The network for 'negative regulation of blood vessel endothelial cell migration' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of blood vessel endothelial cell migration

Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels.

NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 20.979
JAG1jagged 10.933
TEKTEK tyrosine kinase, endothelial0.921
NOTCH1notch 10.835
BMP2bone morphogenetic protein 20.731
TGFB1transforming growth factor, beta 10.725
FKBP1AFK506 binding protein 1A, 12kDa0.708
ENGendoglin0.677
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.676
FGF1fibroblast growth factor 1 (acidic)0.455
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.421
NOTCH3notch 30.400
FGAfibrinogen alpha chain0.344
A2Malpha-2-macroglobulin0.274
KLF4Kruppel-like factor 4 (gut)0.215
FGFR1fibroblast growth factor receptor 10.214
MAP3K3mitogen-activated protein kinase kinase kinase 30.154
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.148
MAP3K2mitogen-activated protein kinase kinase kinase 20.143
MEF2Cmyocyte enhancer factor 2C0.139
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.105
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.101
GFI1Bgrowth factor independent 1B transcription repressor0.089
FGF10fibroblast growth factor 100.088
MEF2Amyocyte enhancer factor 2A0.076
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.062
TGFB3transforming growth factor, beta 30.061
NRP1neuropilin 10.047
SMAD7SMAD family member 70.047
HPhaptoglobin0.046
DLL1delta-like 1 (Drosophila)0.046
GDF5growth differentiation factor 50.046
THBS1thrombospondin 10.045
NOTCH2notch 20.045
ANGPT2angiopoietin 20.040
PRKD2protein kinase D20.039
PRKG1protein kinase, cGMP-dependent, type I0.038
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.037
ACVR1activin A receptor, type I0.036
CTGFconnective tissue growth factor0.034
KLF6Kruppel-like factor 60.034
DCNdecorin0.033
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.033
APOC1apolipoprotein C-I0.032
FOXP3forkhead box P30.030
TGFBR1transforming growth factor, beta receptor 10.029
FGF7fibroblast growth factor 70.028
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.028
SMAD1SMAD family member 10.028
ANGPT1angiopoietin 10.025
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.025
XIAPX-linked inhibitor of apoptosis0.024
HDAC3histone deacetylase 30.022
DUSP1dual specificity phosphatase 10.022
FGF2fibroblast growth factor 2 (basic)0.022
SMURF1SMAD specific E3 ubiquitin protein ligase 10.022
FN1fibronectin 10.021
SKILSKI-like oncogene0.020
GABARAPGABA(A) receptor-associated protein0.020
TIE1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.019
RXRAretinoid X receptor, alpha0.018
FSTL1follistatin-like 10.018
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.018
MAPK7mitogen-activated protein kinase 70.017
NCOR1nuclear receptor corepressor 10.017
JUNjun proto-oncogene0.017
NPR1natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)0.016
BMP4bone morphogenetic protein 40.016
TIMP3TIMP metallopeptidase inhibitor 30.015
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.014
LCATlecithin-cholesterol acyltransferase0.014
HDAC4histone deacetylase 40.014
NEDD4neural precursor cell expressed, developmentally down-regulated 40.014
ASRGL1asparaginase like 10.014
CTBP1C-terminal binding protein 10.013
YAP1Yes-associated protein 10.013
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.013
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.013
REREarginine-glutamic acid dipeptide (RE) repeats0.013
ALBalbumin0.013
FBLN1fibulin 10.013
ACVR2Bactivin A receptor, type IIB0.013
FAF1Fas (TNFRSF6) associated factor 10.012
HSPG2heparan sulfate proteoglycan 20.012
WWTR1WW domain containing transcription regulator 10.012
LRP1low density lipoprotein receptor-related protein 10.012
ANTXR2anthrax toxin receptor 20.011
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.011
COL4A1collagen, type IV, alpha 10.011
EMP1epithelial membrane protein 10.011
APOA1apolipoprotein A-I0.011
VEGFCvascular endothelial growth factor C0.010
JAG2jagged 20.010
NRP2neuropilin 20.010
BCL6B-cell CLL/lymphoma 60.010
PTGISprostaglandin I2 (prostacyclin) synthase0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
notch1anotch homolog 1a0.885
notch3notch homolog 30.827
dlcdeltaC0.825
neurog1neurogenin 10.526
gli2aGLI-Kruppel family member GLI2a0.498
tal1T-cell acute lymphocytic leukemia 10.455
sox3SRY-box containing gene 30.419
eya1eyes absent homolog 10.350
dlddeltaD0.321
sox10SRY-box containing gene 100.286
aldh1a2aldehyde dehydrogenase 1 family, member A20.279
cxcr4bchemokine (C-X-C motif), receptor 4b0.266
ascl1aachaete-scute complex-like 1a (Drosophila)0.253
nrarpanotch-regulated ankyrin repeat protein a0.236
mibmind bomb0.222
her6hairy-related 60.178
her4.2hairy-related 4.20.144
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.143
myod1myogenic differentiation 10.132
jag1bjagged 1b0.129
shhasonic hedgehog a0.116
hes6hairy and enhancer of split 6 (Drosophila)0.112
rad21RAD21 homolog (S. pombe)0.107
kdrlkinase insert domain receptor like0.107
atp1b1aATPase, Na+/K+ transporting, beta 1a polypeptide0.107
cdh2cadherin 2, neuronal0.106
foxj1bforkhead box J1b0.103
alcamaactivated leukocyte cell adhesion molecule a0.102
plekhg4pleckstrin homology domain containing, family G (with RhoGef domain) member 40.101
jag1ajagged 1a0.095
notch2notch homolog 20.095
cxcr4achemokine (C-X-C motif) receptor 4a0.082
jag2jagged 20.077
mmp2matrix metalloproteinase 20.070
nkx2.2aNK2 transcription factor related 2a0.068
lama1laminin, alpha 10.068
cyp1acytochrome P450, family 1, subfamily A0.068
sall1asal-like 1a (Drosophila)0.067
hhiphedgehog interacting protein0.067
si:ch211-212m21.5si:ch211-212m21.50.066
tiparpTCDD-inducible poly(ADP-ribose) polymerase0.063
bmp4bone morphogenetic protein 40.062
crabp2bcellular retinoic acid binding protein 2, b0.059
metmet proto-oncogene (hepatocyte growth factor receptor)0.057
lamc1laminin, gamma 10.057
bmp2bbone morphogenetic protein 2b0.056
copebcore promoter element binding protein0.054
hoxb1ahomeo box B1a0.050
sdprbserum deprivation response b0.049
sox2SRY-box containing gene 20.049
sox19aSRY-box containing gene 19a0.049
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.048
sox11aSRY-box containing gene 11a0.047
id1inhibitor of DNA binding 10.047
scube2signal peptide, CUB domain, EGF-like 20.047
hey1hairy/enhancer-of-split related with YRPW motif 10.046
ahr2aryl hydrocarbon receptor 20.045
lmx1b.1LIM homeobox transcription factor 1, beta 10.044
supt6hsuppressor of Ty 6 homolog0.044
dlbdeltaB0.044
dladeltaA0.044
cdx4caudal type homeo box transcription factor 40.043
egfl6EGF-like-domain, multiple 60.042
spry4sprouty (Drosophila) homolog 40.040
si:dkeyp-51c11.1si:dkeyp-51c11.10.040
evplenvoplakin0.038
edn1endothelin 10.038
tp63tumor protein p630.037
hoxb1bhomeo box B1b0.036
fzd7afrizzled homolog 7a0.036
si:ch211-217k17.9si:ch211-217k17.90.036
rfx2regulatory factor X, 2 (influences HLA class II expression)0.035
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.035
epcamepithelial cell adhesion molecule0.035
cdc25cell division cycle 25 homolog0.035
eif4ebp3leukaryotic translation initiation factor 4E binding protein 3, like0.032
rereaarginine-glutamic acid dipeptide (RE) repeats a0.032
meis1myeloid ecotropic viral integration 10.032
yap1Yes-associated protein 10.032
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.032
vsg1vessel-specific 10.031
ccdc40coiled-coil domain containing 400.031
fgfr2fibroblast growth factor receptor 20.030
atp1b1bATPase, Na+/K+ transporting, beta 1b polypeptide0.029
cldnbclaudin b0.029
fzd8afrizzled homolog 8a0.029
emilin1aelastin microfibril interfacer 1a0.029
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.029
gata3GATA-binding protein 30.028
osr2odd-skipped related 2 (Drosophila)0.028
alcambactivated leukocyte cell adhesion molecule b0.028
her12hairy-related 120.028
efnb2aephrin B2a0.028
lrrc50leucine rich repeat containing 500.028
axin2axin 2 (conductin, axil)0.027
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.026
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.026
wnt11wingless-type MMTV integration site family, member 110.026
hapln3hyaluronan and proteoglycan link protein 30.026
wdr69WD repeat domain 690.025
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Dll1delta-like 1 (Drosophila)1.000
Notch2Notch gene homolog 2 (Drosophila)1.000
Psen1presenilin 11.000
Rbpjrecombination signal binding protein for immunoglobulin kappa J region1.000
Notch1Notch gene homolog 1 (Drosophila)1.000
Engendoglin0.998
Chd7chromodomain helicase DNA binding protein 70.996
Rb1retinoblastoma 10.996
Prl7d1prolactin family 7, subfamily d, member 10.991
Tgfbr2transforming growth factor, beta receptor II0.977
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.943
Tcte3t-complex-associated testis expressed 30.936
Fgfr1fibroblast growth factor receptor 10.935
Prl7a1prolactin family 7, subfamily a, member 10.930
Efnb2ephrin B20.928
Hes1hairy and enhancer of split 1 (Drosophila)0.915
Jag1jagged 10.885
Psen2presenilin 20.809
Cdh5cadherin 50.808
Cdkn1bcyclin-dependent kinase inhibitor 1B0.802
Nos3nitric oxide synthase 3, endothelial cell0.800
Meox2mesenchyme homeobox 20.753
Lyz2lysozyme 20.750
Prl8a2prolactin family 8, subfamily a, member 20.741
Mdm2transformed mouse 3T3 cell double minute 20.721
Nfe2l2nuclear factor, erythroid derived 2, like 20.706
Ctsrcathepsin R0.687
Ctnnb1catenin (cadherin associated protein), beta 10.680
Mef2dmyocyte enhancer factor 2D0.669
Ceacam11carcinoembryonic antigen-related cell adhesion molecule 110.655
Prl8a8prolactin family 8, subfamily a, member 810.627
Klf2Kruppel-like factor 2 (lung)0.592
Serpinb9cserine (or cysteine) peptidase inhibitor, clade B, member 9c0.591
Prl7a2prolactin family 7, subfamily a, member 20.576
Prl2b1prolactin family 2, subfamily b, member 10.575
Mmp1amatrix metallopeptidase 1a (interstitial collagenase)0.563
Trp63transformation related protein 630.563
Trp53transformation related protein 530.555
Sox18SRY-box containing gene 180.548
Itgb1integrin beta 1 (fibronectin receptor beta)0.545
Pkd1polycystic kidney disease 1 homolog0.531
Col1a1collagen, type I, alpha 10.525
Loxlysyl oxidase0.510
Olfr64olfactory receptor 640.472
Prl5a1prolactin family 5, subfamily a, member 10.453
Prl8a9prolactin family8, subfamily a, member 90.447
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.441
Tpbpatrophoblast specific protein alpha0.437
Prl2a1prolactin family 2, subfamily a, member 10.432
Map3k3mitogen-activated protein kinase kinase kinase 30.432
Prl7c1prolactin family 7, subfamily c, member 10.427
Prl8a6prolactin family 8, subfamily a, member 60.422
Rhox9reproductive homeobox 90.419
Runx1runt related transcription factor 10.405
Fbn1fibrillin 10.404
LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.401
Prl3b1prolactin family 3, subfamily b, member 10.390
Prl3d1prolactin family 3, subfamily d, member 10.389
Jag2jagged 20.366
Prl6a1prolactin family 6, subfamily a, member 10.363
Pax3paired box gene 30.341
Erv3endogenous retroviral sequence 30.331
Il6stinterleukin 6 signal transducer0.319
Psg28pregnancy-specific glycoprotein 280.310
Serpinb9gserine (or cysteine) peptidase inhibitor, clade B, member 9g0.280
Svaseminal vesicle antigen0.255
Tmed11transmembrane emp24 protein transport domain containing0.252
Prl3d2prolactin family 3, subfamily d, member 10.249
Ceacam12carcinoembryonic antigen-related cell adhesion molecule 120.233
Egfrepidermal growth factor receptor0.231
Ncor2nuclear receptor co-repressor 20.224
Fiz1Flt3 interacting zinc finger protein 10.223
Foxg1forkhead box G10.217
Ctsjcathepsin J0.209
NrarpNotch-regulated ankyrin repeat protein0.208
Plac1placental specific protein 10.201
Vmn1r42vomeronasal 1 receptor 420.200
Prl7b1prolactin family 7, subfamily b, member 10.194
Hba-xhemoglobin X, alpha-like embryonic chain in Hba complex0.194
Prl3c1prolactin family 3, subfamily c, member 10.187
Obsl1obscurin-like 10.185
Gata3GATA binding protein 30.180
Esamendothelial cell-specific adhesion molecule0.174
Ppargperoxisome proliferator activated receptor gamma0.172
Slco6c1solute carrier organic anion transporter family, member 6c10.168
Ldlrlow density lipoprotein receptor0.168
Egfl7EGF-like domain 70.166
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.157
Obox3oocyte specific homeobox 30.154
Prl2c4prolactin family 2, subfamily c, member 40.153
Hbb-bh1hemoglobin Z, beta-like embryonic chain0.153
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.151
Pltpphospholipid transfer protein0.149
Psg19pregnancy specific glycoprotein 190.148
Elnelastin0.143
Vmn1r49vomeronasal 1, receptor 490.140
Vmn1r172vomeronasal 1 receptor 1720.139
Ptenphosphatase and tensin homolog0.137
Dll4delta-like 4 (Drosophila)0.137
Klk1b1kallikrein 1-related peptidase b10.135
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism