The network for 'inner ear morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

inner ear morphogenesis

The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.

NameDescriptionProbabilityFunc Analog Organism
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.998
DVL3dishevelled, dsh homolog 3 (Drosophila)0.901
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.893
VEGFAvascular endothelial growth factor A0.870
DHCR77-dehydrocholesterol reductase0.870
FSTL1follistatin-like 10.865
DVL1dishevelled, dsh homolog 1 (Drosophila)0.813
TRIP6thyroid hormone receptor interactor 60.792
CSNK1Ecasein kinase 1, epsilon0.764
CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 10.755
TAL1T-cell acute lymphocytic leukemia 10.747
CHD8chromodomain helicase DNA binding protein 80.722
TBC1D10ATBC1 domain family, member 10A0.721
SEC23ASec23 homolog A (S. cerevisiae)0.696
NOTCH3notch 30.662
INSRinsulin receptor0.632
NOTCH1notch 10.615
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.604
CHD7chromodomain helicase DNA binding protein 70.584
BMP1bone morphogenetic protein 10.574
NKX2-1NK2 homeobox 10.560
BMPR1Abone morphogenetic protein receptor, type IA0.559
PTCH1patched 10.507
ATN1atrophin 10.495
ZFYVE9zinc finger, FYVE domain containing 90.484
PPARAperoxisome proliferator-activated receptor alpha0.381
USH1CUsher syndrome 1C (autosomal recessive, severe)0.374
MAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)0.369
FGF10fibroblast growth factor 100.368
PDZK1PDZ domain containing 10.351
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.348
HMGCR3-hydroxy-3-methylglutaryl-CoA reductase0.347
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.336
BBS10Bardet-Biedl syndrome 100.336
MSX2msh homeobox 20.320
AXIN1axin 10.314
DHCR2424-dehydrocholesterol reductase0.298
IDI1isopentenyl-diphosphate delta isomerase 10.293
HNF4Ahepatocyte nuclear factor 4, alpha0.284
COL2A1collagen, type II, alpha 10.282
PAX2paired box 20.280
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.271
WT1Wilms tumor 10.267
HMGCS13-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)0.263
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.258
SC4MOLsterol-C4-methyl oxidase-like0.254
GRB10growth factor receptor-bound protein 100.250
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 120.247
SIX3SIX homeobox 30.245
TJP2tight junction protein 2 (zona occludens 2)0.236
FGFR2fibroblast growth factor receptor 20.235
HOXC8homeobox C80.231
PHLPP1PH domain and leucine rich repeat protein phosphatase 10.230
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.226
LRRK2leucine-rich repeat kinase 20.223
APCadenomatous polyposis coli0.220
HOXA10homeobox A100.218
NEDD4neural precursor cell expressed, developmentally down-regulated 40.203
HIPK2homeodomain interacting protein kinase 20.199
KRTAP4-12keratin associated protein 4-120.190
FGF1fibroblast growth factor 1 (acidic)0.190
GOPCgolgi-associated PDZ and coiled-coil motif containing0.187
IRS1insulin receptor substrate 10.183
RNF11ring finger protein 110.182
LHX1LIM homeobox 10.177
SIM2single-minded homolog 2 (Drosophila)0.172
MDFIMyoD family inhibitor0.170
USH1GUsher syndrome 1G (autosomal recessive)0.168
KCTD1potassium channel tetramerisation domain containing 10.167
DLX2distal-less homeobox 20.167
FZD1frizzled homolog 1 (Drosophila)0.166
SH3BP4SH3-domain binding protein 40.163
APBA3amyloid beta (A4) precursor protein-binding, family A, member 30.159
SOX1SRY (sex determining region Y)-box 10.154
CEP164centrosomal protein 164kDa0.152
HNF1BHNF1 homeobox B0.144
CAV1caveolin 1, caveolae protein, 22kDa0.143
LRP6low density lipoprotein receptor-related protein 60.143
FGF8fibroblast growth factor 8 (androgen-induced)0.142
LBX1ladybird homeobox 10.142
FOXA2forkhead box A20.142
ADAM12ADAM metallopeptidase domain 120.140
FADS1fatty acid desaturase 10.138
EGFRepidermal growth factor receptor0.135
PAX8paired box 80.133
WNT7Awingless-type MMTV integration site family, member 7A0.131
HOXD9homeobox D90.130
AFF2AF4/FMR2 family, member 20.128
WWP1WW domain containing E3 ubiquitin protein ligase 10.128
PRPF3PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)0.126
FRS2fibroblast growth factor receptor substrate 20.124
HOXB9homeobox B90.122
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.121
MSX1msh homeobox 10.121
SQLEsqualene epoxidase0.119
LHX2LIM homeobox 20.118
VAX2ventral anterior homeobox 20.117
TWIST1twist homolog 1 (Drosophila)0.117
HMGA2high mobility group AT-hook 20.115
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
eya1eyes absent homolog 10.994
mibmind bomb0.990
gata3GATA-binding protein 30.990
bmp4bone morphogenetic protein 40.986
bmp2bbone morphogenetic protein 2b0.986
fgf3fibroblast growth factor 30.978
hnf1baHNF1 homeobox Ba0.969
flhfloating head0.957
tbx1T-box 10.948
dlx2adistal-less homeobox gene 2a0.935
msxcmuscle segment homeobox C0.930
pax2apaired box gene 2a0.927
atoh1batonal homolog 1b0.914
ndr2nodal-related 20.903
lmx1b.1LIM homeobox transcription factor 1, beta 10.900
dlx5adistal-less homeobox gene 5a0.893
fgf17fibroblast growth factor 170.879
gpr126G protein-coupled receptor 1260.854
sox10SRY-box containing gene 100.844
sox2SRY-box containing gene 20.839
dlx4bdistal-less homeobox gene 4b0.831
hand2heart and neural crest derivatives expressed transcript 20.822
fgfr4fibroblast growth factor receptor 40.804
gbx2gastrulation brain homeo box 20.801
six4bsine oculis homeobox homolog 4b0.800
hmx3homeo box (H6 family) 30.795
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.795
jag1bjagged 1b0.794
foxc1aforkhead box C1a0.760
foxi1forkhead box I10.759
bmp2abone morphogenetic protein 2a0.734
ncs1aneuronal calcium sensor 1a0.734
dlx4adistal-less homeobox gene 4a0.725
pax8paired box gene 80.724
igfbp3insulin-like growth factor binding protein 30.721
gli2aGLI-Kruppel family member GLI2a0.680
shhasonic hedgehog a0.672
myo7aamyosin VIIAa0.655
foxg1aforkhead box G1a0.653
tbx16T-box gene 160.651
osr1odd-skipped related 1 (Drosophila)0.638
gli1GLI-Kruppel family member 10.637
gata2aGATA-binding protein 2a0.632
pitx3paired-like homeodomain transcription factor 30.632
tbx2bT-box 2b0.618
ntlano tail a0.600
wlswntless homolog (Drosophila)0.591
wnt2bbwingless-type MMTV integration site family, member 2Bb0.580
kdrlkinase insert domain receptor like0.580
pitx2paired-like homeodomain transcription factor 20.572
dlx2bdistal-less homeobox gene 2b0.561
fgfr1afibroblast growth factor receptor 1a0.557
dachadachshund a0.548
fgf10afibroblast growth factor 10a0.522
jag2jagged 20.521
edn1endothelin 10.516
rx2retinal homeobox gene 20.511
sox9aSRY-box containing gene 9a0.496
foxa2forkhead box A20.496
hhiphedgehog interacting protein0.491
snai1bsnail homolog 1b (Drosophila)0.490
pcdh10bprotocadherin 10b0.476
prdm1aPR domain containing 1a, with ZNF domain0.469
tgfb3transforming growth factor, beta 30.460
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.454
fgf8afibroblast growth factor 8 a0.453
myod1myogenic differentiation 10.450
shhbsonic hedgehog b0.449
emx3empty spiracles homeobox 30.442
aldh1a3aldehyde dehydrogenase 1 family, member A30.441
pax9paired box gene 90.435
dlx6adistal-less homeobox gene 6a0.432
vedventrally expressed dharma/bozozok antagonist0.431
eya4eyes absent homolog 4 (Drosophila)0.430
irx1biroquois homeobox protein 1, b0.429
irx3airoquois homeobox protein 3a0.419
atoh1aatonal homolog 1a0.412
cldnhclaudin h0.411
tp63tumor protein p630.408
wnt1wingless-type MMTV integration site family, member 10.395
atp1a1a.2ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide0.395
barhl2BarH-like 20.387
sall4sal-like 4 (Drosophila)0.378
hmx2H6 family homeobox 20.374
atp1b2bATPase, Na+/K+ transporting, beta 2b polypeptide0.374
ascl1aachaete-scute complex-like 1a (Drosophila)0.361
wnt7aawingless-type MMTV integration site family, member 7Aa0.354
hey2hairy/enhancer-of-split related with YRPW motif 20.345
raraaretinoic acid receptor, alpha a0.344
etv5bets variant 5b0.341
irx5airoquois homeobox protein 5a0.340
hoxb3ahomeo box B3a0.338
nr2e1nuclear receptor subfamily 2, group E, member 10.330
wnt3wingless-type MMTV integration site family, member 30.328
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Eya1eyes absent 1 homolog (Drosophila)1.000
Pax2paired box gene 21.000
Gli3GLI-Kruppel family member GLI31.000
Shhsonic hedgehog1.000
Vangl2vang-like 2 (van gogh, Drosophila)0.999
Foxg1forkhead box G10.999
Gbx2gastrulation brain homeobox 20.999
Pax3paired box gene 30.999
Foxc1forkhead box C10.999
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.999
Hoxa1homeobox A10.998
Chd7chromodomain helicase DNA binding protein 70.997
Fgf8fibroblast growth factor 80.996
Dlx5distal-less homeobox 50.995
Hand2heart and neural crest derivatives expressed transcript 20.994
Otx2orthodenticle homolog 2 (Drosophila)0.994
Tbx3T-box 30.993
Msx1homeobox, msh-like 10.993
Fgfr2fibroblast growth factor receptor 20.992
Hand1heart and neural crest derivatives expressed transcript 10.991
Pax6paired box gene 60.990
Sall4sal-like 4 (Drosophila)0.989
Prrx1paired related homeobox 10.988
Fgf10fibroblast growth factor 100.987
Gli2GLI-Kruppel family member GLI20.987
Pax8paired box gene 80.985
Efnb2ephrin B20.985
Sox2SRY-box containing gene 20.985
Rargretinoic acid receptor, gamma0.981
Jag1jagged 10.981
Foxc2forkhead box C20.977
Bmp7bone morphogenetic protein 70.973
Ptk7PTK7 protein tyrosine kinase 70.969
Pou4f3POU domain, class 4, transcription factor 30.969
Gata3GATA binding protein 30.966
Kcne1potassium voltage-gated channel, Isk-related subfamily, member 10.966
Pitx2paired-like homeodomain transcription factor 20.964
Cdh23cadherin 23 (otocadherin)0.964
Lmx1bLIM homeobox transcription factor 1 beta0.964
Bmp4bone morphogenetic protein 40.958
Fgfr1fibroblast growth factor receptor 10.957
Ascl1achaete-scute complex homolog 1 (Drosophila)0.954
Hoxa2homeobox A20.952
Ush1gUsher syndrome 1G homolog (human)0.949
Hoxd13homeobox D130.941
Hmx3H6 homeobox 30.937
Tgfb2transforming growth factor, beta 20.937
Rarbretinoic acid receptor, beta0.928
Pax9paired box gene 90.925
Neurod1neurogenic differentiation 10.914
Lhx3LIM homeobox protein 30.906
Pou3f3POU domain, class 3, transcription factor 30.889
Isl1ISL1 transcription factor, LIM/homeodomain0.888
Ror2receptor tyrosine kinase-like orphan receptor 20.882
Tcfap2atranscription factor AP-2, alpha0.880
Gdnfglial cell line derived neurotrophic factor0.878
Lmx1aLIM homeobox transcription factor 1 alpha0.876
Msx2homeobox, msh-like 20.874
Hes1hairy and enhancer of split 1 (Drosophila)0.867
Ednraendothelin receptor type A0.866
Dvl2dishevelled 2, dsh homolog (Drosophila)0.856
Grxcr1glutaredoxin, cysteine rich 10.844
Gscgoosecoid homeobox0.839
Hoxd3homeobox D30.834
Hoxb1homeobox B10.827
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.813
Hoxa13homeobox A130.807
Pbx1pre B-cell leukemia transcription factor 10.793
Kiss1KiSS-1 metastasis-suppressor0.780
Emx2empty spiracles homolog 2 (Drosophila)0.775
Ush1cUsher syndrome 1C homolog (human)0.764
Pitx1paired-like homeodomain transcription factor 10.763
Nr5a1nuclear receptor subfamily 5, group A, member 10.758
Sall1sal-like 1 (Drosophila)0.755
Smad1MAD homolog 1 (Drosophila)0.748
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.742
Myo6myosin VI0.742
Srrm4serine/arginine repetitive matrix 40.741
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.733
Prrx2paired related homeobox 20.731
Neurog3neurogenin 30.716
Gli1GLI-Kruppel family member GLI10.705
Sox9SRY-box containing gene 90.704
Insm1insulinoma-associated 10.704
Snai1snail homolog 1 (Drosophila)0.701
Dkk1dickkopf homolog 1 (Xenopus laevis)0.700
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 10.694
Emx1empty spiracles homolog 1 (Drosophila)0.692
Sall3sal-like 3 (Drosophila)0.690
Atoh1atonal homolog 1 (Drosophila)0.686
Spry4sprouty homolog 4 (Drosophila)0.673
Dlx1distal-less homeobox 10.671
Tbx1T-box 10.669
Fgf5fibroblast growth factor 50.667
Hmx1H6 homeobox 10.659
Acvr1activin A receptor, type 10.657
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nr4a2nuclear receptor subfamily 4, group A, member 20.101
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.054
Nfibnuclear factor I/B0.046
Appamyloid beta (A4) precursor protein0.043
Fam65afamily with sequence similarity 65, member A0.039
Dab2disabled homolog 2 (Drosophila)0.034
Golph3golgi phosphoprotein 3 (coat-protein)0.033
Fgfr1Fibroblast growth factor receptor 10.032
Mapk3mitogen activated protein kinase 30.030
Col5a1collagen, type V, alpha 10.030
Hk1hexokinase 10.029
Galr2galanin receptor 20.026
Igfbp7insulin-like growth factor binding protein 70.026
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.025
Sirpasignal-regulatory protein alpha0.025
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.025
Tgfbr2transforming growth factor, beta receptor II0.024
Glg1golgi apparatus protein 10.023
Aif1lallograft inflammatory factor 1-like0.023
Unc5bunc-5 homolog B (C. elegans)0.022
HhipHedgehog-interacting protein0.022
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.022
Syngap1synaptic Ras GTPase activating protein 1 homolog (rat)0.022
Lyve1lymphatic vessel endothelial hyaluronan receptor 10.022
Igsf1immunoglobulin superfamily, member 10.022
Sept8septin 80.022
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.021
Crip2cysteine-rich protein 20.021
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.021
Procprotein C0.021
Egr2early growth response 20.021
RGD1305627hypothetical LOC3144670.020
Pxdnperoxidasin homolog (Drosophila)0.020
Cadcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase0.020
Dlg4discs, large homolog 4 (Drosophila)0.020
Gucy2gguanylate cyclase 2G0.019
FynFYN oncogene related to SRC, FGR, YES0.019
Ccnd2cyclin D20.019
Scarf2scavenger receptor class F, member 20.019
Slc22a7solute carrier family 22 (organic anion transporter), member 70.019
Pax8paired box 80.019
Rgrretinal G protein coupled receptor0.019
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.019
Slc1a2solute carrier family 1 (glial high affinity glutamate transporter), member 20.018
Htr65-hydroxytryptamine (serotonin) receptor 60.018
Kcnip3Kv channel interacting protein 3, calsenilin0.018
Igf2insulin-like growth factor 20.018
Cxxc4CXXC finger 40.018
Bmp1bone morphogenetic protein 10.018
Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.018
Akt2v-akt murine thymoma viral oncogene homolog 20.018
Marcksmyristoylated alanine rich protein kinase C substrate0.018
Igfbp5insulin-like growth factor binding protein 50.018
Myl9myosin, light chain 9, regulatory0.018
Nfixnuclear factor I/X (CCAAT-binding transcription factor)0.018
Grm5glutamate receptor, metabotropic 50.018
Akt1v-akt murine thymoma viral oncogene homolog 10.017
Prdm12PR domain containing 120.017
Kcnd1potassium voltage-gated channel, Shal-related subfamily, member 10.017
Ppp2r2cprotein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform0.017
Ppap2bphosphatidic acid phosphatase type 2B0.017
Gna12guanine nucleotide binding protein (G protein) alpha 120.017
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.016
Vax1ventral anterior homeobox 10.016
Ldlrlow density lipoprotein receptor0.016
Nr4a1nuclear receptor subfamily 4, group A, member 10.016
Tgfb3transforming growth factor, beta 30.016
Shox2short stature homeobox 20.016
Nficnuclear factor I/C0.016
Akap4A kinase (PRKA) anchor protein 40.016
Dchs1dachsous 1 (Drosophila)0.016
Trpv4transient receptor potential cation channel, subfamily V, member 40.016
Ehfets homologous factor0.016
Notch1Notch homolog 1, translocation-associated (Drosophila)0.016
B4galt2UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 20.015
Irs3insulin receptor substrate 30.015
Eef2eukaryotic translation elongation factor 20.015
Galr3galanin receptor 30.015
Sox4SRY (sex determining region Y)-box 40.015
Ddah1dimethylarginine dimethylaminohydrolase 10.015
Map3k3mitogen activated protein kinase kinase kinase 30.015
Esr1estrogen receptor 10.015
Sox17SRY (sex determining region Y)-box 170.015
Rhoaras homolog gene family, member A0.015
Itpr2inositol 1,4,5-triphosphate receptor, type 20.015
Map2microtubule-associated protein 20.015
Aldh7a1aldehyde dehydrogenase 7 family, member A10.015
Pnma1paraneoplastic antigen MA10.015
Sardhsarcosine dehydrogenase0.015
Unc5aunc-5 homolog A (C. elegans)0.015
Hapln1hyaluronan and proteoglycan link protein 10.015
Mast2microtubule associated serine/threonine kinase 20.015
Arf6ADP-ribosylation factor 60.014
Kctd15potassium channel tetramerisation domain containing 150.014
Npy5rneuropeptide Y receptor Y50.014
Scarb1scavenger receptor class B, member 10.014
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism