The network for 'response to abiotic stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to abiotic stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus.

NameDescriptionProbabilityFunc Analog Organism
TP53tumor protein p531.000
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 11.000
CREBBPCREB binding protein1.000
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 11.000
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide1.000
BRCA1breast cancer 1, early onset1.000
MDM2Mdm2 p53 binding protein homolog (mouse)1.000
CSNK2A1casein kinase 2, alpha 1 polypeptide0.998
SMN1survival of motor neuron 1, telomeric0.998
UBCubiquitin C0.998
ESR1estrogen receptor 10.997
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.997
H2AFXH2A histone family, member X0.996
EP300E1A binding protein p3000.994
RB1retinoblastoma 10.984
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.982
CAV1caveolin 1, caveolae protein, 22kDa0.982
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.981
CDC37cell division cycle 37 homolog (S. cerevisiae)0.981
PTPN1protein tyrosine phosphatase, non-receptor type 10.979
HDAC1histone deacetylase 10.979
PARP1poly (ADP-ribose) polymerase 10.976
SMAD3SMAD family member 30.974
MAPK1mitogen-activated protein kinase 10.974
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.972
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.972
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.969
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.967
VEGFAvascular endothelial growth factor A0.966
EGFRepidermal growth factor receptor0.963
HSPB1heat shock 27kDa protein 10.960
HNRNPKheterogeneous nuclear ribonucleoprotein K0.959
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.954
SIRT1sirtuin 10.951
MAPK14mitogen-activated protein kinase 140.950
ARRB1arrestin, beta 10.948
PKM2pyruvate kinase, muscle0.937
JUNjun proto-oncogene0.929
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.928
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.924
HDAC4histone deacetylase 40.919
BCL2B-cell CLL/lymphoma 20.916
BMI1BMI1 polycomb ring finger oncogene0.911
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.909
MAPK8mitogen-activated protein kinase 80.902
RHOAras homolog gene family, member A0.901
SFNstratifin0.898
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.897
CASP8caspase 8, apoptosis-related cysteine peptidase0.893
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.892
KAT2BK(lysine) acetyltransferase 2B0.884
HIPK2homeodomain interacting protein kinase 20.882
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.882
JUNBjun B proto-oncogene0.875
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.872
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.872
IL8interleukin 80.870
CASP3caspase 3, apoptosis-related cysteine peptidase0.869
SP1Sp1 transcription factor0.868
PTENphosphatase and tensin homolog0.863
NRP1neuropilin 10.858
ATF2activating transcription factor 20.857
BCL2L11BCL2-like 11 (apoptosis facilitator)0.856
NEDD4neural precursor cell expressed, developmentally down-regulated 40.854
BCAR1breast cancer anti-estrogen resistance 10.851
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.849
NR4A1nuclear receptor subfamily 4, group A, member 10.843
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.841
STK4serine/threonine kinase 40.837
SRFserum response factor (c-fos serum response element-binding transcription factor)0.835
THBS1thrombospondin 10.830
RBBP4retinoblastoma binding protein 40.828
CFLARCASP8 and FADD-like apoptosis regulator0.812
FASFas (TNF receptor superfamily, member 6)0.809
PCGF2polycomb group ring finger 20.809
ATMataxia telangiectasia mutated0.808
XIAPX-linked inhibitor of apoptosis0.805
YY1YY1 transcription factor0.804
MAP2K4mitogen-activated protein kinase kinase 40.801
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.800
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.795
CRYABcrystallin, alpha B0.794
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.789
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.785
RING1ring finger protein 10.784
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.784
NCLnucleolin0.782
SMURF2SMAD specific E3 ubiquitin protein ligase 20.779
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.778
TGFB1transforming growth factor, beta 10.767
NBNnibrin0.763
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.760
BAG3BCL2-associated athanogene 30.759
FGFR2fibroblast growth factor receptor 20.748
ACTN2actinin, alpha 20.739
SOCS3suppressor of cytokine signaling 30.738
HSPB8heat shock 22kDa protein 80.737
AKT1v-akt murine thymoma viral oncogene homolog 10.732
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.728
CHEK1CHK1 checkpoint homolog (S. pombe)0.723
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
glp-1Protein GLP-10.773
unc-9Protein UNC-90.733
atp-2Protein ATP-20.613
mat-3Protein MAT-30.545
vab-3Protein VAB-30.459
par-5Protein PAR-50.374
atn-1Protein ATN-10.366
inx-12Protein INX-120.358
eat-6Protein EAT-60.346
hsp-16.41Protein HSP-16.410.331
pes-7Protein PES-70.326
goa-1Protein GOA-10.316
apl-1Protein APL-10.315
hsp-70Protein HSP-700.299
pmk-1Protein PMK-10.281
rskn-1Protein RSKN-10.271
osm-5Protein OSM-50.268
F17A9.4Protein F17A9.40.267
ugt-46Protein UGT-460.263
egl-8Protein EGL-80.261
osm-3Protein OSM-30.258
rfp-1Protein RFP-10.257
plc-1Protein PLC-10.256
nhr-17Protein NHR-170.255
unc-104Protein UNC-1040.244
hsp-16.2Protein HSP-16.20.235
tax-6Protein TAX-60.234
mes-4Protein MES-40.232
F44E5.4Protein F44E5.40.222
lst-4Protein LST-40.222
lag-1Protein LAG-10.220
unc-32Protein UNC-320.210
nhr-69Protein NHR-690.205
apy-1Protein APY-10.204
egl-44Protein EGL-440.202
daf-11Protein DAF-110.201
hsp-16.1Protein HSP-16.10.201
perm-5Protein PERM-50.198
unc-78Protein UNC-780.194
aak-2Protein AAK-20.194
gei-17Protein GEI-170.189
mel-11Protein MEL-110.186
crt-1Protein CRT-10.186
ipp-5Protein IPP-50.185
CELE_Y39E4B.5Protein Y39E4B.50.184
CELE_Y75B8A.25Protein Y75B8A.250.183
sma-6Protein SMA-60.183
egal-1Protein EGAL-10.182
ida-1Protein IDA-10.178
daf-1Protein DAF-10.174
odr-3Protein ODR-30.171
zyg-9Protein ZYG-90.171
eat-4Protein EAT-40.170
cmd-1Protein CMD-10.170
itr-1Protein ITR-10.169
egl-5Protein EGL-50.168
egl-46Protein EGL-460.167
ant-1.1Protein ANT-1.10.166
egl-27Protein EGL-270.164
csn-6Protein CSN-60.163
daf-2Protein DAF-20.162
zfp-1Protein ZFP-10.161
ace-1Protein ACE-10.159
mls-2Protein MLS-20.159
deb-1Protein DEB-10.158
mec-4Protein MEC-40.157
pha-4Protein PHA-40.155
nap-1Protein NAP-10.153
pkg-1Protein PKG-10.152
pat-12Protein PAT-120.152
dcr-1Protein DCR-10.151
unc-83Protein UNC-830.151
F31D4.2Protein F31D4.20.151
spon-1Protein SPON-10.148
zfp-3Protein ZFP-30.147
unc-115Protein UNC-1150.146
mig-5Protein MIG-50.146
acdh-3Protein ACDH-30.145
R74.8Protein R74.80.145
hif-1Protein HIF-10.143
ess-2Protein ESS-20.143
wrn-1Protein WRN-10.143
mrp-1Protein MRP-10.142
nhr-67Protein NHR-670.141
gei-18Protein GEI-180.138
madd-4Protein MADD-40.137
clp-2Protein CLP-20.136
tax-4Protein TAX-40.136
cdc-42Protein CDC-420.135
odr-1Protein ODR-10.132
egl-13Protein EGL-130.132
cwn-2Protein CWN-20.131
unc-10Protein UNC-100.131
F53F10.2Protein F53F10.20.131
pkc-1Protein PKC-10.130
abts-3Protein ABTS-30.129
cks-1Protein CKS-10.129
egl-36Protein EGL-360.129
ifd-1Protein IFD-10.128
CELE_F20D1.1Protein F20D1.10.128
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
dlx5adistal-less homeobox gene 5a0.997
cdh23cadherin-like 230.993
pitx3paired-like homeodomain transcription factor 30.989
gnrh3gonadotropin-releasing hormone 30.915
fgfr1afibroblast growth factor receptor 1a0.912
col1a2collagen, type I, alpha 20.899
tgfb3transforming growth factor, beta 30.887
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.861
ift88intraflagellar transport 88 homolog0.847
ptprfprotein tyrosine phosphatase, receptor type, F0.814
aldocbaldolase C, fructose-bisphosphate, b0.775
per2period homolog 2 (Drosophila)0.773
opn1lw1opsin 1 (cone pigments), long-wave-sensitive, 10.766
igfbp1binsulin-like growth factor binding protein 1b0.758
spry4sprouty (Drosophila) homolog 40.744
robo3roundabout homolog 30.720
col1a1acollagen, type I, alpha 1a0.719
twist1atwist1a0.701
dladeltaA0.698
opn1sw1opsin 1 (cone pigments), short-wave-sensitive 10.693
gria4bglutamate receptor, ionotropic, AMPA 4b0.690
cyp24a1cytochrome P450, family 24, subfamily A, polypeptide 10.672
bdnfbrain-derived neurotrophic factor0.661
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.658
ywhaqbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b0.642
trpv6transient receptor potential cation channel, subfamily V, member 60.635
gcm2glial cells missing homolog 2 (Drosophila)0.633
cdh1cadherin 1, epithelial0.632
trpm7transient receptor potential cation channel, subfamily M, member 70.626
clockclock0.623
arnt2aryl hydrocarbon receptor nuclear translocator 20.613
thtyrosine hydroxylase0.594
dlx6adistal-less homeobox gene 6a0.587
cryaacrystallin, alpha A0.563
epb41l5erythrocyte membrane protein band 4.1 like 50.561
gc3guanylyl cyclase 30.556
prnprs3prion protein, related sequence 30.553
ddb2damage-specific DNA binding protein 20.545
gria2bglutamate receptor, ionotropic, AMPA 2b0.541
ihhaIndian hedgehog homolog a0.526
gria4aglutamate receptor, ionotropic, AMPA 4a0.525
prdm1aPR domain containing 1a, with ZNF domain0.525
opn1sw2opsin 1 (cone pigments), short-wave-sensitive 20.522
scn8aasodium channel, voltage-gated, type VIII, alpha a0.520
hsp90a.2heat shock protein 90-alpha 20.519
grk7aG-protein-coupled receptor kinase 7a0.508
cdh2cadherin 2, neuronal0.500
mpzmyelin protein zero0.497
th2tyrosine hydroxylase 20.495
plcg1phospholipase C, gamma 10.490
otx5orthodenticle homolog 50.478
ctskcathepsin K0.475
chrm2acholinergic receptor, muscarinic 2a0.470
gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 20.464
otpaorthopedia homolog a0.462
ipo9importin 90.460
icnictacalcin0.451
sox4aSRY-box containing gene 4a0.441
dlx4adistal-less homeobox gene 4a0.439
gria1bglutamate receptor, ionotropic, AMPA 1b0.438
sox8SRY-box containing gene 80.438
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.436
epas1bendothelial PAS domain protein 1b0.434
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.429
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.428
trpv4transient receptor potential cation channel, subfamily V, member 40.425
gnat1guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 10.424
dlx2adistal-less homeobox gene 2a0.423
id2ainhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a0.422
hif1abhypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b0.415
ahcyS-adenosylhomocysteine hydrolase0.415
mapk1mitogen-activated protein kinase 10.414
nap1l1nucleosome assembly protein 1, like 10.409
ca2carbonic anhydrase II0.408
mef2amyocyte enhancer factor 2a0.408
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.407
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.406
dag1dystroglycan 10.404
glra1glycine receptor, alpha 10.400
tac1tachykinin 10.399
nfatc1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 10.397
rhorhodopsin0.395
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.393
zgc:100838zgc:1008380.385
tbpl2TATA box binding protein like 20.378
ascl1aachaete-scute complex-like 1a (Drosophila)0.378
slc9a3.2solute carrier family 9 (sodium/hydrogen exchanger), member 3.20.371
igfbp3insulin-like growth factor binding protein 30.370
bmp2bbone morphogenetic protein 2b0.365
scn1basodium channel, voltage-gated, type I, beta a0.361
chatcholine acetyltransferase0.361
ctsl1acathepsin L, 1 a0.352
synj1synaptojanin 10.351
hsp90b1heat shock protein 90, beta (grp94), member 10.351
dmbx1adiencephalon/mesencephalon homeobox 1a0.350
adrb2aadrenergic receptor, beta 2a0.348
gna12guanine nucleotide binding protein (G protein) alpha 120.338
foxo3bforkhead box O3b0.337
otpborthopedia homolog b0.336
crxcone-rod homeobox0.332
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Fmr1CG6203 gene product from transcript CG6203-RC0.999
Ras85DRas oncogene at 85D0.998
trptransient receptor potential0.988
Vha100-1CG1709 gene product from transcript CG1709-RF0.973
norpAno receptor potential A0.969
paraparalytic0.959
rlrolled0.952
S6kRPS6-p70-protein kinase0.952
uspultraspiracle0.946
shishibire0.941
frufruitless0.937
Atg1Autophagy-specific gene 10.936
atoatonal0.933
inaDinactivation no afterpotential D0.930
EgfrEpidermal growth factor receptor0.923
MhcMyosin heavy chain0.911
Ork1Open rectifier K[+] channel 10.901
MadMothers against dpp0.900
CatCatalase0.899
p53CG33336 gene product from transcript CG33336-RB0.891
rprreaper0.881
plxpollux0.878
RbfRetinoblastoma-family protein0.872
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.825
nanarrow abdomen0.821
lokloki0.820
sesBstress-sensitive B0.813
btvbeethoven0.811
spasspastin0.811
klarklarsicht0.802
inaCinactivation no afterpotential C0.801
GstE6Glutathione S transferase E60.800
aopanterior open0.788
Mekk1CG7717 gene product from transcript CG7717-RB0.787
rutrutabaga0.783
rdgCretinal degeneration C0.780
CSN4COP9 complex homolog subunit 40.767
Trx-2thioredoxin-20.756
5-HT1ASerotonin receptor 1A0.739
TrpA1Transient receptor potential A10.737
AtpalphaNa pump alpha subunit0.735
dncdunce0.728
nannanchung0.725
iavinactive0.723
TpiTriose phosphate isomerase0.715
GstD1Glutathione S transferase D10.699
highikaru genki0.689
sbbscribbler0.687
Vap-33-1CG5014 gene product from transcript CG5014-RB0.678
Arr2Arrestin 20.678
Akt1CG4006 gene product from transcript CG4006-RA0.673
Galpha49BG protein alpha49B0.668
RicRas which interacts with Calmodulin0.664
G-oalpha47AG protein oalpha 47A0.660
Ten-aTenascin accessory0.656
trpltrp-like0.655
nbsCG6754 gene product from transcript CG6754-RC0.655
ChcClathrin heavy chain0.643
HopHsp70/Hsp90 organizing protein homolog0.635
TequilaCG4821 gene product from transcript CG4821-RE0.633
DadDaughters against dpp0.632
cicubitus interruptus0.631
Pi3K92ECG4141 gene product from transcript CG4141-RB0.631
ecdecdysoneless0.626
kcckazachoc0.622
Pka-C1cAMP-dependent protein kinase 10.621
atlatlastin0.611
emcextra macrochaetae0.602
Hsp27Heat shock protein 270.602
nrv2nervana 20.599
lolalongitudinals lacking0.595
Snap25Synapse protein 250.594
scnyscrawny0.594
nejnejire0.590
NrgNeuroglian0.588
effeffete0.585
JraJun-related antigen0.583
nrv3nervana 30.581
comtcomatose0.576
Pink1PTEN-induced putative kinase 10.573
ninaAneither inactivation nor afterpotential A0.568
GstD4Glutathione S transferase D40.559
Hsp70AbHeat-shock-protein-70Ab0.556
NFATNFAT homolog0.554
RdlResistant to dieldrin0.553
elavembryonic lethal abnormal vision0.552
LnkCG17367 gene product from transcript CG17367-RC0.552
Mpk2CG5475 gene product from transcript CG5475-RB0.550
Ncc69sodium chloride cotransporter 690.549
HLHm7E(spl) region transcript m70.548
Ca-P60ACalcium ATPase at 60A0.530
InRInsulin-like receptor0.526
Pp1-87BProtein phosphatase 1 at 87B0.525
G-salpha60AG protein salpha 60A0.522
Nf1Neurofibromin 10.519
panpangolin0.519
ninaEneither inactivation nor afterpotential E0.517
Rh6Rhodopsin 60.513
Mef2Myocyte enhancer factor 20.513
eagether a go-go0.513
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
PBS2Pbs2p0.914
YDJ1Ydj1p0.849
HSP42Hsp42p0.764
SSK1Ssk1p0.673
MYO5Myo5p0.671
PHO85Pho85p0.619
CKA2Cka2p0.614
SIN3Sin3p0.605
SCH9Sch9p0.577
SSA4Ssa4p0.571
HSP104Hsp104p0.568
MSN2Msn2p0.544
STI1Sti1p0.538
SIC1Sic1p0.534
ROM2Rom2p0.524
PPZ1Ppz1p0.499
HOF1Hof1p0.499
NTH1Nth1p0.468
CYC8Cyc8p0.426
KAP95Kap95p0.404
PSR2Psr2p0.387
SSE2Sse2p0.372
MKK1Mkk1p0.369
BTN2Btn2p0.361
AHA1Aha1p0.353
PIL1Pil1p0.353
UFD4Ufd4p0.327
YAK1Yak1p0.325
ALD6Ald6p0.321
UBP3Ubp3p0.314
LSB3Lsb3p0.312
BEM1Bem1p0.299
SIF2Sif2p0.286
NBP2Nbp2p0.286
MSC1Msc1p0.283
HSP82Hsp82p0.283
HSL1Hsl1p0.275
WHI2Whi2p0.269
SGV1Sgv1p0.261
SNT1Snt1p0.259
SLT2Slt2p0.256
CPR1Cpr1p0.247
MID2Mid2p0.246
LAP4Lap4p0.245
FPS1Fps1p0.243
AQY2Aqy2p0.242
BEM3Bem3p0.241
FKH1Fkh1p0.240
ECM22Ecm22p0.237
TSL1Tsl1p0.237
DAK1Dak1p0.236
RVS167Rvs167p0.232
HOG1Hog1p0.231
SSK22Ssk22p0.223
HAL5Hal5p0.223
TOR2Tor2p0.220
HSP26Hsp26p0.220
NUP100Nup100p0.219
SFP1Sfp1p0.218
NUP116Nup116p0.217
ARP8Arp8p0.215
DED1Ded1p0.211
VAC7Vac7p0.209
CPR6Cpr6p0.207
STE20Ste20p0.203
RIM13Rim13p0.203
MSN5Msn5p0.202
RHO1Rho1p0.200
GRE3Gre3p0.196
AHP1Ahp1p0.195
RNR4Rnr4p0.195
SDS24Sds24p0.195
YPK2Ypk2p0.194
RPB2Rpb2p0.191
CLA4Cla4p0.190
CNA1Cna1p0.190
YME1Yme1p0.189
NUP170Nup170p0.189
ILS1Ils1p0.189
RAD52Rad52p0.188
NUP42Nup42p0.188
YOL057Whypothetical protein0.188
RPI1Rpi1p0.188
KRE6Kre6p0.185
WSC3Wsc3p0.182
FMP48Fmp48p0.181
GAL11Gal11p0.180
MIG2Mig2p0.180
LGE1Lge1p0.179
FAR11Far11p0.176
DBF20Dbf20p0.176
MSG5Msg5p0.175
TCB1Tcb1p0.174
RAD54Rad54p0.171
SSD1Ssd1p0.170
STE5Ste5p0.169
PUT3Put3p0.165
UGA2Uga2p0.165
ENA5Ena5p0.164
DBF2Dbf2p0.162