The network for 'response to cytokine' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to cytokine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.

NameDescriptionProbabilityFunc Analog Organism
CREBBPCREB binding protein1.000
STAT1signal transducer and activator of transcription 1, 91kDa1.000
EGFRepidermal growth factor receptor1.000
RIPK2receptor-interacting serine-threonine kinase 21.000
TRAF6TNF receptor-associated factor 61.000
PMLpromyelocytic leukemia0.999
MAP3K7mitogen-activated protein kinase kinase kinase 70.999
IRAK1interleukin-1 receptor-associated kinase 10.999
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.998
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.998
PTPN1protein tyrosine phosphatase, non-receptor type 10.998
MYD88myeloid differentiation primary response gene (88)0.996
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.996
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.995
MAPK14mitogen-activated protein kinase 140.993
IL1Binterleukin 1, beta0.992
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.991
IFIT3interferon-induced protein with tetratricopeptide repeats 30.989
RUNX1runt-related transcription factor 10.988
CXCL10chemokine (C-X-C motif) ligand 100.988
MAP3K3mitogen-activated protein kinase kinase kinase 30.986
CAV1caveolin 1, caveolae protein, 22kDa0.985
GHRgrowth hormone receptor0.985
BIRC3baculoviral IAP repeat containing 30.983
DUSP1dual specificity phosphatase 10.982
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.982
MT1Hmetallothionein 1H0.981
TRAF1TNF receptor-associated factor 10.980
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.979
SOCS3suppressor of cytokine signaling 30.979
CCR7chemokine (C-C motif) receptor 70.976
CXCL9chemokine (C-X-C motif) ligand 90.973
FASFas (TNF receptor superfamily, member 6)0.973
MT2Ametallothionein 2A0.972
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.971
JAK2Janus kinase 20.968
IFIT1interferon-induced protein with tetratricopeptide repeats 10.966
BIRC2baculoviral IAP repeat containing 20.963
CASP8caspase 8, apoptosis-related cysteine peptidase0.961
IL8interleukin 80.957
EP300E1A binding protein p3000.951
CASP3caspase 3, apoptosis-related cysteine peptidase0.944
IL1R1interleukin 1 receptor, type I0.944
ZNF43zinc finger protein 430.943
IFI44Linterferon-induced protein 44-like0.940
NCOR1nuclear receptor corepressor 10.940
IFI44interferon-induced protein 440.937
PLSCR1phospholipid scramblase 10.933
PTPN11protein tyrosine phosphatase, non-receptor type 110.929
CCR5chemokine (C-C motif) receptor 50.928
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.926
PTPRJprotein tyrosine phosphatase, receptor type, J0.924
JUNjun proto-oncogene0.923
CDC37cell division cycle 37 homolog (S. cerevisiae)0.922
MDM2Mdm2 p53 binding protein homolog (mouse)0.922
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.921
PARP9poly (ADP-ribose) polymerase family, member 90.918
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.917
CCL22chemokine (C-C motif) ligand 220.917
UBCubiquitin C0.912
NCF1neutrophil cytosolic factor 10.909
TAL1T-cell acute lymphocytic leukemia 10.908
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.905
NAMPTnicotinamide phosphoribosyltransferase0.905
IRAK2interleukin-1 receptor-associated kinase 20.901
ICAM1intercellular adhesion molecule 10.901
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.893
CCL2chemokine (C-C motif) ligand 20.892
APOEapolipoprotein E0.890
COL1A1collagen, type I, alpha 10.890
IFIT2interferon-induced protein with tetratricopeptide repeats 20.889
TNFAIP3tumor necrosis factor, alpha-induced protein 30.889
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.886
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.879
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.877
IL2RBinterleukin 2 receptor, beta0.876
LATlinker for activation of T cells0.875
IFIH1interferon induced with helicase C domain 10.872
CCL4chemokine (C-C motif) ligand 40.871
BCL2B-cell CLL/lymphoma 20.870
TRAF5TNF receptor-associated factor 50.869
NCOR2nuclear receptor corepressor 20.862
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.860
OAS22'-5'-oligoadenylate synthetase 2, 69/71kDa0.859
C1QAcomplement component 1, q subcomponent, A chain0.848
JAK1Janus kinase 10.847
STAT5Asignal transducer and activator of transcription 5A0.843
BCL2L1BCL2-like 10.842
TRAF2TNF receptor-associated factor 20.841
UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.839
CD40CD40 molecule, TNF receptor superfamily member 50.836
IL6interleukin 6 (interferon, beta 2)0.832
CFLARCASP8 and FADD-like apoptosis regulator0.827
MX2myxovirus (influenza virus) resistance 2 (mouse)0.821
CDK2cyclin-dependent kinase 20.821
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.814
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.811
MAPK1mitogen-activated protein kinase 10.805
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.798
BCL3B-cell CLL/lymphoma 30.798
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.125
col1a2collagen, type I, alpha 20.097
bcl2l1bcl2-like 10.075
junbjun B proto-oncogene0.063
cxcr4bchemokine (C-X-C motif), receptor 4b0.056
spry4sprouty (Drosophila) homolog 40.043
mmp9matrix metalloproteinase 90.043
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.027
ef1aelongation factor 1-alpha0.025
tlr3toll-like receptor 30.025
ikzf1IKAROS family zinc finger 1 (Ikaros)0.024
stat1bsignal transducer and activator of transcription 1b0.024
mcl1amyeloid cell leukemia sequence 1a0.022
socs3asuppressor of cytokine signaling 3a0.021
anxa1aannexin A1a0.021
rspo1R-spondin homolog (Xenopus laevis)0.021
rag1recombination activating gene 10.021
tlr21toll-like receptor 210.020
apoebapolipoprotein Eb0.018
krt4keratin 40.017
mapk3mitogen-activated protein kinase 30.017
pcsk5aproprotein convertase subtilisin/kexin type 5a0.017
stc1lstanniocalcin 1, like0.017
nrp2bneuropilin 2b0.016
igf2ainsulin-like growth factor 2a0.016
col1a1acollagen, type I, alpha 1a0.016
cldneclaudin e0.016
bcl2l10BCL2-like 10 (apoptosis facilitator)0.016
tnfatumor necrosis factor a (TNF superfamily, member 2)0.015
metmet proto-oncogene (hepatocyte growth factor receptor)0.014
pycardPYD and CARD domain containing0.014
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.013
junbljun B proto-oncogene, like0.012
runx1runt-related transcription factor 10.012
hgfahepatocyte growth factor a0.012
tbpl2TATA box binding protein like 20.011
fgf3fibroblast growth factor 30.011
sox9aSRY-box containing gene 9a0.011
mapk6mitogen-activated protein kinase 60.011
cishcytokine inducible SH2-containing protein0.011
stat3signal transduction and activation of transcription 30.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cxcl10chemokine (C-X-C motif) ligand 100.933
Il1r1interleukin 1 receptor, type I0.913
Runx1runt-related transcription factor 10.798
Sellselectin L0.760
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.757
Ccl2chemokine (C-C motif) ligand 20.751
Cxcl2chemokine (C-X-C motif) ligand 20.750
Col1a1collagen, type I, alpha 10.748
Lgals9lectin, galactoside-binding, soluble, 90.742
C1scomplement component 1, s subcomponent0.742
Fgf16fibroblast growth factor 160.722
Col3a1collagen, type III, alpha 10.720
Irf7interferon regulatory factor 70.711
Il8rbinterleukin 8 receptor, beta0.711
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.699
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.698
Icam1intercellular adhesion molecule 10.693
Socs3suppressor of cytokine signaling 30.679
Leprleptin receptor0.672
Orm1orosomucoid 10.642
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.642
Bcl2B-cell CLL/lymphoma 20.625
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.583
Oas1a2'-5' oligoadenylate synthetase 1A0.581
Mx1myxovirus (influenza virus) resistance 10.573
Gfapglial fibrillary acidic protein0.570
RGD1564599RGD15645990.557
Anxa1annexin A10.557
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.555
Rap1bRAP1B, member of RAS oncogene family0.543
Lgals5lectin, galactose binding, soluble 50.537
Il6interleukin 60.531
A2malpha-2-macroglobulin0.522
Myo1bmyosin Ib0.516
Ifitm3interferon induced transmembrane protein 30.515
Ccr5chemokine (C-C motif) receptor 50.514
Tnftumor necrosis factor (TNF superfamily, member 2)0.512
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.505
Il1binterleukin 1 beta0.494
Eif5aeukaryotic translation initiation factor 5A0.487
Il4rainterleukin 4 receptor, alpha0.479
Arpc1bactin related protein 2/3 complex, subunit 1B0.474
Cdc37cell division cycle 37 homolog (S. cerevisiae)0.466
Bdkrb1bradykinin receptor B10.460
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.459
Vcam1vascular cell adhesion molecule 10.456
Oasl2'-5'-oligoadenylate synthetase-like0.455
Cd44Cd44 molecule0.454
Usp18ubiquitin specific peptidase 180.447
Ifit3interferon-induced protein with tetratricopeptide repeats 30.445
Mmp3matrix metallopeptidase 30.444
LOC100363783rCG53773-like0.443
Ggt1gamma-glutamyltransferase 10.441
Testintestin gene0.439
Itgamintegrin, alpha M0.428
Pcolceprocollagen C-endopeptidase enhancer0.422
Ccl4chemokine (C-C motif) ligand 40.419
RhdRh blood group, D antigen0.417
Crisp2cysteine-rich secretory protein 20.416
Mef2dmyocyte enhancer factor 2D0.406
Gpr182G protein-coupled receptor 1820.406
Ppardperoxisome proliferator-activated receptor delta0.401
S1pr2sphingosine-1-phosphate receptor 20.400
Nos2nitric oxide synthase 2, inducible0.397
Cyp2c7cytochrome P450, family 2, subfamily c, polypeptide 70.396
FosFBJ osteosarcoma oncogene0.392
RT1-DaRT1 class II, locus Da0.392
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.390
Klf6Kruppel-like factor 60.387
Junbjun B proto-oncogene0.386
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.384
Hckhemopoietic cell kinase0.383
Igf2insulin-like growth factor 20.382
Jak1Janus kinase 10.381
Thbdthrombomodulin0.380
Stat1signal transducer and activator of transcription 10.365
Cd38CD38 molecule0.360
JunJun oncogene0.360
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.358
Ncr1natural cytotoxicity triggering receptor 10.358
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.355
Tgfbr3transforming growth factor, beta receptor III0.352
Prph2peripherin 20.351
Bgnbiglycan0.348
RT1-BaRT1 class II, locus Ba0.345
LOC100364500RT1 class I, locus CE11-like0.340
Cuzd1CUB and zona pellucida-like domains 10.339
Stc1stanniocalcin 10.329
Cd14CD14 molecule0.326
Ccl3chemokine (C-C motif) ligand 30.324
Timp2TIMP metallopeptidase inhibitor 20.323
Klf4Kruppel-like factor 4 (gut)0.318
Il2rbinterleukin 2 receptor, beta0.317
Slc5a5solute carrier family 5 (sodium iodide symporter), member 50.314
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.313
RGD1310262hypothetical LOC3046500.313
Plauplasminogen activator, urokinase0.311
Rhox5reproductive homeobox 50.309
Slc22a7solute carrier family 22 (organic anion transporter), member 70.309
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.308
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism