The network for 'regulation of tyrosine phosphorylation of stat3 protein' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of tyrosine phosphorylation of stat3 protein

Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat3 protein.

NameDescriptionProbabilityFunc Analog Organism
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1.000
GHRgrowth hormone receptor0.999
EGFRepidermal growth factor receptor0.999
JAK2Janus kinase 20.999
FGF1fibroblast growth factor 1 (acidic)0.998
SOCS3suppressor of cytokine signaling 30.996
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.992
PTPN11protein tyrosine phosphatase, non-receptor type 110.992
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.991
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.990
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.947
LATlinker for activation of T cells0.914
GH1growth hormone 10.884
JAK1Janus kinase 10.864
PTPRBprotein tyrosine phosphatase, receptor type, B0.847
INSRinsulin receptor0.831
CSH1chorionic somatomammotropin hormone 1 (placental lactogen)0.819
HDAC2histone deacetylase 20.751
VEGFAvascular endothelial growth factor A0.734
IL23Ainterleukin 23, alpha subunit p190.688
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.658
IL6Rinterleukin 6 receptor0.615
CD44CD44 molecule (Indian blood group)0.571
GAB1GRB2-associated binding protein 10.552
IL6interleukin 6 (interferon, beta 2)0.538
IRS1insulin receptor substrate 10.507
CSH2chorionic somatomammotropin hormone 20.437
NR4A1nuclear receptor subfamily 4, group A, member 10.407
SOCS1suppressor of cytokine signaling 10.403
STAT1signal transducer and activator of transcription 1, 91kDa0.376
PTPN1protein tyrosine phosphatase, non-receptor type 10.336
CSHL1chorionic somatomammotropin hormone-like 10.308
NRP1neuropilin 10.291
IGF1Rinsulin-like growth factor 1 receptor0.286
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.284
GH2growth hormone 20.282
GRB2growth factor receptor-bound protein 20.280
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.240
IL22interleukin 220.239
SCHIP1schwannomin interacting protein 10.229
PLCG1phospholipase C, gamma 10.210
TBC1D10ATBC1 domain family, member 10A0.199
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.188
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.187
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.164
SHC1SHC (Src homology 2 domain containing) transforming protein 10.147
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.126
CNTFciliary neurotrophic factor0.111
EPORerythropoietin receptor0.087
CAV1caveolin 1, caveolae protein, 22kDa0.082
PTPRJprotein tyrosine phosphatase, receptor type, J0.082
SH2B1SH2B adaptor protein 10.081
PGFplacental growth factor0.078
STAT4signal transducer and activator of transcription 40.075
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.073
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.073
FRS2fibroblast growth factor receptor substrate 20.069
CAPN1calpain 1, (mu/I) large subunit0.062
CDH5cadherin 5, type 2 (vascular endothelium)0.060
EZRezrin0.058
GRB7growth factor receptor-bound protein 70.057
JAK3Janus kinase 30.056
KITLGKIT ligand0.052
CD33CD33 molecule0.051
MED28mediator complex subunit 280.049
SOCS2suppressor of cytokine signaling 20.048
GAB2GRB2-associated binding protein 20.048
ICAM1intercellular adhesion molecule 10.048
IFNGR1interferon gamma receptor 10.048
PTK2PTK2 protein tyrosine kinase 20.047
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.047
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.046
FGF10fibroblast growth factor 100.046
METmet proto-oncogene (hepatocyte growth factor receptor)0.046
STAT5Asignal transducer and activator of transcription 5A0.044
BCAR1breast cancer anti-estrogen resistance 10.042
PDGFAplatelet-derived growth factor alpha polypeptide0.042
SHC2SHC (Src homology 2 domain containing) transforming protein 20.041
SYKspleen tyrosine kinase0.041
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.040
ICA1islet cell autoantigen 1, 69kDa0.039
IL12Ainterleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)0.038
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.036
SNAI1snail homolog 1 (Drosophila)0.033
FGFR1fibroblast growth factor receptor 10.033
MAP3K5mitogen-activated protein kinase kinase kinase 50.033
LIFRleukemia inhibitory factor receptor alpha0.032
MMP14matrix metallopeptidase 14 (membrane-inserted)0.031
NTRK1neurotrophic tyrosine kinase, receptor, type 10.031
PTPN3protein tyrosine phosphatase, non-receptor type 30.030
SOS2son of sevenless homolog 2 (Drosophila)0.029
EXT1exostosin 10.028
TLR3toll-like receptor 30.027
SLASrc-like-adaptor0.026
STC1stanniocalcin 10.026
NR4A3nuclear receptor subfamily 4, group A, member 30.024
GRB10growth factor receptor-bound protein 100.024
CMIPc-Maf-inducing protein0.023
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.022
PDGFCplatelet derived growth factor C0.022
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
stmstarmaker0.393
il6stinterleukin 6 signal transducer0.385
mitfamicrophthalmia-associated transcription factor a0.303
il6rinterleukin 6 receptor0.296
prox1prospero-related homeobox gene 10.249
sema6dlsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like0.229
ednrb1endothelin receptor B0.219
neurodneurogenic differentiation0.214
insm1ainsulinoma-associated 1a0.188
scn1bbsodium channel, voltage-gated, type I, beta b0.169
aox3aldehyde oxidase 30.129
sb:cb429sb:cb4290.112
ltkleukocyte tyrosine kinase0.098
kitakit receptor a0.087
fezf2FEZ family zinc finger 20.086
pcdh17protocadherin 170.080
her4.2hairy-related 4.20.072
dlbdeltaB0.062
scn1basodium channel, voltage-gated, type I, beta a0.058
ntrk3bneurotrophic tyrosine kinase, receptor, type 3b0.055
prom1aprominin 1a0.051
pcsk5aproprotein convertase subtilisin/kexin type 5a0.051
cmybtranscription factor cmyb0.050
smoxspermine oxidase0.050
emx2empty spiracles homeobox 20.049
LOC100149863hairy-related 4.1-like0.048
scrt2scratch homolog 2, zinc finger protein (Drosophila)0.046
spry1sprouty homolog 1 (Drosophila)0.046
mmp9matrix metalloproteinase 90.046
sulf2sulfatase 20.045
nrp2bneuropilin 2b0.045
tagln3btransgelin 3b0.045
cacna1dacalcium channel, voltage-dependent, L type, alpha 1D subunit, a0.041
irf3interferon regulatory factor 30.041
insm1binsulinoma-associated 1b0.040
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.039
zbtb10zinc finger and BTB domain containing 100.037
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.037
rhcgbRhesus blood group, C glycoprotein b0.037
elovl4aelongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4a0.036
abca12ATP-binding cassette, sub-family A (ABC1), member 120.036
trpm7transient receptor potential cation channel, subfamily M, member 70.036
pax7bpaired box gene 7b0.035
fcho2FCH domain only 20.035
ctbp2lC-terminal binding protein 2, like0.035
emx3empty spiracles homeobox 30.034
mtmr8myotubularin related protein 80.034
etv5aets variant 5a0.034
kcnj13potassium inwardly-rectifying channel, subfamily J, member 130.033
ikbkginhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.033
sc:d0319sc:d03190.032
tlr3toll-like receptor 30.032
notch3notch homolog 30.030
il7rinterleukin 7 receptor0.030
elovl6ELOVL family member 6, elongation of long chain fatty acids (yeast)0.029
LOC566020Gig2-like protein DreO0.028
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.028
neurog1neurogenin 10.028
jag2jagged 20.027
ahcyl2S-adenosylhomocysteine hydrolase-like 20.026
chrna6cholinergic receptor, nicotinic, alpha 60.026
stat3signal transduction and activation of transcription 30.025
zgc:66441zgc:664410.024
msi1musashi homolog 1 (Drosophila)0.024
adcyap1r1adenylate cyclase activating polypeptide 1 (pituitary) receptor type I0.023
atp6v1alATPase, H+ transporting, lysosomal V1 subunit A, like0.023
barhl1.1BarH-like 1.10.023
csf1racolony stimulating factor 1 receptor, a0.022
sox4aSRY-box containing gene 4a0.021
otpborthopedia homolog b0.021
cav1caveolin 10.021
fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.021
socs3asuppressor of cytokine signaling 3a0.021
emx1empty spiracles homeobox 10.021
fcer1glFc receptor, IgE, high affinity I, gamma polypeptide like0.020
s100tS100 calcium binding protein T0.020
hoxb8ahomeo box B8a0.020
clic4chloride intracellular channel 40.020
cited3Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 30.020
six1bsine oculis homeobox homolog 1b0.019
crfb7cytokine receptor family member b70.019
sc:d812sc:d8120.019
gadd45ggrowth arrest and DNA-damage-inducible, gamma0.019
grn2granulin 20.019
amotl2aangiomotin like 2a0.019
grn1granulin 10.019
prom1bprominin 1 b0.019
iclp1invariant chain-like protein 10.018
atl1atlastin GTPase 10.018
dnttdeoxynucleotidyltransferase, terminal0.018
runx3runt-related transcription factor 30.018
ildr1bimmunoglobulin-like domain containing receptor 1b0.017
nr3c2nuclear receptor subfamily 3, group C, member 20.017
c21orf59lc21orf59 homolog (H. sapiens), like0.017
scn8absodium channel, voltage-gated, type VIII, alpha b0.017
LOC100003330melanocortin-2 receptor accessory protein 2-like0.017
bmp3bone morphogenetic protein 30.017
tac1tachykinin 10.017
atp1b1aATPase, Na+/K+ transporting, beta 1a polypeptide0.017
nr2f6bnuclear receptor subfamily 2, group F, member 6b0.017
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Leprleptin receptor0.952
Il6stinterleukin 6 signal transducer0.859
Stat3signal transducer and activator of transcription 30.824
Otx2orthodenticle homolog 2 (Drosophila)0.650
Emx2empty spiracles homolog 2 (Drosophila)0.558
Jak2Janus kinase 20.536
Lhx3LIM homeobox protein 30.448
Emx1empty spiracles homolog 1 (Drosophila)0.277
Vegfavascular endothelial growth factor A0.253
Ctnnb1catenin (cadherin associated protein), beta 10.251
Sox2SRY-box containing gene 20.224
Apcadenomatosis polyposis coli0.215
Tgfb1transforming growth factor, beta 10.195
Gli3GLI-Kruppel family member GLI30.184
Kdrkinase insert domain protein receptor0.177
Smad3MAD homolog 3 (Drosophila)0.157
Prf1perforin 1 (pore forming protein)0.128
Pitx2paired-like homeodomain transcription factor 20.127
Ptpn11protein tyrosine phosphatase, non-receptor type 110.119
Cdkn1bcyclin-dependent kinase inhibitor 1B0.102
Nos2nitric oxide synthase 2, inducible0.096
Lyz2lysozyme 20.086
Tnftumor necrosis factor0.079
Hes5hairy and enhancer of split 5 (Drosophila)0.078
Socs3suppressor of cytokine signaling 30.070
Stat5asignal transducer and activator of transcription 5A0.067
Il6interleukin 60.062
Kitlkit ligand0.060
Trp53transformation related protein 530.060
TcraT-cell receptor alpha chain0.059
Phospho1phosphatase, orphan 10.058
Pax6paired box gene 60.055
Foxc2forkhead box C20.052
Sox9SRY-box containing gene 90.052
Meox2mesenchyme homeobox 20.043
Il10interleukin 100.040
Bmpr1abone morphogenetic protein receptor, type 1A0.039
Ptpn2protein tyrosine phosphatase, non-receptor type 20.038
Col1a1collagen, type I, alpha 10.036
Prop1paired like homeodomain factor 10.036
Itgb1integrin beta 1 (fibronectin receptor beta)0.034
Cdh5cadherin 50.030
Pkd1polycystic kidney disease 1 homolog0.030
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.029
Foxp3forkhead box P30.028
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.027
Socs1suppressor of cytokine signaling 10.027
Plcg1phospholipase C, gamma 10.027
Ldlrlow density lipoprotein receptor0.026
Flt4FMS-like tyrosine kinase 40.026
Kitkit oncogene0.026
Nr2e1nuclear receptor subfamily 2, group E, member 10.025
Shhsonic hedgehog0.025
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.023
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.022
Hes3hairy and enhancer of split 3 (Drosophila)0.022
Esr1estrogen receptor 1 (alpha)0.022
Smpd3sphingomyelin phosphodiesterase 3, neutral0.022
Nognoggin0.021
Insm1insulinoma-associated 10.021
Cyldcylindromatosis (turban tumor syndrome)0.021
Fgf8fibroblast growth factor 80.020
Nos3nitric oxide synthase 3, endothelial cell0.020
Inpp5dinositol polyphosphate-5-phosphatase D0.020
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.019
Chd7chromodomain helicase DNA binding protein 70.019
Tsc1tuberous sclerosis 10.018
Pax3paired box gene 30.018
Ifnginterferon gamma0.017
Fgfr3fibroblast growth factor receptor 30.017
Tsc2tuberous sclerosis 20.017
Rag1recombination activating gene 10.017
Gscgoosecoid homeobox0.017
Sh2b1SH2B adaptor protein 10.017
Stat5bsignal transducer and activator of transcription 5B0.017
Ptch1patched homolog 10.017
Socs2suppressor of cytokine signaling 20.017
Gdnfglial cell line derived neurotrophic factor0.017
Ptprbprotein tyrosine phosphatase, receptor type, B0.016
Adam17a disintegrin and metallopeptidase domain 170.016
Csf1colony stimulating factor 1 (macrophage)0.016
CblCasitas B-lineage lymphoma0.015
Nr5a1nuclear receptor subfamily 5, group A, member 10.015
Nlrp3NLR family, pyrin domain containing 30.014
Il1r1interleukin 1 receptor, type I0.014
Ldb2LIM domain binding 20.014
Foxh1forkhead box H10.014
Vegfcvascular endothelial growth factor C0.014
Ednrbendothelin receptor type B0.014
Foxn1forkhead box N10.013
Nodalnodal0.013
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.013
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.013
Acvr1activin A receptor, type 10.013
Flt1FMS-like tyrosine kinase 10.012
Sox17SRY-box containing gene 170.011
FynFyn proto-oncogene0.011
Wt1Wilms tumor 1 homolog0.011
Cd44CD44 antigen0.011
Hesx1homeobox gene expressed in ES cells0.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Rps26ribosomal protein S260.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism