The network for 'cellular response to decreased oxygen levels' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to decreased oxygen levels

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.

NameDescriptionProbabilityFunc Analog Organism
TP53tumor protein p530.982
MDM2Mdm2 p53 binding protein homolog (mouse)0.977
TEKTEK tyrosine kinase, endothelial0.896
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.886
TOB1transducer of ERBB2, 10.882
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.806
HUWE1HECT, UBA and WWE domain containing 10.783
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.618
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.525
RB1retinoblastoma 10.522
TSC2tuberous sclerosis 20.484
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.469
PLAUplasminogen activator, urokinase0.421
VEGFAvascular endothelial growth factor A0.419
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.403
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.389
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.361
TRPC4transient receptor potential cation channel, subfamily C, member 40.323
PCGF2polycomb group ring finger 20.320
EGLN1egl nine homolog 1 (C. elegans)0.311
TNKS2tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 20.302
CDK2cyclin-dependent kinase 20.300
TAL1T-cell acute lymphocytic leukemia 10.274
KDM1Alysine (K)-specific demethylase 1A0.267
AHRaryl hydrocarbon receptor0.266
NR0B1nuclear receptor subfamily 0, group B, member 10.257
BNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-like0.252
MAFGv-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)0.248
KEAP1kelch-like ECH-associated protein 10.235
BCL2L11BCL2-like 11 (apoptosis facilitator)0.224
KAT2BK(lysine) acetyltransferase 2B0.221
SNAI1snail homolog 1 (Drosophila)0.218
JAG1jagged 10.210
PLAURplasminogen activator, urokinase receptor0.202
HIPK2homeodomain interacting protein kinase 20.200
RING1ring finger protein 10.196
HIPK3homeodomain interacting protein kinase 30.194
ATP6V1B2ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B20.190
EPAS1endothelial PAS domain protein 10.189
BECN1beclin 1, autophagy related0.187
ITPR2inositol 1,4,5-trisphosphate receptor, type 20.186
ENO1enolase 1, (alpha)0.184
BCL2L1BCL2-like 10.184
SLC6A2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 20.182
EP300E1A binding protein p3000.168
YAP1Yes-associated protein 10.162
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.161
CREBBPCREB binding protein0.149
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.148
HNF4Ahepatocyte nuclear factor 4, alpha0.143
NR4A1nuclear receptor subfamily 4, group A, member 10.134
MPDZmultiple PDZ domain protein0.133
ANGPT2angiopoietin 20.129
SGK3serum/glucocorticoid regulated kinase family, member 30.125
FGAfibrinogen alpha chain0.124
PPARGperoxisome proliferator-activated receptor gamma0.123
TP53BP2tumor protein p53 binding protein, 20.121
ACTN1actinin, alpha 10.116
ARNTaryl hydrocarbon receptor nuclear translocator0.115
SETD8SET domain containing (lysine methyltransferase) 80.115
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.113
RICTORRPTOR independent companion of MTOR, complex 20.113
EFEMP2EGF containing fibulin-like extracellular matrix protein 20.112
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.109
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)0.107
CASP8caspase 8, apoptosis-related cysteine peptidase0.106
BCL2B-cell CLL/lymphoma 20.102
ESRRGestrogen-related receptor gamma0.102
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.101
NRP1neuropilin 10.097
TSC1tuberous sclerosis 10.094
SQSTM1sequestosome 10.091
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.088
BIDBH3 interacting domain death agonist0.087
ATXN3ataxin 30.087
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.085
CSNK1A1casein kinase 1, alpha 10.084
PLATplasminogen activator, tissue0.083
VDAC2voltage-dependent anion channel 20.082
PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin)0.082
LDHAlactate dehydrogenase A0.081
MAP3K5mitogen-activated protein kinase kinase kinase 50.080
SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila)0.079
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.078
NFE2L2nuclear factor (erythroid-derived 2)-like 20.078
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.076
ACACAacetyl-CoA carboxylase alpha0.075
UBQLN1ubiquilin 10.071
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.071
PRKCGprotein kinase C, gamma0.069
HOXA9homeobox A90.066
AURKBaurora kinase B0.066
CCND1cyclin D10.065
SP1Sp1 transcription factor0.065
MGEA5meningioma expressed antigen 5 (hyaluronidase)0.065
GATA4GATA binding protein 40.064
PELI3pellino homolog 3 (Drosophila)0.063
SOCS1suppressor of cytokine signaling 10.060
BACH1BTB and CNC homology 1, basic leucine zipper transcription factor 10.060
CCND2cyclin D20.059
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
kdrlkinase insert domain receptor like0.372
dab1adisabled homolog 1a (Drosophila)0.140
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.136
ptmaaprothymosin, alpha a0.117
ca8carbonic anhydrase VIII0.116
nrg1neuregulin 10.100
gcm2glial cells missing homolog 2 (Drosophila)0.098
pink1PTEN induced putative kinase 10.097
fgfr1afibroblast growth factor receptor 1a0.091
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.091
notch3notch homolog 30.082
mpzmyelin protein zero0.077
nanos3nanos homolog 30.076
pi4kbphosphatidylinositol 4-kinase, catalytic, beta0.076
zgc:158138zgc:1581380.074
epas1bendothelial PAS domain protein 1b0.071
ptpraprotein tyrosine phosphatase, receptor type, A0.067
zgc:153997zgc:1539970.065
arnt2aryl hydrocarbon receptor nuclear translocator 20.064
mcl1bmyeloid cell leukemia sequence 1b0.060
mef2amyocyte enhancer factor 2a0.059
bcl2l1bcl2-like 10.058
limk2LIM domain kinase 20.058
rdh10aretinol dehydrogenase 10a0.057
ef1aelongation factor 1-alpha0.057
dusp1dual specificity phosphatase 10.056
mapk6mitogen-activated protein kinase 60.056
trpv6transient receptor potential cation channel, subfamily V, member 60.055
meis2.2myeloid ecotropic viral integration site 2.20.055
col7a1lcollagen type VII alpha 1-like0.054
glulaglutamate-ammonia ligase (glutamine synthase) a0.053
ahi1Abelson helper integration site 10.053
foxi3aforkhead box I3a0.052
srfserum response factor0.052
msi1musashi homolog 1 (Drosophila)0.051
dao.2D-amino-acid oxidase 20.051
frem3Fras1 related extracellular matrix 30.050
mapk1mitogen-activated protein kinase 10.050
pkp3plakophilin 30.049
zgc:110298zgc:1102980.049
nrg2aneuregulin 2a0.049
mtmr8myotubularin related protein 80.048
ripk2receptor-interacting serine-threonine kinase 20.047
rhagRhesus blood group-associated glycoprotein0.047
baxabcl2-associated X protein, a0.047
wt1bwilms tumor 1b0.046
mapk8bmitogen-activated protein kinase 8b0.045
wsb1WD repeat and SOCS box-containing 10.045
dnmt4DNA (cytosine-5-)-methyltransferase 40.045
btg2B-cell translocation gene 20.044
rasl11bRAS-like, family 11, member B0.044
prkczprotein kinase C, zeta0.044
atp1a1a.5ATPase, Na+/K+ transporting, alpha 1a.5 polypeptide0.044
zfp36l1azinc finger protein 36, C3H type-like 1a0.043
sema6dlsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like0.043
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.042
ncs1aneuronal calcium sensor 1a0.042
mcl1amyeloid cell leukemia sequence 1a0.042
zbtb4zinc finger and BTB domain containing 40.041
ca15acarbonic anhydrase XV a0.041
sox5SRY-box containing gene 50.041
adob2-aminoethanethiol (cysteamine) dioxygenase b0.041
klf4aKruppel-like transcription factor 4a0.040
cnr1cannabinoid receptor 10.040
mapk12mitogen-activated protein kinase 120.040
cav1caveolin 10.040
taglntransgelin0.039
fbln5fibulin 50.039
oprk1opioid receptor, kappa 10.039
fabp11afatty acid binding protein 11a0.038
drd2bdopamine receptor D2b0.038
myf6myogenic factor 60.038
valopbvertebrate ancient long opsin b0.038
fosv-fos FBJ murine osteosarcoma viral oncogene homolog0.038
rbpms2RNA binding protein with multiple splicing 20.038
gnai2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.037
dag1dystroglycan 10.037
ca2carbonic anhydrase II0.037
mapk7mitogen-activated protein kinase 70.037
dclk2doublecortin-like kinase 20.037
ptgs1prostaglandin-endoperoxide synthase 10.037
zgc:64114zgc:641140.037
csrp3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.037
irf6interferon regulatory factor 60.037
kctd15apotassium channel tetramerisation domain containing 15a0.037
gnasGNAS complex locus0.036
glulbglutamate-ammonia ligase (glutamine synthase) b0.036
ptgdsprostaglandin D2 synthase0.036
foxi3bforkhead box I3b0.036
slc2a12solute carrier family 2 (facilitated glucose transporter), member 120.036
LOC799612prolactin 20.036
tmem161btransmembrane protein 161B0.035
rictorRPTOR independent companion of MTOR, complex 20.035
spi1lspleen focus forming virus (SFFV) proviral integration oncogene spi1 like0.035
pfkfb4l6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4, like0.035
tmprss4atransmembrane protease, serine 4a0.034
oprm1opioid receptor, mu 10.034
etfaelectron-transfer-flavoprotein, alpha polypeptide0.034
cxadrcoxsackie virus and adenovirus receptor0.034
klf2aKruppel-like factor 2a0.034
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
agoarchipelago0.153
Pi3K92ECG4141 gene product from transcript CG4141-RB0.081
dmdiminutive0.074
TbhTyramine beta hydroxylase0.053
CG4389CG4389 gene product from transcript CG4389-RA0.047
Aats-asnAsparaginyl-tRNA synthetase0.047
EndoGIEndonuclease G inhibitor0.047
l(2)03709lethal (2) 037090.046
Vha68-2CG3762 gene product from transcript CG3762-RA0.045
norpAno receptor potential A0.044
simjsimjang0.042
CG13253CG13253 gene product from transcript CG13253-RB0.042
InRInsulin-like receptor0.038
EcREcdysone receptor0.037
Atg1Autophagy-specific gene 10.037
btlbreathless0.035
VhaSFDVacuolar H[+]-ATPase SFD subunit0.034
inaDinactivation no afterpotential D0.033
Lsd-2Lipid storage droplet-20.033
Octbeta2RCG33976 gene product from transcript CG33976-RA0.033
Mef2Myocyte enhancer factor 20.033
CG9821CG9821 gene product from transcript CG9821-RB0.033
Aats-hisHistidyl-tRNA synthetase0.033
Fs(2)KetFemale sterile (2) Ketel0.032
bnlbranchless0.028
lolallola like0.028
Gyc76CGuanylyl cyclase at 76C0.028
CG12084CG12084 gene product from transcript CG12084-RA0.027
Src64BSrc oncogene at 64B0.027
S6kRPS6-p70-protein kinase0.027
kibrakibra ortholog0.027
sinusinuous0.026
CG12384CG12384 gene product from transcript CG12384-RA0.025
CG2678CG2678 gene product from transcript CG2678-RA0.025
BicDBicaudal D0.023
CG12140CG12140 gene product from transcript CG12140-RA0.023
LamLamin0.023
oa2octopamine receptor 20.022
stysprouty0.022
hbhunchback0.022
CG5525CG5525 gene product from transcript CG5525-RA0.022
aretarrest0.022
DpDP transcription factor0.021
CG4194CG4194 gene product from transcript CG4194-RA0.021
Deaf1Deformed epidermal autoregulatory factor-10.021
stumpsCG31317 gene product from transcript CG31317-RC0.020
wtswarts0.020
lqfRliquid facets-Related0.020
rheaCG6831 gene product from transcript CG6831-RA0.020
ScpXSterol carrier protein X-related thiolase0.020
CycGCyclin G0.020
MarfMitochondrial assembly regulatory factor0.020
Ppat-DpckBifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase0.020
Vha55Vacuolar H[+]-ATPase 55kD B subunit0.019
l(2)37Bblethal (2) 37Bb0.019
CG8709CG8709 gene product from transcript CG8709-RK0.019
CG17259CG17259 gene product from transcript CG17259-RA0.019
LamCLamin C0.019
scylscylla0.019
StamSignal transducing adaptor molecule0.019
HandCG18144 gene product from transcript CG18144-RA0.018
oskoskar0.018
Atx2Ataxin-20.018
Ork1Open rectifier K[+] channel 10.018
zfh1Zn finger homeodomain 10.017
TequilaCG4821 gene product from transcript CG4821-RE0.017
B52CG10851 gene product from transcript CG10851-RB0.017
slprslipper0.017
CG8885CG8885 gene product from transcript CG8885-RA0.017
maskmultiple ankyrin repeats single KH domain0.017
mbf1multiprotein bridging factor 10.017
HphHIF prolyl hydroxylase0.017
EnoEnolase0.017
CG42629CG42629 gene product from transcript CG42629-RB0.017
Sam-SS-adenosylmethionine Synthetase0.016
sec5CG8843 gene product from transcript CG8843-RA0.016
CG1749CG1749 gene product from transcript CG1749-RA0.016
PHGPxCG12013 gene product from transcript CG12013-RC0.016
PpnPapilin0.016
GckIIIGerminal centre kinase III0.016
mei-P26CG12218 gene product from transcript CG12218-RA0.016
dpdumpy0.016
Trf2TATA box binding protein-related factor 20.016
Kr-h1Kruppel homolog 10.016
slouslouch0.016
CG6854CG6854 gene product from transcript CG6854-RC0.016
CragCalmodulin-binding protein related to a Rab3 GDP/GTP exchange protein0.016
swshort wing0.016
trpltrp-like0.016
CHOp24CG3564 gene product from transcript CG3564-RA0.015
scuscully0.015
eIF3-S10CG9805 gene product from transcript CG9805-RA0.015
msimusashi0.015
savsalvador0.015
mskmoleskin0.015
HLH106Helix loop helix protein 1060.015
inscinscuteable0.015
CCKLR-17D1CCK-like receptor at 17D10.015
eIF4Geukaryotic translation initiation factor 4G0.015
Upf1CG1559 gene product from transcript CG1559-RA0.015
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Vegfavascular endothelial growth factor A0.885
Ptenphosphatase and tensin homolog0.867
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.863
Trp53transformation related protein 530.817
Vhlvon Hippel-Lindau tumor suppressor0.727
Mdm2transformed mouse 3T3 cell double minute 20.723
Bcl2B-cell leukemia/lymphoma 20.653
Nos3nitric oxide synthase 3, endothelial cell0.598
Gata4GATA binding protein 40.563
Ldb3LIM domain binding 30.559
BaxBCL2-associated X protein0.520
Egln1EGL nine homolog 1 (C. elegans)0.412
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.339
Dab1disabled homolog 1 (Drosophila)0.311
Notch2Notch gene homolog 2 (Drosophila)0.296
Hif1ahypoxia inducible factor 1, alpha subunit0.263
Rxraretinoid X receptor alpha0.220
Ppargperoxisome proliferator activated receptor gamma0.219
Ahraryl-hydrocarbon receptor0.205
Mmp9matrix metallopeptidase 90.187
Tsc2tuberous sclerosis 20.164
Ascl1achaete-scute complex homolog 1 (Drosophila)0.149
Cd44CD44 antigen0.136
Itgb1integrin beta 1 (fibronectin receptor beta)0.127
Nos1nitric oxide synthase 1, neuronal0.115
Csf1colony stimulating factor 1 (macrophage)0.110
Wt1Wilms tumor 1 homolog0.110
Thbs1thrombospondin 10.106
Otporthopedia homolog (Drosophila)0.103
Egln3EGL nine homolog 3 (C. elegans)0.103
Nf2neurofibromatosis 20.102
Lepleptin0.100
Rb1retinoblastoma 10.099
Apcadenomatosis polyposis coli0.098
Foxo1forkhead box O10.096
Insrinsulin receptor0.090
Neurl1aneuralized homolog 1A (Drosophila)0.078
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.076
Neurod1neurogenic differentiation 10.076
Kiss1KiSS-1 metastasis-suppressor0.074
Nab2Ngfi-A binding protein 20.072
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.064
Mdm4transformed mouse 3T3 cell double minute 40.063
Tlr4toll-like receptor 40.062
Gdnfglial cell line derived neurotrophic factor0.061
Gata6GATA binding protein 60.060
Gata1GATA binding protein 10.059
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.058
Isl1ISL1 transcription factor, LIM/homeodomain0.053
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.052
Ptgs2prostaglandin-endoperoxide synthase 20.049
Neurog2neurogenin 20.049
Dll1delta-like 1 (Drosophila)0.048
Fgf8fibroblast growth factor 80.046
Tsc1tuberous sclerosis 10.046
Neurod4neurogenic differentiation 40.045
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.044
Mapkap1mitogen-activated protein kinase associated protein 10.043
Onecut1one cut domain, family member 10.042
Nr3c1nuclear receptor subfamily 3, group C, member 10.041
Ptf1apancreas specific transcription factor, 1a0.040
Hdac1histone deacetylase 10.039
Nf1neurofibromatosis 10.038
Lhx3LIM homeobox protein 30.038
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.037
Cd36CD36 antigen0.036
Cdkn2acyclin-dependent kinase inhibitor 2A0.035
Lama5laminin, alpha 50.035
Acot13acyl-CoA thioesterase 130.034
Gja1gap junction protein, alpha 10.034
Psen2presenilin 20.034
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.033
Epas1endothelial PAS domain protein 10.033
Fgf15fibroblast growth factor 150.032
Hoxa1homeobox A10.032
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.032
SkilSKI-like0.031
Clockcircadian locomotor output cycles kaput0.030
Smad3MAD homolog 3 (Drosophila)0.029
Nos2nitric oxide synthase 2, inducible0.029
Myod1myogenic differentiation 10.029
Hoxc5homeobox C50.029
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.029
Ptpn11protein tyrosine phosphatase, non-receptor type 110.029
MecomMDS1 and EVI1 complex locus0.028
Sfrp2secreted frizzled-related protein 20.028
Fzr1fizzy/cell division cycle 20 related 1 (Drosophila)0.028
Platplasminogen activator, tissue0.026
Nfe2l2nuclear factor, erythroid derived 2, like 20.026
ND6NADH dehydrogenase subunit 60.026
En1engrailed 10.025
Tcfap2atranscription factor AP-2, alpha0.025
Arxaristaless related homeobox0.025
Tbr1T-box brain gene 10.025
Serpine1serine (or cysteine) peptidase inhibitor, clade E, member 10.024
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.024
Hprthypoxanthine guanine phosphoribosyl transferase0.024
Terttelomerase reverse transcriptase0.024
Ltbp1latent transforming growth factor beta binding protein 10.024
Ighimmunoglobulin heavy chain complex0.024
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CLB3Clb3p0.036
BUL2Bul2p0.029
ECM22Ecm22p0.025
YPL014Whypothetical protein0.023
GLN3Gln3p0.023
SNT1Snt1p0.022
MIG1Mig1p0.021
SIC1Sic1p0.020
MIG2Mig2p0.017
CDC6Cdc6p0.017
ECM21Ecm21p0.016
YDL241Whypothetical protein0.013
YRO2Yro2p0.013
CDC5Cdc5p0.013
CLB1Clb1p0.013
GAT2Gat2p0.012
YKR075Chypothetical protein0.012
HXT3Hxt3p0.012
MGA2Mga2p0.012
CLB4Clb4p0.011
BUD4Bud4p0.011
NUP157Nup157p0.011
RIM101Rim101p0.011
MOT2Mot2p0.010
VID24Vid24p0.010