The network for 'regulation of glucose metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of glucose metabolic process

Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.

NameDescriptionProbabilityFunc Analog Organism
INSRinsulin receptor0.999
C1QAcomplement component 1, q subcomponent, A chain0.966
NCOA1nuclear receptor coactivator 10.946
ARandrogen receptor0.873
IRS2insulin receptor substrate 20.859
PGK1phosphoglycerate kinase 10.856
GRB10growth factor receptor-bound protein 100.856
IRS1insulin receptor substrate 10.819
CREBBPCREB binding protein0.736
PRKAB2protein kinase, AMP-activated, beta 2 non-catalytic subunit0.725
ESR1estrogen receptor 10.704
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.668
IGF1Rinsulin-like growth factor 1 receptor0.659
TADA3transcriptional adaptor 30.633
GHRgrowth hormone receptor0.589
RXRAretinoid X receptor, alpha0.538
MDM2Mdm2 p53 binding protein homolog (mouse)0.517
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.438
PTPN1protein tyrosine phosphatase, non-receptor type 10.395
GAPDHglyceraldehyde-3-phosphate dehydrogenase0.353
ZNF746zinc finger protein 7460.331
NOXA1NADPH oxidase activator 10.329
HNF4Ahepatocyte nuclear factor 4, alpha0.276
ALDOAaldolase A, fructose-bisphosphate0.247
TPI1triosephosphate isomerase 10.243
RARAretinoic acid receptor, alpha0.203
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.198
NR0B1nuclear receptor subfamily 0, group B, member 10.196
SQSTM1sequestosome 10.190
ENO1enolase 1, (alpha)0.166
LDHAlactate dehydrogenase A0.159
FHL2four and a half LIM domains 20.152
EP300E1A binding protein p3000.146
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.137
SH2B1SH2B adaptor protein 10.136
C1QCcomplement component 1, q subcomponent, C chain0.132
GSK3Bglycogen synthase kinase 3 beta0.123
BCL2L11BCL2-like 11 (apoptosis facilitator)0.111
PPP1R2protein phosphatase 1, regulatory (inhibitor) subunit 20.108
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme0.098
DYRK1Bdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B0.096
USP22ubiquitin specific peptidase 220.096
ACACAacetyl-CoA carboxylase alpha0.091
PDPK13-phosphoinositide dependent protein kinase-10.088
C1QBcomplement component 1, q subcomponent, B chain0.086
KAT2BK(lysine) acetyltransferase 2B0.085
LZTS2leucine zipper, putative tumor suppressor 20.084
PRKAA1protein kinase, AMP-activated, alpha 1 catalytic subunit0.083
NCOA6nuclear receptor coactivator 60.082
STAT5Bsignal transducer and activator of transcription 5B0.079
RAB6ARAB6A, member RAS oncogene family0.079
ITGB1BP3integrin beta 1 binding protein 30.078
PTPN6protein tyrosine phosphatase, non-receptor type 60.066
ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 10.065
SIRT1sirtuin 10.065
SEMA6Asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.060
TADA2Atranscriptional adaptor 2A0.059
HRhairless homolog (mouse)0.059
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.058
FOXO3forkhead box O30.056
TAF4TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa0.052
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.052
TRRAPtransformation/transcription domain-associated protein0.051
DYRK2dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 20.051
PRKCZprotein kinase C, zeta0.050
FUNDC2FUN14 domain containing 20.049
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.047
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 120.045
MAP1LC3Amicrotubule-associated protein 1 light chain 3 alpha0.045
SORBS3sorbin and SH3 domain containing 30.043
GCKglucokinase (hexokinase 4)0.041
PRKCAprotein kinase C, alpha0.038
DYRK4dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 40.038
TP53tumor protein p530.037
NCOA3nuclear receptor coactivator 30.036
EPM2Aepilepsy, progressive myoclonus type 2A, Lafora disease (laforin)0.035
NR0B2nuclear receptor subfamily 0, group B, member 20.035
PKM2pyruvate kinase, muscle0.035
MED25mediator complex subunit 250.034
PROX1prospero homeobox 10.034
OSBPoxysterol binding protein0.034
GPIglucose-6-phosphate isomerase0.033
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.033
CCDC101coiled-coil domain containing 1010.033
HIPK2homeodomain interacting protein kinase 20.033
CREB1cAMP responsive element binding protein 10.033
SMAD3SMAD family member 30.031
PRKAG2protein kinase, AMP-activated, gamma 2 non-catalytic subunit0.030
PECAM1platelet/endothelial cell adhesion molecule0.030
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.030
ULK1unc-51-like kinase 1 (C. elegans)0.030
GABARAPL1GABA(A) receptor-associated protein like 10.030
APCadenomatous polyposis coli0.030
NCF1neutrophil cytosolic factor 10.029
C5orf41chromosome 5 open reading frame 410.028
PINK1PTEN induced putative kinase 10.027
PRKCBprotein kinase C, beta0.027
CDCP1CUB domain containing protein 10.027
ARIH1ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)0.026
ARF4ADP-ribosylation factor 40.025
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Insrinsulin receptor0.999
Leprleptin receptor0.995
Esr1estrogen receptor 1 (alpha)0.976
Lepleptin0.961
Irs2insulin receptor substrate 20.919
Prlrprolactin receptor0.888
Nos1nitric oxide synthase 1, neuronal0.866
Ghrgrowth hormone receptor0.832
Egfrepidermal growth factor receptor0.759
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.746
Cdkn1bcyclin-dependent kinase inhibitor 1B0.722
Igf1insulin-like growth factor 10.604
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.581
Thrbthyroid hormone receptor beta0.572
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.542
Pim3proviral integration site 30.524
Igf1rinsulin-like growth factor I receptor0.510
Pnpla2patatin-like phospholipase domain containing 20.493
Stat5asignal transducer and activator of transcription 5A0.491
Drd2dopamine receptor D20.477
Arntlaryl hydrocarbon receptor nuclear translocator-like0.476
Akt1thymoma viral proto-oncogene 10.474
Ppargperoxisome proliferator activated receptor gamma0.470
Arandrogen receptor0.443
Hnf4ahepatic nuclear factor 4, alpha0.429
Mup19major urinary protein 190.394
Thrathyroid hormone receptor alpha0.389
Cav1caveolin 1, caveolae protein0.385
Ins2insulin II0.365
Prkab1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.360
Ctnnb1catenin (cadherin associated protein), beta 10.353
Onecut1one cut domain, family member 10.352
LOC100048884novel member of the major urinary protein (Mup) gene family0.329
Foxa2forkhead box A20.327
Lmx1bLIM homeobox transcription factor 1 beta0.326
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.310
Plin4perilipin 40.310
Lipelipase, hormone sensitive0.301
Fggfibrinogen gamma chain0.295
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.293
Npy1rneuropeptide Y receptor Y10.272
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.269
Ren1renin 1 structural0.262
Ccnl2cyclin L20.261
Mup4major urinary protein 40.257
Ambpalpha 1 microglobulin/bikunin0.254
Gli3GLI-Kruppel family member GLI30.248
Fgfr1fibroblast growth factor receptor 10.244
Pdx1pancreatic and duodenal homeobox 10.240
Apoeapolipoprotein E0.239
Mup10major urinary protein 100.237
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.231
Nr3c1nuclear receptor subfamily 3, group C, member 10.226
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.220
MecomMDS1 and EVI1 complex locus0.220
Mup1major urinary protein 10.215
Clk4CDC like kinase 40.214
Fgafibrinogen alpha chain0.214
Ep300E1A binding protein p3000.209
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.208
Fabp1fatty acid binding protein 1, liver0.204
Bmp4bone morphogenetic protein 40.188
Foxc1forkhead box C10.182
Mup7major urinary protein 70.178
Inhbcinhibin beta-C0.177
F2coagulation factor II0.175
Rpgrip1lRpgrip1-like0.174
Klklotho0.174
Apofapolipoprotein F0.170
Esr2estrogen receptor 2 (beta)0.170
Clk1CDC-like kinase 10.168
Fgf21fibroblast growth factor 210.163
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.161
Stat5bsignal transducer and activator of transcription 5B0.154
Rad21RAD21 homolog (S. pombe)0.153
Grb10growth factor receptor bound protein 100.152
Mup12major urinary protein 120.144
Mup8major urinary protein 80.143
Mup13major urinary protein 130.142
Foxo1forkhead box O10.141
Stat3signal transducer and activator of transcription 30.140
Atxn1ataxin 10.140
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.140
Rbl2retinoblastoma-like 20.140
Mup17major urinary protein 170.137
Agrpagouti related protein0.136
Adra2aadrenergic receptor, alpha 2a0.136
Aebp1AE binding protein 10.135
Chrna6cholinergic receptor, nicotinic, alpha polypeptide 60.133
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.132
Hrghistidine-rich glycoprotein0.131
Serpina3cserine (or cysteine) peptidase inhibitor, clade A, member 3C0.130
Wnt1wingless-related MMTV integration site 10.129
Adra1badrenergic receptor, alpha 1b0.128
Mup11major urinary protein 110.126
Otporthopedia homolog (Drosophila)0.123
Foxf2forkhead box F20.123
Mcl1myeloid cell leukemia sequence 10.123
Mup9major urinary protein 90.119
Sim1single-minded homolog 1 (Drosophila)0.118
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Rab1bRAB1B, member RAS oncogene family0.018
DbpD site of albumin promoter (albumin D-box) binding protein0.018
Smad3SMAD family member 30.018
A1cfAPOBEC1 complementation factor0.017
Snrpbsmall nuclear ribonucleoprotein polypeptides B and B10.013
Eef2eukaryotic translation elongation factor 20.013
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.011
Acsl1acyl-CoA synthetase long-chain family member 10.011
Nacc1nucleus accumbens associated 1, BEN and BTB (POZ) domain containing0.011
Mgat3mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
FYV10Fyv10p0.990
VID30Vid30p0.907
GID8Gid8p0.860
GID7Gid7p0.857
RMD5Rmd5p0.803
GSY2Gsy2p0.789
GSY1Gsy1p0.569
VID28Vid28p0.381
TMA10Tma10p0.330
PIG2Pig2p0.237
GLC7Glc7p0.196
HXK1Hxk1p0.161
YIL077Chypothetical protein0.142
YAP6Yap6p0.114
GIP2Gip2p0.113
YLR345Whypothetical protein0.110
GAC1Gac1p0.096
MOH1Moh1p0.090
GLG2Glg2p0.088
SAK1Sak1p0.074
PSK1Psk1p0.065
GPH1Gph1p0.064
BDH1Bdh1p0.064
PFK1Pfk1p0.060
CAK1Cak1p0.059
GBP2Gbp2p0.057
THI3Thi3p0.057
REG1Reg1p0.056
UGP1Ugp1p0.054
YNL194Chypothetical protein0.054
PCL10Pcl10p0.054
OSH2Osh2p0.054
PHO85Pho85p0.053
SUR1Sur1p0.051
AZF1Azf1p0.050
SNF1Snf1p0.049
BCK2Bck2p0.049
PKH2Pkh2p0.046
PPE1Ppe1p0.046
UBP11Ubp11p0.045
HXK2Hxk2p0.045
EMI2Emi2p0.042
SSA4Ssa4p0.042
KIN1Kin1p0.041
VID24Vid24p0.039
DBF2Dbf2p0.037
BPH1Bph1p0.036
YPL229Whypothetical protein0.035
GIS1Gis1p0.035
SPR6Spr6p0.034
MBR1Mbr1p0.034
GLG1Glg1p0.034
PHO81Pho81p0.034
YLR264C-Ahypothetical protein0.032
MIG1Mig1p0.032
RRF1Rrf1p0.032
ATG20Atg20p0.031
PET494Pet494p0.031
CCP1Ccp1p0.031
LEE1Lee1p0.031
MMR1Mmr1p0.030
NGG1Ngg1p0.030
MRK1Mrk1p0.030
SIP1Sip1p0.030
RIM4Rim4p0.030
HER1Her1p0.030
ACF4Acf4p0.029
PCL2Pcl2p0.029
YDR319Chypothetical protein0.029
IRC15Irc15p0.029
AGP2Agp2p0.028
GDS1Gds1p0.028
NCE103Nce103p0.028
GLN1Gln1p0.028
AUS1Aus1p0.028
VMA3Vma3p0.027
YLR177Whypothetical protein0.027
YMR210Whypothetical protein0.027
GYL1Gyl1p0.026
YAP1801hypothetical protein0.026
YOL014Whypothetical protein0.026
IMD2Imd2p0.026
PCL9Pcl9p0.026
LEU2Leu2p0.026
PAM1Pam1p0.026
MMF1Mmf1p0.026
SRD1Srd1p0.026
AST2Ast2p0.025
URN1Urn1p0.025
RCN2Rcn2p0.025
SPO12Spo12p0.025
CUP1-1Cup1-1p0.025
KIN28Kin28p0.024
JHD2Jhd2p0.024
YJR115Whypothetical protein0.024
CKS1Cks1p0.023
ADR1Adr1p0.023
PCD1Pcd1p0.023
NUT2Nut2p0.023
GAL83Gal83p0.023