The network for 'activation of cysteine type endopeptidase activity involved in apoptotic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

activation of cysteine type endopeptidase activity involved in apoptotic process

Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.

NameDescriptionProbabilityFunc Analog Organism
BCL2B-cell CLL/lymphoma 21.000
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)1.000
MDM2Mdm2 p53 binding protein homolog (mouse)1.000
CASP8caspase 8, apoptosis-related cysteine peptidase0.999
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.999
TP53tumor protein p530.998
FASFas (TNF receptor superfamily, member 6)0.998
S100A6S100 calcium binding protein A60.996
CASP10caspase 10, apoptosis-related cysteine peptidase0.995
CFLARCASP8 and FADD-like apoptosis regulator0.993
S100BS100 calcium binding protein B0.987
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.986
FADDFas (TNFRSF6)-associated via death domain0.983
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.979
SMN1survival of motor neuron 1, telomeric0.978
BCL2L11BCL2-like 11 (apoptosis facilitator)0.969
BCL2L1BCL2-like 10.962
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.962
HIPK2homeodomain interacting protein kinase 20.957
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.957
S100A9S100 calcium binding protein A90.940
RB1retinoblastoma 10.938
CASP2caspase 2, apoptosis-related cysteine peptidase0.935
CREBBPCREB binding protein0.915
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.909
HCKhemopoietic cell kinase0.904
BIDBH3 interacting domain death agonist0.904
BAXBCL2-associated X protein0.901
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.892
NLRC4NLR family, CARD domain containing 40.892
MDM4Mdm4 p53 binding protein homolog (mouse)0.874
FYNFYN oncogene related to SRC, FGR, YES0.873
SMAD2SMAD family member 20.866
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.853
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.849
PMLpromyelocytic leukemia0.804
S100A8S100 calcium binding protein A80.802
S100A1S100 calcium binding protein A10.801
CASP3caspase 3, apoptosis-related cysteine peptidase0.797
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.774
DAXXdeath-domain associated protein0.738
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.716
VDAC1voltage-dependent anion channel 10.690
PELP1proline, glutamate and leucine rich protein 10.670
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.660
XIAPX-linked inhibitor of apoptosis0.653
SMAD3SMAD family member 30.617
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.578
S100A4S100 calcium binding protein A40.574
COL4A1collagen, type IV, alpha 10.549
BAK1BCL2-antagonist/killer 10.545
RIPK2receptor-interacting serine-threonine kinase 20.540
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.535
NR4A1nuclear receptor subfamily 4, group A, member 10.509
SUMO3SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)0.504
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.482
GRB2growth factor receptor-bound protein 20.460
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.460
ANXA2annexin A20.460
COL4A2collagen, type IV, alpha 20.452
VDAC2voltage-dependent anion channel 20.446
S100A14S100 calcium binding protein A140.427
HNF4Ahepatocyte nuclear factor 4, alpha0.426
TRAF1TNF receptor-associated factor 10.419
AIFM1apoptosis-inducing factor, mitochondrion-associated, 10.419
PYCARDPYD and CARD domain containing0.414
PSME3proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)0.413
S100A11S100 calcium binding protein A110.409
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.365
RXRAretinoid X receptor, alpha0.354
MAPK8mitogen-activated protein kinase 80.352
SMURF2SMAD specific E3 ubiquitin protein ligase 20.349
CDK2cyclin-dependent kinase 20.346
SMAD7SMAD family member 70.335
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.322
ARRB2arrestin, beta 20.317
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.315
LCKlymphocyte-specific protein tyrosine kinase0.281
SOCS1suppressor of cytokine signaling 10.265
TP53BP2tumor protein p53 binding protein, 20.258
SPRR2Asmall proline-rich protein 2A0.258
BLNKB-cell linker0.255
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.251
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 10.238
COL4A4collagen, type IV, alpha 40.232
VHLvon Hippel-Lindau tumor suppressor0.231
ASB2ankyrin repeat and SOCS box containing 20.229
FHfumarate hydratase0.224
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)0.219
BBS10Bardet-Biedl syndrome 100.214
BECN1beclin 1, autophagy related0.197
EGLN1egl nine homolog 1 (C. elegans)0.197
CAV1caveolin 1, caveolae protein, 22kDa0.197
BADBCL2-associated agonist of cell death0.192
ITKIL2-inducible T-cell kinase0.187
FASLGFas ligand (TNF superfamily, member 6)0.182
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.178
NCOR2nuclear receptor corepressor 20.171
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
imdimmune deficiency0.657
DreddDeath related ced-3/Nedd2-like protein0.646
IceCG7788 gene product from transcript CG7788-RA0.509
NcNedd2-like caspase0.329
CG7033CG7033 gene product from transcript CG7033-RC0.206
Atg1Autophagy-specific gene 10.200
CG5155CG5155 gene product from transcript CG5155-RA0.172
Df31Decondensation factor 310.170
CG4030CG4030 gene product from transcript CG4030-RA0.157
Mcm7Minichromosome maintenance 70.151
grimCG4345 gene product from transcript CG4345-RA0.143
BG4CG12297 gene product from transcript CG12297-RA0.141
CG5355CG5355 gene product from transcript CG5355-RA0.127
OsbpOxysterol binding protein0.122
Cyt-c-dCytochrome c distal0.107
Dcp-1Death caspase-10.100
grhgrainy head0.099
ird5immune response deficient 50.093
AGO2Argonaute 20.091
asf1anti-silencing factor 10.087
CG13597CG13597 gene product from transcript CG13597-RA0.080
CG1129CG1129 gene product from transcript CG1129-RC0.079
Rpt1CG1341 gene product from transcript CG1341-RA0.078
Roc1bCG16988 gene product from transcript CG16988-RA0.072
RASSF8CG5053 gene product from transcript CG5053-RA0.070
CG3875CG3875 gene product from transcript CG3875-RA0.068
mus201mutagen-sensitive 2010.065
CG5384CG5384 gene product from transcript CG5384-RA0.064
betaTub56Dbeta-Tubulin at 56D0.060
EndoGEndonuclease G0.056
Atg6Autophagy-specific gene 60.054
CG5854CG5854 gene product from transcript CG5854-RA0.053
CG9330CG9330 gene product from transcript CG9330-RA0.052
alphaTub84Balpha-Tubulin at 84B0.051
Rpt4CG3455 gene product from transcript CG3455-RA0.049
Sox14Sox box protein 140.049
XNPCG4548 gene product from transcript CG4548-RA0.047
CctgammaCG8977 gene product from transcript CG8977-RC0.046
Hr46Hormone receptor-like in 460.045
RnrLRibonucleoside diphosphate reductase large subunit0.045
CG9772CG9772 gene product from transcript CG9772-RB0.045
Eip74EFEcdysone-induced protein 74EF0.044
nocteno circadian temperature entrainment0.044
Tbp-1Tat-binding protein-10.043
ATPsyn-Cf6ATPase coupling factor 60.042
dre4CG1828 gene product from transcript CG1828-RB0.041
CG5262CG5262 gene product from transcript CG5262-RA0.041
Art4Arginine methyltransferase 40.040
DscamDown syndrome cell adhesion molecule0.039
Myd88CG2078 gene product from transcript CG2078-RA0.038
CG34110CG34110 gene product from transcript CG34110-RC0.038
FBX011FBX011 ortholog0.037
crolcrooked legs0.036
Mst77FMale-specific transcript 77F0.034
CG6412CG6412 gene product from transcript CG6412-RA0.034
PPP4R2rProtein phosphatase 4 regulatory subunit 2-related protein0.033
His3.3BHistone H3.3B0.033
Uba2Smt3 activating enzyme 20.033
Pkd2Polycystic kidney disease gene-20.033
betaTub85Dbeta-Tubulin at 85D0.031
CG5146CG5146 gene product from transcript CG5146-RA0.029
CG1103CG1103 gene product from transcript CG1103-RA0.028
GpdhGlycerol 3 phosphate dehydrogenase0.028
CG3776CG3776 gene product from transcript CG3776-RA0.027
Traf4TNF-receptor-associated factor 40.026
msl-1male-specific lethal 10.026
Sp7Serine protease 70.026
PGRP-LEPeptidoglycan recognition protein LE0.026
Atg13Autophagy-specific gene 130.026
Pvf2PDGF- and VEGF-related factor 20.025
CG10217CG10217 gene product from transcript CG10217-RB0.025
CG1236CG1236 gene product from transcript CG1236-RA0.025
CG2924CG2924 gene product from transcript CG2924-RA0.024
Tak1TGF-beta activated kinase 10.023
CG4612CG4612 gene product from transcript CG4612-RA0.023
CG9135CG9135 gene product from transcript CG9135-RB0.023
Cks85ACyclin-dependent kinase subunit 85A0.023
SAKSak kinase0.023
MESR6Misexpression suppressor of ras 60.022
Vps28Vacuolar protein sorting 280.022
CG2469CG2469 gene product from transcript CG2469-RB0.022
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.981
Tnftumor necrosis factor0.979
Casp4caspase 4, apoptosis-related cysteine peptidase0.833
Kitkit oncogene0.687
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.640
Leprleptin receptor0.487
PycardPYD and CARD domain containing0.397
Casp1caspase 10.365
Rb1retinoblastoma 10.318
Stat5asignal transducer and activator of transcription 5A0.303
Ighimmunoglobulin heavy chain complex0.289
Ikzf1IKAROS family zinc finger 10.262
Bcl2B-cell leukemia/lymphoma 20.259
FasFas (TNF receptor superfamily member 6)0.240
Vhlvon Hippel-Lindau tumor suppressor0.199
Cd44CD44 antigen0.185
Gbp5guanylate binding protein 50.176
BaxBCL2-associated X protein0.171
Mcl1myeloid cell leukemia sequence 10.163
Lyz2lysozyme 20.163
S100a9S100 calcium binding protein A9 (calgranulin B)0.162
Il2rginterleukin 2 receptor, gamma chain0.140
Stat5bsignal transducer and activator of transcription 5B0.127
FaddFas (TNFRSF6)-associated via death domain0.127
XiapX-linked inhibitor of apoptosis0.123
Rararetinoic acid receptor, alpha0.120
Ptpn2protein tyrosine phosphatase, non-receptor type 20.119
Ptenphosphatase and tensin homolog0.119
Irf9interferon regulatory factor 90.103
Cxcr5chemokine (C-X-C motif) receptor 50.103
Il1r1interleukin 1 receptor, type I0.103
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.100
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.090
Ptgs2prostaglandin-endoperoxide synthase 20.087
Myd88myeloid differentiation primary response gene 880.082
Mdm4transformed mouse 3T3 cell double minute 40.080
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.078
Il2rbinterleukin 2 receptor, beta chain0.077
Hspe1heat shock protein 1 (chaperonin 10)0.075
Ngpneutrophilic granule protein0.072
Il2interleukin 20.070
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.070
Rbl1retinoblastoma-like 1 (p107)0.069
Trp73transformation related protein 730.068
Coro1bcoronin, actin binding protein 1B0.068
Jak2Janus kinase 20.066
Socs1suppressor of cytokine signaling 10.065
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.065
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.064
Il10interleukin 100.060
S100a8S100 calcium binding protein A8 (calgranulin A)0.059
Il6stinterleukin 6 signal transducer0.055
Aim2absent in melanoma 20.055
Tgfb1transforming growth factor, beta 10.055
Ncoa3nuclear receptor coactivator 30.055
Casp3caspase 30.054
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.053
Cdkn1bcyclin-dependent kinase inhibitor 1B0.053
Map3k14mitogen-activated protein kinase kinase kinase 140.052
Id2inhibitor of DNA binding 20.052
Notch1Notch gene homolog 1 (Drosophila)0.052
Ptprcprotein tyrosine phosphatase, receptor type, C0.052
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.050
Il7interleukin 70.049
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.049
Il4rainterleukin 4 receptor, alpha0.049
Mfn2mitofusin 20.047
Trim21tripartite motif-containing 210.047
Wt1Wilms tumor 1 homolog0.046
Ilkintegrin linked kinase0.045
Notch2Notch gene homolog 2 (Drosophila)0.044
DaxxFas death domain-associated protein0.043
Stat2signal transducer and activator of transcription 20.043
Hif1ahypoxia inducible factor 1, alpha subunit0.043
Psen1presenilin 10.042
WwoxWW domain-containing oxidoreductase0.042
Bak1BCL2-antagonist/killer 10.041
Huwe1HECT, UBA and WWE domain containing 10.041
Arhgap1Rho GTPase activating protein 10.041
Stat3signal transducer and activator of transcription 30.040
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.040
Emx1empty spiracles homolog 1 (Drosophila)0.040
Lystlysosomal trafficking regulator0.039
Mdm2transformed mouse 3T3 cell double minute 20.039
Wdr1WD repeat domain 10.038
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.038
Ptch2patched homolog 20.038
E2f1E2F transcription factor 10.037
Tlr4toll-like receptor 40.037
Sqstm1sequestosome 10.037
Pold4polymerase (DNA-directed), delta 40.036
Casp7caspase 70.036
Ahraryl-hydrocarbon receptor0.036
Bcl2l1BCL2-like 10.035
Arandrogen receptor0.035
Esr1estrogen receptor 1 (alpha)0.035
Ep300E1A binding protein p3000.033
Rps3ribosomal protein S30.033
Ltblymphotoxin B0.033
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Jak1Janus kinase 10.034
Smad1SMAD family member 10.025
Psmd2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.021
Cyc1cytochrome c-10.018
Vegfavascular endothelial growth factor A0.018
CebpdCCAAT/enhancer binding protein (C/EBP), delta0.017
Rpn2ribophorin II0.017
Impdh2IMP (inosine monophosphate) dehydrogenase 20.017
Syt4synaptotagmin IV0.017
Zfp36zinc finger protein 360.017
Slc25a3solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 30.017
Dlstdihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)0.016
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.016
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.016
Casp3caspase 30.016
Pde4dphosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)0.016
Fuca1fucosidase, alpha-L- 1, tissue0.016
JunJun oncogene0.015
Nek9NIMA (never in mitosis gene a)- related kinase 90.015
Socs3suppressor of cytokine signaling 30.015
Il6interleukin 60.015
Creb1cAMP responsive element binding protein 10.014
Mmp8matrix metallopeptidase 80.014
Cplx1complexin 10.014
Acvr1activin A receptor, type I0.014
Tarsthreonyl-tRNA synthetase0.014
Pgk1phosphoglycerate kinase 10.014
Cyb5r1cytochrome b5 reductase 10.014
Cd38CD38 molecule0.013
Map4k4mitogen-activated protein kinase kinase kinase kinase 40.013
PawrPRKC, apoptosis, WT1, regulator0.013
Ssrp1structure specific recognition protein 10.013
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.013
Zfp36l1zinc finger protein 36, C3H type-like 10.013
Tgfbr3transforming growth factor, beta receptor III0.013
Top2btopoisomerase (DNA) II beta0.013
Ppardperoxisome proliferator-activated receptor delta0.013
Cct4chaperonin containing Tcp1, subunit 4 (delta)0.013
SnrkSNF related kinase0.013
Hspa8heat shock protein 80.013
Ckmt1creatine kinase, mitochondrial 10.013
Tlr4toll-like receptor 40.013
Atp6v1b2ATPase, H transporting, lysosomal V1 subunit B20.013
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.013
Map3k1mitogen activated protein kinase kinase kinase 10.013
Cyp4b1cytochrome P450, family 4, subfamily b, polypeptide 10.013
Wdr26WD repeat domain 260.013
Lig3ligase III, DNA, ATP-dependent0.012
Il2rbinterleukin 2 receptor, beta0.012
Irak3interleukin-1 receptor-associated kinase 30.012
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.012
Map3k8mitogen-activated protein kinase kinase kinase 80.012
Bcl2l1Bcl2-like 10.012
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.012
Cd14CD14 molecule0.012
Gadd45agrowth arrest and DNA-damage-inducible, alpha0.012
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.012
Parp9poly (ADP-ribose) polymerase family, member 90.012
Nat1N-acetyltransferase 10.012
Ralbv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.012
Bcl2l2Bcl2-like 20.012
Rgs3regulator of G-protein signaling 30.012
Enpp3ectonucleotide pyrophosphatase/phosphodiesterase 30.012
Csnk1g1casein kinase 1, gamma 10.012
Prrx1paired related homeobox 10.012
Casp2caspase 20.012
Il1r1interleukin 1 receptor, type I0.012
Nxph4neurexophilin 40.012
B2mbeta-2 microglobulin0.012
Myo1bmyosin Ib0.012
Cd247Cd247 molecule0.012
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.012
Hdlbphigh density lipoprotein binding protein0.012
Casp4caspase 4, apoptosis-related cysteine peptidase0.012
Gfi1growth factor independent 1 transcription repressor0.011
Hexahexosaminidase A0.011
Calcrlcalcitonin receptor-like0.011
Slfn2schlafen 20.011
Gmeb2glucocorticoid modulatory element binding protein 20.011
Tgfbr1transforming growth factor, beta receptor 10.011
Smc1astructural maintenance of chromosomes 1A0.011
Prkchprotein kinase C, eta0.011
Chd6chromodomain helicase DNA binding protein 60.011
Gabrb1gamma-aminobutyric acid (GABA) A receptor, beta 10.011
Icosinducible T-cell co-stimulator0.011
Eif3feukaryotic translation initiation factor 3, subunit F0.011
Cct7chaperonin containing Tcp1, subunit 7 (eta)0.011
Adaradenosine deaminase, RNA-specific0.011
Xdhxanthine dehydrogenase0.011
MaxMYC associated factor X0.011
Sfrp4secreted frizzled-related protein 40.011
Rpl22ribosomal protein L220.011
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.011
Gja3gap junction protein, alpha 30.011
Cishcytokine inducible SH2-containing protein0.011
RT1-A3RT1 class I, locus A30.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism