The network for 'regulation of smad protein import into nucleus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of smad protein import into nucleus

Any process that modulates the rate, frequency or extent of SMAD protein import into the nucleus, i.e. the directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

NameDescriptionProbabilityFunc Analog Organism
TGFB1transforming growth factor, beta 11.000
TGFBR2transforming growth factor, beta receptor II (70/80kDa)1.000
BMPR1Abone morphogenetic protein receptor, type IA0.999
SMAD7SMAD family member 70.997
SMAD2SMAD family member 20.984
BMP2bone morphogenetic protein 20.979
FSTL1follistatin-like 10.976
ENGendoglin0.971
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.969
FKBP1AFK506 binding protein 1A, 12kDa0.948
TGFBR1transforming growth factor, beta receptor 10.938
TGFB3transforming growth factor, beta 30.899
SP1Sp1 transcription factor0.895
SMAD3SMAD family member 30.886
SMURF2SMAD specific E3 ubiquitin protein ligase 20.869
BMPR1Bbone morphogenetic protein receptor, type IB0.843
WWP2WW domain containing E3 ubiquitin protein ligase 20.824
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.823
PAX3paired box 30.673
GDF5growth differentiation factor 50.643
SOX10SRY (sex determining region Y)-box 100.628
FOXD3forkhead box D30.587
NRP1neuropilin 10.426
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.319
ACVR1activin A receptor, type I0.246
SOX2SRY (sex determining region Y)-box 20.178
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.170
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.166
ZFYVE9zinc finger, FYVE domain containing 90.144
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.130
SMAD1SMAD family member 10.122
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.107
HCFC1host cell factor C1 (VP16-accessory protein)0.107
NOGnoggin0.100
SHC1SHC (Src homology 2 domain containing) transforming protein 10.095
SMAD4SMAD family member 40.073
PRKG1protein kinase, cGMP-dependent, type I0.068
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.054
BMP4bone morphogenetic protein 40.054
TEAD1TEA domain family member 1 (SV40 transcriptional enhancer factor)0.048
SMAD6SMAD family member 60.046
RBFOX1RNA binding protein, fox-1 homolog (C. elegans) 10.044
SMURF1SMAD specific E3 ubiquitin protein ligase 10.043
TJP1tight junction protein 1 (zona occludens 1)0.038
ACVR2Bactivin A receptor, type IIB0.036
RXRAretinoid X receptor, alpha0.035
AMOTL1angiomotin like 10.033
TGFBR3transforming growth factor, beta receptor III0.029
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.027
PTPN14protein tyrosine phosphatase, non-receptor type 140.026
ZEB2zinc finger E-box binding homeobox 20.026
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.025
PDLIM4PDZ and LIM domain 40.025
THBS1thrombospondin 10.024
PIAS4protein inhibitor of activated STAT, 40.024
HMGA1high mobility group AT-hook 10.022
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.022
TJP2tight junction protein 2 (zona occludens 2)0.021
TEAD4TEA domain family member 40.020
HTThuntingtin0.019
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.018
MEOX2mesenchyme homeobox 20.018
SMAD5SMAD family member 50.017
QKIquaking homolog, KH domain RNA binding (mouse)0.016
MYO6myosin VI0.016
SOX21SRY (sex determining region Y)-box 210.015
EYA2eyes absent homolog 2 (Drosophila)0.015
NCOR1nuclear receptor corepressor 10.015
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.014
ZMYND11zinc finger, MYND-type containing 110.013
SOX1SRY (sex determining region Y)-box 10.013
EP300E1A binding protein p3000.013
AMOTangiomotin0.012
KLF5Kruppel-like factor 5 (intestinal)0.012
ATXN1ataxin 10.012
CXXC5CXXC finger protein 50.011
ATF7IPactivating transcription factor 7 interacting protein0.011
AMOTL2angiomotin like 20.011
SOX11SRY (sex determining region Y)-box 110.011
DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila)0.011
TGFB2transforming growth factor, beta 20.011
C9orf100chromosome 9 open reading frame 1000.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 11.000
Smad3MAD homolog 3 (Drosophila)1.000
Apcadenomatosis polyposis coli0.995
Smad4MAD homolog 4 (Drosophila)0.977
Trp53transformation related protein 530.973
Smad2MAD homolog 2 (Drosophila)0.971
Tgfbr2transforming growth factor, beta receptor II0.970
Acvr1activin A receptor, type 10.960
Ptenphosphatase and tensin homolog0.950
Axin1axin 10.941
Col1a1collagen, type I, alpha 10.938
Fgfr2fibroblast growth factor receptor 20.938
Yap1yes-associated protein 10.932
Vegfavascular endothelial growth factor A0.846
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.827
Tgfb2transforming growth factor, beta 20.800
Ptpn11protein tyrosine phosphatase, non-receptor type 110.758
Bmpr1abone morphogenetic protein receptor, type 1A0.693
Il6stinterleukin 6 signal transducer0.651
Thbs1thrombospondin 10.622
Fgfr1fibroblast growth factor receptor 10.608
Bmp4bone morphogenetic protein 40.585
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.564
Leprleptin receptor0.530
Map3k7mitogen-activated protein kinase kinase kinase 70.493
Nos3nitric oxide synthase 3, endothelial cell0.445
Ptgs2prostaglandin-endoperoxide synthase 20.437
Erbb2ipErbb2 interacting protein0.429
Gata4GATA binding protein 40.414
Gsk3bglycogen synthase kinase 3 beta0.402
Gata6GATA binding protein 60.361
Stat3signal transducer and activator of transcription 30.353
BrafBraf transforming gene0.349
Csf1colony stimulating factor 1 (macrophage)0.345
Vdrvitamin D receptor0.329
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.304
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.303
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.282
Ptch1patched homolog 10.278
Itgb1integrin beta 1 (fibronectin receptor beta)0.233
Foxc1forkhead box C10.225
Gli3GLI-Kruppel family member GLI30.222
Nr3c1nuclear receptor subfamily 3, group C, member 10.216
Amotl2angiomotin-like 20.207
Adam17a disintegrin and metallopeptidase domain 170.192
Rnf111ring finger 1110.187
Kitlkit ligand0.186
Shhsonic hedgehog0.185
Smurf1SMAD specific E3 ubiquitin protein ligase 10.183
Prkg1protein kinase, cGMP-dependent, type I0.165
Lrp5low density lipoprotein receptor-related protein 50.162
Hspg2perlecan (heparan sulfate proteoglycan 2)0.158
Hif1ahypoxia inducible factor 1, alpha subunit0.158
Rxraretinoid X receptor alpha0.158
Sox9SRY-box containing gene 90.152
Vhlvon Hippel-Lindau tumor suppressor0.149
Meox2mesenchyme homeobox 20.147
Pknox1Pbx/knotted 1 homeobox0.142
XiapX-linked inhibitor of apoptosis0.128
Gpc3glypican 30.127
Bmp2bone morphogenetic protein 20.122
Tbx3T-box 30.120
Wwc2WW, C2 and coiled-coil domain containing 20.114
Nf1neurofibromatosis 10.100
Tgfbr1transforming growth factor, beta receptor I0.100
Twsg1twisted gastrulation homolog 1 (Drosophila)0.098
Stk11serine/threonine kinase 110.098
Kitkit oncogene0.097
Hhexhematopoietically expressed homeobox0.095
Epas1endothelial PAS domain protein 10.094
Fgfr3fibroblast growth factor receptor 30.094
Tgfbr3transforming growth factor, beta receptor III0.094
Smad1MAD homolog 1 (Drosophila)0.093
Shc1src homology 2 domain-containing transforming protein C10.092
Sall1sal-like 1 (Drosophila)0.088
Efnb1ephrin B10.085
H2afxH2A histone family, member X0.085
Smad7MAD homolog 7 (Drosophila)0.084
Tlr4toll-like receptor 40.083
Gja1gap junction protein, alpha 10.080
Fzd7frizzled homolog 7 (Drosophila)0.080
Tgfb1transforming growth factor, beta 10.079
Fzd4frizzled homolog 4 (Drosophila)0.077
Cd44CD44 antigen0.076
Tcfcp2l1transcription factor CP2-like 10.076
Ptpn14protein tyrosine phosphatase, non-receptor type 140.075
Sall4sal-like 4 (Drosophila)0.073
Wwtr1WW domain containing transcription regulator 10.072
Fzd1frizzled homolog 1 (Drosophila)0.070
Fermt2fermitin family homolog 2 (Drosophila)0.069
Rargretinoic acid receptor, gamma0.069
Pkd1polycystic kidney disease 1 homolog0.066
Hes1hairy and enhancer of split 1 (Drosophila)0.066
Bmp7bone morphogenetic protein 70.065
Smad6MAD homolog 6 (Drosophila)0.062
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.062
Ece1endothelin converting enzyme 10.061
Angptl2angiopoietin-like 20.060
Smosmoothened homolog (Drosophila)0.059
Pik3c2aphosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide0.058
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism