The network for 'regulation of vascular endothelial growth factor receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of vascular endothelial growth factor receptor signaling pathway

Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.

NameDescriptionProbabilityFunc Analog Organism
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide1.000
VEGFAvascular endothelial growth factor A1.000
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.998
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.997
NRP1neuropilin 10.986
PLCG1phospholipase C, gamma 10.956
EGFRepidermal growth factor receptor0.915
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.826
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.753
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.732
CAV1caveolin 1, caveolae protein, 22kDa0.519
PTPRBprotein tyrosine phosphatase, receptor type, B0.428
FGFR1fibroblast growth factor receptor 10.399
FYNFYN oncogene related to SRC, FGR, YES0.352
PDCD6IPprogrammed cell death 6 interacting protein0.313
INSRinsulin receptor0.304
GRB2growth factor receptor-bound protein 20.207
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.193
IRS1insulin receptor substrate 10.193
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.186
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.182
SHC1SHC (Src homology 2 domain containing) transforming protein 10.158
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.150
LATlinker for activation of T cells0.149
PTENphosphatase and tensin homolog0.141
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.133
LY6G6Flymphocyte antigen 6 complex, locus G6F0.099
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.097
PTPRJprotein tyrosine phosphatase, receptor type, J0.095
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.093
PDGFAplatelet-derived growth factor alpha polypeptide0.093
PDGFCplatelet derived growth factor C0.089
EPHB1EPH receptor B10.079
HDAC7histone deacetylase 70.076
TMSB4Xthymosin beta 4, X-linked0.068
CDH5cadherin 5, type 2 (vascular endothelium)0.064
KITLGKIT ligand0.060
MAP3K5mitogen-activated protein kinase kinase kinase 50.055
IGF1Rinsulin-like growth factor 1 receptor0.048
FASFas (TNF receptor superfamily, member 6)0.046
PTPN11protein tyrosine phosphatase, non-receptor type 110.045
DAPK1death-associated protein kinase 10.037
BCAR1breast cancer anti-estrogen resistance 10.034
PTK2BPTK2B protein tyrosine kinase 2 beta0.032
CYBAcytochrome b-245, alpha polypeptide0.029
SOS1son of sevenless homolog 1 (Drosophila)0.028
SHC2SHC (Src homology 2 domain containing) transforming protein 20.027
FLT4fms-related tyrosine kinase 40.026
GRB10growth factor receptor-bound protein 100.026
MMP14matrix metallopeptidase 14 (membrane-inserted)0.024
CAV2caveolin 20.020
PGFplacental growth factor0.020
PRKCDprotein kinase C, delta0.019
STC1stanniocalcin 10.019
NCF1neutrophil cytosolic factor 10.018
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.017
METmet proto-oncogene (hepatocyte growth factor receptor)0.017
PTPN23protein tyrosine phosphatase, non-receptor type 230.016
RRBP1ribosome binding protein 1 homolog 180kDa (dog)0.015
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.015
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.015
MAPK1IP1Lmitogen-activated protein kinase 1 interacting protein 1-like0.014
EGLN1egl nine homolog 1 (C. elegans)0.014
IRS2insulin receptor substrate 20.014
SMAD5SMAD family member 50.014
RXRAretinoid X receptor, alpha0.014
NAGKN-acetylglucosamine kinase0.013
GAB1GRB2-associated binding protein 10.013
BTKBruton agammaglobulinemia tyrosine kinase0.012
NDPNorrie disease (pseudoglioma)0.012
SMAD1SMAD family member 10.012
ROBO4roundabout homolog 4, magic roundabout (Drosophila)0.012
TGFB3transforming growth factor, beta 30.012
TTC19tetratricopeptide repeat domain 190.011
EGLN3egl nine homolog 3 (C. elegans)0.011
JAK2Janus kinase 20.011
MAP4K1mitogen-activated protein kinase kinase kinase kinase 10.010
EPAS1endothelial PAS domain protein 10.010
TRIM9tripartite motif containing 90.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
nrp1aneuropilin 1a0.942
ptch2patched 20.799
nrp1bneuropilin 1b0.644
notch3notch homolog 30.393
osr2odd-skipped related 2 (Drosophila)0.321
nrp2aneuropilin 2a0.313
tie2endothelium-specific receptor tyrosine kinase 20.296
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.214
cdh2cadherin 2, neuronal0.164
cdh5cadherin 50.155
sox9aSRY-box containing gene 9a0.146
tbx16T-box gene 160.128
unc45aunc-45 homolog A (C. elegans)0.126
col2a1acollagen type II, alpha-1a0.101
gch2GTP cyclohydrolase 20.097
nkx3.2NK3 homeobox 20.093
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.092
vegfcvascular endothelial growth factor c0.090
dll4delta-like 4 (Drosophila)0.087
eya1eyes absent homolog 10.076
hapln3hyaluronan and proteoglycan link protein 30.061
ascl1aachaete-scute complex-like 1a (Drosophila)0.057
birc2baculoviral IAP repeat-containing 20.056
ihhaIndian hedgehog homolog a0.050
sarsseryl-tRNA synthetase0.050
hdac4histone deacetylase 40.048
efnb2aephrin B2a0.046
plxnd1plexin D10.045
jag1bjagged 1b0.044
nrp2bneuropilin 2b0.039
dlx2adistal-less homeobox gene 2a0.037
fgf8afibroblast growth factor 8 a0.036
pax2apaired box gene 2a0.035
tm4sf4transmembrane 4 L six family member 40.032
tgfb3transforming growth factor, beta 30.031
kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.030
mgpmatrix Gla protein0.029
cdx4caudal type homeo box transcription factor 40.028
ptch1patched 10.028
foxa1forkhead box A10.024
neurog1neurogenin 10.024
ctnnd2bcatenin (cadherin-associated protein), delta 2b0.023
hey1hairy/enhancer-of-split related with YRPW motif 10.022
tfectranscription factor EC0.020
pax9paired box gene 90.020
aox3aldehyde oxidase 30.019
etv2ets variant gene 20.019
hoxa13bhomeo box A13b0.018
flt4fms-related tyrosine kinase 40.018
fbn2bfibrillin 2b0.017
mcambmelanoma cell adhesion molecule b0.016
nkx2.3NK2 transcription factor related 30.016
wtipWilms tumor 1 interacting protein0.016
LOC100332039ectonucleotide pyrophosphatase/phosphodiesterase family member 2-like0.015
sox10SRY-box containing gene 100.015
ccm2cerebral cavernous malformation 20.015
dlx5adistal-less homeobox gene 5a0.015
nf1bneurofibromin 1b0.015
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.014
plxna3plexin A30.014
bmperBMP binding endothelial regulator0.014
dpysl5adihydropyrimidinase-like 5a0.014
cald1caldesmon 10.013
vegfaavascular endothelial growth factor Aa0.013
col8a1acollagen, type VIII, alpha 1a0.013
agr2anterior gradient homolog 2 (Xenopus laevis)0.013
shhasonic hedgehog a0.012
krit1KRIT1, ankyrin repeat containing0.012
pdgfrlplatelet-derived growth factor receptor-like0.012
nf1aneurofibromin 1a0.012
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.012
sec24dSEC24 family, member D (S. cerevisiae)0.012
angpt1angiopoietin 10.011
itgb3bintegrin beta 3b0.011
foxc1aforkhead box C1a0.011
lmx1b.1LIM homeobox transcription factor 1, beta 10.011
crb2acrumbs homolog 2a0.011
sema3dsemaphorin 3d0.010
dpysl3dihydropyrimidinase-like 30.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.776
Gli3GLI-Kruppel family member GLI30.708
Ldb3LIM domain binding 30.644
Kdrkinase insert domain protein receptor0.557
Leprleptin receptor0.519
Grb10growth factor receptor bound protein 100.494
Vegfavascular endothelial growth factor A0.425
Smad6MAD homolog 6 (Drosophila)0.375
Egln1EGL nine homolog 1 (C. elegans)0.327
Ptpn11protein tyrosine phosphatase, non-receptor type 110.318
Twist2twist homolog 2 (Drosophila)0.283
Epas1endothelial PAS domain protein 10.250
Sox17SRY-box containing gene 170.241
Gopcgolgi associated PDZ and coiled-coil motif containing0.207
Ptprbprotein tyrosine phosphatase, receptor type, B0.194
Wnt5awingless-related MMTV integration site 5A0.168
Nos3nitric oxide synthase 3, endothelial cell0.161
Meox2mesenchyme homeobox 20.156
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.139
Dlg1discs, large homolog 1 (Drosophila)0.121
Ece1endothelin converting enzyme 10.118
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.107
Plxnd1plexin D10.093
Acvr1activin A receptor, type 10.093
Vangl2vang-like 2 (van gogh, Drosophila)0.089
Gata4GATA binding protein 40.084
Sema3fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F0.078
Hes1hairy and enhancer of split 1 (Drosophila)0.077
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.073
Arnt2aryl hydrocarbon receptor nuclear translocator 20.072
Plcg1phospholipase C, gamma 10.070
Tbx3T-box 30.069
Efnb2ephrin B20.068
Wt1Wilms tumor 1 homolog0.067
Lmx1bLIM homeobox transcription factor 1 beta0.067
Pax3paired box gene 30.066
Sox9SRY-box containing gene 90.062
Bmp4bone morphogenetic protein 40.062
Pthlhparathyroid hormone-like peptide0.061
Fzd4frizzled homolog 4 (Drosophila)0.060
Plcd1phospholipase C, delta 10.060
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.059
Fgf8fibroblast growth factor 80.057
Pax2paired box gene 20.056
Hand2heart and neural crest derivatives expressed transcript 20.055
Sox18SRY-box containing gene 180.052
Ank1ankyrin 1, erythroid0.052
Vhlvon Hippel-Lindau tumor suppressor0.052
Smad3MAD homolog 3 (Drosophila)0.051
Tbx15T-box 150.049
Shhsonic hedgehog0.049
Flt1FMS-like tyrosine kinase 10.048
Tgfbr3transforming growth factor, beta receptor III0.047
Rdh10retinol dehydrogenase 10 (all-trans)0.047
Esamendothelial cell-specific adhesion molecule0.046
Gata6GATA binding protein 60.046
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.046
Col4a3collagen, type IV, alpha 30.046
Stat3signal transducer and activator of transcription 30.045
Plxna1plexin A10.042
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.041
Flt4FMS-like tyrosine kinase 40.040
Kcnj12potassium inwardly-rectifying channel, subfamily J, member 120.040
Fzd8frizzled homolog 8 (Drosophila)0.038
Ehd2EH-domain containing 20.038
Ebf3early B-cell factor 30.037
Npr3natriuretic peptide receptor 30.037
Fbln1fibulin 10.036
Pitx2paired-like homeodomain transcription factor 20.036
Nr3c1nuclear receptor subfamily 3, group C, member 10.035
Foxc1forkhead box C10.035
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.035
Ror1receptor tyrosine kinase-like orphan receptor 10.033
Smad7MAD homolog 7 (Drosophila)0.033
Prkciprotein kinase C, iota0.032
Gbx2gastrulation brain homeobox 20.031
Otporthopedia homolog (Drosophila)0.031
Sgcdsarcoglycan, delta (dystrophin-associated glycoprotein)0.031
Jag1jagged 10.031
Shesrc homology 2 domain-containing transforming protein E0.031
Anxa2annexin A20.030
Tbx1T-box 10.030
Wwc2WW, C2 and coiled-coil domain containing 20.030
Ptch2patched homolog 20.029
Epha4Eph receptor A40.029
Tcf21transcription factor 210.029
Insrinsulin receptor0.028
Irs1insulin receptor substrate 10.028
Dab1disabled homolog 1 (Drosophila)0.028
Cdh15cadherin 150.028
Fli1Friend leukemia integration 10.028
Itgb1integrin beta 1 (fibronectin receptor beta)0.027
Cd151CD151 antigen0.027
Spry4sprouty homolog 4 (Drosophila)0.027
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.026
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Appamyloid beta (A4) precursor protein0.111
Jak1Janus kinase 10.080
RGD1309414similar to KIAA0913 protein0.059
Gpr116G protein-coupled receptor 1160.059
Gja1gap junction protein, alpha 10.041
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.041
Zfp260zinc finger protein 2600.035
Pls3plastin 3 (T-isoform)0.029
Vldlrvery low density lipoprotein receptor0.026
Cpdcarboxypeptidase D0.023
Itpr2inositol 1,4,5-triphosphate receptor, type 20.022
Ergv-ets erythroblastosis virus E26 oncogene homolog (avian)0.020
Smad6SMAD family member 60.020
Epas1endothelial PAS domain protein 10.020
Nos3nitric oxide synthase 3, endothelial cell0.019
Fapfibroblast activation protein, alpha0.019
Dlc1deleted in liver cancer 10.018
Pdk4pyruvate dehydrogenase kinase, isozyme 40.017
Rxraretinoid X receptor alpha0.016
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.016
Il6stinterleukin 6 signal transducer0.016
Bmp6bone morphogenetic protein 60.015
F13a1coagulation factor XIII, A1 polypeptide0.015
Nek9NIMA (never in mitosis gene a)- related kinase 90.014
Ggt5gamma-glutamyltransferase 50.014
LOC100360403ATP-binding cassette, sub-family C, member 9-like0.014
Nckap1NCK-associated protein 10.014
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.014
Snai1snail homolog 1 (Drosophila)0.013
Adra2badrenergic, alpha-2B-, receptor0.013
Sox17SRY (sex determining region Y)-box 170.013
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.013
Unc5bunc-5 homolog B (C. elegans)0.012
Tspan18tetraspanin 180.012
Gucy2dguanylate cyclase 2d0.012
GperG protein-coupled estrogen receptor 10.011
Timp3TIMP metallopeptidase inhibitor 30.011
Mmp2matrix metallopeptidase 20.011
Plagl1pleiomorphic adenoma gene-like 10.011
Myo1bmyosin Ib0.011
C1qtnf6C1q and tumor necrosis factor related protein 60.011
Bcl6bB-cell CLL/lymphoma 6, member B (zinc finger protein)0.011
Fndc3bfibronectin type III domain containing 3B0.011
Picalmphosphatidylinositol binding clathrin assembly protein0.010
Sh2b3SH2B adaptor protein 30.010
NrarpNotch-regulated ankyrin repeat protein0.010
Slc5a3solute carrier family 5 (sodium/myo-inositol cotransporter), member 30.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism