The network for 'positive regulation of phosphatidylinositol 3 kinase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of phosphatidylinositol 3 kinase activity

Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.

NameDescriptionProbabilityFunc Analog Organism
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)1.000
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1.000
FGFR2fibroblast growth factor receptor 21.000
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.998
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.995
FGF1fibroblast growth factor 1 (acidic)0.995
SHC1SHC (Src homology 2 domain containing) transforming protein 10.990
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.974
VEGFAvascular endothelial growth factor A0.971
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.965
GRB2growth factor receptor-bound protein 20.928
EGFRepidermal growth factor receptor0.927
GRB7growth factor receptor-bound protein 70.889
PLCG1phospholipase C, gamma 10.881
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.837
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.720
FGFR1fibroblast growth factor receptor 10.706
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.650
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.593
CCR5chemokine (C-C motif) receptor 50.572
NRP1neuropilin 10.558
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.539
LATlinker for activation of T cells0.522
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.439
PGFplacental growth factor0.268
ANGPT2angiopoietin 20.250
INSRinsulin receptor0.224
SHC2SHC (Src homology 2 domain containing) transforming protein 20.209
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.185
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.167
ANGPT1angiopoietin 10.077
PIK3R3phosphoinositide-3-kinase, regulatory subunit 3 (gamma)0.075
BLNKB-cell linker0.070
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.068
DPP4dipeptidyl-peptidase 40.064
CCL4chemokine (C-C motif) ligand 40.062
CCL2chemokine (C-C motif) ligand 20.061
ENGendoglin0.060
MED28mediator complex subunit 280.058
FGF10fibroblast growth factor 100.057
FRS2fibroblast growth factor receptor substrate 20.055
CXCL9chemokine (C-X-C motif) ligand 90.055
GRB10growth factor receptor-bound protein 100.054
IL8interleukin 80.054
VAV1vav 1 guanine nucleotide exchange factor0.050
VAV3vav 3 guanine nucleotide exchange factor0.049
SYKspleen tyrosine kinase0.044
CDH5cadherin 5, type 2 (vascular endothelium)0.042
FYNFYN oncogene related to SRC, FGR, YES0.040
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.037
PDGFAplatelet-derived growth factor alpha polypeptide0.034
SPRR2Asmall proline-rich protein 2A0.034
IGF1Rinsulin-like growth factor 1 receptor0.034
CCL13chemokine (C-C motif) ligand 130.033
PDCD6IPprogrammed cell death 6 interacting protein0.031
FGF2fibroblast growth factor 2 (basic)0.031
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.030
CCL8chemokine (C-C motif) ligand 80.029
IL6interleukin 6 (interferon, beta 2)0.027
PTPRBprotein tyrosine phosphatase, receptor type, B0.026
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.026
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.026
CXCL3chemokine (C-X-C motif) ligand 30.023
TNFtumor necrosis factor0.022
GAB2GRB2-associated binding protein 20.021
MATKmegakaryocyte-associated tyrosine kinase0.021
ITKIL2-inducible T-cell kinase0.021
NRG1neuregulin 10.020
SH3RF3SH3 domain containing ring finger 30.020
SHC3SHC (Src homology 2 domain containing) transforming protein 30.020
TGFB3transforming growth factor, beta 30.020
GAS7growth arrest-specific 70.019
CCL19chemokine (C-C motif) ligand 190.019
CXCL2chemokine (C-X-C motif) ligand 20.018
IL1Binterleukin 1, beta0.018
CCR7chemokine (C-C motif) receptor 70.018
IL7Rinterleukin 7 receptor0.017
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.016
SH3BP2SH3-domain binding protein 20.016
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.016
ZNF746zinc finger protein 7460.016
CXCL13chemokine (C-X-C motif) ligand 130.015
DLG4discs, large homolog 4 (Drosophila)0.015
AKT2v-akt murine thymoma viral oncogene homolog 20.015
KITLGKIT ligand0.015
SLASrc-like-adaptor0.015
TNS4tensin 40.015
PDGFCplatelet derived growth factor C0.014
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.014
TNS3tensin 30.013
CCR1chemokine (C-C motif) receptor 10.013
PIK3CAphosphoinositide-3-kinase, catalytic, alpha polypeptide0.013
GAB1GRB2-associated binding protein 10.013
CTGFconnective tissue growth factor0.012
WIPF1WAS/WASL interacting protein family, member 10.012
IBTKinhibitor of Bruton agammaglobulinemia tyrosine kinase0.011
FGF7fibroblast growth factor 70.011
CHN2chimerin (chimaerin) 20.011
HCKhemopoietic cell kinase0.011
CCL5chemokine (C-C motif) ligand 50.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Klk1b5kallikrein 1-related peptidase b50.914
Klk1b8kallikrein 1-related peptidase b80.819
Efnb2ephrin B20.785
Klk1b1kallikrein 1-related peptidase b10.729
Klk1b26kallikrein 1-related petidase b260.636
Klk1kallikrein 10.567
2210010C04RikRIKEN cDNA 2210010C04 gene0.514
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.486
Klk1b21kallikrein 1-related peptidase b210.459
Cd19CD19 antigen0.435
Klk1b11kallikrein 1-related peptidase b110.412
Klk1b16kallikrein 1-related peptidase b160.400
Irs1insulin receptor substrate 10.390
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.387
Nos3nitric oxide synthase 3, endothelial cell0.360
Ghrgrowth hormone receptor0.252
Leprleptin receptor0.237
Ephb2Eph receptor B20.208
Cela2achymotrypsin-like elastase family, member 2A0.201
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.198
Try5trypsin 50.194
Csf1colony stimulating factor 1 (macrophage)0.187
Hcls1hematopoietic cell specific Lyn substrate 10.179
CblCasitas B-lineage lymphoma0.169
Klk1b24kallikrein 1-related peptidase b240.166
Klk1b9kallikrein 1-related peptidase b90.151
Klk1b4kallikrein 1-related pepidase b40.139
Klk1b27kallikrein 1-related peptidase b270.135
Ptprcprotein tyrosine phosphatase, receptor type, C0.135
Cd44CD44 antigen0.128
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.123
BlnkB-cell linker0.119
Ins2insulin II0.117
Grb10growth factor receptor bound protein 100.116
Plcg1phospholipase C, gamma 10.114
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.103
FynFyn proto-oncogene0.102
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.097
Klk1b3kallikrein 1-related peptidase b30.095
Tgfb1transforming growth factor, beta 10.095
Rnase1ribonuclease, RNase A family, 1 (pancreatic)0.081
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.080
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.074
Prkceprotein kinase C, epsilon0.073
WasWiskott-Aldrich syndrome homolog (human)0.065
Nrp1neuropilin 10.065
Grb2growth factor receptor bound protein 20.058
Try10trypsin 100.051
Vav1vav 1 oncogene0.050
Dab1disabled homolog 1 (Drosophila)0.050
Shank3SH3/ankyrin domain gene 30.050
Sykbspleen tyrosine kinase0.049
5430421N21RikRIKEN cDNA 5430421N21 gene0.048
Lyz2lysozyme 20.047
Ctrb1chymotrypsinogen B10.047
Zg16zymogen granule protein 160.044
Ptpreprotein tyrosine phosphatase, receptor type, E0.040
Rac1RAS-related C3 botulinum substrate 10.040
Prss3protease, serine, 30.039
Ncf1neutrophil cytosolic factor 10.038
Nphp3nephronophthisis 3 (adolescent)0.038
Cuzd1CUB and zona pellucida-like domains 10.037
Ptpn6protein tyrosine phosphatase, non-receptor type 60.036
Nf1neurofibromatosis 10.035
Clpscolipase, pancreatic0.034
Cdkn1ccyclin-dependent kinase inhibitor 1C (P57)0.034
SrcRous sarcoma oncogene0.033
Insrinsulin receptor0.033
Ptk2PTK2 protein tyrosine kinase 20.033
Epha4Eph receptor A40.032
Mmp9matrix metallopeptidase 90.031
Reg2regenerating islet-derived 20.030
Ctnnb1catenin (cadherin associated protein), beta 10.030
Kiss1KiSS-1 metastasis-suppressor0.029
Efsembryonal Fyn-associated substrate0.028
Fzd2frizzled homolog 2 (Drosophila)0.028
Prss2protease, serine, 20.028
Apoeapolipoprotein E0.028
Bcar1breast cancer anti-estrogen resistance 10.027
Unc93b1unc-93 homolog B1 (C. elegans)0.026
Sema3fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F0.026
Spry4sprouty homolog 4 (Drosophila)0.025
Il6stinterleukin 6 signal transducer0.025
Epha2Eph receptor A20.025
2310002J15RikRIKEN cDNA 2310002J15 gene0.025
Pxnpaxillin0.025
Itgb2integrin beta 20.025
PycardPYD and CARD domain containing0.025
Arhgap1Rho GTPase activating protein 10.023
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.023
Asap1ArfGAP with SH# domain, ankyrin repeat and PH domain10.022
Tgfbr2transforming growth factor, beta receptor II0.021
Pthlhparathyroid hormone-like peptide0.021
Efnb1ephrin B10.021
Crb3crumbs homolog 3 (Drosophila)0.020
Cd37CD37 antigen0.020
Egfbp2epidermal growth factor binding protein type B0.020
Iappislet amyloid polypeptide0.020
Notch2Notch gene homolog 2 (Drosophila)0.020
Gpc3glypican 30.020
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Sirpasignal-regulatory protein alpha0.261
Klk1c10l2kallikrein 1-related peptidase c10-like 20.129
Tpothyroid peroxidase0.104
Prkcdprotein kinase C, delta0.088
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.086
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.083
Ptprcprotein tyrosine phosphatase, receptor type, C0.081
Klk8kallikrein related-peptidase 80.077
Il2rginterleukin 2 receptor, gamma0.074
Nos3nitric oxide synthase 3, endothelial cell0.073
Plcg2phospholipase C, gamma 20.073
RT1-DOaRT1 class II, locus DOa0.068
Arf6ADP-ribosylation factor 60.068
Ptger4prostaglandin E receptor 4 (subtype EP4)0.066
Ptpn6protein tyrosine phosphatase, non-receptor type 60.064
Inpp5dinositol polyphosphate-5-phosphatase D0.064
Pik3r1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.063
Bhlha15basic helix-loop-helix family, member a150.062
Mobkl2aMOB1, Mps One Binder kinase activator-like 2A (yeast)0.061
Cd37CD37 molecule0.060
Adra2badrenergic, alpha-2B-, receptor0.058
CblCas-Br-M (murine) ecotropic retroviral transforming sequence0.057
Fgfr1Fibroblast growth factor receptor 10.054
Pdgfdplatelet-derived growth factor, D polypeptide0.052
Fam26ffamily with sequence similarity 26, member F0.048
Tpm3tropomyosin 3, gamma0.047
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.046
Hprt1hypoxanthine phosphoribosyltransferase 10.043
Vav1vav 1 guanine nucleotide exchange factor0.043
Stat6signal transducer and activator of transcription 60.043
Hoxc4homeo box C40.043
Il2rbinterleukin 2 receptor, beta0.042
Myo1gmyosin IG0.039
Bak1BCL2-antagonist/killer 10.039
Klk1b21kallikrein 1-related peptidase b210.038
LOC100361261rCG23560-like0.037
Prrx1paired related homeobox 10.037
Mpp3membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)0.036
Eif4heukaryotic translation initiation factor 4H0.036
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.035
Pdgfbplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.034
Gzmfgranzyme F0.032
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.031
Spink1serine peptidase inhibitor, Kazal type 10.031
LOC171161common salivary protein 10.030
LOC363326hypothetical LOC3633260.030
Rab3il1RAB3A interacting protein (rabin3)-like 10.030
Arpc2actin related protein 2/3 complex, subunit 20.029
Batfbasic leucine zipper transcription factor, ATF-like0.028
Plekpleckstrin0.028
Runx1runt-related transcription factor 10.028
Gata3GATA binding protein 30.028
Btnl7butyrophilin-like 70.027
Lbplipopolysaccharide binding protein0.026
LOC100364854similar to RIKEN cDNA A430107P09 gene-like0.026
Ttyh3tweety homolog 3 (Drosophila)0.025
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.025
Sox17SRY (sex determining region Y)-box 170.025
Bst1bone marrow stromal cell antigen 10.025
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.025
Rhohras homolog gene family, member H0.025
Klrc2killer cell lectin-like receptor subfamily C, member 20.024
Acacbacetyl-Coenzyme A carboxylase beta0.024
Msnmoesin0.024
Cyctcytochrome c, testis0.024
Ptprsprotein tyrosine phosphatase, receptor type, S0.024
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.024
Cd38CD38 molecule0.023
Parp14poly (ADP-ribose) polymerase family, member 140.023
Map4k1mitogen activated protein kinase kinase kinase kinase 10.023
Gzmmgranzyme M (lymphocyte met-ase 1)0.023
Alox5aparachidonate 5-lipoxygenase activating protein0.022
Utrnutrophin0.022
Fnbp1formin binding protein 10.022
Emcnendomucin0.022
Arhgap27Rho GTPase activating protein 270.021
Slc5a1solute carrier family 5 (sodium/glucose cotransporter), member 10.021
Rab10RAB10, member RAS oncogene family0.021
Jak2Janus kinase 20.021
Fabp1fatty acid binding protein 1, liver0.021
Irf5interferon regulatory factor 50.021
SpicSpi-C transcription factor (Spi-1/PU.1 related)0.021
Padi4peptidyl arginine deiminase, type IV0.021
Hspa1lheat shock protein 1-like0.021
Atp1a4ATPase, Na+/K+ transporting, alpha 4 polypeptide0.021
Cd14CD14 molecule0.020
Trhthyrotropin releasing hormone0.020
Myo1fmyosin IF0.020
Testintestin gene0.020
Acp5acid phosphatase 5, tartrate resistant0.020
Cd4Cd4 molecule0.020
Cybbcytochrome b-245, beta polypeptide0.020
Cabp1calcium binding protein 10.020
RT1-HaRT1 class II, locus Ha0.020
Hcls1hematopoietic cell specific Lyn substrate 10.019
Cd2Cd2 molecule0.019
Ptpn18protein tyrosine phosphatase, non-receptor type 180.019
Ucp2uncoupling protein 2 (mitochondrial, proton carrier)0.019
Andproandrogen regulated protein0.019
Cd8aCD8a molecule0.019
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism