The network for 'signal release' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

signal release

The process in which a signal is secreted or discharged into the extracellular medium from a cellular source.

NameDescriptionProbabilityFunc Analog Organism
SNAP23synaptosomal-associated protein, 23kDa0.895
PDX1pancreatic and duodenal homeobox 10.894
ZFYVE9zinc finger, FYVE domain containing 90.887
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.870
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.864
KCNJ4potassium inwardly-rectifying channel, subfamily J, member 40.849
TEKTEK tyrosine kinase, endothelial0.825
C1QAcomplement component 1, q subcomponent, A chain0.819
DRD2dopamine receptor D20.804
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.804
VAMP3vesicle-associated membrane protein 3 (cellubrevin)0.782
NAPAN-ethylmaleimide-sensitive factor attachment protein, alpha0.758
SMAD2SMAD family member 20.734
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.728
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.699
EP300E1A binding protein p3000.689
HNF4Ahepatocyte nuclear factor 4, alpha0.677
EGFRepidermal growth factor receptor0.611
GSK3Bglycogen synthase kinase 3 beta0.581
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.567
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.566
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.561
CCR5chemokine (C-C motif) receptor 50.529
SNAP25synaptosomal-associated protein, 25kDa0.498
HSPA1Bheat shock 70kDa protein 1B0.496
CRHR1corticotropin releasing hormone receptor 10.489
CAPNS1calpain, small subunit 10.484
DVL3dishevelled, dsh homolog 3 (Drosophila)0.479
FGAfibrinogen alpha chain0.479
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.473
ATN1atrophin 10.472
FGBfibrinogen beta chain0.469
IGF1Rinsulin-like growth factor 1 receptor0.456
CCL4chemokine (C-C motif) ligand 40.450
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.425
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.423
PRKCAprotein kinase C, alpha0.405
ARRB1arrestin, beta 10.379
MPDZmultiple PDZ domain protein0.354
CCNYcyclin Y0.345
KAT2BK(lysine) acetyltransferase 2B0.340
OCRLoculocerebrorenal syndrome of Lowe0.335
MT1Ametallothionein 1A0.330
HLA-DRB5major histocompatibility complex, class II, DR beta 50.325
FBLN1fibulin 10.307
PTPN1protein tyrosine phosphatase, non-receptor type 10.301
STX5syntaxin 50.294
NEUROD1neurogenic differentiation 10.294
LIN7Blin-7 homolog B (C. elegans)0.277
CHD8chromodomain helicase DNA binding protein 80.272
HSPA1Aheat shock 70kDa protein 1A0.256
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.256
GATA4GATA binding protein 40.249
KCNE1potassium voltage-gated channel, Isk-related family, member 10.247
CLASP1cytoplasmic linker associated protein 10.246
PSEN2presenilin 2 (Alzheimer disease 4)0.244
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.238
DLG4discs, large homolog 4 (Drosophila)0.229
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.225
SNCAsynuclein, alpha (non A4 component of amyloid precursor)0.225
SREBF2sterol regulatory element binding transcription factor 20.223
BLNKB-cell linker0.221
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.213
CCL8chemokine (C-C motif) ligand 80.213
MAPTmicrotubule-associated protein tau0.211
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.211
ADORA2Aadenosine A2a receptor0.207
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.201
KIF5Bkinesin family member 5B0.200
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.198
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.191
NKX2-1NK2 homeobox 10.187
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.183
CRHcorticotropin releasing hormone0.182
CXCL9chemokine (C-X-C motif) ligand 90.182
IL1R1interleukin 1 receptor, type I0.181
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.176
YY1YY1 transcription factor0.174
MARCOmacrophage receptor with collagenous structure0.173
CAPZA2capping protein (actin filament) muscle Z-line, alpha 20.173
ONECUT1one cut homeobox 10.170
C1QCcomplement component 1, q subcomponent, C chain0.170
ESRRGestrogen-related receptor gamma0.169
PTGER3prostaglandin E receptor 3 (subtype EP3)0.169
CDX2caudal type homeobox 20.165
GNB2guanine nucleotide binding protein (G protein), beta polypeptide 20.165
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.163
ARRB2arrestin, beta 20.162
SSTR2somatostatin receptor 20.161
C1QBcomplement component 1, q subcomponent, B chain0.158
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.155
WIPF1WAS/WASL interacting protein family, member 10.153
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.150
LATlinker for activation of T cells0.146
GABBR2gamma-aminobutyric acid (GABA) B receptor, 20.146
MAP3K5mitogen-activated protein kinase kinase kinase 50.146
IL8interleukin 80.145
NSFN-ethylmaleimide-sensitive factor0.145
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
unc-9Protein UNC-90.590
pkg-1Protein PKG-10.239
unc-13Protein UNC-130.228
cyp-35C1Protein CYP-35C10.218
goa-1Protein GOA-10.191
egl-36Protein EGL-360.190
nlg-1Protein NLG-10.178
unc-32Protein UNC-320.144
cyp-35A3Protein CYP-35A30.092
pdfr-1Protein PDFR-10.091
egl-5Protein EGL-50.078
gar-3Protein GAR-30.074
unc-54Protein UNC-540.074
egl-26Protein EGL-260.073
C33A11.1Protein C33A11.10.073
unc-47Protein UNC-470.072
eat-6Protein EAT-60.070
egl-30Protein EGL-300.067
F54G2.1Protein F54G2.10.065
rpy-1Protein RPY-10.059
unc-80Protein UNC-800.059
unc-17Protein UNC-170.058
ist-1Protein IST-10.057
rpm-1Protein RPM-10.057
nrx-1Protein NRX-10.056
lin-11Protein LIN-110.050
egl-23Protein EGL-230.048
madd-4Protein MADD-40.048
cal-4Protein CAL-40.047
hlh-11Protein HLH-110.046
cyp-35A2Protein CYP-35A20.045
nhr-202Protein NHR-2020.044
cmd-1Protein CMD-10.044
unc-10Protein UNC-100.043
magi-1Protein MAGI-10.043
frm-3Protein FRM-30.042
pkn-1Protein PKN-10.042
CELE_T13H5.1Protein T13H5.10.040
eat-4Protein EAT-40.040
nhr-122Protein NHR-1220.040
unc-79Protein UNC-790.040
itr-1Protein ITR-10.039
daf-1Protein DAF-10.039
unc-53Protein UNC-530.038
ugt-20Protein UGT-200.038
clic-1Protein CLIC-10.037
CELE_C29F7.2Protein C29F7.20.036
mrp-1Protein MRP-10.036
unc-36Protein UNC-360.036
aat-5Protein AAT-50.036
prkl-1Protein PRKL-10.035
egl-3Protein EGL-30.035
fbxc-5Protein FBXC-50.035
inx-1Protein INX-10.035
rskn-2Protein RSKN-20.035
flt-1Protein FLT-10.034
sng-1Protein SNG-10.034
glr-5Protein GLR-50.034
Y95B8A.12Protein Y95B8A.120.033
let-23Protein LET-230.033
vab-3Protein VAB-30.033
cyp-35A5Protein CYP-35A50.033
nra-3Protein NRA-30.032
egl-15Protein EGL-150.032
tbck-1Protein TBCK-10.032
dyc-1Protein DYC-10.032
snx-14Protein SNX-140.032
daf-11Protein DAF-110.032
unc-76Protein UNC-760.031
trp-1Protein TRP-10.031
gln-1Protein GLN-10.031
rab-3Protein RAB-30.031
dyb-1Protein DYB-10.030
ida-1Protein IDA-10.030
CELE_F28H1.1Protein F28H1.10.029
attf-4Protein ATTF-40.028
unc-49Protein UNC-490.028
B0491.5Protein B0491.50.028
ntl-4Protein NTL-40.028
pes-7Protein PES-70.028
lin-40Protein LIN-400.027
plc-1Protein PLC-10.027
lin-10Protein LIN-100.027
K02F2.5Protein K02F2.50.027
T23B12.6Protein T23B12.60.027
T05F1.11Protein T05F1.110.026
flp-7Protein FLP-70.026
myo-6Protein MYO-60.026
cit-1.2Protein CIT-1.20.026
F44A2.5Protein F44A2.50.026
F28E10.1Protein F28E10.10.026
oig-1Protein OIG-10.025
C06G3.6Protein C06G3.60.025
mab-9Protein MAB-90.025
egl-27Protein EGL-270.025
grk-2Protein GRK-20.024
M04C3.1Protein M04C3.10.024
ztf-17Protein ZTF-170.024
F10C2.3Protein F10C2.30.023
unc-11Protein UNC-110.023
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
GluRIIAGlutamate receptor IIA1.000
CaMKIICalcium/calmodulin-dependent protein kinase II0.984
witwishful thinking0.961
fz2frizzled 20.934
Syt1Synaptotagmin 10.829
Snap25Synapse protein 250.827
par-1CG8201 gene product from transcript CG8201-RA0.779
Pka-C1cAMP-dependent protein kinase 10.776
norpAno receptor potential A0.751
KaiRIACG18039 gene product from transcript CG18039-RA0.739
unc-13CG2999 gene product from transcript CG2999-RA0.667
Frq1Frequenin 10.664
unc-104CG8566 gene product from transcript CG8566-RB0.616
rtGEFrho-type guanine exchange factor0.587
Nrx-1Neurexin 10.559
RalaRas-related protein0.503
CatsupCatecholamines up0.486
CkIIalphaCasein kinase II alpha subunit0.478
AceAcetylcholine esterase0.474
faffat facets0.431
PP2A-B'CG7913 gene product from transcript CG7913-RK0.393
CG31146CG31146 gene product from transcript CG31146-RD0.388
gbbglass bottom boat0.362
HDAC6CG6170 gene product from transcript CG6170-RA0.361
neuroliginCG13772 gene product from transcript CG13772-RA0.358
cv-ccrossveinless c0.329
LrrkLeucine-rich repeat kinase0.289
Syx1ASyntaxin 1A0.283
Cip4CG15015 gene product from transcript CG15015-RA0.279
Frq2Frequenin 20.262
G-oalpha47AG protein oalpha 47A0.253
CanA1Calcineurin A10.249
Ank2Ankyrin 20.244
alpha-Specalpha Spectrin0.235
eyseyes shut0.233
ShawShaker cognate w0.229
Dap160Dynamin associated protein 1600.227
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.202
Src64BSrc oncogene at 64B0.202
TbhTyramine beta hydroxylase0.193
cicubitus interruptus0.191
AdoRAdenosine receptor0.190
SnapSoluble NSF attachment protein0.184
dcodiscs overgrown0.183
VAChTCG32848 gene product from transcript CG32848-RA0.178
Ork1Open rectifier K[+] channel 10.163
CG34139CG34139 gene product from transcript CG34139-RD0.157
Cdk5alphaCdk5 activator-like protein0.157
ImpIGF-II mRNA-binding protein0.145
PgkPhosphoglycerate kinase0.144
Smg1CG32743 gene product from transcript CG32743-RA0.137
gfAgiant fibre A0.135
Eip63F-1Ecdysone-induced protein 63F 10.127
Sema-1aCG18405 gene product from transcript CG18405-RD0.125
G-salpha60AG protein salpha 60A0.122
tomosynCG17762 gene product from transcript CG17762-RB0.122
Unc-76CG3981 gene product from transcript CG3981-RB0.119
CG32635CG32635 gene product from transcript CG32635-RA0.117
pAbppolyA-binding protein0.113
CG34400CG34400 gene product from transcript CG34400-RD0.112
Plc21CPhospholipase C at 21C0.108
E23Early gene at 230.107
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.104
stmAstambha A0.103
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.101
NFATNFAT homolog0.098
Src42ASrc oncogene at 42A0.097
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.772
Glp1rglucagon-like peptide 1 receptor0.768
Ins2insulin 20.644
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.566
Rims1regulating synaptic membrane exocytosis 10.542
Csf1colony stimulating factor 1 (macrophage)0.522
Grin2dglutamate receptor, ionotropic, N-methyl D-aspartate 2D0.503
F2rl1coagulation factor II (thrombin) receptor-like 10.444
Phkg1phosphorylase kinase, gamma 10.441
Chrna7cholinergic receptor, nicotinic, alpha 70.418
FevFEV (ETS oncogene family)0.412
Casp3caspase 30.409
Prdm2PR domain containing 2, with ZNF domain0.405
Thtyrosine hydroxylase0.395
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.391
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.386
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.378
Gng7guanine nucleotide binding protein (G protein), gamma 70.372
GperG protein-coupled estrogen receptor 10.367
Avparginine vasopressin0.367
Crhr1corticotropin releasing hormone receptor 10.352
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.344
Ascl1achaete-scute complex homolog 1 (Drosophila)0.331
Myt1lmyelin transcription factor 1-like0.323
Tshbthyroid stimulating hormone, beta0.308
Apba2amyloid beta (A4) precursor protein-binding, family A, member 20.300
Vamp2vesicle-associated membrane protein 20.298
Arrb1arrestin, beta 10.298
Gnao1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.296
RGD1310262hypothetical LOC3046500.293
Anxa5annexin A50.291
Prlhrprolactin releasing hormone receptor0.290
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.281
Hpcal4hippocalcin-like 40.281
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.274
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.270
Grm5glutamate receptor, metabotropic 50.262
Kcnk3potassium channel, subfamily K, member 30.262
B3gat1beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)0.260
Ptprz1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.256
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.250
Mapre1microtubule-associated protein, RP/EB family, member 10.247
Cxcr5chemokine (C-X-C motif) receptor 50.245
Ush1cUsher syndrome 1C homolog (human)0.245
Fam108b1family with sequence similarity 108, member B10.239
Tnrtenascin R0.238
Prss3protease, serine, 30.236
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.235
Unc13cunc-13 homolog C (C. elegans)0.235
Cnga4cyclic nucleotide gated channel alpha 40.233
Neurod2neurogenic differentiation 20.232
Cckbrcholecystokinin B receptor0.227
Mllt4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.227
Celsr3cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)0.227
Gabra6gamma-aminobutyric acid (GABA) A receptor, alpha 60.225
Ppyr1pancreatic polypeptide receptor 10.224
Gabrdgamma-aminobutyric acid (GABA) A receptor, delta0.223
Grm6glutamate receptor, metabotropic 60.220
Unc5aunc-5 homolog A (C. elegans)0.212
Serp1stress-associated endoplasmic reticulum protein 10.209
Magi1membrane associated guanylate kinase, WW and PDZ domain containing 10.208
Pecam1platelet/endothelial cell adhesion molecule 10.206
Itgamintegrin, alpha M0.206
Lifleukemia inhibitory factor0.205
Slc14a2solute carrier family 14 (urea transporter), member 20.200
Jak2Janus kinase 20.199
Il23aInterleukin 23, alpha subunit p190.197
Cntn3contactin 3 (plasmacytoma associated)0.196
Dlg4discs, large homolog 4 (Drosophila)0.195
Htr2a5-hydroxytryptamine (serotonin) receptor 2A0.195
Prlrprolactin receptor0.194
Acrv1acrosomal vesicle protein 10.193
Prg2proteoglycan 2, bone marrow0.188
Pnpla8patatin-like phospholipase domain containing 80.187
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.187
Pspparotid secretory protein0.186
Rgs9regulator of G-protein signaling 90.185
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.182
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.182
Slco2a1solute carrier organic anion transporter family, member 2a10.180
Tmem79transmembrane protein 790.178
Pde3aphosphodiesterase 3A, cGMP inhibited0.175
Slc24a2solute carrier family 24 (sodium/potassium/calcium exchanger), member 20.175
Tnp1transition protein 10.174
Stx1asyntaxin 1A (brain)0.173
CamkvCaM kinase-like vesicle-associated0.172
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.172
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.171
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.171
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.170
Ppp2caprotein phosphatase 2, catalytic subunit, alpha isoform0.169
Gabra3gamma-aminobutyric acid (GABA) A receptor, alpha 30.167
Trhr2thyrotropin releasing hormone receptor 20.165
Syt4synaptotagmin IV0.165
Kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.164
Smgbneonatal submandibular gland protein B0.164
Lin7clin-7 homolog C (C. elegans)0.163
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.163
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism