The network for 'lymphocyte homeostasis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lymphocyte homeostasis

The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.

NameDescriptionProbabilityFunc Analog Organism
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.973
BIDBH3 interacting domain death agonist0.935
CASP8caspase 8, apoptosis-related cysteine peptidase0.932
BCL2L11BCL2-like 11 (apoptosis facilitator)0.921
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.920
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.855
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.810
BCL2L1BCL2-like 10.792
CFLARCASP8 and FADD-like apoptosis regulator0.774
SPTBspectrin, beta, erythrocytic0.621
MSNmoesin0.619
CARD11caspase recruitment domain family, member 110.578
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.481
FASFas (TNF receptor superfamily, member 6)0.395
BCL2B-cell CLL/lymphoma 20.305
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.289
CDC37cell division cycle 37 homolog (S. cerevisiae)0.278
NOXA1NADPH oxidase activator 10.276
INSRinsulin receptor0.275
CXCR4chemokine (C-X-C motif) receptor 40.274
PTPN1protein tyrosine phosphatase, non-receptor type 10.260
SOS1son of sevenless homolog 1 (Drosophila)0.238
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.226
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.222
BAK1BCL2-antagonist/killer 10.219
SQSTM1sequestosome 10.218
BIRC2baculoviral IAP repeat containing 20.218
BAXBCL2-associated X protein0.207
PRKCZprotein kinase C, zeta0.203
CASP10caspase 10, apoptosis-related cysteine peptidase0.198
FASLGFas ligand (TNF superfamily, member 6)0.170
ARNTaryl hydrocarbon receptor nuclear translocator0.170
HDAC9histone deacetylase 90.164
C9orf89chromosome 9 open reading frame 890.160
TRAF6TNF receptor-associated factor 60.159
PXMP2peroxisomal membrane protein 2, 22kDa0.144
ENGendoglin0.142
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.136
IRF2interferon regulatory factor 20.132
JAK2Janus kinase 20.126
STAT5Asignal transducer and activator of transcription 5A0.112
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.112
SPTBN1spectrin, beta, non-erythrocytic 10.112
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.105
BADBCL2-associated agonist of cell death0.104
PDPK13-phosphoinositide dependent protein kinase-10.101
CASP9caspase 9, apoptosis-related cysteine peptidase0.099
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.099
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.099
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.096
PTK2BPTK2B protein tyrosine kinase 2 beta0.093
CHUKconserved helix-loop-helix ubiquitous kinase0.087
TGFBR1transforming growth factor, beta receptor 10.083
TNIP1TNFAIP3 interacting protein 10.082
STAP2signal transducing adaptor family member 20.082
MAP3K7mitogen-activated protein kinase kinase kinase 70.081
AKT1v-akt murine thymoma viral oncogene homolog 10.081
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.080
KPNA1karyopherin alpha 1 (importin alpha 5)0.079
IL2RBinterleukin 2 receptor, beta0.078
PICK1protein interacting with PRKCA 10.076
CDCP1CUB domain containing protein 10.074
EPAS1endothelial PAS domain protein 10.071
CDKN3cyclin-dependent kinase inhibitor 30.071
BBC3BCL2 binding component 30.071
FSTL1follistatin-like 10.070
IKZF3IKAROS family zinc finger 3 (Aiolos)0.070
BCAR1breast cancer anti-estrogen resistance 10.070
CAV1caveolin 1, caveolae protein, 22kDa0.070
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.067
HLA-DPB1major histocompatibility complex, class II, DP beta 10.065
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.065
CDK2cyclin-dependent kinase 20.064
SH3RF1SH3 domain containing ring finger 10.064
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.063
MAP3K14mitogen-activated protein kinase kinase kinase 140.063
NCOA7nuclear receptor coactivator 70.063
FADDFas (TNFRSF6)-associated via death domain0.060
IL32interleukin 320.059
VHLvon Hippel-Lindau tumor suppressor0.058
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.057
ZNF282zinc finger protein 2820.057
CASP7caspase 7, apoptosis-related cysteine peptidase0.054
DCTN1dynactin 10.053
ARNTLaryl hydrocarbon receptor nuclear translocator-like0.053
FKBP8FK506 binding protein 8, 38kDa0.053
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.052
AIParyl hydrocarbon receptor interacting protein0.050
GIT2G protein-coupled receptor kinase interacting ArfGAP 20.049
GAB2GRB2-associated binding protein 20.049
MAPK14mitogen-activated protein kinase 140.047
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.046
EP300E1A binding protein p3000.046
CCDC115coiled-coil domain containing 1150.045
NCF1neutrophil cytosolic factor 10.045
BIKBCL2-interacting killer (apoptosis-inducing)0.045
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.045
NCOA3nuclear receptor coactivator 30.045
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.044
NTRK1neurotrophic tyrosine kinase, receptor, type 10.044
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mef2cbmyocyte enhancer factor 2cb0.237
ighzimmunoglobulin heavy constant zeta0.225
lcp1lymphocyte cytosolic plastin 10.112
il7rinterleukin 7 receptor0.105
dnttdeoxynucleotidyltransferase, terminal0.078
ikzf1IKAROS family zinc finger 1 (Ikaros)0.069
mef2camyocyte enhancer factor 2ca0.068
lmnalamin A0.067
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.064
aplp2amyloid beta (A4) precursor-like protein 20.064
kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.062
wu:fv91b12wu:fv91b120.057
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.052
socs1suppressor of cytokine signaling 10.050
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.049
bbc3BCL2 binding component 30.046
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.044
mef2amyocyte enhancer factor 2a0.041
jak1Janus kinase 10.040
smyd1bSET and MYND domain containing 1b0.040
cbfbcore-binding factor, beta subunit0.037
tgfb3transforming growth factor, beta 30.036
rps19ribosomal protein S190.036
og9xOG9 homeobox gene0.035
edn1endothelin 10.035
fasFas (TNF receptor superfamily, member 6)0.034
tbx5aT-box 5a0.034
epas1bendothelial PAS domain protein 1b0.033
xirp1xin actin-binding repeat containing 10.033
keap1akelch-like ECH-associated protein 1a0.031
mmp9matrix metalloproteinase 90.030
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.029
tnfsf18tumor necrosis factor (ligand) superfamily, member 180.028
rad21RAD21 homolog (S. pombe)0.028
cdkn1acyclin-dependent kinase inhibitor 1A0.027
gpr126G protein-coupled receptor 1260.026
stat1bsignal transducer and activator of transcription 1b0.026
fam20bfamily with sequence similarity 20, member B (H. sapiens)0.026
gnb1aguanine nucleotide binding protein (G protein), beta polypeptide 1a0.026
stc1lstanniocalcin 1, like0.026
smyd1aSET and MYND domain containing 1a0.026
igf1insulin-like growth factor 10.025
gadd45aagrowth arrest and DNA-damage-inducible, alpha, a0.024
tbx1T-box 10.024
ptpn23aprotein tyrosine phosphatase, non-receptor type 23, a0.024
tp53tumor protein p530.024
tbx5bT-box 5b0.024
prdx4peroxiredoxin 40.024
hsp90a.1heat shock protein 90-alpha 10.023
sat1aspermidine/spermine N1-acetyltransferase 1a0.023
vmhcventricular myosin heavy chain0.023
bnip3lbBCL2/adenovirus E1B interacting protein 3-like b0.023
ptger4aprostaglandin E receptor 4 (subtype EP4) a0.022
tbx18T-box 180.022
zgc:194876zgc:1948760.022
nkd2naked cuticle homolog 2 and naked 2a0.022
jag1bjagged 1b0.021
svilsupervillin0.021
rpl7aribosomal protein L7a0.021
mitfamicrophthalmia-associated transcription factor a0.021
rbm24aRNA binding motif protein 24a0.021
nfatc1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 10.020
fshbfollicle stimulating hormone, beta polypeptide0.020
zar1zygote arrest 10.020
ppialpeptidylprolyl isomerase A, like0.020
slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.019
hmgb3ahigh-mobility group box 3a0.019
faslgFas ligand (TNF superfamily, member 6)0.019
si:ch211-260p9.1si:ch211-260p9.10.019
scinlascinderin like a0.019
taf3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto0.019
arpc3actin related protein 2/3 complex, subunit 30.019
alcamaactivated leukocyte cell adhesion molecule a0.019
nppanatriuretic peptide precursor A0.019
cmybtranscription factor cmyb0.018
cdca8cell division cycle associated 80.018
malt1mucosa associated lymphoid tissue lymphoma translocation gene 10.018
prnprs3prion protein, related sequence 30.018
bcl2l1bcl2-like 10.018
fabp11afatty acid binding protein 11a0.018
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.018
lrrc33leucine rich repeat containing 330.018
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.018
zgc:112211zgc:1122110.018
mpxmyeloid-specific peroxidase0.018
pcsk5bproprotein convertase subtilisin/kexin type 5b0.018
mxamyxovirus (influenza) resistance A0.017
alkanaplastic lymphoma kinase (Ki-1)0.017
mt2metallothionein 20.017
nt5e5'-nucleotidase, ecto (CD73)0.017
jak2aJanus kinase 2a0.017
znf148zinc finger protein 1480.017
polmpolymerase (DNA directed), mu0.017
LOC566708FL cytokine receptor-like0.016
trpv6transient receptor potential cation channel, subfamily V, member 60.016
sgcdsarcoglycan, delta (dystrophin-associated glycoprotein)0.016
dnm2dynamin 20.016
zgc:73311zgc:733110.016
ptpn6protein tyrosine phosphatase, non-receptor type 60.016
hbaa1hemoglobin alpha adult-10.016
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.999
FasFas (TNF receptor superfamily member 6)0.999
Ighimmunoglobulin heavy chain complex0.999
Lyz2lysozyme 20.999
Ptenphosphatase and tensin homolog0.997
Trp53transformation related protein 530.995
Hif1ahypoxia inducible factor 1, alpha subunit0.991
Cd19CD19 antigen0.981
Tnftumor necrosis factor0.978
Map3k7mitogen-activated protein kinase kinase kinase 70.970
Myd88myeloid differentiation primary response gene 880.962
Stat3signal transducer and activator of transcription 30.956
Rc3h1RING CCCH (C3H) domains 10.931
Ikzf1IKAROS family zinc finger 10.920
Ptgs2prostaglandin-endoperoxide synthase 20.918
Bcl2B-cell leukemia/lymphoma 20.911
Stat5asignal transducer and activator of transcription 5A0.899
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.898
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.879
Smad4MAD homolog 4 (Drosophila)0.872
Il2rginterleukin 2 receptor, gamma chain0.869
Mcl1myeloid cell leukemia sequence 10.854
Stat5bsignal transducer and activator of transcription 5B0.842
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.842
Nfe2l2nuclear factor, erythroid derived 2, like 20.819
CblCasitas B-lineage lymphoma0.789
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.775
Jak2Janus kinase 20.753
Rag2recombination activating gene 20.746
Sykbspleen tyrosine kinase0.745
H2-DMahistocompatibility 2, class II, locus DMa0.733
Nr3c1nuclear receptor subfamily 3, group C, member 10.684
Ptpn11protein tyrosine phosphatase, non-receptor type 110.663
Il6stinterleukin 6 signal transducer0.649
Hbb-b1hemoglobin, beta adult major chain0.628
Casp8caspase 80.626
Vhlvon Hippel-Lindau tumor suppressor0.624
Foxp3forkhead box P30.616
Kitkit oncogene0.614
Adam17a disintegrin and metallopeptidase domain 170.596
TcrdT-cell receptor delta chain0.585
Cd22CD22 antigen0.575
Ank1ankyrin 1, erythroid0.569
Inpp5dinositol polyphosphate-5-phosphatase D0.567
Il2interleukin 20.553
Casp1caspase 10.517
Ifnginterferon gamma0.513
Grb2growth factor receptor bound protein 20.496
Bcl6B-cell leukemia/lymphoma 60.494
Tlr4toll-like receptor 40.489
Spnb2spectrin beta 20.476
Prf1perforin 1 (pore forming protein)0.441
Ptk2PTK2 protein tyrosine kinase 20.437
Ttc7tetratricopeptide repeat domain 70.436
Tgfb1transforming growth factor, beta 10.418
Cd40CD40 antigen0.402
Hdac5histone deacetylase 50.394
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.385
Ptprcprotein tyrosine phosphatase, receptor type, C0.382
FaddFas (TNFRSF6)-associated via death domain0.378
WasWiskott-Aldrich syndrome homolog (human)0.374
PycardPYD and CARD domain containing0.371
Tnfaip3tumor necrosis factor, alpha-induced protein 30.363
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.361
Il10interleukin 100.360
BaxBCL2-associated X protein0.338
H2-Ab1histocompatibility 2, class II antigen A, beta 10.338
Socs1suppressor of cytokine signaling 10.337
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.335
Ube2cubiquitin-conjugating enzyme E2C0.332
Latlinker for activation of T cells0.328
Casp4caspase 4, apoptosis-related cysteine peptidase0.316
Il2rbinterleukin 2 receptor, beta chain0.314
Cdk1cyclin-dependent kinase 10.309
Spna1spectrin alpha 10.308
Ncoa3nuclear receptor coactivator 30.308
TcrbT-cell receptor beta chain0.304
Traf6TNF receptor-associated factor 60.297
Mef2cmyocyte enhancer factor 2C0.293
Tgfbr1transforming growth factor, beta receptor I0.288
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.286
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.285
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.280
Card11caspase recruitment domain family, member 110.279
Irf9interferon regulatory factor 90.265
Kif20akinesin family member 20A0.259
Smad3MAD homolog 3 (Drosophila)0.258
Lcklymphocyte protein tyrosine kinase0.258
Arntaryl hydrocarbon receptor nuclear translocator0.258
Kitlkit ligand0.254
Egln1EGL nine homolog 1 (C. elegans)0.251
Il1r1interleukin 1 receptor, type I0.243
Spnb1spectrin beta 10.243
Cyldcylindromatosis (turban tumor syndrome)0.240
Mef2dmyocyte enhancer factor 2D0.239
Il6interleukin 60.238
Cpceruloplasmin0.237
Ikbkginhibitor of kappaB kinase gamma0.227
Lystlysosomal trafficking regulator0.226
Nckap1lNCK associated protein 1 like0.219
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.156
RT1-DMbRT1 class II, locus DMb0.137
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.119
RT1-Db1RT1 class II, locus Db10.115
Pcdhga11protocadherin gamma subfamily A, 110.095
RT1-DaRT1 class II, locus Da0.074
Phkg1phosphorylase kinase, gamma 10.062
Tp53tumor protein p530.053
Spnsialophorin0.051
Il1r1interleukin 1 receptor, type I0.049
RT1-BaRT1 class II, locus Ba0.049
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.046
Cd37CD37 molecule0.046
Arrb2arrestin, beta 20.045
Slfn2schlafen 20.041
Cotl1coactosin-like 1 (Dictyostelium)0.039
Crygfcrystallin, gamma F0.039
Il2rginterleukin 2 receptor, gamma0.039
Flt1FMS-related tyrosine kinase 10.037
Acvr1bactivin A receptor, type IB0.036
Ucp2uncoupling protein 2 (mitochondrial, proton carrier)0.035
Egfl7EGF-like-domain, multiple 70.034
Dkc1dyskeratosis congenita 1, dyskerin0.034
RT1-BbRT1 class II, locus Bb0.031
Hyal2hyaluronoglucosaminidase 20.030
Bak1BCL2-antagonist/killer 10.029
Ghrhrgrowth hormone releasing hormone receptor0.028
Podxlpodocalyxin-like0.028
Mapkapk3mitogen-activated protein kinase-activated protein kinase 30.028
Tln1talin 10.028
Pecam1platelet/endothelial cell adhesion molecule 10.027
Irf2interferon regulatory factor 20.026
Trim47tripartite motif-containing 470.026
RT1-EC2RT1 class Ib, locus EC20.026
Jak2Janus kinase 20.026
Epn2epsin 20.026
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.026
Coro1bcoronin, actin-binding protein, 1B0.025
Nudcd1NudC domain containing 10.025
TrabdTraB domain containing0.024
RT1-DMaRT1 class II, locus DMa0.024
Sec31aSEC31 homolog A (S. cerevisiae)0.024
Tfebtranscription factor EB0.024
Prrx1paired related homeobox 10.023
Bat3HLA-B-associated transcript 30.023
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.023
Capns1calpain, small subunit 10.023
Dhx40DEAH (Asp-Glu-Ala-His) box polypeptide 400.022
Smad3SMAD family member 30.022
Leprleptin receptor0.022
Lrg1leucine-rich alpha-2-glycoprotein 10.022
Vom2r50vomeronasal 2 receptor, 500.021
Spastspastin0.021
Cd5Cd5 molecule0.021
Olr37olfactory receptor 370.021
Prkchprotein kinase C, eta0.021
Nudt3nudix (nucleoside diphosphate linked moiety X)-type motif 30.020
Ptpn6protein tyrosine phosphatase, non-receptor type 60.020
Csnk1g1casein kinase 1, gamma 10.020
Laptm5lysosomal protein transmembrane 50.019
Prkcdprotein kinase C, delta0.019
Ptger2prostaglandin E receptor 2 (subtype EP2)0.019
Cd247Cd247 molecule0.019
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.018
Ptafrplatelet-activating factor receptor0.018
FynFYN oncogene related to SRC, FGR, YES0.018
Tmem88transmembrane protein 880.018
Kif2akinesin family member 2A0.018
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.018
Olr837olfactory receptor 8370.018
MGC112715hypothetical protein LOC6908990.017
Ccnd3cyclin D30.017
ShprhSNF2 histone linker PHD RING helicase0.017
Nos3nitric oxide synthase 3, endothelial cell0.017
Ccl3chemokine (C-C motif) ligand 30.017
Socs3suppressor of cytokine signaling 30.017
Sh3bgrl3SH3 domain binding glutamic acid-rich protein-like 30.017
Lyz2lysozyme 20.017
Zbp1Z-DNA binding protein 10.017
Chl1cell adhesion molecule with homology to L1CAM0.017
LOC100363783rCG53773-like0.017
Ugt1a7cUDP glucuronosyltransferase 1 family, polypeptide A7C0.016
Pgm3phosphoglucomutase 30.016
Zfp94zinc finger protein 940.016
Mvpmajor vault protein0.016
Dlg1discs, large homolog 1 (Drosophila)0.016
Ubdubiquitin D0.016
RT1-M4RT1 class Ib, locus M40.016
Slc15a3solute carrier family 15, member 30.016
Sirpasignal-regulatory protein alpha0.016
Thumpd3THUMP domain containing 30.016
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.016
Mov10Moloney leukemia virus 100.016
Olr1346olfactory receptor 13460.016
Pspnpersephin0.016
Gja4gap junction protein, alpha 40.015
PcnpPEST proteolytic signal containing nuclear protein0.015
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.015
Akap1A kinase (PRKA) anchor protein 10.015
Irf5interferon regulatory factor 50.015
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism