The network for 'negative regulation of microtubule polymerization or depolymerization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of microtubule polymerization or depolymerization

Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization.

NameDescriptionProbabilityFunc Analog Organism
RACGAP1Rac GTPase activating protein 10.891
BIRC5baculoviral IAP repeat containing 50.833
AURKBaurora kinase B0.769
ITGB4integrin, beta 40.719
CDK1cyclin-dependent kinase 10.663
CDK2cyclin-dependent kinase 20.649
KIF23kinesin family member 230.521
INCENPinner centromere protein antigens 135/155kDa0.445
KIF1Bkinesin family member 1B0.430
CDC20cell division cycle 20 homolog (S. cerevisiae)0.368
MAPRE3microtubule-associated protein, RP/EB family, member 30.364
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.349
PSEN2presenilin 2 (Alzheimer disease 4)0.347
SASS6spindle assembly 6 homolog (C. elegans)0.303
CDCA8cell division cycle associated 80.299
MAPRE2microtubule-associated protein, RP/EB family, member 20.254
CDKN3cyclin-dependent kinase inhibitor 30.218
PRC1protein regulator of cytokinesis 10.216
NEK6NIMA (never in mitosis gene a)-related kinase 60.212
APCadenomatous polyposis coli0.199
MAPTmicrotubule-associated protein tau0.186
ARL2ADP-ribosylation factor-like 20.186
SPTBN1spectrin, beta, non-erythrocytic 10.164
KIF20Akinesin family member 20A0.160
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.151
TUBBtubulin, beta0.149
CKS2CDC28 protein kinase regulatory subunit 20.144
EXOC1exocyst complex component 10.142
MARK2MAP/microtubule affinity-regulating kinase 20.141
DSTdystonin0.133
LMO2LIM domain only 2 (rhombotin-like 1)0.130
AURKAaurora kinase A0.120
DLGAP5discs, large (Drosophila) homolog-associated protein 50.112
GLIS2GLIS family zinc finger 20.110
CKAP5cytoskeleton associated protein 50.107
AKAP9A kinase (PRKA) anchor protein (yotiao) 90.100
CENPEcentromere protein E, 312kDa0.100
TPX2TPX2, microtubule-associated, homolog (Xenopus laevis)0.096
XPO1exportin 1 (CRM1 homolog, yeast)0.091
CCDC85Acoiled-coil domain containing 85A0.084
ADRBK1adrenergic, beta, receptor kinase 10.078
LBRlamin B receptor0.078
ANKRD28ankyrin repeat domain 280.075
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.073
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.072
CENPJcentromere protein J0.069
CCNA2cyclin A20.067
ATF7IPactivating transcription factor 7 interacting protein0.067
GPSM2G-protein signaling modulator 20.059
EXOC7exocyst complex component 70.059
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.056
SMC4structural maintenance of chromosomes 40.055
TEX11testis expressed 110.054
KPNA2karyopherin alpha 2 (RAG cohort 1, importin alpha 1)0.052
CENPFcentromere protein F, 350/400kDa (mitosin)0.051
KIF5Bkinesin family member 5B0.051
CCNE1cyclin E10.051
CCNB2cyclin B20.050
EXOC2exocyst complex component 20.049
KIF4Akinesin family member 4A0.046
TUBA1Ctubulin, alpha 1c0.044
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.042
WASLWiskott-Aldrich syndrome-like0.040
WHSC1Wolf-Hirschhorn syndrome candidate 10.040
MZT1mitotic spindle organizing protein 10.038
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.037
ARL6IP1ADP-ribosylation factor-like 6 interacting protein 10.037
UBE2Subiquitin-conjugating enzyme E2S0.035
TTKTTK protein kinase0.033
CKS1BCDC28 protein kinase regulatory subunit 1B0.033
PTTG1pituitary tumor-transforming 10.032
CCNB1cyclin B10.031
SNCAIPsynuclein, alpha interacting protein0.031
DOCK7dedicator of cytokinesis 70.031
KIF20Bkinesin family member 20B0.030
TUBG1tubulin, gamma 10.030
TNIKTRAF2 and NCK interacting kinase0.029
CEP55centrosomal protein 55kDa0.028
ZFP106zinc finger protein 106 homolog (mouse)0.027
SMAD9SMAD family member 90.027
NCAPD2non-SMC condensin I complex, subunit D20.026
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.026
TOP2Atopoisomerase (DNA) II alpha 170kDa0.025
MOBKL1AMOB1, Mps One Binder kinase activator-like 1A (yeast)0.025
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)0.025
PSRC1proline/serine-rich coiled-coil 10.024
TUBA1Btubulin, alpha 1b0.024
TUBGCP5tubulin, gamma complex associated protein 50.024
SEPT2septin 20.024
KIF2Ckinesin family member 2C0.024
GAS2L3growth arrest-specific 2 like 30.023
TIAM1T-cell lymphoma invasion and metastasis 10.023
TNKStankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase0.022
TRAF3IP1TNF receptor-associated factor 3 interacting protein 10.022
SUFUsuppressor of fused homolog (Drosophila)0.022
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)0.022
TUBB2Ctubulin, beta 2C0.021
THRAP3thyroid hormone receptor associated protein 30.021
DISC1disrupted in schizophrenia 10.021
NEK2NIMA (never in mitosis gene a)-related kinase 20.021
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
exo84CG6095 gene product from transcript CG6095-RA0.970
CG32038CG32038 gene product from transcript CG32038-RA0.965
brubrunelleschi0.944
diadiaphanous0.931
DetDeterin0.930
vibvibrator0.896
Klp67AKinesin-like protein at 67A0.751
fwdfour wheel drive0.736
scrascraps0.620
stisticky0.619
Grip75CG6176 gene product from transcript CG6176-RA0.550
fwsfour way stop0.541
Spc25CG7242 gene product from transcript CG7242-RA0.537
Grip128CG9201 gene product from transcript CG9201-RB0.429
aspabnormal spindle0.398
tefteflon0.347
Klp3AKinesin-like protein at 3A0.341
aslasterless0.339
sec8CG2095 gene product from transcript CG2095-RA0.285
pblpebble0.235
alpha-Specalpha Spectrin0.229
marsCG17064 gene product from transcript CG17064-RB0.138
pavpavarotti0.127
ncdnon-claret disjunctional0.116
ana3anastral spindle 30.115
nudECG8104 gene product from transcript CG8104-RB0.114
Poc1Proteome of centrioles 10.114
Sas-4CG10061 gene product from transcript CG10061-RA0.111
mib2mind bomb 20.104
bondjames bond0.104
Klp10ACG1453 gene product from transcript CG1453-RA0.104
BubR1Bub1-related kinase0.102
toctoucan0.083
eglegalitarian0.083
ifcinfertile crescent0.082
nebnebbish0.082
twetwine0.079
htshu li tai shao0.074
vasvasa0.073
DAAMDishevelled Associated Activator of Morphogenesis0.072
larpLa related protein0.070
Cep135CG17081 gene product from transcript CG17081-RB0.067
austaustralin0.065
beta-Specbeta Spectrin0.063
Pak3CG14895 gene product from transcript CG14895-RA0.062
Orc5Origin recognition complex subunit 50.060
eIF4G2eukaryotic translation initiation factor 4G20.059
mtrmmatrimony0.059
PpcsPhosphopantothenoylcysteine synthetase0.056
bolboule0.056
sas-6spindle assembly abnormal 60.055
mei-P26CG12218 gene product from transcript CG12218-RA0.055
Grip163CG5688 gene product from transcript CG5688-RA0.055
Ndc80CG9938 gene product from transcript CG9938-RA0.054
Lis-1Lissencephaly-10.054
flwflapwing0.054
Nuf2CG8902 gene product from transcript CG8902-RA0.053
Cenp-CCG31258 gene product from transcript CG31258-RA0.049
Spc105RSpc105-related0.047
opa1-likeoptic atrophy 1-like0.047
borrborealin-related0.046
CG14442CG14442 gene product from transcript CG14442-RB0.046
CG11874CG11874 gene product from transcript CG11874-RA0.045
dpadisc proliferation abnormal0.045
CG10722CG10722 gene product from transcript CG10722-RA0.044
cal1chromosome alignment defect 10.039
CG5741CG5741 gene product from transcript CG5741-RC0.039
Klp61FKinesin-like protein at 61F0.038
spd-2spindle defective 20.037
Grip71CG10346 gene product from transcript CG10346-RA0.036
WASpCG1520 gene product from transcript CG1520-RA0.036
trctricornered0.034
NC2alphaCG10318 gene product from transcript CG10318-RA0.032
foifear-of-intimacy0.031
CG31224CG31224 gene product from transcript CG31224-RA0.030
encencore0.030
stetstem cell tumor0.029
Rae1CG9862 gene product from transcript CG9862-RA0.028
Rab11Rab-protein 110.028
Cog7CG31040 gene product from transcript CG31040-RA0.028
ph-ppolyhomeotic proximal0.027
CycB3Cyclin B30.027
mei-38meiotic 380.026
lkb1CG9374 gene product from transcript CG9374-RJ0.025
SbfSET domain binding factor0.025
mod(mdg4)modifier of mdg40.024
CG10631CG10631 gene product from transcript CG10631-RA0.023
Pink1PTEN-induced putative kinase 10.023
CG12734CG12734 gene product from transcript CG12734-RA0.023
poloCG12306 gene product from transcript CG12306-RA0.023
mspsmini spindles0.023
synjsynaptojanin0.022
SMC2CG10212 gene product from transcript CG10212-RA0.022
Br140CG1845 gene product from transcript CG1845-RA0.022
l(2)03659lethal (2) 036590.022
gammaTub37Cgamma-Tubulin at 37C0.022
Dlc90FDynein light chain 90F0.022
rad50CG6339 gene product from transcript CG6339-RD0.021
SRPKCG8174 gene product from transcript CG8174-RA0.021
RhoGAP93BCG3421 gene product from transcript CG3421-RA0.021
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Cdk1cyclin-dependent kinase 10.996
Ccnb1cyclin B10.989
Macf1microtubule-actin crosslinking factor 10.988
Ccna2cyclin A20.986
Prc1protein regulator of cytokinesis 10.978
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.963
Ccnb2cyclin B20.956
Kif20akinesin family member 20A0.864
Plk1polo-like kinase 1 (Drosophila)0.864
Anlnanillin, actin binding protein0.850
Birc5baculoviral IAP repeat-containing 50.850
Ckap2cytoskeleton associated protein 20.818
Dcxdoublecortin0.750
Hmmrhyaluronan mediated motility receptor (RHAMM)0.738
Kif22kinesin family member 220.710
Kif11kinesin family member 110.689
Kif2ckinesin family member 2C0.612
Racgap1Rac GTPase-activating protein 10.589
Kif4kinesin family member 40.588
Dlgap5discs, large (Drosophila) homolog-associated protein 50.562
Cdca8cell division cycle associated 80.511
Aurkbaurora kinase B0.474
Cdc25ccell division cycle 25 homolog C (S. pombe)0.464
Cdca5cell division cycle associated 50.429
Ncaphnon-SMC condensin I complex, subunit H0.423
Top2atopoisomerase (DNA) II alpha0.418
Aurkaaurora kinase A0.368
Pax2paired box gene 20.355
Dclk1doublecortin-like kinase 10.354
Bdnfbrain derived neurotrophic factor0.353
BrafBraf transforming gene0.325
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.308
Ube2cubiquitin-conjugating enzyme E2C0.307
Clasp1CLIP associating protein 10.294
Spag5sperm associated antigen 50.285
Tbx10T-box 100.283
Gtse1G two S phase expressed protein 10.282
Trim55tripartite motif-containing 550.272
Ect2ect2 oncogene0.223
Fam64afamily with sequence similarity 64, member A0.215
Aspmasp (abnormal spindle)-like, microcephaly associated (Drosophila)0.215
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.206
Trim63tripartite motif-containing 630.206
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.202
H2afxH2A histone family, member X0.193
Gria4glutamate receptor, ionotropic, AMPA4 (alpha 4)0.191
Kif23kinesin family member 230.186
Tuba1atubulin, alpha 1A0.178
Cdkn3cyclin-dependent kinase inhibitor 30.170
Sae1SUMO1 activating enzyme subunit 10.169
Nr2e1nuclear receptor subfamily 2, group E, member 10.168
Otx2orthodenticle homolog 2 (Drosophila)0.164
Lmnb1lamin B10.161
C330027C09RikRIKEN cDNA C330027C09 gene0.155
Smc4structural maintenance of chromosomes 40.153
Mki67antigen identified by monoclonal antibody Ki 670.137
Cks2CDC28 protein kinase regulatory subunit 20.126
Mis18bp1MIS18 binding protein 10.125
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.125
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.123
Mad2l1MAD2 mitotic arrest deficient-like 1 (yeast)0.123
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.117
Pcdhgb1protocadherin gamma subfamily B, 10.115
Gsk3bglycogen synthase kinase 3 beta0.113
Mxd3Max dimerization protein 30.110
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.097
Ccdc99coiled-coil domain containing 990.092
Cenpacentromere protein A0.089
Pou3f4POU domain, class 3, transcription factor 40.084
D2Ertd750eDNA segment, Chr 2, ERATO Doi 750, expressed0.082
Vcpvalosin containing protein0.079
Tacc3transforming, acidic coiled-coil containing protein 30.075
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.075
TtkTtk protein kinase0.074
Foxm1forkhead box M10.073
Ctnnb1catenin (cadherin associated protein), beta 10.070
Neflneurofilament, light polypeptide0.067
Cenpfcentromere protein F0.065
Exoc3exocyst complex component 30.065
Nuf2NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.065
Trim59tripartite motif-containing 590.064
Arandrogen receptor0.062
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.061
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.060
Fam83dfamily with sequence similarity 83, member D0.060
Fgf10fibroblast growth factor 100.057
Kcnc3potassium voltage gated channel, Shaw-related subfamily, member 30.056
Itgb1integrin beta 1 (fibronectin receptor beta)0.054
Cdkn1bcyclin-dependent kinase inhibitor 1B0.050
Nusap1nucleolar and spindle associated protein 10.050
Nefmneurofilament, medium polypeptide0.050
Fgfbp1fibroblast growth factor binding protein 10.050
Trp53transformation related protein 530.049
Smc2structural maintenance of chromosomes 20.049
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.049
Foxg1forkhead box G10.048
Eya1eyes absent 1 homolog (Drosophila)0.048
Clasp2CLIP associating protein 20.048
Ccnfcyclin F0.047
Cdca2cell division cycle associated 20.047
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Errfi1ERBB receptor feedback inhibitor 10.080
Traf4af1TRAF4 associated factor 10.023
Ube2cubiquitin-conjugating enzyme E2C0.023
Pttg1pituitary tumor-transforming 10.018
Rhoaras homolog gene family, member A0.015
Stip1stress-induced phosphoprotein 10.015
Hmmrhyaluronan mediated motility receptor (RHAMM)0.015
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
KAR9Kar9p0.380
CLB3Clb3p0.128
BMH1Bmh1p0.111
STU2Stu2p0.092
DAM1Dam1p0.091
CKS1Cks1p0.083
KIP2Kip2p0.080
CIN8Cin8p0.077
CLB1Clb1p0.063
CIK1Cik1p0.063
CDC6Cdc6p0.057
SPC29Spc29p0.056
VIK1Vik1p0.053
MPS1Mps1p0.041
NDD1Ndd1p0.039
SHE1She1p0.038
DYN3Dyn3p0.035
AKL1Akl1p0.031
BIK1Bik1p0.029
KIP3Kip3p0.028
CLB4Clb4p0.028
KAR3Kar3p0.026
NUP157Nup157p0.025
MDS3Mds3p0.024
CLB6Clb6p0.020
VPS70Vps70p0.019
HST3Hst3p0.018
ACM1Acm1p0.017
SLI15Sli15p0.017
SRD1Srd1p0.017
YLR162Whypothetical protein0.015
NUF2Nuf2p0.015
ARP10Arp10p0.015
PTI1Pti1p0.014
YOL038C-Ahypothetical protein0.014
YLR264C-Ahypothetical protein0.014
BIM1Bim1p0.014
LEU2Leu2p0.014
SPC97Spc97p0.013
YIR014Whypothetical protein0.013
YPL014Whypothetical protein0.013
IPL1Ipl1p0.013
CDC15Cdc15p0.013
ASE1Ase1p0.012
SLK19Slk19p0.012
DYN1Dyn1p0.012
FAA2Faa2p0.012
PDS1Pds1p0.012
MSA2Msa2p0.012
MER1Mer1p0.011
GIP3Gip3p0.011
OPT2Opt2p0.011
YAR068Whypothetical protein0.011
YJL107Chypothetical protein0.011
YKL105Chypothetical protein0.011
ARG8Arg8p0.010
WSC4Wsc4p0.010
IRC8Irc8p0.010
SPC98Spc98p0.010
CUP1-1Cup1-1p0.010