The network for 'necrotic cell death' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

necrotic cell death

A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues.

NameDescriptionProbabilityFunc Analog Organism
CASP8caspase 8, apoptosis-related cysteine peptidase1.000
FASFas (TNF receptor superfamily, member 6)0.941
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.903
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.797
CFLARCASP8 and FADD-like apoptosis regulator0.791
CASP10caspase 10, apoptosis-related cysteine peptidase0.752
FADDFas (TNFRSF6)-associated via death domain0.732
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.660
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.610
BIRC3baculoviral IAP repeat containing 30.585
BIRC2baculoviral IAP repeat containing 20.544
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.496
TANKTRAF family member-associated NFKB activator0.349
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.310
GABARAPGABA(A) receptor-associated protein0.270
TRADDTNFRSF1A-associated via death domain0.234
CASP7caspase 7, apoptosis-related cysteine peptidase0.228
TRAF1TNF receptor-associated factor 10.222
BIDBH3 interacting domain death agonist0.200
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.172
SQSTM1sequestosome 10.164
TBK1TANK-binding kinase 10.130
NLRC4NLR family, CARD domain containing 40.123
ATP6V1E1ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E10.122
FASLGFas ligand (TNF superfamily, member 6)0.089
CASP9caspase 9, apoptosis-related cysteine peptidase0.085
CLTCclathrin, heavy chain (Hc)0.085
CTSAcathepsin A0.080
RNF31ring finger protein 310.072
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.070
NFE2L2nuclear factor (erythroid-derived 2)-like 20.069
TRAF3TNF receptor-associated factor 30.066
SLC25A3solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 30.066
RIPK2receptor-interacting serine-threonine kinase 20.062
CASP3caspase 3, apoptosis-related cysteine peptidase0.060
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.058
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)0.058
DNM1dynamin 10.055
ARNTaryl hydrocarbon receptor nuclear translocator0.053
BCL2L11BCL2-like 11 (apoptosis facilitator)0.053
RIPK3receptor-interacting serine-threonine kinase 30.053
APCadenomatous polyposis coli0.049
MAPK1mitogen-activated protein kinase 10.047
ATG16L1ATG16 autophagy related 16-like 1 (S. cerevisiae)0.046
SMCR7Smith-Magenis syndrome chromosome region, candidate 70.045
RNF144Bring finger protein 144B0.043
TRAF2TNF receptor-associated factor 20.042
VDAC1voltage-dependent anion channel 10.040
MAP2K4mitogen-activated protein kinase kinase 40.039
AP2B1adaptor-related protein complex 2, beta 1 subunit0.034
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.034
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.034
ATP6V0BATPase, H+ transporting, lysosomal 21kDa, V0 subunit b0.032
CLASP1cytoplasmic linker associated protein 10.031
BBS10Bardet-Biedl syndrome 100.029
ADAM9ADAM metallopeptidase domain 90.029
TYK2tyrosine kinase 20.027
BCL2B-cell CLL/lymphoma 20.027
MAP2K7mitogen-activated protein kinase kinase 70.026
ATP5A1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle0.026
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.026
HDAC6histone deacetylase 60.026
CASP4caspase 4, apoptosis-related cysteine peptidase0.026
PDCD6programmed cell death 60.025
MYH9myosin, heavy chain 9, non-muscle0.024
ANKFY1ankyrin repeat and FYVE domain containing 10.023
ATP6AP1ATPase, H+ transporting, lysosomal accessory protein 10.023
RB1CC1RB1-inducible coiled-coil 10.022
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.022
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 30.022
CLN3ceroid-lipofuscinosis, neuronal 30.022
ATP6V0D1ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d10.021
BAK1BCL2-antagonist/killer 10.020
BIKBCL2-interacting killer (apoptosis-inducing)0.020
MAVSmitochondrial antiviral signaling protein0.020
SNAP25synaptosomal-associated protein, 25kDa0.020
ATG13ATG13 autophagy related 13 homolog (S. cerevisiae)0.019
ARRB1arrestin, beta 10.019
ZBTB16zinc finger and BTB domain containing 160.019
PACSIN2protein kinase C and casein kinase substrate in neurons 20.018
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.018
DAB2IPDAB2 interacting protein0.018
SMCR7LSmith-Magenis syndrome chromosome region, candidate 7-like0.017
AKT1v-akt murine thymoma viral oncogene homolog 10.017
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.016
NCOA7nuclear receptor coactivator 70.016
APAF1apoptotic peptidase activating factor 10.016
CAPNS1calpain, small subunit 10.016
OXA1Loxidase (cytochrome c) assembly 1-like0.016
TNFAIP3tumor necrosis factor, alpha-induced protein 30.016
PHB2prohibitin 20.016
MAPK14mitogen-activated protein kinase 140.016
XIAPX-linked inhibitor of apoptosis0.016
MICALL1MICAL-like 10.015
TUBA1Btubulin, alpha 1b0.015
BADBCL2-associated agonist of cell death0.015
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
atg-13Protein ATG-130.050
lin-8Protein LIN-80.040
bec-1Protein BEC-10.037
lgg-2Protein LGG-20.036
Y45G5AM.9Protein Y45G5AM.90.035
vha-13Protein VHA-130.031
Y17G7B.17Protein Y17G7B.170.029
tpa-1Protein TPA-10.027
K10C8.3Protein K10C8.30.023
cyn-13Protein CYN-130.022
mltn-1Protein MLTN-10.022
rab-3Protein RAB-30.021
Y17G7B.10Protein Y17G7B.100.021
C41D11.3Protein C41D11.30.020
T04F8.2Protein T04F8.20.020
gpb-1Protein GPB-10.020
CELE_Y47G6A.18Protein Y47G6A.180.020
C34D10.2Protein C34D10.20.020
clec-63Protein CLEC-630.019
agl-1Protein AGL-10.019
obr-1Protein OBR-10.019
acp-1Protein ACP-10.019
CELE_R102.5Protein R102.50.019
epg-6Protein EPG-60.019
cdl-1Protein CDL-10.019
ceh-44Protein CEH-440.018
hop-1Protein HOP-10.018
cnp-3Protein CNP-30.018
unc-9Protein UNC-90.018
ikke-1Protein IKKE-10.017
cul-2Protein CUL-20.017
mpst-3Protein MPST-30.017
abts-1Protein ABTS-10.017
wdr-23Protein WDR-230.017
hpo-13Protein HPO-130.017
clec-87Protein CLEC-870.017
F47A4.5Protein F47A4.50.016
tag-180Protein TAG-1800.016
ret-1Protein RET-10.016
snx-14Protein SNX-140.016
atg-16.1Protein ATG-16.10.016
sma-10Protein SMA-100.016
eat-6Protein EAT-60.015
toe-4Protein TOE-40.015
rab-5Protein RAB-50.015
hmr-1Protein HMR-10.015
sli-1Protein SLI-10.015
hrdl-1Protein HRDL-10.015
unc-26Protein UNC-260.015
zer-1Protein ZER-10.015
ced-12Protein CED-120.015
wdfy-2Protein WDFY-20.015
tra-1Protein TRA-10.015
prmt-5Protein PRMT-50.015
grk-1Protein GRK-10.014
pkc-3Protein PKC-30.014
bath-42Protein BATH-420.014
ZK484.1Protein ZK484.10.014
fat-1Protein FAT-10.014
Y54G2A.2Protein Y54G2A.20.014
Y51H7C.3Protein Y51H7C.30.014
ppk-2Protein PPK-20.014
unc-14Protein UNC-140.014
C04B4.2Protein C04B4.20.014
spas-1Protein SPAS-10.013
csnk-1Protein CSNK-10.013
nos-2Protein NOS-20.013
unc-45Protein UNC-450.013
itsn-1Protein ITSN-10.013
CELE_F53C11.4Protein F53C11.40.013
vha-3Protein VHA-30.013
D2030.2Protein D2030.20.013
hipr-1Protein HIPR-10.013
his-35Protein HIS-350.013
F59F4.3Protein F59F4.30.013
tra-3Protein TRA-30.012
let-363Protein LET-3630.012
gdh-1Protein GDH-10.012
mom-4Protein MOM-40.012
flh-2Protein FLH-20.012
nhr-1Protein NHR-10.012
T24H10.4Protein T24H10.40.012
ercc-1Protein ERCC-10.012
ugt-60Protein UGT-600.012
egl-1Protein EGL-10.012
CELE_Y69H2.7Protein Y69H2.70.012
F25B3.6Protein F25B3.60.012
K11H12.8Protein K11H12.80.012
vps-45Protein VPS-450.012
amph-1Protein AMPH-10.012
vha-14Protein VHA-140.012
C10G11.7Protein C10G11.70.012
D2085.5Protein D2085.50.012
mca-1Protein MCA-10.012
clp-7Protein CLP-70.012
eef-1A.1Protein EEF-1A.10.012
aat-9Protein AAT-90.012
mdt-1.2Protein MDT-1.20.012
CELE_F10G7.10Protein F10G7.100.012
scm-1Protein SCM-10.012
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
stnAstoned A0.183
Toll-6CG7250 gene product from transcript CG7250-RA0.069
OsbpOxysterol binding protein0.056
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.051
Pink1PTEN-induced putative kinase 10.048
Toll-7CG8595 gene product from transcript CG8595-RA0.046
ird1immune response deficient 10.045
Eip93FCG18389 gene product from transcript CG18389-RB0.041
unc-104CG8566 gene product from transcript CG8566-RB0.041
tefutelomere fusion0.039
Myd88CG2078 gene product from transcript CG2078-RA0.038
LrrkLeucine-rich repeat kinase0.037
Vha100-1CG1709 gene product from transcript CG1709-RF0.037
trioCG18214 gene product from transcript CG18214-RA0.034
Gcn2CG1609 gene product from transcript CG1609-RA0.034
RfabgRetinoid- and fatty acid-binding glycoprotein0.033
CG9063CG9063 gene product from transcript CG9063-RA0.033
Pka-C1cAMP-dependent protein kinase 10.031
su(f)suppressor of forked0.031
G-salpha60AG protein salpha 60A0.030
Rab5Rab-protein 50.030
HtrA2CG8464 gene product from transcript CG8464-RA0.029
beta-Specbeta Spectrin0.028
ChcClathrin heavy chain0.027
PcafCG4107 gene product from transcript CG4107-RA0.026
Cct1CTP:phosphocholine cytidylyltransferase 10.026
VGlutVesicular glutamate transporter0.026
Traf4TNF-receptor-associated factor 40.025
ATP7CG1886 gene product from transcript CG1886-RB0.025
PP2A-B'CG7913 gene product from transcript CG7913-RK0.024
Cdk5alphaCdk5 activator-like protein0.024
dre4CG1828 gene product from transcript CG1828-RB0.024
PGRP-LEPeptidoglycan recognition protein LE0.023
SaraSmad anchor for receptor activation0.023
Sox14Sox box protein 140.021
stmAstambha A0.021
Pi3K59FPhosphotidylinositol 3 kinase 59F0.021
18w18 wheeler0.020
Fmr1CG6203 gene product from transcript CG6203-RC0.020
Tak1TGF-beta activated kinase 10.020
Vha16Vacuolar H[+] ATPase 16kD subunit0.019
VmatVesicular monoamine transporter0.019
toytwin of eyeless0.019
endoAendophilin A0.019
RASSF8CG5053 gene product from transcript CG5053-RA0.019
BG4CG12297 gene product from transcript CG12297-RA0.019
Psf2CG18013 gene product from transcript CG18013-RA0.018
CG4030CG4030 gene product from transcript CG4030-RA0.018
JhI-1Juvenile hormone-inducible protein 10.018
l(2)05510lethal (2) 055100.017
DreddDeath related ced-3/Nedd2-like protein0.017
Atg1Autophagy-specific gene 10.017
Nrx-1Neurexin 10.017
grimCG4345 gene product from transcript CG4345-RA0.017
highikaru genki0.016
AdarAdenosine deaminase acting on RNA0.016
CG11055CG11055 gene product from transcript CG11055-RB0.016
dvedefective proventriculus0.016
Vps33BVacuolar protein sorting 33B0.016
unc-13CG2999 gene product from transcript CG2999-RA0.016
acj6abnormal chemosensory jump 60.016
DAAMDishevelled Associated Activator of Morphogenesis0.016
foxoforkhead box, sub-group O0.015
GgaCG3002 gene product from transcript CG3002-RB0.015
Aplip1APP-like protein interacting protein 10.015
Mekk1CG7717 gene product from transcript CG7717-RB0.015
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor0.935
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.925
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.914
Trp53transformation related protein 530.853
Traf2TNF receptor-associated factor 20.851
Ptenphosphatase and tensin homolog0.844
Ikbkginhibitor of kappaB kinase gamma0.753
Bak1BCL2-antagonist/killer 10.746
Casp8caspase 80.713
Stat2signal transducer and activator of transcription 20.659
Atf2activating transcription factor 20.610
Itchitchy, E3 ubiquitin protein ligase0.579
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.577
FaddFas (TNFRSF6)-associated via death domain0.550
Cd19CD19 antigen0.547
Traf6TNF receptor-associated factor 60.545
Tnfaip3tumor necrosis factor, alpha-induced protein 30.544
Map3k7mitogen-activated protein kinase kinase kinase 70.538
ArhgdiaRho GDP dissociation inhibitor (GDI) alpha0.481
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.453
Map3k14mitogen-activated protein kinase kinase kinase 140.431
Cyldcylindromatosis (turban tumor syndrome)0.414
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.403
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.387
Capns1calpain, small subunit 10.375
PycardPYD and CARD domain containing0.361
Atp6v0bATPase, H+ transporting, lysosomal V0 subunit B0.334
Birc3baculoviral IAP repeat-containing 30.329
Snap25synaptosomal-associated protein 250.301
Ctsbcathepsin B0.295
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.275
Gbp5guanylate binding protein 50.240
Fliiflightless I homolog (Drosophila)0.233
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.227
Rnf31ring finger protein 310.223
Rhogras homolog gene family, member G0.218
Casp4caspase 4, apoptosis-related cysteine peptidase0.211
Il10interleukin 100.197
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.195
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.184
Cxcl13chemokine (C-X-C motif) ligand 130.177
Trp63transformation related protein 630.167
Ifnginterferon gamma0.164
Mvpmajor vault protein0.160
Ripk3receptor-interacting serine-threonine kinase 30.159
Sh3gl2SH3-domain GRB2-like 20.158
Mapk14mitogen-activated protein kinase 140.154
FasFas (TNF receptor superfamily member 6)0.152
Atp6v0d1ATPase, H+ transporting, lysosomal V0 subunit D10.150
Cd40CD40 antigen0.150
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.149
Il7interleukin 70.145
Mapkapk2MAP kinase-activated protein kinase 20.145
Hccsholocytochrome c synthetase0.141
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.139
Ctslcathepsin L0.137
Aim2absent in melanoma 20.132
Sesn2sestrin 20.132
Card11caspase recruitment domain family, member 110.131
Stat6signal transducer and activator of transcription 60.130
Nlrp3NLR family, pyrin domain containing 30.126
Ighimmunoglobulin heavy chain complex0.123
Lag3lymphocyte-activation gene 30.120
Pacsin1protein kinase C and casein kinase substrate in neurons 10.119
Vamp2vesicle-associated membrane protein 20.117
BaxBCL2-associated X protein0.115
Ikbkbinhibitor of kappaB kinase beta0.114
Atg13ATG13 autophagy related 13 homolog (S. cerevisiae)0.112
Icosinducible T-cell co-stimulator0.110
Stim2stromal interaction molecule 20.104
Smad3MAD homolog 3 (Drosophila)0.097
Aicdaactivation-induced cytidine deaminase0.097
Mdm2transformed mouse 3T3 cell double minute 20.095
Mx1myxovirus (influenza virus) resistance 10.095
Ltalymphotoxin A0.095
Mknk2MAP kinase-interacting serine/threonine kinase 20.094
Batfbasic leucine zipper transcription factor, ATF-like0.094
1810019J16RikRIKEN cDNA 1810019J16 gene0.093
Dnm1dynamin 10.089
Coro1bcoronin, actin binding protein 1B0.089
Irf8interferon regulatory factor 80.088
Arpc4actin related protein 2/3 complex, subunit 40.088
Il2rbinterleukin 2 receptor, beta chain0.088
Trp73transformation related protein 730.088
Tlr4toll-like receptor 40.085
Tcf3transcription factor 30.083
Ltbrlymphotoxin B receptor0.082
Map3k8mitogen-activated protein kinase kinase kinase 80.081
Ltblymphotoxin B0.081
Trim21tripartite motif-containing 210.079
Eya2eyes absent 2 homolog (Drosophila)0.077
Uba7ubiquitin-like modifier activating enzyme 70.076
Mdm4transformed mouse 3T3 cell double minute 40.076
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.074
Necap2NECAP endocytosis associated 20.073
Map3k1mitogen-activated protein kinase kinase kinase 10.071
XiapX-linked inhibitor of apoptosis0.070
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism