc6p0.117
SIZ1Siz1p0.096
MMS21Mms21p0.069
KAR2Kar2p0.069
DAS1Das1p0.045
HFM1Hfm1p0.041
CKS1Cks1p0.033
CDC20Cdc20p0.033
HPR1Hpr1p0.031
NFI1Nfi1p0.030
CDC16Cdc16p0.030
SLX8Slx8p0.029
HDA2Hda2p0.028
PDS5Pds5p0.026
HST3Hst3p0.026
RPN14Rpn14p0.025
PCH2Pch2p0.025
ZIP1Zip1p0.025
IME2Ime2p0.024
MSH4Msh4p0.024
ULP2Ulp2p0.023
APC2Apc2p0.022
CST9Cst9p0.022
UFO1Ufo1p0.020
CLB6Clb6p0.019
SGS1Sgs1p0.019
RAD53Rad53p0.018
YDR506Chypothetical protein0.018
KCC4Kcc4p0.017
SIL1Sil1p0.017
ZIP2Zip2p0.017
CDC34Cdc34p0.017
SPO22Spo22p0.017
BUL1Bul1p0.017
IRC15Irc15p0.016
YGR126Whypothetical protein0.016
CDC23Cdc23p0.016
CLB1Clb1p0.015
GLO4Glo4p0.015
PDS1Pds1p0.015
ECM11Ecm11p0.015
SRD1Srd1p0.015
IME4Ime4p0.014
LEU2Leu2p0.013
PRS2Prs2p0.013
SPR3Spr3p0.013
TGL2Tgl2p0.013
AHA1Aha1p0.013
YLR264C-Ahypothetical protein0.012
YOL038C-Ahypothetical protein0.012
YBR296C-Ahypothetical protein0.012
CHA1Cha1p0.012
FMT1Fmt1p0.012
YLR162Whypothetical protein0.012
CUP1-1Cup1-1p0.012
DTR1Dtr1p0.012
MER1Mer1p0.012
UFD2Ufd2p0.012
SPS22Sps22p0.012
SWM1Swm1p0.011
ZPS1Zps1p0.011
SMA1Sma1p0.011
ARP10Arp10p0.011
MMS1Mms1p0.011
WSS1Wss1p0.011
YLR445Whypothetical protein0.011
YDR374Chypothetical protein0.011
RED1Red1p0.011
MND1Mnd1p0.011
BSC2Bsc2p0.011
RGI2Rgi2p0.011
GIC1Gic1p0.011
YDL129Whypothetical protein0.011
YBR138Chypothetical protein0.011
ATP6Atp6p0.011
NMT1Nmt1p0.011
AHP1Ahp1p0.011
SPS4Sps4p0.011
YBR013Chypothetical protein0.010
AAD6Aad6p0.010
SUM1Sum1p0.010
ATG4Atg4p0.010
RIF1Rif1p0.010
HXT3Hxt3p0.010
SAE3Sae3p0.010
MCH4Mch4p0.010
AMA1Ama1p0.010
IME1Ime1p0.010
YAR068Whypothetical protein0.010