The network for 'regulation of phagocytosis engulfment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of phagocytosis engulfment

Any process that modulates the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.

NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.948
SOS1son of sevenless homolog 1 (Drosophila)0.938
HIPK2homeodomain interacting protein kinase 20.855
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.797
ADAM19ADAM metallopeptidase domain 190.749
PXNpaxillin0.733
EGFRepidermal growth factor receptor0.712
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.651
TFF1trefoil factor 10.640
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.592
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.581
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.551
FN1fibronectin 10.546
ABI2abl-interactor 20.491
MSH5mutS homolog 5 (E. coli)0.435
ENGendoglin0.404
WASF1WAS protein family, member 10.367
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.313
SPRR2Asmall proline-rich protein 2A0.292
MUC1mucin 1, cell surface associated0.289
TCF4transcription factor 40.287
NCK1NCK adaptor protein 10.284
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.237
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.236
MAP3K1mitogen-activated protein kinase kinase kinase 10.228
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.227
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.221
SIGLEC7sialic acid binding Ig-like lectin 70.160
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.152
SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.134
NME3non-metastatic cells 3, protein expressed in0.128
DYRK1Bdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B0.124
RIN1Ras and Rab interactor 10.120
HK3hexokinase 3 (white cell)0.118
CALD1caldesmon 10.115
EPS8epidermal growth factor receptor pathway substrate 80.101
FLNAfilamin A, alpha0.100
CTGFconnective tissue growth factor0.098
NCKAP1NCK-associated protein 10.095
S100BS100 calcium binding protein B0.094
YES1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.090
SIGLEC9sialic acid binding Ig-like lectin 90.088
CAV1caveolin 1, caveolae protein, 22kDa0.081
VCLvinculin0.076
ROCK1Rho-associated, coiled-coil containing protein kinase 10.073
CYTH4cytohesin 40.072
CAV2caveolin 20.066
EP300E1A binding protein p3000.066
LAMC1laminin, gamma 1 (formerly LAMB2)0.061
RASA1RAS p21 protein activator (GTPase activating protein) 10.059
RPL38ribosomal protein L380.057
PTPN6protein tyrosine phosphatase, non-receptor type 60.054
RB1retinoblastoma 10.053
MSH4mutS homolog 4 (E. coli)0.051
NFAM1NFAT activating protein with ITAM motif 10.051
FHL2four and a half LIM domains 20.051
CRIM1cysteine rich transmembrane BMP regulator 1 (chordin-like)0.050
SMAD2SMAD family member 20.047
PDLIM5PDZ and LIM domain 50.043
ITGA6integrin, alpha 60.043
PLS3plastin 30.042
SYKspleen tyrosine kinase0.042
ADAM9ADAM metallopeptidase domain 90.041
PLCG1phospholipase C, gamma 10.040
LZTS2leucine zipper, putative tumor suppressor 20.040
VAV1vav 1 guanine nucleotide exchange factor0.039
CD300CCD300c molecule0.039
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.038
TNS4tensin 40.038
CD33CD33 molecule0.037
PDIA3protein disulfide isomerase family A, member 30.037
HIPK3homeodomain interacting protein kinase 30.037
SHBSrc homology 2 domain containing adaptor protein B0.036
FAM117Bfamily with sequence similarity 117, member B0.036
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.035
CMIPc-Maf-inducing protein0.033
SSFA2sperm specific antigen 20.033
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.033
CD2APCD2-associated protein0.032
METmet proto-oncogene (hepatocyte growth factor receptor)0.031
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.031
CEACAM3carcinoembryonic antigen-related cell adhesion molecule 30.031
APOBRapolipoprotein B receptor0.031
TGFBR1transforming growth factor, beta receptor 10.030
ERBB2IPerbb2 interacting protein0.030
RUNX1runt-related transcription factor 10.030
CD300ACD300a molecule0.030
CYFIP1cytoplasmic FMR1 interacting protein 10.029
MMP1matrix metallopeptidase 1 (interstitial collagenase)0.029
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.029
ITGB1BP1integrin beta 1 binding protein 10.028
TLN2talin 20.028
ITGB5integrin, beta 50.028
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.027
PILRApaired immunoglobin-like type 2 receptor alpha0.027
TMEM30Atransmembrane protein 30A0.026
RIN3Ras and Rab interactor 30.026
SIGLEC5sialic acid binding Ig-like lectin 50.026
SASH3SAM and SH3 domain containing 30.026
LAIR1leukocyte-associated immunoglobulin-like receptor 10.026
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
rskn-1Protein RSKN-10.065
ZK973.11Protein ZK973.110.060
C27F2.8Protein C27F2.80.053
perm-5Protein PERM-50.042
rde-1Protein RDE-10.041
acly-2Protein ACLY-20.041
C52B9.4Protein C52B9.40.036
K08E3.4Protein K08E3.40.032
T23B12.6Protein T23B12.60.031
R74.8Protein R74.80.030
F21C10.7Protein F21C10.70.030
pat-2Protein PAT-20.025
W06B4.2Protein W06B4.20.024
CELE_C12D8.1Protein C12D8.10.023
vav-1Protein VAV-10.023
nrde-3Protein NRDE-30.023
glo-4Protein GLO-40.023
unc-68Protein UNC-680.022
lin-2Protein LIN-20.021
CELE_M01B12.4Protein M01B12.40.021
mys-1Protein MYS-10.021
vha-7Protein VHA-70.021
ZC373.4Protein ZC373.40.021
pptr-2Protein PPTR-20.021
F26H9.2Protein F26H9.20.020
obr-3Protein OBR-30.020
unc-97Protein UNC-970.020
bre-1Protein BRE-10.019
B0511.12Protein B0511.120.019
CELE_F30B5.4Protein F30B5.40.019
CELE_F52B11.1Protein F52B11.10.019
vab-1Protein VAB-10.018
tim-1Protein TIM-10.018
T13C2.6Protein T13C2.60.018
rme-4Protein RME-40.018
ced-7Protein CED-70.017
F31C3.3Protein F31C3.30.017
sorb-1Protein SORB-10.017
pat-3Protein PAT-30.017
F11E6.8Protein F11E6.80.017
upb-1Protein UPB-10.016
CELE_C25A1.5Protein C25A1.50.016
pcaf-1Protein PCAF-10.016
rpl-25.2Protein RPL-25.20.016
C52B9.8Protein C52B9.80.016
R151.8Protein R151.80.016
plc-3Protein PLC-30.016
pqn-89Protein PQN-890.015
taf-1Protein TAF-10.015
mig-6Protein MIG-60.015
R08E3.3Protein R08E3.30.015
cogc-3Protein COGC-30.015
phy-2Protein PHY-20.015
ZC449.5Protein ZC449.50.014
chat-1Protein CHAT-10.014
CELE_F15A8.6Protein F15A8.60.014
aap-1Protein AAP-10.014
C02F5.12Protein C02F5.120.014
R05H10.3Protein R05H10.30.014
gly-7Protein GLY-70.014
C47D12.8Protein C47D12.80.014
K07E3.2Protein K07E3.20.014
clp-7Protein CLP-70.014
W07E11.1Protein W07E11.10.014
lgg-2Protein LGG-20.013
hpo-22Protein HPO-220.013
prdx-2Protein PRDX-20.013
epi-1Protein EPI-10.013
F23H11.4Protein F23H11.40.013
CELE_W02F12.4Protein W02F12.40.013
unc-70Protein UNC-700.013
B0416.5Protein B0416.50.013
eat-18Protein EAT-180.013
sli-1Protein SLI-10.013
lipl-7Protein LIPL-70.013
tag-163Protein TAG-1630.012
ehs-1Protein EHS-10.012
srp-7Protein SRP-70.012
jamp-1Protein JAMP-10.012
atg-4.2Protein ATG-4.20.012
tag-123Protein TAG-1230.012
R08E3.1Protein R08E3.10.012
B0001.3Protein B0001.30.012
unc-73Protein UNC-730.012
lron-7Protein LRON-70.012
C06G1.5Protein C06G1.50.012
C49H3.6Protein C49H3.60.012
K10B3.5Protein K10B3.50.012
CELE_F36D3.1Protein F36D3.10.012
lin-54Protein LIN-540.012
eri-7Protein ERI-70.012
W01C8.5Protein W01C8.50.012
sptl-3Protein SPTL-30.012
F10D7.2Protein F10D7.20.011
agl-1Protein AGL-10.011
oga-1Protein OGA-10.011
ergo-1Protein ERGO-10.011
unc-112Protein UNC-1120.011
C09H10.10Protein C09H10.100.011
F08B12.1Protein F08B12.10.011
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
dockdreadlocks0.044
Sra-1specifically Rac1-associated protein 10.034
mbcmyoblast city0.033
Eb1CG3265 gene product from transcript CG3265-RF0.026
gekgenghis khan0.023
Atg1Autophagy-specific gene 10.023
Cf2Chorion factor 20.021
sxcsuper sex combs0.021
sunstunted0.019
rokRho-kinase0.018
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.018
HemHEM-protein0.017
WnkCG7177 gene product from transcript CG7177-RA0.017
Dcr-2Dicer-20.016
mib1mind bomb 10.015
AckCG14992 gene product from transcript CG14992-RA0.014
laceCG4162 gene product from transcript CG4162-RA0.014
dltdiscs lost0.013
porinCG6647 gene product from transcript CG6647-RA0.013
retnretained0.013
Ptp69DProtein tyrosine phosphatase 69D0.012
kstkarst0.012
svrsilver0.012
CtBPC-terminal Binding Protein0.012
cpbcapping protein beta0.012
Sulf1Sulfated0.011
PknProtein kinase related to protein kinase N0.011
slprslipper0.011
Cdc42CG12530 gene product from transcript CG12530-RA0.011
RYBPRing and YY1 Binding Protein0.011
SaraSmad anchor for receptor activation0.011
SbfSET domain binding factor0.011
plexBplexin B0.010
ClC-cChloride channel-c0.010
enaenabled0.010
ari-1ariadne0.010
FhosCG42610 gene product from transcript CG42610-RC0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Apoeapolipoprotein E0.975
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.553
Lrp1low density lipoprotein receptor-related protein 10.233
Ptk2PTK2 protein tyrosine kinase 20.209
Alox5aparachidonate 5-lipoxygenase activating protein0.171
Itgb1integrin beta 1 (fibronectin receptor beta)0.146
Ptenphosphatase and tensin homolog0.138
Dok3docking protein 30.127
Ric8resistance to inhibitors of cholinesterase 8 homolog (C. elegans)0.120
Cav1caveolin 1, caveolae protein0.111
CebpeCCAAT/enhancer binding protein (C/EBP), epsilon0.110
Npc1Niemann Pick type C10.095
Leprleptin receptor0.093
Treml1triggering receptor expressed on myeloid cells-like 10.086
Rdh8retinol dehydrogenase 80.084
Notch2Notch gene homolog 2 (Drosophila)0.072
Becn1beclin 1, autophagy related0.068
9430031J16RikRIKEN cDNA 9430031J16 gene0.064
Itgb3integrin beta 30.064
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.061
Lepleptin0.056
Stat5bsignal transducer and activator of transcription 5B0.055
Abcg1ATP-binding cassette, sub-family G (WHITE), member 10.053
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.046
Nr3c1nuclear receptor subfamily 3, group C, member 10.044
Engendoglin0.043
Lyz2lysozyme 20.042
Ghrgrowth hormone receptor0.039
Tgfbr1transforming growth factor, beta receptor I0.038
Ncf1neutrophil cytosolic factor 10.036
Ate1arginyltransferase 10.030
Plin1perilipin 10.027
Stat5asignal transducer and activator of transcription 5A0.026
Rpl35ribosomal protein L350.024
Slc12a6solute carrier family 12, member 60.023
Tmem40transmembrane protein 400.023
Orai1ORAI calcium release-activated calcium modulator 10.022
Ldlrlow density lipoprotein receptor0.022
Ptgesprostaglandin E synthase0.020
Mapk14mitogen-activated protein kinase 140.019
Mapk9mitogen-activated protein kinase 90.019
Nfibnuclear factor I/B0.019
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.018
Gp1baglycoprotein 1b, alpha polypeptide0.017
Gp9glycoprotein 9 (platelet)0.017
P2rx6purinergic receptor P2X, ligand-gated ion channel, 60.016
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.016
Lipalysosomal acid lipase A0.015
Atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.014
Rbl2retinoblastoma-like 20.014
Clockcircadian locomotor output cycles kaput0.013
Inpp5dinositol polyphosphate-5-phosphatase D0.013
Wasf2WAS protein family, member 20.013
Mplmyeloproliferative leukemia virus oncogene0.013
Abca1ATP-binding cassette, sub-family A (ABC1), member 10.013
Rtn4rreticulon 4 receptor0.012
Pacsin2protein kinase C and casein kinase substrate in neurons 20.012
Lama5laminin, alpha 50.012
En1engrailed 10.012
Prnpprion protein0.012
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)0.011
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.011
Rfx2regulatory factor X, 2 (influences HLA class II expression)0.011
Bola2bolA-like 2 (E. coli)0.010
Scd1stearoyl-Coenzyme A desaturase 10.010
BrafBraf transforming gene0.010
Fabp4fatty acid binding protein 4, adipocyte0.010
Ppifpeptidylprolyl isomerase F (cyclophilin F)0.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.533
Mef2dmyocyte enhancer factor 2D0.418
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.356
Gja5gap junction protein, alpha 50.272
Ptafrplatelet-activating factor receptor0.251
Fgf1fibroblast growth factor 10.250
Slco2a1solute carrier organic anion transporter family, member 2a10.175
Ptprhprotein tyrosine phosphatase, receptor type, H0.169
Slc22a1solute carrier family 22 (organic cation transporter), member 10.155
Slc4a1solute carrier family 4 (anion exchanger), member 10.150
Gata6GATA binding protein 60.136
Gzmbgranzyme B0.135
Prg2proteoglycan 2, bone marrow0.127
Ednraendothelin receptor type A0.119
Ceacam1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.118
Podxlpodocalyxin-like0.094
Abcc6ATP-binding cassette, subfamily C (CFTR/MRP), member 60.092
Acot12acyl-CoA thioesterase 120.088
Tnftumor necrosis factor (TNF superfamily, member 2)0.081
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.079
Aqp7aquaporin 70.078
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.072
Pdk4pyruvate dehydrogenase kinase, isozyme 40.071
Rdh2retinol dehydrogenase 20.070
Ccl5chemokine (C-C motif) ligand 50.070
Lpllipoprotein lipase0.070
Trib1tribbles homolog 1 (Drosophila)0.069
Il1r1interleukin 1 receptor, type I0.069
MrgprfMAS-related GPR, member F0.068
Nkg7natural killer cell group 7 sequence0.067
Cideacell death-inducing DFFA-like effector a0.065
Prdm2PR domain containing 2, with ZNF domain0.063
Runx3runt-related transcription factor 30.063
Cyp4b1cytochrome P450, family 4, subfamily b, polypeptide 10.061
Gpr4G protein-coupled receptor 40.061
Dhdpsldihydrodipicolinate synthase-like, mitochondrial0.061
Sgk2serum/glucocorticoid regulated kinase 20.060
Mettl7bmethyltransferase like 7B0.058
Zbp1Z-DNA binding protein 10.057
Il1ainterleukin 1 alpha0.052
Smad6SMAD family member 60.052
Slc23a1solute carrier family 23 (nucleobase transporters), member 10.052
Hmha1histocompatibility (minor) HA-10.052
Ddcdopa decarboxylase (aromatic L-amino acid decarboxylase)0.050
Cd8bCD8b molecule0.049
Colqcollagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase0.048
Cdc25acell division cycle 25 homolog A (S. pombe)0.048
Fli1Friend leukemia virus integration 10.048
Efnb1ephrin B10.048
Cpt1bcarnitine palmitoyltransferase 1b, muscle0.047
Cybbcytochrome b-245, beta polypeptide0.047
Gcgrglucagon receptor0.047
Casq2calsequestrin 2 (cardiac muscle)0.046
P2ry4pyrimidinergic receptor P2Y, G-protein coupled, 40.046
Slco2b1solute carrier organic anion transporter family, member 2b10.046
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.046
Slc7a9solute carrier family 7 (cationic amino acid transporter, y+ system), member 90.043
Adra2badrenergic, alpha-2B-, receptor0.042
Lypd3Ly6/Plaur domain containing 30.040
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.039
Asb2ankyrin repeat and SOCS box-containing 20.039
Crybb1crystallin, beta B10.039
Ros1c-ros oncogene 1 , receptor tyrosine kinase0.038
Gckrglucokinase (hexokinase 4) regulator0.036
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.035
Il2rbinterleukin 2 receptor, beta0.035
Capn9calpain 90.035
Hnf4ahepatocyte nuclear factor 4, alpha0.035
Gipgastric inhibitory polypeptide0.034
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.034
LOC679368similar to carboxylesterase 50.034
Icam2intercellular adhesion molecule 20.033
Ly6g6elymphocyte antigen 6 complex, locus G6E0.033
Fcer2Fc fragment of IgE, low affinity II, receptor for (CD23)0.032
RGD1561143similar to cell surface receptor FDFACT0.032
Scn5asodium channel, voltage-gated, type V, alpha subunit0.031
Abcd1ATP-binding cassette, subfamily D (ALD), member 10.031
TriobpTRIO and F-actin binding protein0.030
Rt1.aaMHC class I RT1.Aa alpha-chain0.030
Acsl1acyl-CoA synthetase long-chain family member 10.030
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.029
Cdh17cadherin 170.029
Psgb1pregnancy-specific beta 1-glycoprotein0.029
Pdp2pyruvate dehyrogenase phosphatase catalytic subunit 20.028
Galnt10UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)0.028
Slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.028
Defb1defensin beta 10.028
Slc5a1solute carrier family 5 (sodium/glucose cotransporter), member 10.026
Cps1carbamoyl-phosphate synthetase 10.026
Hsd17b6hydroxysteroid (17-beta) dehydrogenase 60.026
Elf1E74-like factor 10.026
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.025
MlxiplMLX interacting protein-like0.025
Epha2Eph receptor A20.025
Clcn5chloride channel 50.024
Prss8protease, serine, 80.024
Foxe1forkhead box E1 (thyroid transcription factor 2)0.024
Gcnt3glucosaminyl (N-acetyl) transferase 3, mucin type0.024
Fzd4frizzled homolog 4 (Drosophila)0.024
Hadhhydroxyacyl-Coenzyme A dehydrogenase0.024
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism