The network for 'rab protein signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

rab protein signal transduction

A series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state.

NameDescriptionProbabilityFunc Analog Organism
GDI2GDP dissociation inhibitor 20.999
GABARAPL1GABA(A) receptor-associated protein like 10.999
RAB4ARAB4A, member RAS oncogene family0.999
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.997
BIN1bridging integrator 10.996
RABGAP1RAB GTPase activating protein 10.996
RAB5ARAB5A, member RAS oncogene family0.991
C19orf50chromosome 19 open reading frame 500.989
NUDT18nudix (nucleoside diphosphate linked moiety X)-type motif 180.989
NBR1neighbor of BRCA1 gene 10.962
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.955
RAB3IPRAB3A interacting protein (rabin3)0.942
EEA1early endosome antigen 10.937
MYCBP2MYC binding protein 20.929
RAB11FIP1RAB11 family interacting protein 1 (class I)0.914
RAB3GAP1RAB3 GTPase activating protein subunit 1 (catalytic)0.884
ABL2v-abl Abelson murine leukemia viral oncogene homolog 20.870
CHD3chromodomain helicase DNA binding protein 30.840
RAB3IL1RAB3A interacting protein (rabin3)-like 10.806
RABEP1rabaptin, RAB GTPase binding effector protein 10.739
KCTD13potassium channel tetramerisation domain containing 130.737
PRKCZprotein kinase C, zeta0.701
HRASv-Ha-ras Harvey rat sarcoma viral oncogene homolog0.699
CELSR3cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)0.676
RAB11FIP2RAB11 family interacting protein 2 (class I)0.630
PDPK13-phosphoinositide dependent protein kinase-10.612
MAP1LC3Amicrotubule-associated protein 1 light chain 3 alpha0.597
RGMARGM domain family, member A0.594
VAMP2vesicle-associated membrane protein 2 (synaptobrevin 2)0.572
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.559
RAB3GAP2RAB3 GTPase activating protein subunit 2 (non-catalytic)0.554
TAB1TGF-beta activated kinase 1/MAP3K7 binding protein 10.553
VPS13Dvacuolar protein sorting 13 homolog D (S. cerevisiae)0.543
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.515
PNPLA6patatin-like phospholipase domain containing 60.510
EZRezrin0.485
RGS2regulator of G-protein signaling 2, 24kDa0.477
STBD1starch binding domain 10.438
HADHAhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit0.401
RAB11ARAB11A, member RAS oncogene family0.400
WBP2WW domain binding protein 20.372
NCKAP1NCK-associated protein 10.369
PIP5K1Cphosphatidylinositol-4-phosphate 5-kinase, type I, gamma0.364
RABGAP1LRAB GTPase activating protein 1-like0.337
CRTC2CREB regulated transcription coactivator 20.330
SPHARS-phase response (cyclin related)0.322
ATG9AATG9 autophagy related 9 homolog A (S. cerevisiae)0.310
SPOPspeckle-type POZ protein0.307
EIF2S3eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa0.305
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.301
FRMD6FERM domain containing 60.282
GIT1G protein-coupled receptor kinase interacting ArfGAP 10.281
FRYLFRY-like0.273
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.265
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.263
TSC2tuberous sclerosis 20.260
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.249
OCRLoculocerebrorenal syndrome of Lowe0.246
ATG14ATG14 autophagy related 14 homolog (S. cerevisiae)0.240
RAB11FIP3RAB11 family interacting protein 3 (class II)0.235
TSC1tuberous sclerosis 10.228
MECP2methyl CpG binding protein 2 (Rett syndrome)0.227
MINK1misshapen-like kinase 10.226
SIRT6sirtuin 60.219
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.216
PLCG1phospholipase C, gamma 10.209
KIAA0930KIAA09300.203
PPP6R1protein phosphatase 6, regulatory subunit 10.203
RASSF1Ras association (RalGDS/AF-6) domain family member 10.201
NISCHnischarin0.195
CNOT8CCR4-NOT transcription complex, subunit 80.182
RAB14RAB14, member RAS oncogene family0.178
FAM193Afamily with sequence similarity 193, member A0.177
DCAF10DDB1 and CUL4 associated factor 100.177
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.176
RABAC1Rab acceptor 1 (prenylated)0.175
GGA1golgi-associated, gamma adaptin ear containing, ARF binding protein 10.171
RAB1BRAB1B, member RAS oncogene family0.163
RAB24RAB24, member RAS oncogene family0.160
SIN3BSIN3 homolog B, transcription regulator (yeast)0.159
CARD11caspase recruitment domain family, member 110.153
RAB2ARAB2A, member RAS oncogene family0.146
USP47ubiquitin specific peptidase 470.135
RPS6KC1ribosomal protein S6 kinase, 52kDa, polypeptide 10.133
NCK1NCK adaptor protein 10.132
LZTR1leucine-zipper-like transcription regulator 10.132
PIK3R4phosphoinositide-3-kinase, regulatory subunit 40.130
RALGDSral guanine nucleotide dissociation stimulator0.128
TROVE2TROVE domain family, member 20.127
GDI1GDP dissociation inhibitor 10.126
ROR1receptor tyrosine kinase-like orphan receptor 10.125
SETXsenataxin0.120
RAB22ARAB22A, member RAS oncogene family0.120
SQSTM1sequestosome 10.114
FNBP1formin binding protein 10.111
GOLGB1golgin B10.111
CUL7cullin 70.110
AKT1S1AKT1 substrate 1 (proline-rich)0.108
TRAPPC10trafficking protein particle complex 100.108
PGRMC1progesterone receptor membrane component 10.108
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
HphHIF prolyl hydroxylase0.037
RalaRas-related protein0.029
bazbazooka0.029
CG6509CG6509 gene product from transcript CG6509-RB0.028
staistathmin0.024
Su(H)Suppressor of Hairless0.024
CG4552CG4552 gene product from transcript CG4552-RA0.021
simasimilar0.017
synjsynaptojanin0.017
sec15CG7034 gene product from transcript CG7034-RA0.016
RhebCG1081 gene product from transcript CG1081-RA0.014
Syx7Syntaxin 70.013
kenken and barbie0.013
CG11178CG11178 gene product from transcript CG11178-RA0.012
CG1233CG1233 gene product from transcript CG1233-RB0.012
DlicDynein light intermediate chain0.012
rab3-GAPCG7061 gene product from transcript CG7061-RA0.011
SCARCG4636 gene product from transcript CG4636-RA0.011
mopmyopic0.011
Lis-1Lissencephaly-10.011
CG11055CG11055 gene product from transcript CG11055-RB0.011
CalpBCalpain-B0.011
Kap3Kinesin associated protein 30.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Itsn1intersectin 1 (SH3 domain protein 1A)0.523
Zdhhc17zinc finger, DHHC domain containing 170.385
Rab5aRAB5A, member RAS oncogene family0.224
Anapc2anaphase promoting complex subunit 20.194
Stx12syntaxin 120.193
Dhx40DEAH (Asp-Glu-Ala-His) box polypeptide 400.133
Dnm1dynamin 10.133
Chmp2bchromatin modifying protein 2B0.132
Pcnxl3pecanex-like 3 (Drosophila)0.130
Eps15epidermal growth factor receptor pathway substrate 150.125
RragcRas-related GTP binding C0.125
D15Ertd621eDNA segment, Chr 15, ERATO Doi 621, expressed0.122
Iqsec1IQ motif and Sec7 domain 10.110
Stxbp3asyntaxin binding protein 3A0.106
Nckap1NCK-associated protein 10.101
Rbm7RNA binding motif protein 70.095
Abtb1ankyrin repeat and BTB (POZ) domain containing 10.089
Tab2TGF-beta activated kinase 1/MAP3K7 binding protein 20.088
Tmem30atransmembrane protein 30A0.088
Strn4striatin, calmodulin binding protein 40.081
Ciccapicua homolog (Drosophila)0.079
Rab18RAB18, member RAS oncogene family0.075
Lamp2lysosomal-associated membrane protein 20.073
Glg1golgi apparatus protein 10.068
Ube3bubiquitin protein ligase E3B0.068
Ppp3caprotein phosphatase 3, catalytic subunit, alpha isoform0.068
Cc2d1acoiled-coil and C2 domain containing 1A0.066
R3hdm2R3H domain containing 20.063
Camta2calmodulin binding transcription activator 20.061
Ap1b1adaptor protein complex AP-1, beta 1 subunit0.061
Phlpp1PH domain and leucine rich repeat protein phosphatase 10.061
Copb1coatomer protein complex, subunit beta 10.059
Sacm1lSAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae)0.058
Abcg2ATP-binding cassette, sub-family G (WHITE), member 20.058
Nek7NIMA (never in mitosis gene a)-related expressed kinase 70.057
Evi5ecotropic viral integration site 50.057
Fbxw5F-box and WD-40 domain protein 50.055
Lrp1low density lipoprotein receptor-related protein 10.053
Camk2gcalcium/calmodulin-dependent protein kinase II gamma0.053
Fnip1folliculin interacting protein 10.052
Cpne3copine III0.051
Golga2golgi autoantigen, golgin subfamily a, 20.051
Rnf103ring finger protein 1030.048
C78339expressed sequence C783390.048
Hdac5histone deacetylase 50.045
Atg13ATG13 autophagy related 13 homolog (S. cerevisiae)0.043
Sh2d3cSH2 domain containing 3C0.042
Mtap7d1microtubule-associated protein 7 domain containing 10.042
Bnip3lBCL2/adenovirus E1B interacting protein 3-like0.042
Dctn1dynactin 10.041
Tmem184btransmembrane protein 184b0.041
Fndc3afibronectin type III domain containing 3A0.040
Dlgap4discs, large homolog-associated protein 4 (Drosophila)0.040
March7membrane-associated ring finger (C3HC4) 70.039
Ccz1CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)0.039
Ap1m2adaptor protein complex AP-1, mu 2 subunit0.039
Bap1Brca1 associated protein 10.039
Arhgap31Rho GTPase activating protein 310.039
Rxrbretinoid X receptor beta0.038
Ubr4ubiquitin protein ligase E3 component n-recognin 40.038
Numa1nuclear mitotic apparatus protein 10.037
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.037
Neurl4neuralized homolog 4 (Drosophila)0.037
Golga4golgi autoantigen, golgin subfamily a, 40.037
Rabep1rabaptin, RAB GTPase binding effector protein 10.037
Igsf8immunoglobulin superfamily, member 80.037
Rasa1RAS p21 protein activator 10.036
Fliiflightless I homolog (Drosophila)0.036
Atxn2ataxin 20.036
Cdc42bpbCDC42 binding protein kinase beta0.035
A930001N09RikRIKEN cDNA A930001N09 gene0.035
Nek9NIMA (never in mitosis gene a)-related expressed kinase 90.035
Megf8multiple EGF-like-domains 80.035
3230401D17RikRIKEN cDNA 3230401D17 gene0.035
Arhgap21Rho GTPase activating protein 210.035
Rab14RAB14, member RAS oncogene family0.035
Tmem184atransmembrane protein 184a0.034
Atxn7l3ataxin 7-like 30.034
Copb2coatomer protein complex, subunit beta 2 (beta prime)0.034
Ipo13importin 130.034
Bahd1bromo adjacent homology domain containing 10.034
Chmp5chromatin modifying protein 50.034
Slc30a9solute carrier family 30 (zinc transporter), member 90.034
Ankrd13dankyrin repeat domain 13 family, member D0.033
Dgkddiacylglycerol kinase, delta0.033
Mkl1MKL (megakaryoblastic leukemia)/myocardin-like 10.033
Pip4k2cphosphatidylinositol-5-phosphate 4-kinase, type II, gamma0.033
Adam9a disintegrin and metallopeptidase domain 9 (meltrin gamma)0.032
Rusc2RUN and SH3 domain containing 20.032
Dstndestrin0.032
Criptcysteine-rich PDZ-binding protein0.032
Dync1i2dynein cytoplasmic 1 intermediate chain 20.031
Myo18amyosin XVIIIA0.031
Ypel3yippee-like 3 (Drosophila)0.031
Abca7ATP-binding cassette, sub-family A (ABC1), member 70.031
Osbpl11oxysterol binding protein-like 110.030
Pitpnm1phosphatidylinositol transfer protein, membrane-associated 10.030
Arl6ADP-ribosylation factor-like 60.030
Plxnd1plexin D10.030
Gclcglutamate-cysteine ligase, catalytic subunit0.030
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Rab1RAB1, member RAS oncogene family0.091
Arl1ADP-ribosylation factor-like 10.091
Rap1bRAP1B, member of RAS oncogene family0.026
Hk1hexokinase 10.025
Arf1ADP-ribosylation factor 10.024
Tmem59transmembrane protein 590.024
Rab7aRAB7A, member RAS oncogene family0.023
Wdfy1WD repeat and FYVE domain containing 10.021
Scamp1secretory carrier membrane protein 10.021
Arf3ADP-ribosylation factor 30.020
Smg5Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)0.020
Tmem30atransmembrane protein 30A0.019
RGD1564560similar to RCK0.019
Sec62SEC62 homolog (S. cerevisiae)0.018
Zfp91zinc finger protein 910.018
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.017
Copb1coatomer protein complex, subunit beta 10.017
Ube2d3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.017
Pafah1b2platelet-activating factor acetylhydrolase, isoform 1b, subunit 20.017
Tnrc6btrinucleotide repeat containing 6B0.017
Cttncortactin0.016
NsfN-ethylmaleimide-sensitive factor0.016
Pum1pumilio homolog 1 (Drosophila)0.016
Map1lc3bmicrotubule-associated protein 1 light chain 3 beta0.015
Synrgsynergin, gamma0.015
Ulk1Unc-51 like kinase 1 (C. elegans)0.015
Dync1i2dynein cytoplasmic 1 intermediate chain 20.015
Ppp2caprotein phosphatase 2, catalytic subunit, alpha isoform0.015
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.015
Exoc5exocyst complex component 50.014
Apbb1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.014
Yme1l1YME1-like 1 (S. cerevisiae)0.014
Ubn2ubinuclein 20.014
Snx2sorting nexin 20.014
Atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.014
Eif2c2eukaryotic translation initiation factor 2C, 20.014
Pitpnaphosphatidylinositol transfer protein, alpha0.014
Dctn1dynactin 10.014
Ppm1aprotein phosphatase 1A, magnesium dependent, alpha isoform0.013
Aplp2amyloid beta (A4) precursor-like protein 20.013
Pigmphosphatidylinositol glycan anchor biosynthesis, class M0.013
Trim3tripartite motif-containing 30.013
Sgtasmall glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha0.013
Pik3r2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.013
Arf4ADP-ribosylation factor 40.013
Jarid1ajumonji, AT rich interactive domain 1A (Rbp2 like)0.013
Atp6v1b2ATPase, H transporting, lysosomal V1 subunit B20.013
Tmed2transmembrane emp24 domain trafficking protein 20.013
TriobpTRIO and F-actin binding protein0.013
Inpp4ainositol polyphosphate-4-phosphatase, type 10.013
Cdkn2aipCDKN2A interacting protein0.013
Vps4bvacuolar protein sorting 4 homolog B (S. cerevisiae)0.013
Rab18RAB18, member RAS oncogene family0.012
Vps29vacuolar protein sorting 29 homolog (S. cerevisiae)0.012
Hdac7histone deacetylase 70.012
Glg1golgi apparatus protein 10.012
Snap23synaptosomal-associated protein 230.012
Pik3c2aphosphoinositide-3-kinase, class 2, alpha polypeptide0.012
Mtpnmyotrophin0.012
Gnb5guanine nucleotide binding protein (G protein), beta 50.012
Gclmglutamate cysteine ligase, modifier subunit0.012
Alg2asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)0.012
Sptlc1serine palmitoyltransferase, long chain base subunit 10.012
Map2k7mitogen activated protein kinase kinase 70.012
RGD1565411similar to 2610317D23Rik protein0.012
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.012
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.012
Ap2a2adaptor-related protein complex 2, alpha 2 subunit0.012
LOC100359595hypothetical protein LOC1003595950.011
RGD621098similar to RIKEN cDNA D230025D16Rik0.011
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.011
LOC100360986mCG1035404-like0.011
Arcn1archain 10.011
Zer1zer-1 homolog (C. elegans)0.011
Vps52vacuolar protein sorting 52 homolog (S. cerevisiae)0.011
Abractive BCR-related gene0.011
Bmpr2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.011
Ppp6cprotein phosphatase 6, catalytic subunit0.011
Serp1stress-associated endoplasmic reticulum protein 10.011
Arpc5actin related protein 2/3 complex, subunit 50.011
Lrp6low density lipoprotein receptor-related protein 60.011
Mospd2motile sperm domain containing 20.011
Rab3aRAB3A, member RAS oncogene family0.011
Arhgap5Rho GTPase activating protein 50.011
Pafah1b1platelet-activating factor acetylhydrolase, isoform 1b, subunit 10.011
Bin2bridging integrator 20.011
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.011
Spryd3SPRY domain containing 30.011
Nfe2l2nuclear factor, erythroid derived 2, like 20.011
Suds3suppressor of defective silencing 3 homolog (S. cerevisiae)0.011
Pcsk1nproprotein convertase subtilisin/kexin type 1 inhibitor0.010
Btdbiotinidase0.010
Rbm9RNA binding motif protein 90.010
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.010
Akirin2akirin 20.010
Slc22a17solute carrier family 22, member 170.010
Vps4avacuolar protein sorting 4 homolog A (S. cerevisiae)0.010
Slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.010
Toporstopoisomerase I binding, arginine/serine-rich0.010
Atp6v1hATPase, H+ transporting, lysosomal V1 subunit H0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
GYL1Gyl1p0.029
BET3Bet3p0.021
SEC2Sec2p0.012
YIP3Yip3p0.012
YPT52Ypt52p0.010