The network for 'regulation of lymphocyte activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of lymphocyte activation

Any process that modulates the frequency, rate or extent of lymphocyte activation.

NameDescriptionProbabilityFunc Analog Organism
LCKlymphocyte-specific protein tyrosine kinase0.992
TRAF1TNF receptor-associated factor 10.982
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.970
CASP8caspase 8, apoptosis-related cysteine peptidase0.964
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.957
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.949
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.947
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.945
CD2CD2 molecule0.936
SH3KBP1SH3-domain kinase binding protein 10.935
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.908
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.904
BIRC3baculoviral IAP repeat containing 30.903
FASFas (TNF receptor superfamily, member 6)0.898
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.891
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.873
FGFR2fibroblast growth factor receptor 20.863
TNFAIP3tumor necrosis factor, alpha-induced protein 30.862
IL4Rinterleukin 4 receptor0.827
CFLARCASP8 and FADD-like apoptosis regulator0.811
CD80CD80 molecule0.809
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.796
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.796
CCR7chemokine (C-C motif) receptor 70.756
IL1R1interleukin 1 receptor, type I0.751
SYKspleen tyrosine kinase0.751
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.742
IL2RGinterleukin 2 receptor, gamma0.740
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.738
SHC1SHC (Src homology 2 domain containing) transforming protein 10.712
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.709
SH2D1ASH2 domain containing 1A0.699
CXCL9chemokine (C-X-C motif) ligand 90.688
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.665
PTPRCprotein tyrosine phosphatase, receptor type, C0.661
PTK2PTK2 protein tyrosine kinase 20.658
BCL2B-cell CLL/lymphoma 20.637
CCL22chemokine (C-C motif) ligand 220.627
HLA-Amajor histocompatibility complex, class I, A0.626
HLA-Fmajor histocompatibility complex, class I, F0.615
IRAK1interleukin-1 receptor-associated kinase 10.590
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.578
PLCG1phospholipase C, gamma 10.573
HCKhemopoietic cell kinase0.572
TGIF1TGFB-induced factor homeobox 10.572
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.566
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.565
EGFRepidermal growth factor receptor0.561
ICAM1intercellular adhesion molecule 10.547
GRB2growth factor receptor-bound protein 20.545
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.531
IRF4interferon regulatory factor 40.516
NR4A1nuclear receptor subfamily 4, group A, member 10.516
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.516
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.505
CTLA4cytotoxic T-lymphocyte-associated protein 40.503
PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.503
TNFRSF9tumor necrosis factor receptor superfamily, member 90.502
RIPK2receptor-interacting serine-threonine kinase 20.493
IL2RBinterleukin 2 receptor, beta0.493
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.492
HLA-Bmajor histocompatibility complex, class I, B0.482
FASLGFas ligand (TNF superfamily, member 6)0.477
CD247CD247 molecule0.475
VAV1vav 1 guanine nucleotide exchange factor0.469
CARD11caspase recruitment domain family, member 110.466
LTAlymphotoxin alpha (TNF superfamily, member 1)0.459
CD6CD6 molecule0.445
STAT4signal transducer and activator of transcription 40.440
CASP10caspase 10, apoptosis-related cysteine peptidase0.439
CD86CD86 molecule0.416
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.405
GAB1GRB2-associated binding protein 10.393
PILRApaired immunoglobin-like type 2 receptor alpha0.393
HLA-Emajor histocompatibility complex, class I, E0.377
TRAF2TNF receptor-associated factor 20.377
HLA-Gmajor histocompatibility complex, class I, G0.375
SLAMF1signaling lymphocytic activation molecule family member 10.369
ABI1abl-interactor 10.361
IL10RAinterleukin 10 receptor, alpha0.360
CD1CCD1c molecule0.358
SMAD7SMAD family member 70.356
JAK1Janus kinase 10.355
CXCR6chemokine (C-X-C motif) receptor 60.351
HLA-DMBmajor histocompatibility complex, class II, DM beta0.342
CAV1caveolin 1, caveolae protein, 22kDa0.336
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.327
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.323
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.321
CD3GCD3g molecule, gamma (CD3-TCR complex)0.317
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.298
SIGLEC7sialic acid binding Ig-like lectin 70.294
IL16interleukin 16 (lymphocyte chemoattractant factor)0.293
PTPN6protein tyrosine phosphatase, non-receptor type 60.284
HLA-DRB5major histocompatibility complex, class II, DR beta 50.280
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.274
HLA-DQB1major histocompatibility complex, class II, DQ beta 10.272
CD2APCD2-associated protein0.270
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tlr4toll-like receptor 40.995
Cd40CD40 antigen0.995
Stat3signal transducer and activator of transcription 30.992
Rnf2ring finger protein 20.989
Ccr2chemokine (C-C motif) receptor 20.988
Ptpn11protein tyrosine phosphatase, non-receptor type 110.987
Lcklymphocyte protein tyrosine kinase0.983
Icosinducible T-cell co-stimulator0.979
Cd19CD19 antigen0.978
Jak2Janus kinase 20.967
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.962
Pax2paired box gene 20.955
Ptprcprotein tyrosine phosphatase, receptor type, C0.951
Tnftumor necrosis factor0.951
Leprleptin receptor0.946
Ccr7chemokine (C-C motif) receptor 70.945
Tnfaip3tumor necrosis factor, alpha-induced protein 30.941
Efnb2ephrin B20.927
Il1binterleukin 1 beta0.914
Klrd1killer cell lectin-like receptor, subfamily D, member 10.900
Fgfr2fibroblast growth factor receptor 20.899
Latlinker for activation of T cells0.897
FynFyn proto-oncogene0.891
Wt1Wilms tumor 1 homolog0.881
Casp1caspase 10.878
Arandrogen receptor0.878
Ikzf1IKAROS family zinc finger 10.877
Tgfb1transforming growth factor, beta 10.876
Il27rainterleukin 27 receptor, alpha0.873
Lyz2lysozyme 20.873
Grb2growth factor receptor bound protein 20.870
Slamf1signaling lymphocytic activation molecule family member 10.863
BtkBruton agammaglobulinemia tyrosine kinase0.853
Cd28CD28 antigen0.850
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.844
FasFas (TNF receptor superfamily member 6)0.844
FaslFas ligand (TNF superfamily, member 6)0.841
Csf1colony stimulating factor 1 (macrophage)0.838
Cdkn1bcyclin-dependent kinase inhibitor 1B0.833
Ifnginterferon gamma0.828
Pdcd1programmed cell death 10.816
Map3k8mitogen-activated protein kinase kinase kinase 80.815
Klrk1killer cell lectin-like receptor subfamily K, member 10.813
Cd86CD86 antigen0.812
Traf6TNF receptor-associated factor 60.807
Rb1retinoblastoma 10.801
Il1r1interleukin 1 receptor, type I0.792
Casp4caspase 4, apoptosis-related cysteine peptidase0.792
Sh2d2aSH2 domain protein 2A0.786
Vangl2vang-like 2 (van gogh, Drosophila)0.781
Il2rbinterleukin 2 receptor, beta chain0.776
Stat6signal transducer and activator of transcription 60.776
Il7rinterleukin 7 receptor0.776
Ltblymphotoxin B0.771
CblCasitas B-lineage lymphoma0.770
Ltalymphotoxin A0.763
Clec4nC-type lectin domain family 4, member n0.762
Mmp9matrix metallopeptidase 90.757
Ccr6chemokine (C-C motif) receptor 60.756
Gli3GLI-Kruppel family member GLI30.753
Cd180CD180 antigen0.750
Cd7CD7 antigen0.744
Il2rginterleukin 2 receptor, gamma chain0.736
Sfpi1SFFV proviral integration 10.731
Nckap1lNCK associated protein 1 like0.729
Map3k14mitogen-activated protein kinase kinase kinase 140.729
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.727
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.727
Birc3baculoviral IAP repeat-containing 30.727
Il10rainterleukin 10 receptor, alpha0.719
Prf1perforin 1 (pore forming protein)0.718
Stat5bsignal transducer and activator of transcription 5B0.716
Klra9killer cell lectin-like receptor subfamily A, member 90.714
Rargretinoic acid receptor, gamma0.711
Adora2aadenosine A2a receptor0.711
H2-Aahistocompatibility 2, class II antigen A, alpha0.709
Myd88myeloid differentiation primary response gene 880.707
Tbx3T-box 30.703
Stat5asignal transducer and activator of transcription 5A0.698
Batfbasic leucine zipper transcription factor, ATF-like0.691
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.691
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.679
Tbx21T-box 210.679
Zeb1zinc finger E-box binding homeobox 10.676
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.676
AxlAXL receptor tyrosine kinase0.675
Itgb2integrin beta 20.673
Cd96CD96 antigen0.671
Ccr9chemokine (C-C motif) receptor 90.667
Ighimmunoglobulin heavy chain complex0.664
Ccl5chemokine (C-C motif) ligand 50.663
BlkB lymphoid kinase0.656
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.654
Clec4dC-type lectin domain family 4, member d0.653
Smad6MAD homolog 6 (Drosophila)0.651
Rxraretinoid X receptor alpha0.650
Nlrp3NLR family, pyrin domain containing 30.647
Ccl2chemokine (C-C motif) ligand 20.646
Plcg1phospholipase C, gamma 10.645
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.641
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cd247Cd247 molecule0.246
Cd2Cd2 molecule0.151
Cd37CD37 molecule0.111
Ptprcprotein tyrosine phosphatase, receptor type, C0.066
RT1-DaRT1 class II, locus Da0.063
Cd4Cd4 molecule0.058
Cd5Cd5 molecule0.055
Ciitaclass II, major histocompatibility complex, transactivator0.051
Laptm5lysosomal protein transmembrane 50.048
Ctsscathepsin S0.048
Gzmkgranzyme K0.042
Casp1caspase 10.039
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.034
Ccr5chemokine (C-C motif) receptor 50.034
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.031
Fcgr2aFc fragment of IgG, low affinity IIa, receptor (CD32)0.029
Cxcr3chemokine (C-X-C motif) receptor 30.029
Il1r1interleukin 1 receptor, type I0.028
Mmp10matrix metallopeptidase 100.028
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.027
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.027
Il9rinterleukin 9 receptor0.026
Il2rbinterleukin 2 receptor, beta0.026
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.025
Inpp5dinositol polyphosphate-5-phosphatase D0.025
Hckhemopoietic cell kinase0.024
Nek9NIMA (never in mitosis gene a)- related kinase 90.024
Alox5aparachidonate 5-lipoxygenase activating protein0.023
Tas2r123taste receptor, type 2, member 1230.023
Itgadintegrin, alpha D0.023
Ptger4prostaglandin E receptor 4 (subtype EP4)0.022
RT1-DMbRT1 class II, locus DMb0.022
Rassf5Ras association (RalGDS/AF-6) domain family member 50.022
Latlinker for activation of T cells0.022
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.022
Il6stinterleukin 6 signal transducer0.021
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.021
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.021
LOC100364854similar to RIKEN cDNA A430107P09 gene-like0.021
Mcpt2mast cell protease 20.021
RT1-DMaRT1 class II, locus DMa0.020
Map4k1mitogen activated protein kinase kinase kinase kinase 10.020
Itgb7integrin, beta 70.020
Vipvasoactive intestinal peptide0.020
Anpepalanyl (membrane) aminopeptidase0.020
Cd44Cd44 molecule0.019
Prrx1paired related homeobox 10.019
Scn11asodium channel, voltage-gated, type XI, alpha0.019
Alox5arachidonate 5-lipoxygenase0.019
Lcp2lymphocyte cytosolic protein 20.018
Calcrcalcitonin receptor0.018
TcrbT-cell receptor beta chain0.018
Slfn2schlafen 20.017
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.017
Nkg7natural killer cell group 7 sequence0.017
C1qbcomplement component 1, q subcomponent, B chain0.017
Flt1FMS-related tyrosine kinase 10.017
Anxa2annexin A20.017
Socs3suppressor of cytokine signaling 30.017
Ccr2chemokine (C-C motif) receptor 20.016
Gja4gap junction protein, alpha 40.016
Lef1lymphoid enhancer binding factor 10.016
Cd3gCD3 molecule, gamma0.016
Csf1colony stimulating factor 1 (macrophage)0.016
Kcns1potassium voltage-gated channel, delayed-rectifier, subfamily S, member 10.016
Pthparathyroid hormone0.016
Cacng1calcium channel, voltage-dependent, gamma subunit 10.015
Icam1intercellular adhesion molecule 10.015
Kcnv1potassium channel, subfamily V, member 10.015
Reg3gregenerating islet-derived 3 gamma0.015
Cd53Cd53 molecule0.015
Rac1ras-related C3 botulinum toxin substrate 10.015
Mylk2myosin light chain kinase 20.015
Svs1seminal vesicle secretory protein 10.015
Cd86CD86 molecule0.015
Ralbp1ralA binding protein 10.015
Scp2sterol carrier protein 20.015
Bin2bridging integrator 20.015
Il6interleukin 60.014
Serpinb1aserine (or cysteine) proteinase inhibitor, clade B, member 1a0.014
Stat6signal transducer and activator of transcription 60.014
Cfpcomplement factor properdin0.014
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.014
Ccl4chemokine (C-C motif) ligand 40.014
Il1binterleukin 1 beta0.014
Ddr2discoidin domain receptor tyrosine kinase 20.014
Cxcl3chemokine (C-X-C motif) ligand 30.014
LOC100361706lambda-chain C1-region-like0.014
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.014
Fgfr2fibroblast growth factor receptor 20.014
Arhgap25Rho GTPase activating protein 250.014
Plcg2phospholipase C, gamma 20.013
Tgfbr3transforming growth factor, beta receptor III0.013
Psbpc2prostatic steroid-binding protein C20.013
Wipf1WAS/WASL interacting protein family, member 10.013
Cd200r1CD200 receptor 10.013
Sellselectin L0.013
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism