The network for 'regulation of epidermis development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of epidermis development

Any process that modulates the frequency, rate or extent of epidermis development.

NameDescriptionProbabilityFunc Analog Organism
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.872
BMPR1Abone morphogenetic protein receptor, type IA0.622
ARandrogen receptor0.591
CREBBPCREB binding protein0.581
HOXB5homeobox B50.551
NCOR2nuclear receptor corepressor 20.499
ESR1estrogen receptor 10.468
SFNstratifin0.452
JAG1jagged 10.444
NCOA1nuclear receptor coactivator 10.440
HOXA5homeobox A50.401
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.400
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.387
NCOR1nuclear receptor corepressor 10.348
NFE2L2nuclear factor (erythroid-derived 2)-like 20.320
BBS10Bardet-Biedl syndrome 100.319
HOXA10homeobox A100.307
DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila)0.302
NOTCH3notch 30.258
FSTL1follistatin-like 10.254
HOXA7homeobox A70.227
NME2non-metastatic cells 2, protein (NM23B) expressed in0.210
PKP3plakophilin 30.185
CTNND1catenin (cadherin-associated protein), delta 10.182
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.137
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.128
HOXB3homeobox B30.125
HOXA11homeobox A110.124
NCOA2nuclear receptor coactivator 20.124
ZNF746zinc finger protein 7460.120
JUPjunction plakoglobin0.109
HOXB9homeobox B90.108
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.103
RXRAretinoid X receptor, alpha0.100
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.087
HOXB6homeobox B60.087
BACH1BTB and CNC homology 1, basic leucine zipper transcription factor 10.086
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.085
KRT5keratin 50.084
HOXA4homeobox A40.084
HIPK2homeodomain interacting protein kinase 20.083
MSX1msh homeobox 10.076
DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.074
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.074
TGFB1transforming growth factor, beta 10.068
EPPK1epiplakin 10.067
HOXC6homeobox C60.065
TRAF1TNF receptor-associated factor 10.065
HOXC10homeobox C100.063
NCOA3nuclear receptor coactivator 30.063
HOXB7homeobox B70.062
NME1non-metastatic cells 1, protein (NM23A) expressed in0.060
NOTCH1notch 10.057
RND3Rho family GTPase 30.057
DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.056
HOXA2homeobox A20.055
ZNF775zinc finger protein 7750.053
JUBjub, ajuba homolog (Xenopus laevis)0.051
WNT3Awingless-type MMTV integration site family, member 3A0.050
SUZ12suppressor of zeste 12 homolog (Drosophila)0.050
LAD1ladinin 10.049
RUNX1runt-related transcription factor 10.049
NME3non-metastatic cells 3, protein expressed in0.048
HRhairless homolog (mouse)0.046
PSEN1presenilin 10.045
WNT5Awingless-type MMTV integration site family, member 5A0.044
ZFYVE9zinc finger, FYVE domain containing 90.043
HOXA6homeobox A60.043
DDIT3DNA-damage-inducible transcript 30.043
BHLHE40basic helix-loop-helix family, member e400.041
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.041
STMN2stathmin-like 20.038
TJP1tight junction protein 1 (zona occludens 1)0.038
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.038
NDPNorrie disease (pseudoglioma)0.037
ESR2estrogen receptor 2 (ER beta)0.035
FOXO1forkhead box O10.035
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.034
NFIL3nuclear factor, interleukin 3 regulated0.034
INHBAinhibin, beta A0.033
EP300E1A binding protein p3000.033
ENGendoglin0.032
NCOA6nuclear receptor coactivator 60.032
NME4non-metastatic cells 4, protein expressed in0.031
EHFets homologous factor0.031
ELF5E74-like factor 5 (ets domain transcription factor)0.030
SFRP1secreted frizzled-related protein 10.030
WHSC1L1Wolf-Hirschhorn syndrome candidate 1-like 10.029
TNK2tyrosine kinase, non-receptor, 20.029
NR4A1nuclear receptor subfamily 4, group A, member 10.029
KRT6Ckeratin 6C0.029
SPINT1serine peptidase inhibitor, Kunitz type 10.028
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.028
CREB1cAMP responsive element binding protein 10.028
HTThuntingtin0.028
SKILSKI-like oncogene0.027
CABLES1Cdk5 and Abl enzyme substrate 10.027
SATB2SATB homeobox 20.027
TNS4tensin 40.027
RBM39RNA binding motif protein 390.026
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.855
cdh1cadherin 1, epithelial0.643
fgf24fibroblast growth factor 240.302
slc17a7solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 70.269
tbx20T-box 200.234
pitx3paired-like homeodomain transcription factor 30.151
notch1anotch homolog 1a0.130
dlcdeltaC0.115
celsr1acadherin EGF LAG seven-pass G-type receptor 1a0.104
tp63tumor protein p630.101
tfap2atranscription factor AP-2 alpha0.101
foxi1forkhead box I10.085
zgc:92533zgc:925330.075
ptf1apancreas specific transcription factor, 1a0.073
dlbdeltaB0.072
atoh1batonal homolog 1b0.071
krt4keratin 40.067
notch3notch homolog 30.066
mibmind bomb0.065
hapln3hyaluronan and proteoglycan link protein 30.063
llgl2lethal giant larvae homolog 2 (Drosophila)0.062
hoxb1ahomeo box B1a0.062
pax2apaired box gene 2a0.061
slc24a5solute carrier family 24, member 50.061
disp1dispatched homolog 1 (Drosophila)0.059
eng2bengrailed 2b0.057
atoh1aatonal homolog 1a0.056
gabra1gamma-aminobutyric acid (GABA) A receptor, alpha 10.055
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.052
atoh1catonal homolog 1c0.052
krt5keratin 50.050
id3inhibitor of DNA binding 30.048
dlx3bdistal-less homeobox gene 3b0.047
anxa1aannexin A1a0.047
cav1caveolin 10.047
six4bsine oculis homeobox homolog 4b0.046
xbp1X-box binding protein 10.046
gata2aGATA-binding protein 2a0.046
szlsizzled0.045
perpPERP, TP53 apoptosis effector0.045
trpm7transient receptor potential cation channel, subfamily M, member 70.042
hnrnpa0heterogeneous nuclear ribonucleoprotein A00.039
fstl1bfollistatin-like 1b0.039
cdh23cadherin-like 230.039
vgll4lvestigial like 4 like0.039
rasl11bRAS-like, family 11, member B0.039
crabp2acellular retinoic acid binding protein 2, a0.038
foxi3aforkhead box I3a0.038
slc1a3bsolute carrier family 1 (glial high affinity glutamate transporter), member 3b0.037
tm9sf2transmembrane 9 superfamily member 20.037
anxa2aannexin A2a0.036
znf703zinc finger protein 7030.036
cxcr4achemokine (C-X-C motif) receptor 4a0.036
dlx4adistal-less homeobox gene 4a0.036
cldnbclaudin b0.035
lmx1b.1LIM homeobox transcription factor 1, beta 10.035
esrraestrogen-related receptor alpha0.034
pcf11cleavage and polyadenylation factor subunit, homolog (S. cerevisiae)0.034
pitx2paired-like homeodomain transcription factor 20.034
hoxd3ahomeo box D3a0.034
irx4biroquois homeobox protein 4b0.034
lama5laminin, alpha 50.033
six1bsine oculis homeobox homolog 1b0.033
irx1biroquois homeobox protein 1, b0.033
crb2acrumbs homolog 2a0.033
tbx5aT-box 5a0.032
ctsl1bcathepsin L, 1 b0.032
creb3l3lcAMP responsive element binding protein 3-like 3 like0.031
lamc1laminin, gamma 10.030
cldnaclaudin a0.030
dlddeltaD0.029
supt6hsuppressor of Ty 6 homolog0.029
epcamepithelial cell adhesion molecule0.029
tagln2transgelin 20.028
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.028
leo1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.028
egr2bearly growth response 2b0.028
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.028
cldniclaudin i0.028
klf2bKruppel-like factor 2b0.027
hnrplheterogeneous nuclear ribonucleoprotein L0.027
arrdc3aarrestin domain containing 3a0.027
dmddystrophin0.027
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.027
neurog1neurogenin 10.027
nppanatriuretic peptide precursor A0.027
restRE1-silencing transcription factor0.026
gyltl1bglycosyltransferase-like 1b0.026
aldobaldolase b, fructose-bisphosphate0.025
kdrlkinase insert domain receptor like0.025
rhoaaras homolog gene family, member Aa0.025
smarca5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 50.025
tfap2ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.025
col14a1collagen, type XIV, alpha 10.025
jupjunction plakoglobin0.025
cfl1cofilin 1 (non-muscle)0.024
eya1eyes absent homolog 10.024
trim33tripartite motif-containing 330.023
zgc:64161zgc:641610.023
pplperiplakin0.023
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
DlDelta0.020
MadMothers against dpp0.017
NNotch0.014
rorough0.013
stgstring0.012
hhhedgehog0.012
lqfRliquid facets-Related0.011
diadiaphanous0.011
PebProtein ejaculatory bulb0.011
dltdiscs lost0.011
bazbazooka0.011
dibdisembodied0.011
E(spl)Enhancer of split0.011
senssenseless0.010
CycECyclin E0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog0.990
Notch1Notch gene homolog 1 (Drosophila)0.986
Otx2orthodenticle homolog 2 (Drosophila)0.966
Fgf8fibroblast growth factor 80.925
Foxc1forkhead box C10.907
Gli3GLI-Kruppel family member GLI30.895
Fgfr1fibroblast growth factor receptor 10.851
Wnt3awingless-related MMTV integration site 3A0.842
Hes1hairy and enhancer of split 1 (Drosophila)0.793
Krt27keratin 270.734
Dlx3distal-less homeobox 30.722
Hand2heart and neural crest derivatives expressed transcript 20.708
Smad4MAD homolog 4 (Drosophila)0.702
Trp63transformation related protein 630.699
Emx1empty spiracles homolog 1 (Drosophila)0.672
Ptf1apancreas specific transcription factor, 1a0.664
Ascl1achaete-scute complex homolog 1 (Drosophila)0.661
En1engrailed 10.656
Krt17keratin 170.643
Gata4GATA binding protein 40.633
Foxn1forkhead box N10.624
Ptenphosphatase and tensin homolog0.622
Krt8keratin 80.613
Efnb2ephrin B20.611
Psen1presenilin 10.587
Hes5hairy and enhancer of split 5 (Drosophila)0.566
Twist2twist homolog 2 (Drosophila)0.548
Dll1delta-like 1 (Drosophila)0.520
Hand1heart and neural crest derivatives expressed transcript 10.493
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.486
Egr2early growth response 20.475
Pax6paired box gene 60.453
Krt5keratin 50.449
Nognoggin0.439
Map3k14mitogen-activated protein kinase kinase kinase 140.431
Hoxa1homeobox A10.426
Krt14keratin 140.425
Smad3MAD homolog 3 (Drosophila)0.409
Krt6akeratin 6A0.380
Egfrepidermal growth factor receptor0.380
Ptpn11protein tyrosine phosphatase, non-receptor type 110.366
Krtdapkeratinocyte differentiation associated protein0.355
Tlx3T-cell leukemia, homeobox 30.334
Isl1ISL1 transcription factor, LIM/homeodomain0.313
Ctnnb1catenin (cadherin associated protein), beta 10.308
Tnftumor necrosis factor0.306
Fgf5fibroblast growth factor 50.305
Efna2ephrin A20.299
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.298
Foxc2forkhead box C20.296
Krt33bkeratin 33B0.289
Lhx5LIM homeobox protein 50.286
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.278
Krtap8-1keratin associated protein 8-10.277
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.274
Nhlh1nescient helix loop helix 10.272
Padi3peptidyl arginine deiminase, type III0.272
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.270
Ntf3neurotrophin 30.268
Krt36keratin 360.263
Pitx2paired-like homeodomain transcription factor 20.258
Wnt6wingless-related MMTV integration site 60.249
Fgfr2fibroblast growth factor receptor 20.245
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.245
Ldb3LIM domain binding 30.245
Krt71keratin 710.223
Wnt1wingless-related MMTV integration site 10.215
Irf6interferon regulatory factor 60.213
Hoxd13homeobox D130.212
Gli2GLI-Kruppel family member GLI20.212
Dlx5distal-less homeobox 50.209
Wnt4wingless-related MMTV integration site 40.203
Tcf3transcription factor 30.198
Snai1snail homolog 1 (Drosophila)0.196
Msx2homeobox, msh-like 20.195
Dlx2distal-less homeobox 20.195
Lhx3LIM homeobox protein 30.186
Psapl1prosaposin-like 10.186
Lgals7lectin, galactose binding, soluble 70.186
Hoxa13homeobox A130.181
Fgf15fibroblast growth factor 150.177
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.172
Pax3paired box gene 30.171
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.169
Smad1MAD homolog 1 (Drosophila)0.169
Etv4ets variant gene 4 (E1A enhancer binding protein, E1AF)0.167
Krt18keratin 180.164
Dkk1dickkopf homolog 1 (Xenopus laevis)0.164
Ltblymphotoxin B0.163
Emx2empty spiracles homolog 2 (Drosophila)0.162
Klk6kallikrein related-peptidase 60.162
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.161
Bnc1basonuclin 10.159
Krt35keratin 350.159
Dlx1distal-less homeobox 10.158
Fosl2fos-like antigen 20.157
Col22a1collagen, type XXII, alpha 10.156
Krt15keratin 150.154
Cldn3claudin 30.153
Rxraretinoid X receptor alpha0.148
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism