The network for 'brain development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

brain development

The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).

NameDescriptionProbabilityFunc Analog Organism
TP53tumor protein p530.999
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.994
EGFRepidermal growth factor receptor0.969
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.957
ESR1estrogen receptor 10.945
MDM2Mdm2 p53 binding protein homolog (mouse)0.902
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.897
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.889
FGFR2fibroblast growth factor receptor 20.808
PKM2pyruvate kinase, muscle0.796
HDAC2histone deacetylase 20.772
APCadenomatous polyposis coli0.757
CASP3caspase 3, apoptosis-related cysteine peptidase0.625
CREBBPCREB binding protein0.608
SMAD3SMAD family member 30.607
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.559
POU3F2POU class 3 homeobox 20.518
CASP8caspase 8, apoptosis-related cysteine peptidase0.505
SMAD2SMAD family member 20.501
MYOD1myogenic differentiation 10.500
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.476
FGFR1fibroblast growth factor receptor 10.475
ZNF43zinc finger protein 430.465
ATXN1ataxin 10.460
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.452
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.450
DAXXdeath-domain associated protein0.447
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.445
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.444
TAL1T-cell acute lymphocytic leukemia 10.431
SORBS3sorbin and SH3 domain containing 30.426
RB1retinoblastoma 10.422
BCL2L1BCL2-like 10.391
PSEN1presenilin 10.388
CASP9caspase 9, apoptosis-related cysteine peptidase0.377
ATN1atrophin 10.376
SOX11SRY (sex determining region Y)-box 110.371
LBX1ladybird homeobox 10.364
MDFIMyoD family inhibitor0.361
AKT1v-akt murine thymoma viral oncogene homolog 10.346
SOX1SRY (sex determining region Y)-box 10.331
BMP2bone morphogenetic protein 20.331
FLNAfilamin A, alpha0.318
FGF1fibroblast growth factor 1 (acidic)0.303
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.299
TP73tumor protein p730.295
AXIN1axin 10.278
JAG1jagged 10.277
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.277
NCOA1nuclear receptor coactivator 10.276
LAMB1laminin, beta 10.266
SKIv-ski sarcoma viral oncogene homolog (avian)0.260
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.258
MAPK1mitogen-activated protein kinase 10.257
ZMYND11zinc finger, MYND-type containing 110.251
MAP3K5mitogen-activated protein kinase kinase kinase 50.250
PBX1pre-B-cell leukemia homeobox 10.248
UBR1ubiquitin protein ligase E3 component n-recognin 10.247
FOXD3forkhead box D30.244
IGF1Rinsulin-like growth factor 1 receptor0.242
TRRAPtransformation/transcription domain-associated protein0.240
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.239
XIAPX-linked inhibitor of apoptosis0.235
CAV1caveolin 1, caveolae protein, 22kDa0.235
SIX3SIX homeobox 30.234
EPAS1endothelial PAS domain protein 10.232
BMP7bone morphogenetic protein 70.228
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.227
HMGA2high mobility group AT-hook 20.223
S100BS100 calcium binding protein B0.223
GATA4GATA binding protein 40.221
TBX5T-box 50.219
FGF3fibroblast growth factor 30.217
SMURF2SMAD specific E3 ubiquitin protein ligase 20.215
CRHR1corticotropin releasing hormone receptor 10.214
FKBP1AFK506 binding protein 1A, 12kDa0.214
PEX19peroxisomal biogenesis factor 190.210
PTPN11protein tyrosine phosphatase, non-receptor type 110.208
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.207
ATP5OATP synthase, H+ transporting, mitochondrial F1 complex, O subunit0.207
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.206
SOCS3suppressor of cytokine signaling 30.206
SIX6SIX homeobox 60.206
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.205
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.200
SFRP1secreted frizzled-related protein 10.200
NTRK3neurotrophic tyrosine kinase, receptor, type 30.196
PDX1pancreatic and duodenal homeobox 10.192
LDHAlactate dehydrogenase A0.190
JUNjun proto-oncogene0.189
PAX3paired box 30.187
PAX2paired box 20.186
LRP6low density lipoprotein receptor-related protein 60.186
QKIquaking homolog, KH domain RNA binding (mouse)0.185
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.183
ZNF273zinc finger protein 2730.178
S100A9S100 calcium binding protein A90.178
PAX8paired box 80.178
NR4A1nuclear receptor subfamily 4, group A, member 10.177
RAXretina and anterior neural fold homeobox0.177
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
hnf1baHNF1 homeobox Ba1.000
gata3GATA-binding protein 31.000
pitx3paired-like homeodomain transcription factor 30.999
foxd3forkhead box D30.999
fgf3fibroblast growth factor 30.999
shhasonic hedgehog a0.999
eya1eyes absent homolog 10.998
pax8paired box gene 80.998
lmx1b.1LIM homeobox transcription factor 1, beta 10.998
olig2oligodendrocyte lineage transcription factor 20.998
otx2orthodenticle homolog 20.997
hoxb3ahomeo box B3a0.996
epha4aeph receptor A4a0.995
aldh1a2aldehyde dehydrogenase 1 family, member A20.993
fgf8afibroblast growth factor 8 a0.993
tbx1T-box 10.992
fezf2FEZ family zinc finger 20.992
tbx16T-box gene 160.991
lef1lymphocyte enhancer binding factor 10.991
cdh2cadherin 2, neuronal0.990
otpborthopedia homolog b0.986
wnt8bwingless-type MMTV integration site family, member 8b0.983
wnt11wingless-type MMTV integration site family, member 110.983
fgfr2fibroblast growth factor receptor 20.983
ndr2nodal-related 20.982
sox10SRY-box containing gene 100.979
rx3retinal homeobox gene 30.978
hoxc6ahomeo box C6a0.977
myod1myogenic differentiation 10.975
wnt5bwingless-type MMTV integration site family, member 5b0.973
neurodneurogenic differentiation0.973
tfap2atranscription factor AP-2 alpha0.973
gbx2gastrulation brain homeo box 20.972
dlcdeltaC0.967
epb41l5erythrocyte membrane protein band 4.1 like 50.966
dlx2adistal-less homeobox gene 2a0.964
six3bsine oculis homeobox homolog 3b0.963
six4bsine oculis homeobox homolog 4b0.962
sox3SRY-box containing gene 30.961
pax2apaired box gene 2a0.960
isl2aislet2a0.959
otpaorthopedia homolog a0.958
hoxb5bhomeo box B5b0.957
jag2jagged 20.956
fzd8afrizzled homolog 8a0.955
gli2aGLI-Kruppel family member GLI2a0.955
kif17kinesin family member 170.955
crabp2acellular retinoic acid binding protein 2, a0.952
dladeltaA0.951
her5hairy-related 50.950
chdchordin0.946
meis2.1myeloid ecotropic viral integration site 2.10.945
six3asine oculis homeobox homolog 3a0.943
neurod4neurogenic differentiation 40.943
lhx5LIM homeobox 50.942
hoxb5ahomeo box B5a0.942
pbx1apre-B-cell leukemia transcription factor 1a0.941
hoxa3ahomeo box A3a0.941
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.941
dlx3bdistal-less homeobox gene 3b0.939
gata2aGATA-binding protein 2a0.939
dlddeltaD0.936
mab21l2mab-21-like 20.936
egr2bearly growth response 2b0.936
guca1cguanylate cyclase activator 1C0.936
hoxb1bhomeo box B1b0.933
eve1even-skipped-like10.933
cxcr4achemokine (C-X-C motif) receptor 4a0.932
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.930
prickle1aprickle-like 1 (Drosophila) a0.929
sox11bSRY-box containing gene 11b0.927
foxp2forkhead box P20.924
ift88intraflagellar transport 88 homolog0.921
foxa2forkhead box A20.920
fzd7afrizzled homolog 7a0.919
sp5lSp5 transcription factor-like0.918
bocbrother of CDO0.914
tbx2bT-box 2b0.910
gdf6agrowth differentiation factor 6a0.908
dlbdeltaB0.904
cdh1cadherin 1, epithelial0.904
neo1neogenin 10.902
gli1GLI-Kruppel family member 10.902
wnt4awingless-type MMTV integration site family, member 4a0.902
dlx4bdistal-less homeobox gene 4b0.900
sox2SRY-box containing gene 20.899
raraaretinoic acid receptor, alpha a0.895
mibmind bomb0.895
pax6apaired box gene 6a0.895
gbx1gastrulation brain homeobox 10.894
her15.1hairy and enhancer of split-related 15.10.893
hey1hairy/enhancer-of-split related with YRPW motif 10.890
irx7iroquois homeobox protein 70.889
ntlano tail a0.886
cdx4caudal type homeo box transcription factor 40.876
mapk3mitogen-activated protein kinase 30.875
phox2apaired-like homeobox 2a0.874
spry4sprouty (Drosophila) homolog 40.874
mespamesoderm posterior a0.872
atoh1aatonal homolog 1a0.870
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
dacdachshund0.998
wgwingless0.997
EgfrEpidermal growth factor receptor0.996
E(spl)Enhancer of split0.995
spispitz0.994
shishibire0.992
atoatonal0.992
drlderailed0.989
Fmr1CG6203 gene product from transcript CG6203-RC0.978
DscamDown syndrome cell adhesion molecule0.977
eygeyegone0.976
roboroundabout0.968
rstroughest0.968
babobaboon0.966
tkvthickveins0.964
esgescargot0.961
numbCG3779 gene product from transcript CG3779-RB0.960
DadDaughters against dpp0.950
Dhc64CDynein heavy chain 64C0.945
amosabsent MD neurons and olfactory sensilla0.934
Ten-aTenascin accessory0.932
vvlventral veins lacking0.928
argosCG4531 gene product from transcript CG4531-RA0.917
LIMK1LIM-kinase10.906
Su(H)Suppressor of Hairless0.906
lolalongitudinals lacking0.902
sleslender lobes0.899
InRInsulin-like receptor0.898
mammastermind0.898
stanstarry night0.895
Fas2Fasciclin 20.894
fkhfork head0.889
trioCG18214 gene product from transcript CG18214-RA0.887
vapvacuolar peduncle0.887
NNotch0.887
KhcKinesin heavy chain0.885
eyeyeless0.882
araaraucan0.851
scascabrous0.845
emsempty spiracles0.844
rorough0.842
drprdraper0.841
dshdishevelled0.837
nejnejire0.832
sglsugarless0.832
tefutelomere fusion0.829
ococelliless0.827
Nup153Nucleoporin 1530.817
Ras85DRas oncogene at 85D0.815
lealeak0.811
rgrugose0.805
dppdecapentaplegic0.795
slp1sloppy paired 10.795
rhorhomboid0.795
PtpmegCG1228 gene product from transcript CG1228-RD0.789
hkbhuckebein0.777
kluklumpfuss0.774
gbbglass bottom boat0.758
hbshibris0.758
chicoCG5686 gene product from transcript CG5686-RB0.757
dockdreadlocks0.756
ph-ppolyhomeotic proximal0.748
cascastor0.744
HLHm5E(spl) region transcript m50.735
ari-2ariadne 20.732
armarmadillo0.727
grimCG4345 gene product from transcript CG4345-RA0.722
PoxnPox neuro0.718
pbproboscipedia0.709
eyaeyes absent0.709
MadMothers against dpp0.706
GscGoosecoid0.702
Lis-1Lissencephaly-10.692
MAN1CG3167 gene product from transcript CG3167-RA0.689
norpAno receptor potential A0.688
AntpAntennapedia0.678
S6kIIRPS6-protein kinase-II0.669
tuptailup0.666
Tao-1CG14217 gene product from transcript CG14217-RF0.665
Act5CActin 5C0.659
staustaufen0.658
Exp6Exportin 60.655
drkdownstream of receptor kinase0.646
katanin-60katanin 600.645
EphrinCG1862 gene product from transcript CG1862-RA0.643
UbxUltrabithorax0.634
pydpolychaetoid0.629
effeffete0.623
sevsevenless0.622
abd-Aabdominal A0.606
AlkCG8250 gene product from transcript CG8250-RA0.601
ssspineless0.597
jebjelly belly0.587
pashapartner of drosha0.573
Src42ASrc oncogene at 42A0.562
senssenseless0.562
p53CG33336 gene product from transcript CG33336-RB0.562
HLHm7E(spl) region transcript m70.557
arrarrow0.540
trxtrithorax0.539
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.773
Gria4glutamate receptor, ionotrophic, AMPA 40.711
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 10.689
Dlg4discs, large homolog 4 (Drosophila)0.684
Syt4synaptotagmin IV0.680
Gabra1gamma-aminobutyric acid (GABA) A receptor, alpha 10.662
Atxn1ataxin 10.632
Hcn1hyperpolarization-activated cyclic nucleotide-gated potassium channel 10.599
Eporerythropoietin receptor0.558
Ctnnd2catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)0.519
Itgamintegrin, alpha M0.495
Trim29tripartite motif-containing 290.492
Crhr1corticotropin releasing hormone receptor 10.464
Robo2roundabout homolog 2 (Drosophila)0.463
LOC246267resection-induced TPI (rs11)0.460
Adra2cadrenergic, alpha-2C-, receptor0.456
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.455
Gad2glutamate decarboxylase 20.454
Grik1glutamate receptor, ionotropic, kainate 10.453
Crxcone-rod homeobox0.445
Ncanneurocan0.443
Grm7glutamate receptor, metabotropic 70.441
Drd1adopamine receptor D1A0.441
Unc5bunc-5 homolog B (C. elegans)0.439
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.433
Cgaglycoprotein hormones, alpha polypeptide0.428
Ahraryl hydrocarbon receptor0.411
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.405
Hoxa2homeo box A20.395
Nfascneurofascin0.395
St18suppression of tumorigenicity 180.394
Slc6a11solute carrier family 6 (neurotransmitter transporter, GABA), member 110.393
Sirpasignal-regulatory protein alpha0.391
Creb1cAMP responsive element binding protein 10.388
Tmod2tropomodulin 20.371
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.371
Sdc3syndecan 30.365
Ptafrplatelet-activating factor receptor0.355
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.354
Gabbr1gamma-aminobutyric acid (GABA) B receptor 10.354
Dlgap3discs, large (Drosophila) homolog-associated protein 30.351
Id3inhibitor of DNA binding 30.348
Rhobtb2Rho-related BTB domain containing 20.346
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.343
Cd4Cd4 molecule0.336
Slit1slit homolog 1 (Drosophila)0.335
Prdm2PR domain containing 2, with ZNF domain0.332
Hrh4histamine receptor H40.332
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.332
Cntn4contactin 40.331
Pip4k2bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.328
Galr3galanin receptor 30.328
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.327
Faim2Fas apoptotic inhibitory molecule 20.326
Arandrogen receptor0.323
Odf4outer dense fiber of sperm tails 40.321
Chrna7cholinergic receptor, nicotinic, alpha 70.320
Nedd4neural precursor cell expressed, developmentally down-regulated 40.319
Sstr2somatostatin receptor 20.315
Mapre1microtubule-associated protein, RP/EB family, member 10.310
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.310
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.307
Hapln1hyaluronan and proteoglycan link protein 10.306
Olr1078olfactory receptor 10780.302
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.296
C1qccomplement component 1, q subcomponent, C chain0.294
Kcnq2potassium voltage-gated channel, KQT-like subfamily, member 20.291
Crhbpcorticotropin releasing hormone binding protein0.291
NrarpNotch-regulated ankyrin repeat protein0.290
Ppp1r9aprotein phosphatase 1, regulatory (inhibitor) subunit 9A0.288
Syt9synaptotagmin IX0.286
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.284
Cntfrciliary neurotrophic factor receptor0.282
Hoxc4homeo box C40.282
Spock2sparc/osteonectin, cwcv and kazal-like domains proteoglycan 20.281
Cacng5calcium channel, voltage-dependent, gamma subunit 50.279
Adora3adenosine A3 receptor0.279
Prlhrprolactin releasing hormone receptor0.276
Prdx1peroxiredoxin 10.275
Grm5glutamate receptor, metabotropic 50.271
Gabra5gamma-aminobutyric acid (GABA) A receptor, alpha 50.269
Ageradvanced glycosylation end product-specific receptor0.268
Tacr3tachykinin receptor 30.264
Dlgap1discs, large (Drosophila) homolog-associated protein 10.263
Pou3f2POU class 3 homeobox 20.261
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.260
Rph3arabphilin 3A0.260
Agtr1aangiotensin II receptor, type 1a0.259
Npy1rneuropeptide Y receptor Y10.258
A3galt2alpha 1,3-galactosyltransferase 20.256
Marcksl1MARCKS-like 10.255
Stc1stanniocalcin 10.255
Grin3aglutamate receptor, ionotropic, N-methyl-D-aspartate 3A0.252
Kcnt1potassium channel, subfamily T, member 10.251
Npy5rneuropeptide Y receptor Y50.251
Nalcnsodium leak channel, non-selective0.249
Mchr1melanin-concentrating hormone receptor 10.248
Chrm1cholinergic receptor, muscarinic 10.248
Insrrinsulin receptor-related receptor0.248
Lama5laminin, alpha 50.247
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism