The network for 'cdc42 protein signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cdc42 protein signal transduction

A series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state.

NameDescriptionProbabilityFunc Analog Organism
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.999
TRAF5TNF receptor-associated factor 50.994
APOC1apolipoprotein C-I0.984
TRAF2TNF receptor-associated factor 20.966
HPhaptoglobin0.966
SNTB2syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)0.952
A2Malpha-2-macroglobulin0.934
APOA1apolipoprotein A-I0.908
ATP7AATPase, Cu++ transporting, alpha polypeptide0.870
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.866
ALBalbumin0.861
EFNA1ephrin-A10.802
GRB7growth factor receptor-bound protein 70.796
TRAF1TNF receptor-associated factor 10.746
TRAF3TNF receptor-associated factor 30.737
EFNA5ephrin-A50.735
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.706
ECT2epithelial cell transforming sequence 2 oncogene0.686
LCATlecithin-cholesterol acyltransferase0.667
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.633
APOC3apolipoprotein C-III0.613
ZNF746zinc finger protein 7460.566
KIF23kinesin family member 230.552
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.483
SH3KBP1SH3-domain kinase binding protein 10.459
FGAfibrinogen alpha chain0.453
APOA2apolipoprotein A-II0.453
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.373
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.338
TRADDTNFRSF1A-associated via death domain0.322
TNFRSF10Ctumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain0.314
PVRL2poliovirus receptor-related 2 (herpesvirus entry mediator B)0.310
PVRL1poliovirus receptor-related 1 (herpesvirus entry mediator C)0.304
PPP2R5Eprotein phosphatase 2, regulatory subunit B', epsilon isoform0.229
TNFtumor necrosis factor0.219
SH3BP2SH3-domain binding protein 20.201
PRC1protein regulator of cytokinesis 10.196
BCRbreakpoint cluster region0.192
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)0.187
ZMYND11zinc finger, MYND-type containing 110.180
CD14CD14 molecule0.159
LMO2LIM domain only 2 (rhombotin-like 1)0.157
IL4Rinterleukin 4 receptor0.156
GRB10growth factor receptor-bound protein 100.155
FAM118Bfamily with sequence similarity 118, member B0.149
LY6G6Flymphocyte antigen 6 complex, locus G6F0.145
DCKdeoxycytidine kinase0.141
NUMBLnumb homolog (Drosophila)-like0.140
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.134
LBRlamin B receptor0.130
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.125
TTRtransthyretin0.122
SH3RF3SH3 domain containing ring finger 30.122
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.115
SYNJ2synaptojanin 20.115
APPamyloid beta (A4) precursor protein0.113
TNFRSF9tumor necrosis factor receptor superfamily, member 90.113
TNFSF14tumor necrosis factor (ligand) superfamily, member 140.112
TAB1TGF-beta activated kinase 1/MAP3K7 binding protein 10.112
SEMA3Fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F0.109
PVRL3poliovirus receptor-related 30.109
EPHA7EPH receptor A70.107
CD40CD40 molecule, TNF receptor superfamily member 50.106
TIFATRAF-interacting protein with forkhead-associated domain0.105
TXNDC2thioredoxin domain containing 2 (spermatozoa)0.103
APOC2apolipoprotein C-II0.102
EPHB3EPH receptor B30.101
LRP1low density lipoprotein receptor-related protein 10.100
APOEapolipoprotein E0.100
AP2M1adaptor-related protein complex 2, mu 1 subunit0.098
TJP1tight junction protein 1 (zona occludens 1)0.097
FMNL1formin-like 10.096
SH3RF1SH3 domain containing ring finger 10.096
NCKAP1NCK-associated protein 10.093
MAP3K14mitogen-activated protein kinase kinase kinase 140.092
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.091
CALM1calmodulin 1 (phosphorylase kinase, delta)0.089
PLTPphospholipid transfer protein0.087
PRKCAprotein kinase C, alpha0.087
EGFRepidermal growth factor receptor0.082
TRAF3IP1TNF receptor-associated factor 3 interacting protein 10.081
SPRY2sprouty homolog 2 (Drosophila)0.080
SFNstratifin0.074
TCIRG1T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A30.073
PTPN5protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)0.073
CDK2AP1cyclin-dependent kinase 2 associated protein 10.073
FESfeline sarcoma oncogene0.069
PLD2phospholipase D20.068
TCEA2transcription elongation factor A (SII), 20.067
FHOD1formin homology 2 domain containing 10.066
ZBTB48zinc finger and BTB domain containing 480.065
STAU1staufen, RNA binding protein, homolog 1 (Drosophila)0.065
TRAF3IP2TRAF3 interacting protein 20.065
RALAv-ral simian leukemia viral oncogene homolog A (ras related)0.064
RACGAP1Rac GTPase activating protein 10.064
C12orf48chromosome 12 open reading frame 480.064
GAS2L3growth arrest-specific 2 like 30.062
TNFRSF11Atumor necrosis factor receptor superfamily, member 11a, NFKB activator0.062
STAB1stabilin 10.060
GGHgamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)0.060
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pafah1b1platelet-activating factor acetylhydrolase, isoform 1b, subunit 10.999
Ccl2chemokine (C-C motif) ligand 20.994
Ifnginterferon gamma0.972
Lyz2lysozyme 20.961
Apoeapolipoprotein E0.895
Tnftumor necrosis factor0.855
Ccl8chemokine (C-C motif) ligand 80.852
Ccr2chemokine (C-C motif) receptor 20.765
Ccr1chemokine (C-C motif) receptor 10.709
Cttncortactin0.706
Npc1Niemann Pick type C10.643
Ccl7chemokine (C-C motif) ligand 70.548
Il1binterleukin 1 beta0.543
C3complement component 30.542
Batfbasic leucine zipper transcription factor, ATF-like0.538
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.507
Ccl12chemokine (C-C motif) ligand 120.504
Ccl3chemokine (C-C motif) ligand 30.475
Mmp12matrix metallopeptidase 120.451
Gzmagranzyme A0.442
Abcg1ATP-binding cassette, sub-family G (WHITE), member 10.414
Ccl9chemokine (C-C motif) ligand 90.400
Il1rninterleukin 1 receptor antagonist0.375
Ccl22chemokine (C-C motif) ligand 220.368
Ccr5chemokine (C-C motif) receptor 50.364
Lrp1low density lipoprotein receptor-related protein 10.348
Folr2folate receptor 2 (fetal)0.345
Cxcl9chemokine (C-X-C motif) ligand 90.337
Cxcl2chemokine (C-X-C motif) ligand 20.332
Irg1immunoresponsive gene 10.327
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.319
Cxcl10chemokine (C-X-C motif) ligand 100.299
Socs1suppressor of cytokine signaling 10.295
Ch25hcholesterol 25-hydroxylase0.290
Fcgr2bFc receptor, IgG, low affinity IIb0.274
Epha4Eph receptor A40.268
Batf2basic leucine zipper transcription factor, ATF-like 20.263
Ldlrlow density lipoprotein receptor0.261
Ubdubiquitin D0.260
C1qccomplement component 1, q subcomponent, C chain0.259
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.251
Fcgr1Fc receptor, IgG, high affinity I0.246
Itgaxintegrin alpha X0.231
Ctswcathepsin W0.231
Sh2d2aSH2 domain protein 2A0.223
C3ar1complement component 3a receptor 10.222
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.219
FasFas (TNF receptor superfamily member 6)0.207
Pdcd1programmed cell death 10.198
Cxcl1chemokine (C-X-C motif) ligand 10.180
Gzmbgranzyme B0.178
Clec4dC-type lectin domain family 4, member d0.176
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.175
BtkBruton agammaglobulinemia tyrosine kinase0.174
Pkp3plakophilin 30.172
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.169
Dckdeoxycytidine kinase0.167
Abca1ATP-binding cassette, sub-family A (ABC1), member 10.164
Ccr7chemokine (C-C motif) receptor 70.163
FaslFas ligand (TNF superfamily, member 6)0.160
Lag3lymphocyte-activation gene 30.155
Efnb2ephrin B20.155
Ltalymphotoxin A0.153
Xcl1chemokine (C motif) ligand 10.152
Il6interleukin 60.149
Mx2myxovirus (influenza virus) resistance 20.149
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.148
Cep55centrosomal protein 550.145
Selpselectin, platelet0.143
Cd8aCD8 antigen, alpha chain0.142
Ccl17chemokine (C-C motif) ligand 170.138
Icosinducible T-cell co-stimulator0.138
Hcsthematopoietic cell signal transducer0.136
Cdc7cell division cycle 7 (S. cerevisiae)0.129
Msr1macrophage scavenger receptor 10.128
Ifngr1interferon gamma receptor 10.125
Saa3serum amyloid A 30.125
Ccl11chemokine (C-C motif) ligand 110.119
Batf3basic leucine zipper transcription factor, ATF-like 30.117
Cd3eCD3 antigen, epsilon polypeptide0.114
Cd7CD7 antigen0.108
Ccl4chemokine (C-C motif) ligand 40.104
Loxlysyl oxidase0.102
Anlnanillin, actin binding protein0.099
Efemp2epidermal growth factor-containing fibulin-like extracellular matrix protein 20.095
Slamf8SLAM family member 80.095
Tnfrsf18tumor necrosis factor receptor superfamily, member 180.094
Cd14CD14 antigen0.093
Traf1TNF receptor-associated factor 10.090
Ctla4cytotoxic T-lymphocyte-associated protein 40.089
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.088
Tbxas1thromboxane A synthase 1, platelet0.086
Cxcl13chemokine (C-X-C motif) ligand 130.085
Retnlaresistin like alpha0.085
Itchitchy, E3 ubiquitin protein ligase0.083
Desdesmin0.081
Mmp3matrix metallopeptidase 30.080
Ccnb2cyclin B20.080
Kif20akinesin family member 20A0.079
Tnfaip3tumor necrosis factor, alpha-induced protein 30.077
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism