The network for 'protein k48 linked ubiquitination' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

protein k48 linked ubiquitination

A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.

NameDescriptionProbabilityFunc Analog Organism
UBE2D2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)1.000
UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)1.000
UBE2V1ubiquitin-conjugating enzyme E2 variant 11.000
RNF11ring finger protein 111.000
XIAPX-linked inhibitor of apoptosis1.000
UBE2Nubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)1.000
RNF5ring finger protein 51.000
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)1.000
ZNRF1zinc and ring finger 10.997
RNF111ring finger protein 1110.991
SMURF2SMAD specific E3 ubiquitin protein ligase 20.991
RNF14ring finger protein 140.985
TRIM39tripartite motif containing 390.984
FBXW11F-box and WD repeat domain containing 110.980
BIRC2baculoviral IAP repeat containing 20.979
DZIP3DAZ interacting protein 3, zinc finger0.974
UBE2E1ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)0.973
TRAF6TNF receptor-associated factor 60.955
UBE3Aubiquitin protein ligase E3A0.916
UBE2Wubiquitin-conjugating enzyme E2W (putative)0.911
RNF4ring finger protein 40.903
UBE2L3ubiquitin-conjugating enzyme E2L 30.894
ARIH2ariadne homolog 2 (Drosophila)0.874
MARCH7membrane-associated ring finger (C3HC4) 70.870
CUL3cullin 30.837
CUL1cullin 10.824
MARCH5membrane-associated ring finger (C3HC4) 50.820
UBE2E3ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)0.803
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.803
UBE2E2ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)0.775
RNF114ring finger protein 1140.762
UBE2Bubiquitin-conjugating enzyme E2B (RAD6 homolog)0.743
OPTNoptineurin0.740
UBA1ubiquitin-like modifier activating enzyme 10.739
CDC20cell division cycle 20 homolog (S. cerevisiae)0.724
WWP1WW domain containing E3 ubiquitin protein ligase 10.722
UBE2Aubiquitin-conjugating enzyme E2A (RAD6 homolog)0.714
RNF38ring finger protein 380.706
OTUB1OTU domain, ubiquitin aldehyde binding 10.629
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.628
TRIM43tripartite motif containing 430.616
SKP1S-phase kinase-associated protein 10.611
SIAH1seven in absentia homolog 1 (Drosophila)0.589
TRIM23tripartite motif containing 230.587
BTRCbeta-transducin repeat containing0.582
BIRC3baculoviral IAP repeat containing 30.567
USP4ubiquitin specific peptidase 4 (proto-oncogene)0.558
KLHL12kelch-like 12 (Drosophila)0.535
UBE2Hubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)0.526
NEDD4neural precursor cell expressed, developmentally down-regulated 40.489
TAX1BP1Tax1 (human T-cell leukemia virus type I) binding protein 10.480
CHFRcheckpoint with forkhead and ring finger domains0.467
ZNF746zinc finger protein 7460.462
RNF26ring finger protein 260.452
RNF168ring finger protein 1680.425
DCUN1D1DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)0.403
RNF2ring finger protein 20.396
PJA2praja ring finger 20.391
RNF10ring finger protein 100.364
UBCubiquitin C0.364
TRIM32tripartite motif containing 320.363
MIB1mindbomb homolog 1 (Drosophila)0.347
DTX3Ldeltex 3-like (Drosophila)0.340
RNF130ring finger protein 1300.331
UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)0.328
AMFRautocrine motility factor receptor0.327
ANKRD13Aankyrin repeat domain 13A0.308
RNF185ring finger protein 1850.286
ZFAND5zinc finger, AN1-type domain 50.282
UBQLN2ubiquilin 20.282
WNK4WNK lysine deficient protein kinase 40.278
KLHL2kelch-like 2, Mayven (Drosophila)0.278
TRIM27tripartite motif containing 270.238
NFE2L2nuclear factor (erythroid-derived 2)-like 20.233
RNF146ring finger protein 1460.220
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.214
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.213
RLIMring finger protein, LIM domain interacting0.211
STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase0.205
DAPK1death-associated protein kinase 10.192
STAM2signal transducing adaptor molecule (SH3 domain and ITAM motif) 20.184
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.172
UBOX5U-box domain containing 50.162
BFARbifunctional apoptosis regulator0.161
WWP2WW domain containing E3 ubiquitin protein ligase 20.158
STAMsignal transducing adaptor molecule (SH3 domain and ITAM motif) 10.155
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.155
TRIM8tripartite motif containing 80.152
PCGF2polycomb group ring finger 20.143
TRAF1TNF receptor-associated factor 10.142
RNF103ring finger protein 1030.140
BIRC8baculoviral IAP repeat containing 80.136
UBE2G1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.134
SCAMP1secretory carrier membrane protein 10.131
ZMYND11zinc finger, MYND-type containing 110.131
USP15ubiquitin specific peptidase 150.123
SQSTM1sequestosome 10.120
PTTG1pituitary tumor-transforming 10.118
MED28mediator complex subunit 280.116
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)0.115
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
chic2cysteine-rich hydrophobic domain 20.164
vps28vacuolar protein sorting 28 (yeast)0.121
si:ch211-239j15.4si:ch211-239j15.40.117
crsp6cofactor required for Sp1 transcriptional activation, subunit 60.096
tceb1btranscription elongation factor B (SIII), polypeptide 1b0.086
h3f3cH3 histone, family 3C0.075
rab5aaRAB5A, member RAS oncogene family, a0.070
lsrlipolysis stimulated lipoprotein receptor0.069
bmpr1aabone morphogenetic protein receptor, type 1aa0.069
cnpy1canopy10.067
zgc:77849zgc:778490.065
zgc:55573zgc:555730.062
elof1elongation factor 1 homolog (S. cerevisiae)0.055
golga7golgi autoantigen, golgin subfamily a, 70.055
smndc1survival motor neuron domain containing 10.055
zgc:55671zgc:556710.055
tmed4transmembrane emp24 protein transport domain containing 40.050
oaz2aornithine decarboxylase antizyme 2a0.050
tpd52l2atumor protein D52-like 2a0.050
fbxw11bF-box and WD-40 domain protein 11b0.049
nipblbnovel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila)0.049
bnip3lbBCL2/adenovirus E1B interacting protein 3-like b0.048
sfswapsplicing factor, suppressor of white-apricot homolog (Drosophila)0.047
march6membrane-associated ring finger (C3HC4) 60.047
zgc:103670zgc:1036700.045
gtf2bgeneral transcription factor IIB0.044
ranbp9RAN binding protein 90.041
fzr1fizzy/cell division cycle 20 related 1 (Drosophila)0.040
cdc34acell division cycle 34 homolog (S. cerevisiae) a0.040
yy1bYY1 transcription factor b0.038
pdzd11PDZ domain containing 110.038
akap8lA kinase (PRKA) anchor protein 8-like0.037
clasp2cytoplasmic linker associated protein 20.037
ppp6cprotein phosphatase 6, catalytic subunit0.037
zgc:55512zgc:555120.037
tial1TIA1 cytotoxic granule-associated RNA binding protein-like 10.037
zgc:101121zgc:1011210.037
aktipakt interacting protein0.036
maeamacrophage erythroblast attacher0.035
wdr45lwdr45 like0.035
mapkapk2amitogen-activated protein kinase-activated protein kinase 2a0.035
ube2d1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.034
rab5abRAB5A, member RAS oncogene family, b0.034
zgc:56706zgc:567060.034
st14asuppression of tumorigenicity 14 (colon carcinoma) a0.033
rab1aRAB1A, member RAS oncogene family0.033
zgc:100869zgc:1008690.033
tmem50atransmembrane protein 50A0.033
ube2d2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)0.033
zgc:77304zgc:773040.033
klhl20kelch-like 20 (Drosophila)0.031
zgc:73311zgc:733110.030
tmem199transmembrane protein 1990.030
vps26bvacuolar protein sorting 26 homolog B0.030
zgc:92606zgc:926060.029
timm17atranslocase of inner mitochondrial membrane 17 homolog A (yeast)0.028
exoc7exocyst complex component 70.028
snx6sorting nexin 60.028
ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.028
taf8TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor0.028
mmgt1membrane magnesium transporter 10.028
cdc34bcell division cycle 34 homolog (S. cerevisiae) b0.028
fbxw11aF-box and WD-40 domain protein 11a0.027
rmnd5brequired for meiotic nuclear division 5 homolog B (S. cerevisiae)0.027
zgc:114169zgc:1141690.027
zgc:112356zgc:1123560.027
zgc:63992zgc:639920.027
ubbubiquitin B0.027
zgc:56223zgc:562230.026
slc7a6ossolute carrier family 7, member 6 opposite strand0.026
tuba1l2tubulin, alpha 1, like 20.026
zgc:86598zgc:865980.026
rab11baRAB11B, member RAS oncogene family, a0.026
ubcubiquitin C0.025
zgc:55886zgc:558860.025
wipi2WD repeat domain, phosphoinositide interacting 20.025
ankhaankylosis, progressive homolog a0.025
zfand2azinc finger, AN1-type domain 2A0.024
ccnicyclin I0.024
cnot6CCR4-NOT transcription complex, subunit 60.023
fbxo42F-box protein 420.023
dnaja2lDnaJ (Hsp40) homolog, subfamily A, member 2, like0.023
sirt1sirtuin (silent mating type information regulation 2 homolog) 10.023
mospd1motile sperm domain containing 10.023
mobkl1aaMOB1, Mps One Binder kinase activator-like 1A (yeast), genome duplicate a0.023
parnpoly(A)-specific ribonuclease (deadenylation nuclease)0.023
arglu1aarginine and glutamate rich 1a0.023
eif1beukaryotic translation initiation factor 1B0.023
zgc:56525zgc:565250.022
zgc:92624zgc:926240.022
bmpr1abbone morphogenetic protein receptor, type 1ab0.022
zc3h14zinc finger CCCH-type containing 140.022
zgc:55448zgc:554480.022
ing3inhibitor of growth family, member 30.022
zgc:77880zgc:778800.022
zgc:101080zgc:1010800.022
ing4inhibitor of growth family, member 40.022
dcun1d2DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae)0.022
LOC100536647disintegrin and metalloproteinase domain-containing protein 10-like0.021
pbx2pre-B-cell leukemia transcription factor 20.021
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG32581CG32581 gene product from transcript CG32581-RB0.845
trptransient receptor potential0.564
endosendosulfine0.204
l(3)05822lethal (3) 058220.203
NcNedd2-like caspase0.194
CG8974CG8974 gene product from transcript CG8974-RD0.193
ththread0.163
Sap30SIN3-associated polypeptide 300.144
CG32486CG32486 gene product from transcript CG32486-RD0.111
Rpn6Proteasome p44.5 subunit0.110
CG4495CG4495 gene product from transcript CG4495-RA0.110
MiroMitochondrial Rho0.088
Rab14Rab-protein 140.080
loqsloquacious0.074
CG15098CG15098 gene product from transcript CG15098-RA0.068
RhoBTBCG5701 gene product from transcript CG5701-RA0.061
StamSignal transducing adaptor molecule0.060
UbcD2Ubiquitin conjugating enzyme 20.059
CG2924CG2924 gene product from transcript CG2924-RA0.059
inaCinactivation no afterpotential C0.056
CG3305CG3305 gene product from transcript CG3305-RA0.054
Rad23CG1836 gene product from transcript CG1836-RB0.052
CG11984CG11984 gene product from transcript CG11984-RD0.050
CG7967CG7967 gene product from transcript CG7967-RA0.050
mtsmicrotubule star0.045
drongoCG3365 gene product from transcript CG3365-RH0.043
CG7220CG7220 gene product from transcript CG7220-RD0.042
CG1943CG1943 gene product from transcript CG1943-RA0.042
Snx6CG8282 gene product from transcript CG8282-RA0.041
HIP-RHsc/Hsp70-interacting protein related0.041
CG42557CG42557 gene product from transcript CG42557-RA0.040
Arr2Arrestin 20.040
CG9855CG9855 gene product from transcript CG9855-RA0.040
Ef1alpha48DElongation factor 1alpha48D0.040
LaspCG3849 gene product from transcript CG3849-RB0.038
Hsp27Heat shock protein 270.036
CG11009CG11009 gene product from transcript CG11009-RB0.036
Uev1ACG10640 gene product from transcript CG10640-RA0.036
Dlc90FDynein light chain 90F0.036
Vps26Vacuolar protein sorting 260.035
Mkrn1Makorin 10.034
CG12299CG12299 gene product from transcript CG12299-RA0.032
Uch-L3Ubiquitin C-terminal hydrolase0.032
SmGSmall ribonucleoprotein particle protein SmG0.032
CG3678CG3678 gene product from transcript CG3678-RA0.032
ArkApaf-1-related-killer0.032
ninaCneither inactivation nor afterpotential C0.032
CG6961CG6961 gene product from transcript CG6961-RA0.031
trpltrp-like0.030
UbcD10Ubiquitin conjugating enzyme 100.030
CG9866CG9866 gene product from transcript CG9866-RA0.030
UbcD4Ubiquitin conjugating enzyme 40.030
MSBPmembrane steroid binding protein0.029
CG8116CG8116 gene product from transcript CG8116-RB0.029
NcaNeurocalcin0.028
CG5555CG5555 gene product from transcript CG5555-RA0.028
pholpleiohomeotic like0.028
Fer1HCHFerritin 1 heavy chain homologue0.028
wmdwing morphogenesis defect0.027
Tango9Transport and Golgi organization 90.027
CG5059CG5059 gene product from transcript CG5059-RD0.027
mubmushroom-body expressed0.026
CG4502CG4502 gene product from transcript CG4502-RB0.026
UnrUpstream of N-ras0.026
squsquash0.026
CG3016CG3016 gene product from transcript CG3016-RA0.026
galectinCG11372 gene product from transcript CG11372-RA0.026
CG5978CG5978 gene product from transcript CG5978-RA0.026
CG7656CG7656 gene product from transcript CG7656-RA0.025
IceCG7788 gene product from transcript CG7788-RA0.025
CprCytochrome P450 reductase0.025
CG13366CG13366 gene product from transcript CG13366-RA0.025
CG4165CG4165 gene product from transcript CG4165-RD0.024
l(3)L1231lethal (3) L12310.024
r2d2CG7138 gene product from transcript CG7138-RB0.024
f-cupflyers-cup0.024
CG10267CG10267 gene product from transcript CG10267-RB0.024
CG8481CG8481 gene product from transcript CG8481-RB0.023
CG10158CG10158 gene product from transcript CG10158-RA0.023
Syx13Syntaxin 130.022
Gprk2G protein-coupled receptor kinase 20.022
hhairy0.022
CG31919CG31919 gene product from transcript CG31919-RC0.022
ruxroughex0.021
CG4996CG4996 gene product from transcript CG4996-RA0.021
tefteflon0.021
Sgt1CG9617 gene product from transcript CG9617-RA0.021
ttan0.021
Syx7Syntaxin 70.021
kermitCG11546 gene product from transcript CG11546-RB0.020
LacLachesin0.020
granny-smithgranny smith0.020
CG30344CG30344 gene product from transcript CG30344-RA0.020
jarjaguar0.020
CamCalmodulin0.020
l(1)G0269lethal (1) G02690.020
TrnTransportin0.020
CG12162CG12162 gene product from transcript CG12162-RA0.019
CG12404CG12404 gene product from transcript CG12404-RA0.019
CG4603CG4603 gene product from transcript CG4603-RA0.019
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trim30dtripartite motif-containing 30D0.113
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.085
Trim30atripartite motif-containing 30A0.070
Ube2d3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.070
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.053
Rnf11ring finger protein 110.049
Ythdf3YTH domain family 30.046
Rmnd5arequired for meiotic nuclear division 5 homolog A (S. cerevisiae)0.046
Traf6TNF receptor-associated factor 60.027
Mgea5meningioma expressed antigen 5 (hyaluronidase)0.022
Zmynd11zinc finger, MYND domain containing 110.021
Cyldcylindromatosis (turban tumor syndrome)0.019
Msl1male-specific lethal 1 homolog (Drosophila)0.017
Rac1RAS-related C3 botulinum substrate 10.017
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.015
Grb10growth factor receptor bound protein 100.015
Paip2polyadenylate-binding protein-interacting protein 20.014
Spastspastin0.014
Csnk2bcasein kinase 2, beta polypeptide0.014
Fzr1fizzy/cell division cycle 20 related 1 (Drosophila)0.013
Birc5baculoviral IAP repeat-containing 50.013
Trim12atripartite motif-containing 12A0.012
Atl2atlastin GTPase 20.012
Ulk2Unc-51 like kinase 2 (C. elegans)0.012
Ndfip1Nedd4 family interacting protein 10.011
Zfand6zinc finger, AN1-type domain 60.011
Zfand5zinc finger, AN1-type domain 50.011
Trp53bp1transformation related protein 53 binding protein 10.010
Ccnb2cyclin B20.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism