The network for 'peripheral nervous system development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

peripheral nervous system development

The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.

NameDescriptionProbabilityFunc Analog Organism
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1.000
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)1.000
EGFRepidermal growth factor receptor0.998
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.991
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.988
NOTCH1notch 10.987
EGR1early growth response 10.986
JAG1jagged 10.968
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.960
PAX3paired box 30.942
POU5F1POU class 5 homeobox 10.920
POU3F2POU class 3 homeobox 20.919
CDK2cyclin-dependent kinase 20.913
CAB39calcium binding protein 390.907
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.740
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.734
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.689
ARHGAP1Rho GTPase activating protein 10.685
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein0.658
DTNAdystrobrevin, alpha0.653
NOTCH3notch 30.625
NTRK1neurotrophic tyrosine kinase, receptor, type 10.612
MEIS1Meis homeobox 10.577
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.563
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.539
IGF1Rinsulin-like growth factor 1 receptor0.515
PVRL1poliovirus receptor-related 1 (herpesvirus entry mediator C)0.507
SHC1SHC (Src homology 2 domain containing) transforming protein 10.496
ZNF746zinc finger protein 7460.488
NCF1neutrophil cytosolic factor 10.482
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.474
F11RF11 receptor0.463
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.457
EP300E1A binding protein p3000.445
MEIS2Meis homeobox 20.435
NLRC4NLR family, CARD domain containing 40.425
TCF4transcription factor 40.412
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)0.408
CCND1cyclin D10.407
NAV1neuron navigator 10.395
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.390
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.378
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.362
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.357
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.345
INADLInaD-like (Drosophila)0.345
RARAretinoic acid receptor, alpha0.338
MAP3K8mitogen-activated protein kinase kinase kinase 80.325
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.322
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.316
EPHA7EPH receptor A70.310
DLL1delta-like 1 (Drosophila)0.309
RIN1Ras and Rab interactor 10.299
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.296
JAM3junctional adhesion molecule 30.294
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.291
SPG21spastic paraplegia 21 (autosomal recessive, Mast syndrome)0.283
AP2M1adaptor-related protein complex 2, mu 1 subunit0.281
PRKCZprotein kinase C, zeta0.281
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.279
APPamyloid beta (A4) precursor protein0.279
NKX2-1NK2 homeobox 10.278
INSRinsulin receptor0.277
LSM3LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)0.277
JAG2jagged 20.268
EIF2C2eukaryotic translation initiation factor 2C, 20.262
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.262
MED29mediator complex subunit 290.250
PTPN1protein tyrosine phosphatase, non-receptor type 10.247
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.237
JAK2Janus kinase 20.232
HOXA9homeobox A90.232
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.230
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.229
GRB10growth factor receptor-bound protein 100.228
PVRL2poliovirus receptor-related 2 (herpesvirus entry mediator B)0.226
MAP2K1mitogen-activated protein kinase kinase 10.225
PVRL3poliovirus receptor-related 30.223
CLNS1Achloride channel, nucleotide-sensitive, 1A0.219
SOCS1suppressor of cytokine signaling 10.216
ABL2v-abl Abelson murine leukemia viral oncogene homolog 20.213
JAM2junctional adhesion molecule 20.210
BARX1BARX homeobox 10.209
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.208
NOTCH2notch 20.204
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.200
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.197
SNRPGsmall nuclear ribonucleoprotein polypeptide G0.197
OS9osteosarcoma amplified 9, endoplasmic reticulum lectin0.195
HIPK2homeodomain interacting protein kinase 20.190
SKP2S-phase kinase-associated protein 2 (p45)0.186
DEDDdeath effector domain containing0.184
MYD88myeloid differentiation primary response gene (88)0.179
DLG4discs, large homolog 4 (Drosophila)0.177
NAPAN-ethylmaleimide-sensitive factor attachment protein, alpha0.176
CAV1caveolin 1, caveolae protein, 22kDa0.175
CCL14chemokine (C-C motif) ligand 140.172
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
notch1anotch homolog 1a0.985
eya1eyes absent homolog 10.980
sox3SRY-box containing gene 30.960
neurog1neurogenin 10.953
pax2apaired box gene 2a0.934
cdh2cadherin 2, neuronal0.869
alcamaactivated leukocyte cell adhesion molecule a0.784
foxi1forkhead box I10.781
fgf3fibroblast growth factor 30.775
gata3GATA-binding protein 30.748
sox1aSRY-box containing gene 1a0.714
cntn2contactin 20.707
foxa2forkhead box A20.624
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.622
slc17a7solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 70.618
shhasonic hedgehog a0.608
ascl1aachaete-scute complex-like 1a (Drosophila)0.590
lhx5LIM homeobox 50.579
dpysl3dihydropyrimidinase-like 30.569
otpborthopedia homolog b0.563
tbx2bT-box 2b0.552
fzd8afrizzled homolog 8a0.532
pitx3paired-like homeodomain transcription factor 30.516
her6hairy-related 60.463
notch3notch homolog 30.453
pax6apaired box gene 6a0.434
fstafollistatin a0.425
olig2oligodendrocyte lineage transcription factor 20.382
sox2SRY-box containing gene 20.378
fgf8afibroblast growth factor 8 a0.373
tp53tumor protein p530.372
nr2e1nuclear receptor subfamily 2, group E, member 10.371
dbx1adeveloping brain homeobox 1a0.370
efnb1ephrin B10.366
neurodneurogenic differentiation0.362
cxcr4bchemokine (C-X-C motif), receptor 4b0.356
rx3retinal homeobox gene 30.343
emx3empty spiracles homeobox 30.326
lmx1b.2LIM homeobox transcription factor 1, beta 20.318
bmp4bone morphogenetic protein 40.309
fgf10afibroblast growth factor 10a0.302
barhl2BarH-like 20.298
spry1sprouty homolog 1 (Drosophila)0.297
otx1aorthodenticle homolog 1a0.291
foxp2forkhead box P20.289
six3asine oculis homeobox homolog 3a0.283
foxa1forkhead box A10.271
jag2jagged 20.260
six3bsine oculis homeobox homolog 3b0.256
sox10SRY-box containing gene 100.253
tp63tumor protein p630.248
sox19aSRY-box containing gene 19a0.248
pcdh10bprotocadherin 10b0.240
kitakit receptor a0.236
pax6bpaired box gene 6b0.235
atoh1batonal homolog 1b0.224
bhlhe22basic helix-loop-helix family, member e220.214
six4bsine oculis homeobox homolog 4b0.205
irx4biroquois homeobox protein 4b0.203
irx1biroquois homeobox protein 1, b0.201
crabp2acellular retinoic acid binding protein 2, a0.198
dpysl2bdihydropyrimidinase-like 2b0.198
dhrs3adehydrogenase/reductase (SDR family) member 3a0.193
scn8aasodium channel, voltage-gated, type VIII, alpha a0.192
eng2aengrailed 2a0.192
hey1hairy/enhancer-of-split related with YRPW motif 10.190
her8ahairy-related 8a0.188
msi1musashi homolog 1 (Drosophila)0.186
pax8paired box gene 80.179
atoh1aatonal homolog 1a0.177
epb41l5erythrocyte membrane protein band 4.1 like 50.176
hmx3homeo box (H6 family) 30.173
nkx2.1bNK2 homeobox 1b0.168
dmbx1adiencephalon/mesencephalon homeobox 1a0.168
prnprs3prion protein, related sequence 30.167
appaamyloid beta (A4) precursor protein a0.165
her3hairy-related 30.164
tfe3btranscription factor binding to IGHM enhancer 3b0.163
crb1crumbs homolog 1 (Drosophila)0.162
eng2bengrailed 2b0.161
ndr2nodal-related 20.160
foxi3aforkhead box I3a0.160
gata4GATA-binding protein 40.159
zic6zic family member 60.154
pou3f1POU class 3 homeobox 10.151
nrg1neuregulin 10.150
slc17a6bsolute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b0.150
rarabretinoic acid receptor, alpha b0.150
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.145
fgfr4fibroblast growth factor receptor 40.143
prkczprotein kinase C, zeta0.141
fgf24fibroblast growth factor 240.140
phox2apaired-like homeobox 2a0.137
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
aopanterior open0.886
EphrinCG1862 gene product from transcript CG1862-RA0.864
HLHmdeltaE(spl) region transcript mdelta0.850
HLHm7E(spl) region transcript m70.773
rapretina aberrant in pattern0.740
Su(H)Suppressor of Hairless0.710
HLHmbetaE(spl) region transcript mbeta0.659
argosCG4531 gene product from transcript CG4531-RA0.637
JraJun-related antigen0.591
emcextra macrochaetae0.553
l(2)gllethal (2) giant larvae0.543
PtenCG5671 gene product from transcript CG5671-RB0.493
SAKSak kinase0.335
eyaeyes absent0.324
Ras85DRas oncogene at 85D0.317
stanstarry night0.315
malphaE(spl) region transcript malpha0.301
bibbig brain0.298
MadMothers against dpp0.296
E(spl)Enhancer of split0.287
mbcmyoblast city0.260
G-oalpha47AG protein oalpha 47A0.250
HLHm3E(spl) region transcript m30.248
Ten-mTenascin major0.228
HLHmgammaE(spl) region transcript mgamma0.223
Akt1CG4006 gene product from transcript CG4006-RA0.218
bowlbrother of odd with entrails limited0.211
LanB2Laminin B20.196
Rac1CG2248 gene product from transcript CG2248-RA0.195
CtBPC-terminal Binding Protein0.182
l(3)82FdCG32464 gene product from transcript CG32464-RR0.174
Vap-33-1CG5014 gene product from transcript CG5014-RB0.171
IceCG7788 gene product from transcript CG7788-RA0.171
HGTXCG13475 gene product from transcript CG13475-RB0.148
S6kRPS6-p70-protein kinase0.145
CycJCyclin J0.143
amosabsent MD neurons and olfactory sensilla0.135
ovoCG6824 gene product from transcript CG6824-RE0.135
svpseven up0.130
chbchromosome bows0.126
sqhspaghetti squash0.126
CycACyclin A0.123
edlETS-domain lacking0.122
numbCG3779 gene product from transcript CG3779-RB0.120
HLHm5E(spl) region transcript m50.118
RhebCG1081 gene product from transcript CG1081-RA0.118
tbcetubulin-specific chaperone E0.115
Syx7Syntaxin 70.107
Mpk2CG5475 gene product from transcript CG5475-RB0.102
frcfringe connection0.100
EphEph receptor tyrosine kinase0.097
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Isl1ISL1 transcription factor, LIM/homeodomain0.996
Retret proto-oncogene0.982
Ntf3neurotrophin 30.977
Sox10SRY-box containing gene 100.965
Ptpn11protein tyrosine phosphatase, non-receptor type 110.943
Pax6paired box gene 60.943
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.941
Epha4Eph receptor A40.925
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.901
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.837
Notch1Notch gene homolog 1 (Drosophila)0.833
Phox2bpaired-like homeobox 2b0.828
Egr2early growth response 20.819
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.791
Neurod1neurogenic differentiation 10.763
Ascl1achaete-scute complex homolog 1 (Drosophila)0.759
Nrg1neuregulin 10.735
Otx2orthodenticle homolog 2 (Drosophila)0.705
Hoxa1homeobox A10.692
Emx1empty spiracles homolog 1 (Drosophila)0.661
Sox2SRY-box containing gene 20.659
Gbx2gastrulation brain homeobox 20.643
Ptf1apancreas specific transcription factor, 1a0.641
Pitx2paired-like homeodomain transcription factor 20.614
Pax3paired box gene 30.598
Shhsonic hedgehog0.580
Vegfavascular endothelial growth factor A0.567
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.566
Lhx1LIM homeobox protein 10.566
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.556
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.547
Foxc2forkhead box C20.547
Phox2apaired-like homeobox 2a0.530
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.529
Gli3GLI-Kruppel family member GLI30.515
Efnb2ephrin B20.509
Fgfr2fibroblast growth factor receptor 20.501
Tcf3transcription factor 30.485
Wnt6wingless-related MMTV integration site 60.480
Dab1disabled homolog 1 (Drosophila)0.476
Adam12a disintegrin and metallopeptidase domain 12 (meltrin alpha)0.450
Hoxa9homeobox A90.448
Tcfap2atranscription factor AP-2, alpha0.419
Hes1hairy and enhancer of split 1 (Drosophila)0.419
Emx2empty spiracles homolog 2 (Drosophila)0.415
Hoxb1homeobox B10.412
Onecut1one cut domain, family member 10.402
Lhx9LIM homeobox protein 90.397
Hoxa10homeobox A100.391
Itgb1integrin beta 1 (fibronectin receptor beta)0.388
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.387
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.373
Nf1neurofibromatosis 10.351
Emid2EMI domain containing 20.349
Rararetinoic acid receptor, alpha0.347
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.346
Atoh7atonal homolog 7 (Drosophila)0.344
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.338
Efna2ephrin A20.333
Neurog2neurogenin 20.321
Gata4GATA binding protein 40.320
Hoxc4homeobox C40.319
Prnpprion protein0.316
Insm1insulinoma-associated 10.313
Lhx3LIM homeobox protein 30.308
Gata6GATA binding protein 60.305
Gdnfglial cell line derived neurotrophic factor0.304
Pbx1pre B-cell leukemia transcription factor 10.300
Aplp2amyloid beta (A4) precursor-like protein 20.295
Lamc1laminin, gamma 10.290
Lhx5LIM homeobox protein 50.289
Pou4f3POU domain, class 4, transcription factor 30.285
Hoxb9homeobox B90.275
Hes5hairy and enhancer of split 5 (Drosophila)0.270
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.265
Appamyloid beta (A4) precursor protein0.260
Pax2paired box gene 20.260
Dll1delta-like 1 (Drosophila)0.252
Pax1paired box gene 10.244
Tlx3T-cell leukemia, homeobox 30.226
Nr3c1nuclear receptor subfamily 3, group C, member 10.224
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.222
Foxd1forkhead box D10.218
Chd7chromodomain helicase DNA binding protein 70.213
Bdnfbrain derived neurotrophic factor0.211
Wt1Wilms tumor 1 homolog0.208
Prox1prospero-related homeobox 10.207
En1engrailed 10.206
Gscgoosecoid homeobox0.198
Hand2heart and neural crest derivatives expressed transcript 20.197
Hoxc5homeobox C50.195
Nrp1neuropilin 10.191
Pou3f3POU domain, class 3, transcription factor 30.188
Hspg2perlecan (heparan sulfate proteoglycan 2)0.188
Dccdeleted in colorectal carcinoma0.181
Pou3f1POU domain, class 3, transcription factor 10.176
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.175
Ebf3early B-cell factor 30.175
Meis2Meis homeobox 20.175
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism