IMP
Process View
The network for 'necrotic cell death' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
necrotic cell death
A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| CASP8 | caspase 8, apoptosis-related cysteine peptidase | 1.000 | |
| FAS | Fas (TNF receptor superfamily, member 6) | 0.941 | |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.903 | |
| ATG3 | ATG3 autophagy related 3 homolog (S. cerevisiae) | 0.797 | |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.791 | |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 0.752 | |
| FADD | Fas (TNFRSF6)-associated via death domain | 0.732 | |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.660 | |
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | 0.610 | |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.585 | |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.544 | |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.496 | |
| TANK | TRAF family member-associated NFKB activator | 0.349 | |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.310 | |
| GABARAP | GABA(A) receptor-associated protein | 0.270 | |
| TRADD | TNFRSF1A-associated via death domain | 0.234 | |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | 0.228 | |
| TRAF1 | TNF receptor-associated factor 1 | 0.222 | |
| BID | BH3 interacting domain death agonist | 0.200 | |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.172 | |
| SQSTM1 | sequestosome 1 | 0.164 | |
| TBK1 | TANK-binding kinase 1 | 0.130 | |
| NLRC4 | NLR family, CARD domain containing 4 | 0.123 | |
| ATP6V1E1 | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 | 0.122 | |
| FASLG | Fas ligand (TNF superfamily, member 6) | 0.089 | |
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | 0.085 | |
| CLTC | clathrin, heavy chain (Hc) | 0.085 | |
| PSAP | prosaposin | 0.085 | |
| CTSA | cathepsin A | 0.080 | |
| RNF31 | ring finger protein 31 | 0.072 | |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | 0.070 | |
| NFE2L2 | nuclear factor (erythroid-derived 2)-like 2 | 0.069 | |
| TRAF3 | TNF receptor-associated factor 3 | 0.066 | |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | 0.066 | |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.062 | |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | 0.060 | |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.058 | |
| CDC14B | CDC14 cell division cycle 14 homolog B (S. cerevisiae) | 0.058 | |
| DNM1 | dynamin 1 | 0.055 | |
| ARNT | aryl hydrocarbon receptor nuclear translocator | 0.053 | |
| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 0.053 | |
| RIPK3 | receptor-interacting serine-threonine kinase 3 | 0.053 | |
| TTR | transthyretin | 0.050 | |
| APC | adenomatous polyposis coli | 0.049 | |
| MAPK1 | mitogen-activated protein kinase 1 | 0.047 | |
| ATG16L1 | ATG16 autophagy related 16-like 1 (S. cerevisiae) | 0.046 | |
| SMCR7 | Smith-Magenis syndrome chromosome region, candidate 7 | 0.045 | |
| RNF144B | ring finger protein 144B | 0.043 | |
| TRAF2 | TNF receptor-associated factor 2 | 0.042 | |
| VDAC1 | voltage-dependent anion channel 1 | 0.040 | |
| MAP2K4 | mitogen-activated protein kinase kinase 4 | 0.039 | |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.034 | |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.034 | |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | 0.034 | |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | 0.032 | |
| CLASP1 | cytoplasmic linker associated protein 1 | 0.031 | |
| BBS10 | Bardet-Biedl syndrome 10 | 0.029 | |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.029 | |
| TYK2 | tyrosine kinase 2 | 0.027 | |
| BCL2 | B-cell CLL/lymphoma 2 | 0.027 | |
| MAP2K7 | mitogen-activated protein kinase kinase 7 | 0.026 | |
| ATP5A1 | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle | 0.026 | |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.026 | |
| HDAC6 | histone deacetylase 6 | 0.026 | |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | 0.026 | |
| PDCD6 | programmed cell death 6 | 0.025 | |
| CAST | calpastatin | 0.024 | |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.024 | |
| ANKFY1 | ankyrin repeat and FYVE domain containing 1 | 0.023 | |
| ATP6AP1 | ATPase, H+ transporting, lysosomal accessory protein 1 | 0.023 | |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.022 | |
| TNFRSF1B | tumor necrosis factor receptor superfamily, member 1B | 0.022 | |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.022 | |
| CLN3 | ceroid-lipofuscinosis, neuronal 3 | 0.022 | |
| ATP6V0D1 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 | 0.021 | |
| BAK1 | BCL2-antagonist/killer 1 | 0.020 | |
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.020 | |
| MAVS | mitochondrial antiviral signaling protein | 0.020 | |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.020 | |
| ATG13 | ATG13 autophagy related 13 homolog (S. cerevisiae) | 0.019 | |
| ARRB1 | arrestin, beta 1 | 0.019 | |
| ZBTB16 | zinc finger and BTB domain containing 16 | 0.019 | |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.018 | |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 0.018 | |
| DAB2IP | DAB2 interacting protein | 0.018 | |
| SMCR7L | Smith-Magenis syndrome chromosome region, candidate 7-like | 0.017 | |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | 0.017 | |
| AHCY | adenosylhomocysteinase | 0.017 | |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 0.016 | |
| NCOA7 | nuclear receptor coactivator 7 | 0.016 | |
| APAF1 | apoptotic peptidase activating factor 1 | 0.016 | |
| CAPNS1 | calpain, small subunit 1 | 0.016 | |
| OXA1L | oxidase (cytochrome c) assembly 1-like | 0.016 | |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.016 | |
| PHB2 | prohibitin 2 | 0.016 | |
| MAPK14 | mitogen-activated protein kinase 14 | 0.016 | |
| XIAP | X-linked inhibitor of apoptosis | 0.016 | |
| MICALL1 | MICAL-like 1 | 0.015 | |
| TUBA1B | tubulin, alpha 1b | 0.015 | |
| BAD | BCL2-associated agonist of cell death | 0.015 |
Loading network...
Caenorhabditis elegans| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| atg-13 | Protein ATG-13 | 0.050 | |
| lin-8 | Protein LIN-8 | 0.040 | |
| bec-1 | Protein BEC-1 | 0.037 | |
| lgg-2 | Protein LGG-2 | 0.036 | |
| Y45G5AM.9 | Protein Y45G5AM.9 | 0.035 | |
| vha-13 | Protein VHA-13 | 0.031 | |
| Y17G7B.17 | Protein Y17G7B.17 | 0.029 | |
| tpa-1 | Protein TPA-1 | 0.027 | |
| K10C8.3 | Protein K10C8.3 | 0.023 | |
| cyn-13 | Protein CYN-13 | 0.022 | |
| mltn-1 | Protein MLTN-1 | 0.022 | |
| rab-3 | Protein RAB-3 | 0.021 | |
| Y17G7B.10 | Protein Y17G7B.10 | 0.021 | |
| C41D11.3 | Protein C41D11.3 | 0.020 | |
| T04F8.2 | Protein T04F8.2 | 0.020 | |
| gpb-1 | Protein GPB-1 | 0.020 | |
| CELE_Y47G6A.18 | Protein Y47G6A.18 | 0.020 | |
| C34D10.2 | Protein C34D10.2 | 0.020 | |
| clec-63 | Protein CLEC-63 | 0.019 | |
| agl-1 | Protein AGL-1 | 0.019 | |
| obr-1 | Protein OBR-1 | 0.019 | |
| acp-1 | Protein ACP-1 | 0.019 | |
| CELE_R102.5 | Protein R102.5 | 0.019 | |
| epg-6 | Protein EPG-6 | 0.019 | |
| cdl-1 | Protein CDL-1 | 0.019 | |
| ceh-44 | Protein CEH-44 | 0.018 | |
| hop-1 | Protein HOP-1 | 0.018 | |
| cnp-3 | Protein CNP-3 | 0.018 | |
| unc-9 | Protein UNC-9 | 0.018 | |
| ikke-1 | Protein IKKE-1 | 0.017 | |
| cul-2 | Protein CUL-2 | 0.017 | |
| mpst-3 | Protein MPST-3 | 0.017 | |
| abts-1 | Protein ABTS-1 | 0.017 | |
| wdr-23 | Protein WDR-23 | 0.017 | |
| hpo-13 | Protein HPO-13 | 0.017 | |
| clec-87 | Protein CLEC-87 | 0.017 | |
| F47A4.5 | Protein F47A4.5 | 0.016 | |
| tag-180 | Protein TAG-180 | 0.016 | |
| ret-1 | Protein RET-1 | 0.016 | |
| snx-14 | Protein SNX-14 | 0.016 | |
| atg-16.1 | Protein ATG-16.1 | 0.016 | |
| sma-10 | Protein SMA-10 | 0.016 | |
| eat-6 | Protein EAT-6 | 0.015 | |
| toe-4 | Protein TOE-4 | 0.015 | |
| rab-5 | Protein RAB-5 | 0.015 | |
| hmr-1 | Protein HMR-1 | 0.015 | |
| sli-1 | Protein SLI-1 | 0.015 | |
| hrdl-1 | Protein HRDL-1 | 0.015 | |
| unc-26 | Protein UNC-26 | 0.015 | |
| zer-1 | Protein ZER-1 | 0.015 | |
| ced-12 | Protein CED-12 | 0.015 | |
| wdfy-2 | Protein WDFY-2 | 0.015 | |
| tra-1 | Protein TRA-1 | 0.015 | |
| prmt-5 | Protein PRMT-5 | 0.015 | |
| grk-1 | Protein GRK-1 | 0.014 | |
| pkc-3 | Protein PKC-3 | 0.014 | |
| bath-42 | Protein BATH-42 | 0.014 | |
| ZK484.1 | Protein ZK484.1 | 0.014 | |
| fat-1 | Protein FAT-1 | 0.014 | |
| Y54G2A.2 | Protein Y54G2A.2 | 0.014 | |
| Y51H7C.3 | Protein Y51H7C.3 | 0.014 | |
| ppk-2 | Protein PPK-2 | 0.014 | |
| unc-14 | Protein UNC-14 | 0.014 | |
| C04B4.2 | Protein C04B4.2 | 0.014 | |
| spas-1 | Protein SPAS-1 | 0.013 | |
| csnk-1 | Protein CSNK-1 | 0.013 | |
| nos-2 | Protein NOS-2 | 0.013 | |
| unc-45 | Protein UNC-45 | 0.013 | |
| itsn-1 | Protein ITSN-1 | 0.013 | |
| CELE_F53C11.4 | Protein F53C11.4 | 0.013 | |
| vha-3 | Protein VHA-3 | 0.013 | |
| D2030.2 | Protein D2030.2 | 0.013 | |
| hipr-1 | Protein HIPR-1 | 0.013 | |
| his-35 | Protein HIS-35 | 0.013 | |
| F59F4.3 | Protein F59F4.3 | 0.013 | |
| tra-3 | Protein TRA-3 | 0.012 | |
| let-363 | Protein LET-363 | 0.012 | |
| gdh-1 | Protein GDH-1 | 0.012 | |
| mom-4 | Protein MOM-4 | 0.012 | |
| flh-2 | Protein FLH-2 | 0.012 | |
| nhr-1 | Protein NHR-1 | 0.012 | |
| T24H10.4 | Protein T24H10.4 | 0.012 | |
| ercc-1 | Protein ERCC-1 | 0.012 | |
| ugt-60 | Protein UGT-60 | 0.012 | |
| egl-1 | Protein EGL-1 | 0.012 | |
| CELE_Y69H2.7 | Protein Y69H2.7 | 0.012 | |
| F25B3.6 | Protein F25B3.6 | 0.012 | |
| K11H12.8 | Protein K11H12.8 | 0.012 | |
| vps-45 | Protein VPS-45 | 0.012 | |
| amph-1 | Protein AMPH-1 | 0.012 | |
| vha-14 | Protein VHA-14 | 0.012 | |
| C10G11.7 | Protein C10G11.7 | 0.012 | |
| D2085.5 | Protein D2085.5 | 0.012 | |
| mca-1 | Protein MCA-1 | 0.012 | |
| clp-7 | Protein CLP-7 | 0.012 | |
| eef-1A.1 | Protein EEF-1A.1 | 0.012 | |
| aat-9 | Protein AAT-9 | 0.012 | |
| mdt-1.2 | Protein MDT-1.2 | 0.012 | |
| CELE_F10G7.10 | Protein F10G7.10 | 0.012 | |
| scm-1 | Protein SCM-1 | 0.012 |
Loading network...
Drosophila melanogaster| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| stnA | stoned A | 0.183 | |
| stj | straightjacket | 0.150 | |
| egr | eiger | 0.111 | |
| Toll-6 | CG7250 gene product from transcript CG7250-RA | 0.069 | |
| lin19 | lin-19-like | 0.068 | |
| Osbp | Oxysterol binding protein | 0.056 | |
| Hrs | Hepatocyte growth factor regulated tyrosine kinase substrate | 0.051 | |
| Pink1 | PTEN-induced putative kinase 1 | 0.048 | |
| cdm | cadmus | 0.046 | |
| Toll-7 | CG8595 gene product from transcript CG8595-RA | 0.046 | |
| ird1 | immune response deficient 1 | 0.045 | |
| Eip93F | CG18389 gene product from transcript CG18389-RB | 0.041 | |
| unc-104 | CG8566 gene product from transcript CG8566-RB | 0.041 | |
| milt | milton | 0.041 | |
| tefu | telomere fusion | 0.039 | |
| comt | comatose | 0.039 | |
| Myd88 | CG2078 gene product from transcript CG2078-RA | 0.038 | |
| Lrrk | Leucine-rich repeat kinase | 0.037 | |
| sm | smooth | 0.037 | |
| Vha100-1 | CG1709 gene product from transcript CG1709-RF | 0.037 | |
| ds | dachsous | 0.035 | |
| trio | CG18214 gene product from transcript CG18214-RA | 0.034 | |
| Gcn2 | CG1609 gene product from transcript CG1609-RA | 0.034 | |
| Rfabg | Retinoid- and fatty acid-binding glycoprotein | 0.033 | |
| CG9063 | CG9063 gene product from transcript CG9063-RA | 0.033 | |
| bdg | bedraggled | 0.033 | |
| lap | like-AP180 | 0.033 | |
| g | garnet | 0.033 | |
| Pka-C1 | cAMP-dependent protein kinase 1 | 0.031 | |
| su(f) | suppressor of forked | 0.031 | |
| Rel | Relish | 0.030 | |
| G-salpha60A | G protein salpha 60A | 0.030 | |
| Rab5 | Rab-protein 5 | 0.030 | |
| spin | spinster | 0.029 | |
| tna | tonalli | 0.029 | |
| HtrA2 | CG8464 gene product from transcript CG8464-RA | 0.029 | |
| beta-Spec | beta Spectrin | 0.028 | |
| Chc | Clathrin heavy chain | 0.027 | |
| Pcaf | CG4107 gene product from transcript CG4107-RA | 0.026 | |
| Cct1 | CTP:phosphocholine cytidylyltransferase 1 | 0.026 | |
| VGlut | Vesicular glutamate transporter | 0.026 | |
| Traf4 | TNF-receptor-associated factor 4 | 0.025 | |
| ATP7 | CG1886 gene product from transcript CG1886-RB | 0.025 | |
| pb | proboscipedia | 0.024 | |
| PP2A-B' | CG7913 gene product from transcript CG7913-RK | 0.024 | |
| Cdk5alpha | Cdk5 activator-like protein | 0.024 | |
| Ubi-p63E | Ubiquitin-63E | 0.024 | |
| dre4 | CG1828 gene product from transcript CG1828-RB | 0.024 | |
| jar | jaguar | 0.023 | |
| PGRP-LE | Peptidoglycan recognition protein LE | 0.023 | |
| Taz | Tafazzin | 0.023 | |
| Sara | Smad anchor for receptor activation | 0.023 | |
| park | parkin | 0.022 | |
| hiw | highwire | 0.022 | |
| cac | cacophony | 0.022 | |
| Sox14 | Sox box protein 14 | 0.021 | |
| slo | slowpoke | 0.021 | |
| Med | Medea | 0.021 | |
| stmA | stambha A | 0.021 | |
| sei | seizure | 0.021 | |
| Pi3K59F | Phosphotidylinositol 3 kinase 59F | 0.021 | |
| 18w | 18 wheeler | 0.020 | |
| Fmr1 | CG6203 gene product from transcript CG6203-RC | 0.020 | |
| n-syb | n-synaptobrevin | 0.020 | |
| Tak1 | TGF-beta activated kinase 1 | 0.020 | |
| pzg | putzig | 0.020 | |
| ec | echinus | 0.020 | |
| Vha16 | Vacuolar H[+] ATPase 16kD subunit | 0.019 | |
| Vmat | Vesicular monoamine transporter | 0.019 | |
| btz | barentsz | 0.019 | |
| Mer | Merlin | 0.019 | |
| toy | twin of eyeless | 0.019 | |
| endoA | endophilin A | 0.019 | |
| RASSF8 | CG5053 gene product from transcript CG5053-RA | 0.019 | |
| BG4 | CG12297 gene product from transcript CG12297-RA | 0.019 | |
| Psf2 | CG18013 gene product from transcript CG18013-RA | 0.018 | |
| lmg | lemming | 0.018 | |
| CG4030 | CG4030 gene product from transcript CG4030-RA | 0.018 | |
| JhI-1 | Juvenile hormone-inducible protein 1 | 0.018 | |
| l(2)05510 | lethal (2) 05510 | 0.017 | |
| ct | cut | 0.017 | |
| Dredd | Death related ced-3/Nedd2-like protein | 0.017 | |
| Atg1 | Autophagy-specific gene 1 | 0.017 | |
| Nrx-1 | Neurexin 1 | 0.017 | |
| Awh | Arrowhead | 0.017 | |
| grim | CG4345 gene product from transcript CG4345-RA | 0.017 | |
| hig | hikaru genki | 0.016 | |
| Adar | Adenosine deaminase acting on RNA | 0.016 | |
| CG11055 | CG11055 gene product from transcript CG11055-RB | 0.016 | |
| Lis-1 | Lissencephaly-1 | 0.016 | |
| dve | defective proventriculus | 0.016 | |
| Vps33B | Vacuolar protein sorting 33B | 0.016 | |
| unc-13 | CG2999 gene product from transcript CG2999-RA | 0.016 | |
| acj6 | abnormal chemosensory jump 6 | 0.016 | |
| DAAM | Dishevelled Associated Activator of Morphogenesis | 0.016 | |
| hfw | halfway | 0.016 | |
| foxo | forkhead box, sub-group O | 0.015 | |
| Gga | CG3002 gene product from transcript CG3002-RB | 0.015 | |
| Aplip1 | APP-like protein interacting protein 1 | 0.015 | |
| Mekk1 | CG7717 gene product from transcript CG7717-RB | 0.015 |
Loading network...
Mus musculus| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Tnf | tumor necrosis factor | 0.935 | |
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.925 | |
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.914 | |
| Trp53 | transformation related protein 53 | 0.853 | |
| Traf2 | TNF receptor-associated factor 2 | 0.851 | |
| Pten | phosphatase and tensin homolog | 0.844 | |
| Ikbkg | inhibitor of kappaB kinase gamma | 0.753 | |
| Bak1 | BCL2-antagonist/killer 1 | 0.746 | |
| Casp8 | caspase 8 | 0.713 | |
| Stat2 | signal transducer and activator of transcription 2 | 0.659 | |
| Sfn | stratifin | 0.626 | |
| Atf2 | activating transcription factor 2 | 0.610 | |
| Itch | itchy, E3 ubiquitin protein ligase | 0.579 | |
| Mapk8ip3 | mitogen-activated protein kinase 8 interacting protein 3 | 0.577 | |
| Fadd | Fas (TNFRSF6)-associated via death domain | 0.550 | |
| Cd19 | CD19 antigen | 0.547 | |
| Traf6 | TNF receptor-associated factor 6 | 0.545 | |
| Tnfaip3 | tumor necrosis factor, alpha-induced protein 3 | 0.544 | |
| Map3k7 | mitogen-activated protein kinase kinase kinase 7 | 0.538 | |
| Arhgdia | Rho GDP dissociation inhibitor (GDI) alpha | 0.481 | |
| Relb | avian reticuloendotheliosis viral (v-rel) oncogene related B | 0.453 | |
| Map3k14 | mitogen-activated protein kinase kinase kinase 14 | 0.431 | |
| Cyld | cylindromatosis (turban tumor syndrome) | 0.414 | |
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.403 | |
| Tnfrsf9 | tumor necrosis factor receptor superfamily, member 9 | 0.387 | |
| Capns1 | calpain, small subunit 1 | 0.375 | |
| Pycard | PYD and CARD domain containing | 0.361 | |
| Atp6v0b | ATPase, H+ transporting, lysosomal V0 subunit B | 0.334 | |
| Birc3 | baculoviral IAP repeat-containing 3 | 0.329 | |
| Snap25 | synaptosomal-associated protein 25 | 0.301 | |
| Ctsb | cathepsin B | 0.295 | |
| Crim1 | cysteine rich transmembrane BMP regulator 1 (chordin like) | 0.275 | |
| Gbp5 | guanylate binding protein 5 | 0.240 | |
| Flii | flightless I homolog (Drosophila) | 0.233 | |
| Tnfrsf11a | tumor necrosis factor receptor superfamily, member 11a | 0.227 | |
| Rnf31 | ring finger protein 31 | 0.223 | |
| Rhog | ras homolog gene family, member G | 0.218 | |
| Casp4 | caspase 4, apoptosis-related cysteine peptidase | 0.211 | |
| Il10 | interleukin 10 | 0.197 | |
| Ripk1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.195 | |
| Pmaip1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.184 | |
| Cxcl13 | chemokine (C-X-C motif) ligand 13 | 0.177 | |
| Trp63 | transformation related protein 63 | 0.167 | |
| Ifng | interferon gamma | 0.164 | |
| Mvp | major vault protein | 0.160 | |
| Ripk3 | receptor-interacting serine-threonine kinase 3 | 0.159 | |
| Sh3gl2 | SH3-domain GRB2-like 2 | 0.158 | |
| Mapk14 | mitogen-activated protein kinase 14 | 0.154 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.152 | |
| Atp6v0d1 | ATPase, H+ transporting, lysosomal V0 subunit D1 | 0.150 | |
| Cd40 | CD40 antigen | 0.150 | |
| Ywhab | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 0.149 | |
| Il7 | interleukin 7 | 0.145 | |
| Mapkapk2 | MAP kinase-activated protein kinase 2 | 0.145 | |
| Hccs | holocytochrome c synthetase | 0.141 | |
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.139 | |
| Ctsl | cathepsin L | 0.137 | |
| Aim2 | absent in melanoma 2 | 0.132 | |
| Sesn2 | sestrin 2 | 0.132 | |
| Card11 | caspase recruitment domain family, member 11 | 0.131 | |
| Stat6 | signal transducer and activator of transcription 6 | 0.130 | |
| Nlrp3 | NLR family, pyrin domain containing 3 | 0.126 | |
| Igh | immunoglobulin heavy chain complex | 0.123 | |
| Hr | hairless | 0.121 | |
| Lag3 | lymphocyte-activation gene 3 | 0.120 | |
| Pacsin1 | protein kinase C and casein kinase substrate in neurons 1 | 0.119 | |
| Vamp2 | vesicle-associated membrane protein 2 | 0.117 | |
| Bax | BCL2-associated X protein | 0.115 | |
| Ikbkb | inhibitor of kappaB kinase beta | 0.114 | |
| Atg13 | ATG13 autophagy related 13 homolog (S. cerevisiae) | 0.112 | |
| Icos | inducible T-cell co-stimulator | 0.110 | |
| Stim2 | stromal interaction molecule 2 | 0.104 | |
| Smad3 | MAD homolog 3 (Drosophila) | 0.097 | |
| Aicda | activation-induced cytidine deaminase | 0.097 | |
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.095 | |
| Mx1 | myxovirus (influenza virus) resistance 1 | 0.095 | |
| Lta | lymphotoxin A | 0.095 | |
| Mknk2 | MAP kinase-interacting serine/threonine kinase 2 | 0.094 | |
| Batf | basic leucine zipper transcription factor, ATF-like | 0.094 | |
| 1810019J16Rik | RIKEN cDNA 1810019J16 gene | 0.093 | |
| Dnm1 | dynamin 1 | 0.089 | |
| Coro1b | coronin, actin binding protein 1B | 0.089 | |
| Irf8 | interferon regulatory factor 8 | 0.088 | |
| Arpc4 | actin related protein 2/3 complex, subunit 4 | 0.088 | |
| Il2rb | interleukin 2 receptor, beta chain | 0.088 | |
| Trp73 | transformation related protein 73 | 0.088 | |
| Tlr4 | toll-like receptor 4 | 0.085 | |
| Tcf3 | transcription factor 3 | 0.083 | |
| Ltbr | lymphotoxin B receptor | 0.082 | |
| Map3k8 | mitogen-activated protein kinase kinase kinase 8 | 0.081 | |
| Ltb | lymphotoxin B | 0.081 | |
| Trim21 | tripartite motif-containing 21 | 0.079 | |
| Eya2 | eyes absent 2 homolog (Drosophila) | 0.077 | |
| Skil | SKI-like | 0.077 | |
| Uba7 | ubiquitin-like modifier activating enzyme 7 | 0.076 | |
| Mdm4 | transformed mouse 3T3 cell double minute 4 | 0.076 | |
| Eif2ak2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.074 | |
| Necap2 | NECAP endocytosis associated 2 | 0.073 | |
| Map3k1 | mitogen-activated protein kinase kinase kinase 1 | 0.071 | |
| Xiap | X-linked inhibitor of apoptosis | 0.070 |