The network for 'positive regulation of endopeptidase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of endopeptidase activity

Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.

NameDescriptionProbabilityFunc Analog Organism
BCL2B-cell CLL/lymphoma 21.000
CASP8caspase 8, apoptosis-related cysteine peptidase0.997
MDM2Mdm2 p53 binding protein homolog (mouse)0.994
BCL2L1BCL2-like 10.993
BCL2L11BCL2-like 11 (apoptosis facilitator)0.960
BAXBCL2-associated X protein0.953
RB1retinoblastoma 10.914
CREBBPCREB binding protein0.905
CASP10caspase 10, apoptosis-related cysteine peptidase0.901
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.897
PYCARDPYD and CARD domain containing0.839
XIAPX-linked inhibitor of apoptosis0.838
PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.833
BIDBH3 interacting domain death agonist0.831
SMAD1SMAD family member 10.822
POU5F1POU class 5 homeobox 10.815
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.802
S100BS100 calcium binding protein B0.773
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.751
FASFas (TNF receptor superfamily, member 6)0.751
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.703
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.700
TP53tumor protein p530.668
CASP2caspase 2, apoptosis-related cysteine peptidase0.663
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.660
CASP3caspase 3, apoptosis-related cysteine peptidase0.654
CFLARCASP8 and FADD-like apoptosis regulator0.622
SMAD2SMAD family member 20.605
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.595
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.542
RIPK2receptor-interacting serine-threonine kinase 20.540
BCAP31B-cell receptor-associated protein 310.540
CARD11caspase recruitment domain family, member 110.530
SMN1survival of motor neuron 1, telomeric0.529
BIRC3baculoviral IAP repeat containing 30.515
S100A6S100 calcium binding protein A60.504
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.483
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.467
PSMC5proteasome (prosome, macropain) 26S subunit, ATPase, 50.447
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.427
FMR1fragile X mental retardation 10.419
NR4A1nuclear receptor subfamily 4, group A, member 10.405
COL4A2collagen, type IV, alpha 20.401
PSMC4proteasome (prosome, macropain) 26S subunit, ATPase, 40.394
PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.392
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.390
POU3F2POU class 3 homeobox 20.377
MDM4Mdm4 p53 binding protein homolog (mouse)0.374
SP1Sp1 transcription factor0.368
DAXXdeath-domain associated protein0.356
CAV1caveolin 1, caveolae protein, 22kDa0.349
HCKhemopoietic cell kinase0.348
SOCS1suppressor of cytokine signaling 10.348
PSMD13proteasome (prosome, macropain) 26S subunit, non-ATPase, 130.346
FADDFas (TNFRSF6)-associated via death domain0.318
S100A14S100 calcium binding protein A140.312
BMP2bone morphogenetic protein 20.309
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.298
S100A1S100 calcium binding protein A10.297
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.292
PSMC1proteasome (prosome, macropain) 26S subunit, ATPase, 10.291
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.264
MAPK8mitogen-activated protein kinase 80.255
CASP9caspase 9, apoptosis-related cysteine peptidase0.239
NCK1NCK adaptor protein 10.239
HMGB2high mobility group box 20.228
COL4A1collagen, type IV, alpha 10.228
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.226
PSMC2proteasome (prosome, macropain) 26S subunit, ATPase, 20.224
FKBP1AFK506 binding protein 1A, 12kDa0.223
ARandrogen receptor0.219
HNF4Ahepatocyte nuclear factor 4, alpha0.216
NLRC4NLR family, CARD domain containing 40.203
PMLpromyelocytic leukemia0.202
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.198
S100A4S100 calcium binding protein A40.191
SMURF2SMAD specific E3 ubiquitin protein ligase 20.189
UCHL5ubiquitin carboxyl-terminal hydrolase L50.180
SMAD7SMAD family member 70.177
PSMD3proteasome (prosome, macropain) 26S subunit, non-ATPase, 30.177
USP14ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)0.176
HMGB1high mobility group box 10.169
PSMD1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.164
PSME1proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)0.162
FASLGFas ligand (TNF superfamily, member 6)0.156
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.153
HIPK2homeodomain interacting protein kinase 20.152
PSMD10proteasome (prosome, macropain) 26S subunit, non-ATPase, 100.149
TMSB10thymosin beta 100.148
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.148
RAD23BRAD23 homolog B (S. cerevisiae)0.148
TP53BP2tumor protein p53 binding protein, 20.147
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.145
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.143
NMIN-myc (and STAT) interactor0.136
PSME3proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)0.134
RXRAretinoid X receptor, alpha0.134
HDAC1histone deacetylase 10.132
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.129
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
gata5GATA-binding protein 50.097
bcl2B-cell leukemia/lymphoma 20.091
mcl1amyeloid cell leukemia sequence 1a0.049
socs3asuppressor of cytokine signaling 3a0.041
sulf1sulfatase 10.040
ikzf1IKAROS family zinc finger 1 (Ikaros)0.036
plxnb2aplexin b2a0.036
bidaBH3 interacting domain death agonist0.034
mcl1bmyeloid cell leukemia sequence 1b0.029
adipor1badiponectin receptor 1b0.025
irf6interferon regulatory factor 60.025
caspacaspase a0.025
ighzimmunoglobulin heavy constant zeta0.024
ahcyS-adenosylhomocysteine hydrolase0.024
serpinb1serpin peptidase inhibitor, clade B (ovalbumin), member 10.024
col5a2lcollagen, type V, alpha 2-like0.023
bcl2l1bcl2-like 10.023
hmgb1ahigh-mobility group box 1a0.023
cmybtranscription factor cmyb0.022
igfbp1ainsulin-like growth factor binding protein 1a0.022
psma6bproteasome (prosome, macropain) subunit, alpha type, 6b0.022
gpiaglucose phosphate isomerase a0.019
socs1suppressor of cytokine signaling 10.019
psmc1bproteasome (prosome, macropain) 26S subunit, ATPase, 1b0.019
duoxdual oxidase0.019
bbc3BCL2 binding component 30.018
ube2iubiquitin-conjugating enzyme E2I0.018
blfbloody fingers0.018
mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.018
runx3runt-related transcription factor 30.017
gadd45aagrowth arrest and DNA-damage-inducible, alpha, a0.017
psme2proteasome activator subunit 20.017
eporerythropoietin receptor0.016
hmgb2ahigh-mobility group box 2a0.016
pccbpropionyl Coenzyme A carboxylase, beta polypeptide0.016
chac1ChaC, cation transport regulator-like 10.016
LOC567131calcitonin gene-related peptide type 1 receptor-like0.015
tfe3btranscription factor binding to IGHM enhancer 3b0.015
psmb4proteasome (prosome, macropain) subunit, beta type, 40.015
foxn1forkhead box N10.015
ptrfbpolymerase I and transcript release factor b0.014
sec23bSec23 homolog B (S. cerevisiae)0.014
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.014
ighz2immunoglobulin heavy constant zeta20.014
foxn4forkhead box N40.014
per2period homolog 2 (Drosophila)0.014
blmhbleomycin hydrolase0.014
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.014
s100a10bS100 calcium binding protein A10b0.014
psma1proteasome (prosome, macropain) subunit, alpha type, 10.014
cebpaCCAAT/enhancer binding protein (C/EBP), alpha0.014
mychmyelocytomatosis oncogene homolog0.014
stc1lstanniocalcin 1, like0.013
rnf17ring finger protein 170.013
s100v2S100 calcium binding protein V20.013
ptgs2aprostaglandin-endoperoxide synthase 2a0.013
egr1early growth response 10.013
psmd1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.013
ranras-related nuclear protein0.013
tnfsf10l2tumor necrosis factor (ligand) superfamily, member 10 like 20.013
foxo3bforkhead box O3b0.012
stab2stabilin 20.012
card14caspase recruitment domain family, member 140.012
copebcore promoter element binding protein0.012
rag1recombination activating gene 10.012
hbae1hemoglobin alpha embryonic-10.012
hif1anhypoxia-inducible factor 1, alpha subunit inhibitor0.011
wnt9awingless-type MMTV integration site family, member 9A0.011
bcl2l10BCL2-like 10 (apoptosis facilitator)0.011
col1a2collagen, type I, alpha 20.011
psmd13proteasome (prosome, macropain) 26S subunit, non-ATPase, 130.011
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.011
pcnaproliferating cell nuclear antigen0.011
mmp2matrix metalloproteinase 20.011
cct5chaperonin containing TCP1, subunit 5 (epsilon)0.011
trpv6transient receptor potential cation channel, subfamily V, member 60.011
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.010
psma8proteasome (prosome, macropain) subunit, alpha type, 80.010
ef1aelongation factor 1-alpha0.010
pmaip1phorbol-12-myristate-13-acetate-induced protein 10.010
gata1aGATA binding protein 1a0.010
eif3s2eukaryotic translation initiation factor 3, subunit 2 beta0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Dcp-1Death caspase-10.884
NcNedd2-like caspase0.856
CG9772CG9772 gene product from transcript CG9772-RB0.798
DreddDeath related ced-3/Nedd2-like protein0.780
imdimmune deficiency0.728
grimCG4345 gene product from transcript CG4345-RA0.722
Tbp-1Tat-binding protein-10.657
Rpt1CG1341 gene product from transcript CG1341-RA0.650
Eip74EFEcdysone-induced protein 74EF0.565
BG4CG12297 gene product from transcript CG12297-RA0.525
Prosbeta3Proteasome beta3 subunit0.480
yuriyuri gagarin0.439
Rac1CG2248 gene product from transcript CG2248-RA0.423
bchsblue cheese0.376
p53CG33336 gene product from transcript CG33336-RB0.373
RnrLRibonucleoside diphosphate reductase large subunit0.327
X11LCG5675 gene product from transcript CG5675-RB0.317
growlCG14648 gene product from transcript CG14648-RA0.297
Cyt-c-dCytochrome c distal0.292
Rpt4CG3455 gene product from transcript CG3455-RA0.288
IceCG7788 gene product from transcript CG7788-RA0.287
Rpn6Proteasome p44.5 subunit0.275
LaspCG3849 gene product from transcript CG3849-RB0.269
betaTub85Dbeta-Tubulin at 85D0.266
CG5384CG5384 gene product from transcript CG5384-RA0.255
CG5355CG5355 gene product from transcript CG5355-RA0.253
snssticks and stones0.237
XNPCG4548 gene product from transcript CG4548-RA0.215
kirrekin of irre0.200
Trxr-1Thioredoxin reductase-10.192
ird5immune response deficient 50.189
CG3875CG3875 gene product from transcript CG3875-RA0.185
CG13364CG13364 gene product from transcript CG13364-RA0.185
GmdGDP-mannose 4,6-dehydratase0.163
Mov34CG3416 gene product from transcript CG3416-RA0.156
Traf4TNF-receptor-associated factor 40.155
djdon juan0.153
B52CG10851 gene product from transcript CG10851-RB0.134
Art4Arginine methyltransferase 40.132
RASSF8CG5053 gene product from transcript CG5053-RA0.129
AGO2Argonaute 20.127
Pros26.4Proteasome 26S subunit subunit 4 ATPase0.125
Rpn3Regulatory particle non-ATPase 30.118
msl-1male-specific lethal 10.115
edlETS-domain lacking0.115
zfh1Zn finger homeodomain 10.114
Sox14Sox box protein 140.111
UnrUpstream of N-ras0.111
Chrac-14CG13399 gene product from transcript CG13399-RA0.110
CG7998CG7998 gene product from transcript CG7998-RA0.110
hipkhomeodomain interacting protein kinase0.109
RanGapRan GTPase activating protein0.108
Hr38Hormone receptor-like in 380.106
CG6479CG6479 gene product from transcript CG6479-RB0.102
His3.3BHistone H3.3B0.099
Pkd2Polycystic kidney disease gene-20.097
CG10576CG10576 gene product from transcript CG10576-RA0.091
nkdnaked cuticle0.086
CG5731CG5731 gene product from transcript CG5731-RA0.085
CG9894CG9894 gene product from transcript CG9894-RB0.081
nocteno circadian temperature entrainment0.077
Galpha49BG protein alpha49B0.074
Glut1Glucose transporter 10.072
Bsg25DBlastoderm-specific gene 25D0.072
mbtmushroom bodies tiny0.071
eastenhanced adult sensory threshold0.070
CG7033CG7033 gene product from transcript CG7033-RC0.066
CG5146CG5146 gene product from transcript CG5146-RA0.066
pr-set7CG3307 gene product from transcript CG3307-RC0.065
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor0.996
Trp53transformation related protein 530.993
Cd44CD44 antigen0.957
Casp4caspase 4, apoptosis-related cysteine peptidase0.905
Stat5bsignal transducer and activator of transcription 5B0.894
Casp1caspase 10.880
FasFas (TNF receptor superfamily member 6)0.865
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.852
Stat5asignal transducer and activator of transcription 5A0.821
PycardPYD and CARD domain containing0.814
Gbp5guanylate binding protein 50.780
Mcl1myeloid cell leukemia sequence 10.734
Il10interleukin 100.687
Mndalmyeloid nuclear differentiation antigen like0.592
Sfrp2secreted frizzled-related protein 20.590
Lyz2lysozyme 20.559
Kitkit oncogene0.532
Trp73transformation related protein 730.518
Rararetinoic acid receptor, alpha0.511
Lama5laminin, alpha 50.510
Psme2proteasome (prosome, macropain) 28 subunit, beta0.508
S100a9S100 calcium binding protein A9 (calgranulin B)0.493
Wt1Wilms tumor 1 homolog0.491
Ptgs2prostaglandin-endoperoxide synthase 20.446
Il2rginterleukin 2 receptor, gamma chain0.436
Leprleptin receptor0.412
Cd151CD151 antigen0.357
S100a8S100 calcium binding protein A8 (calgranulin A)0.334
Bcl2B-cell leukemia/lymphoma 20.330
Ltblymphotoxin B0.324
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.317
Stat6signal transducer and activator of transcription 60.309
Nphs2nephrosis 2 homolog, podocin (human)0.306
Itga3integrin alpha 30.305
Coro1bcoronin, actin binding protein 1B0.301
Il1r1interleukin 1 receptor, type I0.297
Socs1suppressor of cytokine signaling 10.296
Ptpn2protein tyrosine phosphatase, non-receptor type 20.283
Wnt3awingless-related MMTV integration site 3A0.276
Il6stinterleukin 6 signal transducer0.271
Ptprcprotein tyrosine phosphatase, receptor type, C0.270
Ncoa3nuclear receptor coactivator 30.261
Bcl2l1BCL2-like 10.249
Gdnfglial cell line derived neurotrophic factor0.248
Irf9interferon regulatory factor 90.231
BaxBCL2-associated X protein0.230
Wnt4wingless-related MMTV integration site 40.225
Nr3c1nuclear receptor subfamily 3, group C, member 10.218
Hoxa10homeobox A100.215
Vhlvon Hippel-Lindau tumor suppressor0.214
Rb1retinoblastoma 10.207
XiapX-linked inhibitor of apoptosis0.203
Psme1proteasome (prosome, macropain) 28 subunit, alpha0.202
Spna1spectrin alpha 10.201
Ctgfconnective tissue growth factor0.201
Casp7caspase 70.200
Cycscytochrome c, somatic0.199
Ilkintegrin linked kinase0.196
Ighimmunoglobulin heavy chain complex0.188
Stat1signal transducer and activator of transcription 10.188
Mfn2mitofusin 20.186
Notch2Notch gene homolog 2 (Drosophila)0.182
Ptch2patched homolog 20.180
Npm1nucleophosmin 10.171
Irgm1immunity-related GTPase family M member 10.169
Tlr4toll-like receptor 40.167
Cftrcystic fibrosis transmembrane conductance regulator homolog0.165
Pax2paired box gene 20.161
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.160
Ikzf1IKAROS family zinc finger 10.156
Hbb-b1hemoglobin, beta adult major chain0.156
Esr2estrogen receptor 2 (beta)0.155
Rxraretinoid X receptor alpha0.154
Tgfb1transforming growth factor, beta 10.146
Mapk14mitogen-activated protein kinase 140.142
Arandrogen receptor0.142
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.137
Emx1empty spiracles homolog 1 (Drosophila)0.135
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.135
Ccr1chemokine (C-C motif) receptor 10.135
Gli2GLI-Kruppel family member GLI20.125
Cd4CD4 antigen0.118
E2f1E2F transcription factor 10.117
Cscitrate synthase0.115
Sfrp1secreted frizzled-related protein 10.113
Stc2stanniocalcin 20.111
Il2rbinterleukin 2 receptor, beta chain0.110
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.109
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.109
Psma2proteasome (prosome, macropain) subunit, alpha type 20.108
Dkk1dickkopf homolog 1 (Xenopus laevis)0.106
Hoxc6homeobox C60.105
Inpp5dinositol polyphosphate-5-phosphatase D0.105
Wnt7bwingless-related MMTV integration site 7B0.105
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.104
Exoc6exocyst complex component 60.102
Il22interleukin 220.100
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.100
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism