The network for 'proteolysis involved in cellular protein catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

proteolysis involved in cellular protein catabolic process

The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.

NameDescriptionProbabilityFunc Analog Organism
UBCubiquitin C1.000
UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)1.000
UBE2D2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)1.000
XIAPX-linked inhibitor of apoptosis1.000
RNF11ring finger protein 111.000
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)1.000
TP53tumor protein p531.000
UBE2V1ubiquitin-conjugating enzyme E2 variant 11.000
VCPvalosin containing protein0.999
UBE2Nubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)0.999
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.998
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.998
MDM2Mdm2 p53 binding protein homolog (mouse)0.998
TRAF6TNF receptor-associated factor 60.997
SKP1S-phase kinase-associated protein 10.996
CDC27cell division cycle 27 homolog (S. cerevisiae)0.996
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.993
RB1retinoblastoma 10.993
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.993
CDC20cell division cycle 20 homolog (S. cerevisiae)0.992
BTRCbeta-transducin repeat containing0.991
HSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)0.991
PSMD1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.991
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.989
RBX1ring-box 1, E3 ubiquitin protein ligase0.988
ATXN3ataxin 30.987
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 140.987
PSMB2proteasome (prosome, macropain) subunit, beta type, 20.985
BIRC2baculoviral IAP repeat containing 20.984
PSMA7proteasome (prosome, macropain) subunit, alpha type, 70.983
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.982
PSMC2proteasome (prosome, macropain) 26S subunit, ATPase, 20.980
PSMA6proteasome (prosome, macropain) subunit, alpha type, 60.978
PSMA2proteasome (prosome, macropain) subunit, alpha type, 20.977
PTK2PTK2 protein tyrosine kinase 20.977
CCNB1cyclin B10.975
PSMC5proteasome (prosome, macropain) 26S subunit, ATPase, 50.974
CASP8caspase 8, apoptosis-related cysteine peptidase0.974
CUL3cullin 30.973
PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.972
ANAPC4anaphase promoting complex subunit 40.971
SMAD4SMAD family member 40.970
RNF111ring finger protein 1110.970
UBQLN1ubiquilin 10.969
TRIM39tripartite motif containing 390.967
CDK2cyclin-dependent kinase 20.967
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.965
SMURF2SMAD specific E3 ubiquitin protein ligase 20.964
PSMA1proteasome (prosome, macropain) subunit, alpha type, 10.961
PSMC3proteasome (prosome, macropain) 26S subunit, ATPase, 30.955
PSMC6proteasome (prosome, macropain) 26S subunit, ATPase, 60.954
SQSTM1sequestosome 10.951
ADRM1adhesion regulating molecule 10.950
UBE3Aubiquitin protein ligase E3A0.950
PSMD6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.948
SMAD2SMAD family member 20.948
PSME3proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)0.946
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.944
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.941
POMPproteasome maturation protein0.941
MAP3K5mitogen-activated protein kinase kinase kinase 50.933
FBXW11F-box and WD repeat domain containing 110.932
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.929
PSMA5proteasome (prosome, macropain) subunit, alpha type, 50.928
PSMC1proteasome (prosome, macropain) 26S subunit, ATPase, 10.924
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.923
CCNA2cyclin A20.918
SYVN1synovial apoptosis inhibitor 1, synoviolin0.916
RNF126ring finger protein 1260.912
RNF5ring finger protein 50.908
OTUB1OTU domain, ubiquitin aldehyde binding 10.902
MDM4Mdm4 p53 binding protein homolog (mouse)0.900
ZNRF1zinc and ring finger 10.893
CUL1cullin 10.893
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.892
COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.891
ANAPC7anaphase promoting complex subunit 70.889
PLK1polo-like kinase 10.889
STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase0.880
ANAPC11anaphase promoting complex subunit 110.873
MARCH7membrane-associated ring finger (C3HC4) 70.868
FAF2Fas associated factor family member 20.865
CUL2cullin 20.864
CDC5LCDC5 cell division cycle 5-like (S. pombe)0.863
PDCD6IPprogrammed cell death 6 interacting protein0.861
GSK3Bglycogen synthase kinase 3 beta0.861
HSPA8heat shock 70kDa protein 80.852
PSMB3proteasome (prosome, macropain) subunit, beta type, 30.851
PSMD12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.845
CASP3caspase 3, apoptosis-related cysteine peptidase0.837
TCEB1transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)0.828
SIAH1seven in absentia homolog 1 (Drosophila)0.825
FBXO5F-box protein 50.823
UBXN7UBX domain protein 70.820
UBE2Hubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)0.813
SKP2S-phase kinase-associated protein 2 (p45)0.810
DERL1Der1-like domain family, member 10.805
PJA2praja ring finger 20.798
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.798
PSMB4proteasome (prosome, macropain) subunit, beta type, 40.793
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
rpt-2Protein RPT-20.856
rpt-3Protein RPT-30.773
rpn-7Protein RPN-70.771
imb-2Protein IMB-20.679
rpn-12Protein RPN-120.666
rpt-5Protein RPT-50.641
rpn-3Protein RPN-30.632
pas-4Protein PAS-40.566
pbs-5Protein PBS-50.543
rpn-6.1Protein RPN-6.10.532
app-1Protein APP-10.426
rod-1Protein ROD-10.346
hgrs-1Protein HGRS-10.338
cul-1Protein CUL-10.336
pbs-6Protein PBS-60.313
rpn-2Protein RPN-20.304
pas-2Protein PAS-20.276
stam-1Protein STAM-10.262
rnr-1Protein RNR-10.244
npl-4.2Protein NPL-4.20.244
npl-4.1Protein NPL-4.10.244
E04D5.1Protein E04D5.10.234
pas-1Protein PAS-10.227
cdc-48.2Protein CDC-48.20.225
tba-2Protein TBA-20.221
pas-6Protein PAS-60.221
rpn-10Protein RPN-100.216
pbs-3Protein PBS-30.209
pbs-2Protein PBS-20.189
rpn-5Protein RPN-50.169
pbs-1Protein PBS-10.152
mig-5Protein MIG-50.149
bub-1Protein BUB-10.149
rpt-4Protein RPT-40.145
ima-2Protein IMA-20.137
zyg-1Protein ZYG-10.126
mat-3Protein MAT-30.124
egl-18Protein EGL-180.123
D1081.8Protein D1081.80.122
syx-17Protein SYX-170.116
rpl-11.1Protein RPL-11.10.108
rpn-9Protein RPN-90.106
zen-4Protein ZEN-40.099
daf-21Protein DAF-210.098
C31E10.6Protein C31E10.60.098
Y54E5A.7Protein Y54E5A.70.095
R11A8.7Protein R11A8.70.093
taf-5Protein TAF-50.088
pbs-7Protein PBS-70.088
hda-1Protein HDA-10.086
rad-26Protein RAD-260.085
syx-5Protein SYX-50.084
klp-16Protein KLP-160.084
ZK180.6Protein ZK180.60.078
T22F3.2Protein T22F3.20.076
crt-1Protein CRT-10.072
pas-5Protein PAS-50.070
T08A11.2Protein T08A11.20.070
rbg-1Protein RBG-10.069
his-6Protein HIS-60.068
CELE_C24H12.5Protein C24H12.50.068
rpn-1Protein RPN-10.068
CELE_R102.5Protein R102.50.066
cpr-4Protein CPR-40.065
R186.3Protein R186.30.064
smc-3Protein SMC-30.062
mom-2Protein MOM-20.062
ZK1055.7Protein ZK1055.70.062
pup-2Protein PUP-20.061
F46F11.6Protein F46F11.60.060
rpt-1Protein RPT-10.059
ung-1Protein UNG-10.058
sym-4Protein SYM-40.056
CELE_T10C6.6Protein T10C6.60.054
ubc-3Protein UBC-30.054
dli-1Protein DLI-10.054
pbs-4Protein PBS-40.053
tag-353Protein TAG-3530.053
sel-12Protein SEL-120.053
snr-4Protein SNR-40.052
pas-7Protein PAS-70.052
mel-26Protein MEL-260.051
B0454.9Protein B0454.90.050
hrp-1Protein HRP-10.050
mex-5Protein MEX-50.050
ZK507.6Protein ZK507.60.049
K08E3.5Protein K08E3.50.048
pcn-1Protein PCN-10.047
rfc-2Protein RFC-20.047
CELE_C39E9.11Protein C39E9.110.047
sur-2Protein SUR-20.046
skr-1Protein SKR-10.045
Y110A7A.6Protein Y110A7A.60.044
usp-14Protein USP-140.044
ztf-7Protein ZTF-70.044
dsh-2Protein DSH-20.044
dlc-1Protein DLC-10.044
goa-1Protein GOA-10.043
asb-1Protein ASB-10.043
sel-2Protein SEL-20.043
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
psmb1proteasome (prosome, macropain) subunit, beta type, 10.968
psma6aproteasome (prosome, macropain) subunit, alpha type, 6a0.958
psmd12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.919
psmc5proteasome (prosome, macropain) 26S subunit, ATPase, 50.900
psmb4proteasome (prosome, macropain) subunit, beta type, 40.894
psmd6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.881
psmc4proteasome (prosome, macropain) 26S subunit, ATPase, 40.829
psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.813
hspa4bheat shock protein 4b0.772
psma8proteasome (prosome, macropain) subunit, alpha type, 80.754
psmc6proteasome (prosome, macropain) 26S subunit, ATPase, 60.714
ccnb1cyclin B10.702
zgc:92775zgc:927750.695
psmd4bproteasome (prosome, macropain) 26S subunit, non-ATPase, 4b0.690
zgc:86903zgc:869030.671
psmb5proteasome (prosome, macropain) subunit, beta type, 50.656
ctsccathepsin C0.626
ddx42DEAD (Asp-Glu-Ala-Asp) box polypeptide 420.585
ywhabbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b0.551
plk1polo-like kinase 1 (Drosophila)0.544
ctskcathepsin K0.534
hspa5heat shock protein 50.524
adrm1badhesion regulating molecule 1b0.524
psmd11aproteasome (prosome, macropain) 216S subunit, non-ATPase, 11a0.513
wnt4awingless-type MMTV integration site family, member 4a0.499
gro2groucho 20.492
kif23kinesin family member 230.488
usp5ubiquitin specific protease 50.471
psmb7proteasome (prosome, macropain) subunit, beta type, 70.458
psmb3proteasome (prosome, macropain) subunit, beta type, 30.455
exoc3exocyst complex component 30.455
psma4proteasome (prosome, macropain) subunit, alpha type, 40.454
psmc1bproteasome (prosome, macropain) 26S subunit, ATPase, 1b0.441
psmd11bproteasome (prosome, macropain) 216S subunit, non-ATPase, 11b0.436
vedventrally expressed dharma/bozozok antagonist0.431
psmd8proteasome (prosome, macropain) 26S subunit, non-ATPase, 80.403
aurkbaurora kinase B0.377
vcpvalosin containing protein0.369
xbp1X-box binding protein 10.367
eif4heukaryotic translation initiation factor 4h0.363
ctszcathepsin Z0.359
baxabcl2-associated X protein, a0.359
runx2arunt-related transcription factor 2a0.353
nploc4nuclear protein localization 4 homolog (S. cerevisiae)0.346
lancl1LanC antibiotic synthetase component C-like 1 (bacterial)0.345
si:ch211-239j15.4si:ch211-239j15.40.331
zgc:64051zgc:640510.330
zgc:73111zgc:731110.324
LOC100330405transmembrane protein 176B-like0.308
tia1lcytotoxic granule-associated RNA binding protein 1, like0.307
maxmyc-associated factor X0.307
psmb2proteasome (prosome, macropain) subunit, beta type, 20.306
snai1asnail homolog 1a (Drosophila)0.305
bsdc1BSD domain containing 10.303
psmd3proteasome (prosome, macropain) 26S subunit, non-ATPase, 30.301
cdc20cell division cycle 20 homolog0.300
psmd13proteasome (prosome, macropain) 26S subunit, non-ATPase, 130.300
akt2v-akt murine thymoma viral oncogene homolog 20.290
rangap1Ran GTPase activating protein 10.289
zgc:110116zgc:1101160.284
bc2putative breast adenocarcinoma marker0.281
rae1RAE1 RNA export 1 homolog (S. pombe)0.279
ip6k2inositol hexaphosphate kinase 20.276
prkrirprotein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)0.276
ccnb2cyclin B20.275
rplp0ribosomal protein, large, P00.268
zgc:92765zgc:927650.267
rqcd1RCD1 required for cell differentiation1 homolog (S. pombe)0.266
ihhaIndian hedgehog homolog a0.262
psma2proteasome (prosome, macropain) subunit, alpha type, 20.260
mcts1malignant T cell amplified sequence 10.259
hyou1hypoxia up-regulated 10.258
psapprosaposin0.258
gps1G protein pathway suppressor 10.252
ctsdcathepsin D0.251
snx3sorting nexin 30.247
hsp90b1heat shock protein 90, beta (grp94), member 10.238
ube2g2ubiquitin-conjugating enzyme E2G 20.233
usp14ubiquitin specific protease 14 (tRNA-guanine transglycosylase)0.231
psma1proteasome (prosome, macropain) subunit, alpha type, 10.231
ck2bcasein kinase 2 beta0.227
racgap1Rac GTPase-activating protein 10.225
dnm1ldynamin 1-like0.225
zgc:55683zgc:556830.224
kpna4karyopherin alpha 4 (importin alpha 3)0.223
cand1cullin-associated and neddylation-dissociated 10.223
psmc1aproteasome (prosome, macropain) 26S subunit, ATPase, 1a0.222
faf2Fas associated factor family member 20.221
fliiflightless I homolog (Drosophila)0.221
syvn1synovial apoptosis inhibitor 1, synoviolin0.220
supt5hsuppressor of Ty 5 homolog (S. cerevisiae)0.220
gna13aguanine nucleotide binding protein (G protein), alpha 13a0.219
ctsbacathepsin B, a0.219
zgc:92139zgc:921390.216
ccna2cyclin A20.213
cdt1chromatin licensing and DNA replication factor 10.211
fmnl2bformin-like 2b0.211
sox32SRY-box containing gene 320.208
zgc:158603zgc:1586030.205
cul2cullin 20.205
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
tefutelomere fusion0.980
Prosbeta2Proteasome beta2 subunit0.953
CG12321CG12321 gene product from transcript CG12321-RA0.948
Ras85DRas oncogene at 85D0.889
Rpn9CG10230 gene product from transcript CG10230-RB0.863
Rpt1CG1341 gene product from transcript CG1341-RA0.852
CycBCyclin B0.812
Rpt3CG16916 gene product from transcript CG16916-RA0.809
Pros29Proteasome 29kD subunit0.752
Pros28.1Proteasome 28kD subunit 10.705
nejnejire0.621
Mov34CG3416 gene product from transcript CG3416-RA0.616
Nipped-ACG33554 gene product from transcript CG33554-RE0.597
Rpt4CG3455 gene product from transcript CG3455-RA0.594
Rpn2CG11888 gene product from transcript CG11888-RA0.549
dcodiscs overgrown0.539
Hsp83Heat shock protein 830.538
Prosbeta3Proteasome beta3 subunit0.530
Rpn1CG7762 gene product from transcript CG7762-RA0.530
Pros26.4Proteasome 26S subunit subunit 4 ATPase0.526
Vap-33-1CG5014 gene product from transcript CG5014-RB0.479
brmbrahma0.453
betaTub56Dbeta-Tubulin at 56D0.443
CG13349CG13349 gene product from transcript CG13349-RA0.441
Pros54Proteasome 54kD subunit0.433
Prosbeta1Proteasome beta1 subunit0.416
Vps25Vacuolar protein sorting 250.415
ncdnon-claret disjunctional0.409
slmbsupernumerary limbs0.403
RagACG11968 gene product from transcript CG11968-RA0.391
Prosbeta5Proteasome beta5 subunit0.378
pr-set7CG3307 gene product from transcript CG3307-RC0.375
CG5555CG5555 gene product from transcript CG5555-RA0.366
IncenpInner centromere protein0.361
Rpn5CG1100 gene product from transcript CG1100-RA0.342
Rpn6Proteasome p44.5 subunit0.333
Tip60CG6121 gene product from transcript CG6121-RA0.329
Fcp1CG12252 gene product from transcript CG12252-RA0.306
smosmoothened0.303
Prosalpha5Proteasome alpha5 subunit0.294
Akt1CG4006 gene product from transcript CG4006-RA0.294
Tbp-1Tat-binding protein-10.290
skpACG16983 gene product from transcript CG16983-RD0.290
ykiyorkie0.279
Rpn12CG4157 gene product from transcript CG4157-RA0.274
CG32581CG32581 gene product from transcript CG32581-RB0.274
Rpn3Regulatory particle non-ATPase 30.267
Top1Topoisomerase 10.265
mspsmini spindles0.244
Rpn11CG18174 gene product from transcript CG18174-RA0.239
gwlgreatwall0.231
CycDCyclin D0.231
RYBPRing and YY1 Binding Protein0.228
Rpd3CG7471 gene product from transcript CG7471-RA0.227
agoarchipelago0.222
Rpn7CG5378 gene product from transcript CG5378-RA0.221
Pp1-87BProtein phosphatase 1 at 87B0.211
PsaPuromycin sensitive aminopeptidase0.211
lqfliquid facets0.211
stepsteppke0.209
hpohippo0.208
RhoGEF2CG9635 gene product from transcript CG9635-RF0.208
Caf1Chromatin assembly factor 1 subunit0.201
Cap-GCG34438 gene product from transcript CG34438-RF0.201
aspabnormal spindle0.200
CG8979CG8979 gene product from transcript CG8979-RC0.198
lsnlarsen0.194
CSN3COP9 complex homolog subunit 30.187
Prosbeta7Proteasome beta7 subunit0.186
panpangolin0.174
Act5CActin 5C0.171
dhddeadhead0.171
Mgat1UDP-GlcNAc:a-3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I0.170
CycGCyclin G0.167
Tak1TGF-beta activated kinase 10.166
RhebCG1081 gene product from transcript CG1081-RA0.165
cal1chromosome alignment defect 10.162
CycECyclin E0.158
ttvtout-velu0.157
UchUbiquitin carboxy-terminal hydrolase0.156
Su(H)Suppressor of Hairless0.154
MadMothers against dpp0.151
fzyfizzy0.150
CSN8COP9 complex homolog subunit 80.149
Ube3aUbiquitin protein ligase E3A0.147
Pros35Proteasome 35kD subunit0.146
SaraSmad anchor for receptor activation0.145
Pros26Proteasome 26kD subunit0.144
UbcD2Ubiquitin conjugating enzyme 20.143
poloCG12306 gene product from transcript CG12306-RA0.142
wdbwiderborst0.142
CG4673CG4673 gene product from transcript CG4673-RB0.139
TSG101tumor suppressor protein 1010.137
ash2absent, small, or homeotic discs 20.133
krzkurtz0.133
lin19lin-19-like0.133
Rad23CG1836 gene product from transcript CG1836-RB0.133
CG9135CG9135 gene product from transcript CG9135-RB0.132
yrtyurt0.131
Tab2TAK1-associated binding protein 20.131
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 11.000
Trp53transformation related protein 531.000
Axin1axin 11.000
Psen1presenilin 10.999
Per2period homolog 2 (Drosophila)0.998
Vcpvalosin containing protein0.992
Clockcircadian locomotor output cycles kaput0.990
Akt1thymoma viral proto-oncogene 10.989
Map3k7mitogen-activated protein kinase kinase kinase 70.989
Ncoa3nuclear receptor coactivator 30.989
Gsk3bglycogen synthase kinase 3 beta0.985
Ptenphosphatase and tensin homolog0.985
Usp9xubiquitin specific peptidase 9, X chromosome0.976
Psmb7proteasome (prosome, macropain) subunit, beta type 70.965
Nedd4neural precursor cell expressed, developmentally down-regulated 40.959
Fgfr1fibroblast growth factor receptor 10.955
Cul3cullin 30.951
Psma7proteasome (prosome, macropain) subunit, alpha type 70.941
Apcadenomatosis polyposis coli0.934
Ncstnnicastrin0.934
Psmb6proteasome (prosome, macropain) subunit, beta type 60.929
Mdm2transformed mouse 3T3 cell double minute 20.929
Traf6TNF receptor-associated factor 60.927
Psma3proteasome (prosome, macropain) subunit, alpha type 30.906
Smad7MAD homolog 7 (Drosophila)0.898
Cdk1cyclin-dependent kinase 10.892
Skp1aS-phase kinase-associated protein 1A0.887
Psmd4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.871
Ccnb1cyclin B10.870
SkilSKI-like0.853
Psma5proteasome (prosome, macropain) subunit, alpha type 50.851
Psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.838
Psma1proteasome (prosome, macropain) subunit, alpha type 10.826
Aampangio-associated migratory protein0.819
Appamyloid beta (A4) precursor protein0.812
Mgea5meningioma expressed antigen 5 (hyaluronidase)0.812
Mbd3methyl-CpG binding domain protein 30.807
Cyldcylindromatosis (turban tumor syndrome)0.806
Dyrk1adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a0.806
Manfmesencephalic astrocyte-derived neurotrophic factor0.801
Mdm4transformed mouse 3T3 cell double minute 40.800
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)0.791
Psma2proteasome (prosome, macropain) subunit, alpha type 20.760
Bag6BCL2-associated athanogene 60.758
Pompproteasome maturation protein0.750
Psmc3proteasome (prosome, macropain) 26S subunit, ATPase 30.750
Cops5COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)0.744
Ccne1cyclin E10.721
Ube2d3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.717
Vhlvon Hippel-Lindau tumor suppressor0.709
Prc1protein regulator of cytokinesis 10.700
Pax8paired box gene 80.697
Agap3ArfGAP with GTPase domain, ankyrin repeat and PH domain 30.695
Psma4proteasome (prosome, macropain) subunit, alpha type 40.695
Itgb1integrin beta 1 (fibronectin receptor beta)0.688
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.671
Sqstm1sequestosome 10.649
Bcl2B-cell leukemia/lymphoma 20.646
Kpna1karyopherin (importin) alpha 10.645
Csnk1g2casein kinase 1, gamma 20.635
Stat3signal transducer and activator of transcription 30.630
Glrx3glutaredoxin 30.616
Ehmt2euchromatic histone lysine N-methyltransferase 20.614
Gli3GLI-Kruppel family member GLI30.611
Psme4proteasome (prosome, macropain) activator subunit 40.603
Add1adducin 1 (alpha)0.599
Yap1yes-associated protein 10.599
Ahraryl-hydrocarbon receptor0.593
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.592
Arrb1arrestin, beta 10.590
Hif1ahypoxia inducible factor 1, alpha subunit0.590
Ppargperoxisome proliferator activated receptor gamma0.589
H2afzH2A histone family, member Z0.586
Rnf111ring finger 1110.586
Ikbkginhibitor of kappaB kinase gamma0.584
Ubcubiquitin C0.581
Rnf19aring finger protein 19A0.579
Mapk8mitogen-activated protein kinase 80.578
Skiski sarcoma viral oncogene homolog (avian)0.573
Kpna3karyopherin (importin) alpha 30.571
Tab3TGF-beta activated kinase 1/MAP3K7 binding protein 30.569
Brca1breast cancer 10.566
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.564
Rbl2retinoblastoma-like 20.562
Cul4acullin 4A0.558
Amfrautocrine motility factor receptor0.557
Arntlaryl hydrocarbon receptor nuclear translocator-like0.556
Adrm1adhesion regulating molecule 10.553
Birc5baculoviral IAP repeat-containing 50.552
Ranbp9RAN binding protein 90.551
Thrathyroid hormone receptor alpha0.550
Gli2GLI-Kruppel family member GLI20.537
Wdr26WD repeat domain 260.533
Arrb2arrestin, beta 20.533
Mllt1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10.530
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.525
Notch1Notch gene homolog 1 (Drosophila)0.517
Psmc5protease (prosome, macropain) 26S subunit, ATPase 50.517
Map3k1mitogen-activated protein kinase kinase kinase 10.516
Fzr1fizzy/cell division cycle 20 related 1 (Drosophila)0.515
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Psma5proteasome (prosome, macropain) subunit, alpha type 50.987
Psmb3proteasome (prosome, macropain) subunit, beta type 30.943
Psma4proteasome (prosome, macropain) subunit, alpha type 40.902
Psma3proteasome (prosome, macropain) subunit, alpha type 30.900
Psmc1proteasome (prosome, macropain) 26S subunit, ATPase, 10.710
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.694
Psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.687
Psma7proteasome (prosome, macropain) subunit, alpha type 70.600
Psmb6proteasome (prosome, macropain) subunit, beta type 60.550
Ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform0.536
Eef2eukaryotic translation elongation factor 20.392
Psmc4proteasome (prosome, macropain) 26S subunit, ATPase, 40.364
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.358
Zfand5zinc finger, AN1-type domain 50.300
Psmb2proteasome (prosome, macropain) subunit, beta type 20.272
Psmd6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.270
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.245
Psme2proteasome (prosome, macropain) activator subunit 20.234
Psmb7proteasome (prosome, macropain) subunit, beta type 70.204
Dctn4dynactin 40.194
Dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.189
Psmb5proteasome (prosome, macropain) subunit, beta type 50.188
Csnk1dcasein kinase 1, delta0.180
Psma6proteasome (prosome, macropain) subunit, alpha type 60.172
Rpn2ribophorin II0.157
Dnajb9DnaJ (Hsp40) homolog, subfamily B, member 90.150
Rab11aRAB11a, member RAS oncogene family0.140
Jtbjumping translocation breakpoint0.136
Psmd13proteasome (prosome, macropain) 26S subunit, non-ATPase, 130.127
Vcpvalosin-containing protein0.124
Pdia4protein disulfide isomerase family A, member 40.122
Psma2proteasome (prosome, macropain) subunit, alpha type 20.122
Syngr2synaptogyrin 20.113
Psmc5proteasome (prosome, macropain) 26S subunit, ATPase, 50.110
DbpD site of albumin promoter (albumin D-box) binding protein0.104
Psmd4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.103
Magi2membrane associated guanylate kinase, WW and PDZ domain containing 20.103
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.100
Psmb10proteasome (prosome, macropain) subunit, beta type 100.100
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.096
Hsph1heat shock 105/110 protein 10.093
P4hbprolyl 4-hydroxylase, beta polypeptide0.090
Traf4af1TRAF4 associated factor 10.085
Psmb4proteasome (prosome, macropain) subunit, beta type 40.082
Psmd7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.080
CnbpCCHC-type zinc finger, nucleic acid binding protein0.075
Manfmesencephalic astrocyte-derived neurotrophic factor0.075
Txnl1thioredoxin-like 10.074
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.073
Prdx1peroxiredoxin 10.073
Cltcclathrin, heavy chain (Hc)0.072
Psmd3proteasome (prosome, macropain) 26S subunit, non-ATPase, 30.071
Dusp11dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)0.070
Psmb1proteasome (prosome, macropain) subunit, beta type 10.069
Ptges3prostaglandin E synthase 3 (cytosolic)0.069
Hprt1hypoxanthine phosphoribosyltransferase 10.069
Ypel5yippee-like 5 (Drosophila)0.068
Hspa5heat shock protein 50.067
Nudt3nudix (nucleoside diphosphate linked moiety X)-type motif 30.064
Ccnb1cyclin B10.063
Usp47ubiquitin specific peptidase 470.060
Rab21RAB21, member RAS oncogene family0.058
Hspe1heat shock protein 1 (chaperonin 10)0.058
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.058
Ppp1r2protein phosphatase 1, regulatory (inhibitor) subunit 20.057
Psmd1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.056
Lman1lectin, mannose-binding, 10.055
Cand1cullin-associated and neddylation-dissociated 10.054
Cops2COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)0.054
Rbbp7retinoblastoma binding protein 70.053
Psma1proteasome (prosome, macropain) subunit, alpha type 10.052
Plk1polo-like kinase 1 (Drosophila)0.052
Mgat2mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase0.051
Rfc1replication factor C (activator 1) 10.050
Creld2cysteine-rich with EGF-like domains 20.050
Lamp2lysosomal-associated membrane protein 20.048
Castcalpastatin0.048
Cenpicentromere protein I0.047
Calrcalreticulin0.046
Tcf12transcription factor 120.045
Ubcubiquitin C0.045
Karslysyl-tRNA synthetase0.044
Wdr26WD repeat domain 260.043
Cmtm6CKLF-like MARVEL transmembrane domain containing 60.043
Pkn2protein kinase N20.042
Tle4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)0.041
Sec61a1Sec61 alpha 1 subunit (S. cerevisiae)0.041
Mdm2Mdm2 p53 binding protein homolog (mouse)0.041
Ube2d3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.039
Senp2Sumo1/sentrin/SMT3 specific peptidase 20.038
Foxm1forkhead box M10.038
Usp15ubiquitin specific peptidase 150.037
GraspGRP1 (general receptor for phosphoinositides 1)-associated scaffold protein0.036
Sdf2l1stromal cell-derived factor 2-like 10.036
Dlg1discs, large homolog 1 (Drosophila)0.035
Cdc37cell division cycle 37 homolog (S. cerevisiae)0.034
Eif2s2eukaryotic translation initiation factor 2, subunit 2 beta0.034
VapaVAMP (vesicle-associated membrane protein)-associated protein A0.034
Serp1stress-associated endoplasmic reticulum protein 10.033
Taok1TAO kinase 10.032
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CDC48Cdc48p1.000
PRE1Pre1p1.000
RPT1Rpt1p0.999
RAD23Rad23p0.999
RPT6Rpt6p0.998
ECM29Ecm29p0.992
RPN10Rpn10p0.992
RPT2Rpt2p0.987
RPT4Rpt4p0.977
RPN11Rpn11p0.970
PRE10Pre10p0.968
RPN12Rpn12p0.967
RPT3Rpt3p0.965
OTU1Otu1p0.964
PRE2Pre2p0.963
PPH22Pph22p0.957
HRD1Hrd1p0.948
MND2Mnd2p0.944
MAD2Mad2p0.944
KAR2Kar2p0.943
PUP2Pup2p0.941
FYV10Fyv10p0.940
CDC53Cdc53p0.938
UBC4Ubc4p0.920
SKP1Skp1p0.916
RPN3Rpn3p0.900
UFD2Ufd2p0.897
VPS36Vps36p0.885
DSK2Dsk2p0.882
CDC20Cdc20p0.874
PRE4Pre4p0.872
UFD4Ufd4p0.869
PUP1Pup1p0.868
UBP3Ubp3p0.864
UBR1Ubr1p0.861
CDC23Cdc23p0.860
RPN9Rpn9p0.858
PRE6Pre6p0.857
MGR1Mgr1p0.857
SHP1Shp1p0.849
RPT5Rpt5p0.847
RPN8Rpn8p0.841
DOC1Doc1p0.840
UBP6Ubp6p0.836
RPN2Rpn2p0.830
APC5Apc5p0.824
CDC16Cdc16p0.819
APC2Apc2p0.817
CDC27Cdc27p0.802
VID30Vid30p0.792
SWM1Swm1p0.790
HRD3Hrd3p0.784
PRE9Pre9p0.782
PRE7Pre7p0.777
LAG2Lag2p0.776
NPL4Npl4p0.763
RPN6Rpn6p0.744
CDC4Cdc4p0.743
UBA1Uba1p0.718
PPH21Pph21p0.700
GID7Gid7p0.696
UFD1Ufd1p0.693
MAD3Mad3p0.677
RKR1Rkr1p0.676
ELC1Elc1p0.662
APC4Apc4p0.658
CDC26Cdc26p0.656
DER1Der1p0.655
APC1Apc1p0.644
CTF13Ctf13p0.639
PRE8Pre8p0.624
UBX3Ubx3p0.609
RPN1Rpn1p0.602
UBC13Ubc13p0.590
RPN7Rpn7p0.584
UBX4Ubx4p0.579
DOA1Doa1p0.570
PRE5Pre5p0.561
BRE5Bre5p0.551
MCM21Mcm21p0.551
SCL1Scl1p0.546
USA1Usa1p0.537
PRE3Pre3p0.530
YDJ1Ydj1p0.523
VPS27Vps27p0.516
PUP3Pup3p0.515
RMD5Rmd5p0.510
SGT2Sgt2p0.504
DFM1Dfm1p0.495
MOH1Moh1p0.491
UBC7Ubc7p0.491
MET30Met30p0.490
HRT1Hrt1p0.489
HSM3Hsm3p0.485
PMT1Pmt1p0.484
MNR2Mnr2p0.479
YDR306Chypothetical protein0.477
RPN13Rpn13p0.476
SSM4Ssm4p0.476
RTS1Rts1p0.473