The network for 'positive regulation of transmembrane transport' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of transmembrane transport

Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.

NameDescriptionProbabilityFunc Analog Organism
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.998
GSTM1glutathione S-transferase mu 10.998
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.975
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.957
S100BS100 calcium binding protein B0.922
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.893
KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 10.832
GSTM2glutathione S-transferase mu 2 (muscle)0.798
KCNE1potassium voltage-gated channel, Isk-related family, member 10.774
CCR5chemokine (C-C motif) receptor 50.732
GUCY2Cguanylate cyclase 2C (heat stable enterotoxin receptor)0.630
TBX5T-box 50.594
KIAA1683KIAA16830.526
CCL4chemokine (C-C motif) ligand 40.500
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.401
NRP1neuropilin 10.320
CCL2chemokine (C-C motif) ligand 20.315
PDZK1PDZ domain containing 10.291
CRHR1corticotropin releasing hormone receptor 10.291
S100A4S100 calcium binding protein A40.281
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.278
GSTM4glutathione S-transferase mu 40.276
ADORA2Aadenosine A2a receptor0.264
CXCL9chemokine (C-X-C motif) ligand 90.252
KCNA5potassium voltage-gated channel, shaker-related subfamily, member 50.211
PLAUplasminogen activator, urokinase0.189
CANXcalnexin0.189
CCL5chemokine (C-C motif) ligand 50.189
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.185
KLHL3kelch-like 3 (Drosophila)0.184
MPDZmultiple PDZ domain protein0.163
GOPCgolgi-associated PDZ and coiled-coil motif containing0.161
CALCOCO2calcium binding and coiled-coil domain 20.147
PDLIM1PDZ and LIM domain 10.146
ITPR2inositol 1,4,5-trisphosphate receptor, type 20.139
TBC1D10ATBC1 domain family, member 10A0.139
SSTR2somatostatin receptor 20.125
TGIF1TGFB-induced factor homeobox 10.124
DPP4dipeptidyl-peptidase 40.123
CCL13chemokine (C-C motif) ligand 130.123
VAC14Vac14 homolog (S. cerevisiae)0.120
DTNAdystrobrevin, alpha0.116
S100A6S100 calcium binding protein A60.094
CXCL10chemokine (C-X-C motif) ligand 100.093
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.092
SOD1superoxide dismutase 1, soluble0.090
TRPC3transient receptor potential cation channel, subfamily C, member 30.087
SSTR3somatostatin receptor 30.086
CA12carbonic anhydrase XII0.082
ADAM11ADAM metallopeptidase domain 110.079
CCL8chemokine (C-C motif) ligand 80.078
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.078
WNK1WNK lysine deficient protein kinase 10.075
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.074
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.070
CCL3chemokine (C-C motif) ligand 30.067
ORAI1ORAI calcium release-activated calcium modulator 10.066
PTENphosphatase and tensin homolog0.065
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.064
CCL22chemokine (C-C motif) ligand 220.064
CALM1calmodulin 1 (phosphorylase kinase, delta)0.063
SCNN1Bsodium channel, nonvoltage-gated 1, beta0.063
EMP3epithelial membrane protein 30.063
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.063
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.062
CHRNA4cholinergic receptor, nicotinic, alpha 40.062
CXCL11chemokine (C-X-C motif) ligand 110.061
MYOZ1myozenin 10.059
TRPC1transient receptor potential cation channel, subfamily C, member 10.059
MICAMHC class I polypeptide-related sequence A0.059
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.059
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.058
SLC9A3solute carrier family 9 (sodium/hydrogen exchanger), member 30.058
TSC22D4TSC22 domain family, member 40.055
KCNQ2potassium voltage-gated channel, KQT-like subfamily, member 20.053
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.051
HTR2C5-hydroxytryptamine (serotonin) receptor 2C0.051
EZRezrin0.051
SDC2syndecan 20.051
OXSR1oxidative-stress responsive 10.050
CLCN3chloride channel 30.050
GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)0.049
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.049
CCKBRcholecystokinin B receptor0.049
KCNB1potassium voltage-gated channel, Shab-related subfamily, member 10.046
TMSB10thymosin beta 100.046
IDEinsulin-degrading enzyme0.046
IL6interleukin 6 (interferon, beta 2)0.043
CCL19chemokine (C-C motif) ligand 190.042
SYNMsynemin, intermediate filament protein0.042
KIF1Akinesin family member 1A0.042
SLC9A1solute carrier family 9 (sodium/hydrogen exchanger), member 10.042
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.041
TRIM29tripartite motif containing 290.040
PRKACAprotein kinase, cAMP-dependent, catalytic, alpha0.040
HRH3histamine receptor H30.039
CXCL13chemokine (C-X-C motif) ligand 130.039
IFNGinterferon, gamma0.039
MMP23Bmatrix metallopeptidase 23B0.039
PRKCGprotein kinase C, gamma0.039
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog0.609
Vegfavascular endothelial growth factor A0.465
Lin7clin-7 homolog C (C. elegans)0.280
Kdrkinase insert domain protein receptor0.263
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.248
Slc34a1solute carrier family 34 (sodium phosphate), member 10.227
Ikbkginhibitor of kappaB kinase gamma0.209
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.189
Ednrbendothelin receptor type B0.186
Slc9a3r2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.170
Casq2calsequestrin 20.162
Tcirg1T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A30.153
Slc4a4solute carrier family 4 (anion exchanger), member 40.145
Mybpc3myosin binding protein C, cardiac0.129
Ttntitin0.111
Flt1FMS-like tyrosine kinase 10.110
Emx1empty spiracles homolog 1 (Drosophila)0.108
Pthlhparathyroid hormone-like peptide0.107
Tectatectorin alpha0.099
Pygmmuscle glycogen phosphorylase0.097
Hand1heart and neural crest derivatives expressed transcript 10.096
Ptenphosphatase and tensin homolog0.087
Kcnk3potassium channel, subfamily K, member 30.084
Plcg1phospholipase C, gamma 10.084
Sox9SRY-box containing gene 90.080
Fgfr3fibroblast growth factor receptor 30.078
Tcf21transcription factor 210.075
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.072
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.069
Eya1eyes absent 1 homolog (Drosophila)0.065
Runx2runt related transcription factor 20.064
Cckbrcholecystokinin B receptor0.064
Myo6myosin VI0.063
Dlg4discs, large homolog 4 (Drosophila)0.062
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.062
Fgfr2fibroblast growth factor receptor 20.061
Ptprbprotein tyrosine phosphatase, receptor type, B0.059
Zeb1zinc finger E-box binding homeobox 10.057
Dag1dystroglycan 10.056
Sema6dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D0.054
WwoxWW domain-containing oxidoreductase0.053
Kitlkit ligand0.053
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.053
Ctnnb1catenin (cadherin associated protein), beta 10.052
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.050
Gli2GLI-Kruppel family member GLI20.050
Stim1stromal interaction molecule 10.049
Sufusuppressor of fused homolog (Drosophila)0.048
Hif3ahypoxia inducible factor 3, alpha subunit0.048
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.048
Stim2stromal interaction molecule 20.046
Hand2heart and neural crest derivatives expressed transcript 20.046
Kcnq2potassium voltage-gated channel, subfamily Q, member 20.046
Fgf8fibroblast growth factor 80.045
Apcadenomatosis polyposis coli0.045
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.045
Drd2dopamine receptor D20.045
Traf3ip2TRAF3 interacting protein 20.044
Srpk3serine/arginine-rich protein specific kinase 30.044
Itpr1inositol 1,4,5-trisphosphate receptor 10.043
Ptch1patched homolog 10.042
Atoh7atonal homolog 7 (Drosophila)0.042
Kcne1potassium voltage-gated channel, Isk-related subfamily, member 10.042
Foxc2forkhead box C20.041
Bmp7bone morphogenetic protein 70.041
Espnespin0.041
Scn1asodium channel, voltage-gated, type I, alpha0.041
Inhainhibin alpha0.041
Adrb3adrenergic receptor, beta 30.040
St14suppression of tumorigenicity 14 (colon carcinoma)0.040
Cyldcylindromatosis (turban tumor syndrome)0.039
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.039
Fgf22fibroblast growth factor 220.038
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.038
Car7carbonic anhydrase 70.038
Kcnc3potassium voltage gated channel, Shaw-related subfamily, member 30.038
Frmd5FERM domain containing 50.038
Pax2paired box gene 20.038
Fgf23fibroblast growth factor 230.037
Dtnadystrobrevin alpha0.037
Cacna2d1calcium channel, voltage-dependent, alpha2/delta subunit 10.037
Dlgap1discs, large (Drosophila) homolog-associated protein 10.037
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.036
Hoxd3homeobox D30.036
Plp1proteolipid protein (myelin) 10.035
Sstr4somatostatin receptor 40.035
Spock2sparc/osteonectin, cwcv and kazal-like domains proteoglycan 20.035
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.034
Grm1glutamate receptor, metabotropic 10.034
Tcf15transcription factor 150.034
Flt4FMS-like tyrosine kinase 40.034
Pou3f4POU domain, class 3, transcription factor 40.034
Desdesmin0.034
Eporerythropoietin receptor0.033
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.033
Chukconserved helix-loop-helix ubiquitous kinase0.032
Meox2mesenchyme homeobox 20.032
Acvrl1activin A receptor, type II-like 10.032
Ift88intraflagellar transport 88 homolog (Chlamydomonas)0.032
Fktnfukutin0.032
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Anxa2annexin A20.387
S100a6S100 calcium binding protein A60.304
S100a9S100 calcium binding protein A90.255
S100a10S100 calcium binding protein A100.207
S100a8S100 calcium binding protein A80.196
Anxa1annexin A10.160
Slc34a1solute carrier family 34 (sodium phosphate), member 10.157
Fgf14fibroblast growth factor 140.127
Atp1a2ATPase, Na+/K+ transporting, alpha 2 polypeptide0.090
Dccdeleted in colorectal carcinoma0.090
Plp2proteolipid protein 2 (colonic epithelium-enriched)0.085
Phkg1phosphorylase kinase, gamma 10.074
Ctrcchymotrypsin C (caldecrin)0.065
Slc25a3solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 30.063
Cmtm2aCKLF-like MARVEL transmembrane domain containing 2A0.058
S100a4S100 calcium-binding protein A40.051
Sox17SRY (sex determining region Y)-box 170.050
Kcna6potassium voltage gated channel, shaker related subfamily, member 60.047
Lgals3lectin, galactoside-binding, soluble, 30.047
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.046
Fgfr2fibroblast growth factor receptor 20.045
Pdynprodynorphin0.044
Rims1regulating synaptic membrane exocytosis 10.043
Timp1TIMP metallopeptidase inhibitor 10.042
Inhainhibin alpha0.041
Rph3arabphilin 3A0.041
Slc6a17solute carrier family 6 (neurotransmitter transporter), member 170.041
Mdh1malate dehydrogenase 1, NAD (soluble)0.039
Tspotranslocator protein0.039
Nfascneurofascin0.035
Klk1b3kallikrein 1-related peptidase b30.035
Csrnp2cysteine-serine-rich nuclear protein 20.035
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.032
Pdzk1ip1PDZK1 interacting protein 10.031
Crhr1corticotropin releasing hormone receptor 10.030
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.030
Dlgap3discs, large (Drosophila) homolog-associated protein 30.029
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.029
Nptxrneuronal pentraxin receptor0.028
Arpc1bactin related protein 2/3 complex, subunit 1B0.028
Anxa5annexin A50.028
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.028
S100a11S100 calcium binding protein A11 (calizzarin)0.027
Htr5a5-hydroxytryptamine (serotonin) receptor 5A0.026
Pax6paired box 60.025
Kif12kinesin family member 120.025
Sftpdsurfactant protein D0.025
Kalrnkalirin, RhoGEF kinase0.025
Fabp5fatty acid binding protein 5, epidermal0.025
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.024
Cd79bCd79b molecule, immunoglobulin-associated beta0.024
Ptprn2protein tyrosine phosphatase, receptor type, N polypeptide 20.023
Pnliprp2pancreatic lipase-related protein 20.023
Spata9spermatogenesis associated 90.022
Atp1b1ATPase, Na+/K+ transporting, beta 1 polypeptide0.022
Nos3nitric oxide synthase 3, endothelial cell0.022
LOC100363469ribosomal protein S24-like0.021
Prr13proline rich 130.021
Nrxn2neurexin 20.021
Cripcysteine-rich intestinal protein0.021
Mc5rmelanocortin 5 receptor0.021
St18suppression of tumorigenicity 180.021
Casq2calsequestrin 2 (cardiac muscle)0.021
Cav3caveolin 30.021
Adra1aadrenergic, alpha-1A-, receptor0.020
Edn2endothelin 20.020
Grk4G protein-coupled receptor kinase 40.020
Gucy2eguanylate cyclase 2E0.020
Prl8a2prolactin family 8, subfamily a, member 20.020
Nxph3neurexophilin 30.020
Cstbcystatin B (stefin B)0.019
Mep1ameprin 1 alpha0.019
Enpp6ectonucleotide pyrophosphatase/phosphodiesterase 60.019
Fgf10fibroblast growth factor 100.019
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.019
Acracrosin0.019
Cd9CD9 molecule0.019
Sstr1somatostatin receptor 10.018
RGD1564327similar to integrin alpha 80.018
Spt1salivary protein 10.018
Htr65-hydroxytryptamine (serotonin) receptor 60.018
Gnb3guanine nucleotide binding protein (G protein), beta polypeptide 30.018
Gja1gap junction protein, alpha 10.018
Celcarboxyl ester lipase0.018
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.018
Kcnt1potassium channel, subfamily T, member 10.018
Tff2trefoil factor 20.018
Ndufa4NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 40.017
Myh6myosin, heavy chain 6, cardiac muscle, alpha0.017
Lim2lens intrinsic membrane protein 20.017
Kcnk13potassium channel, subfamily K, member 130.017
Admadrenomedullin0.017
Fibcd1fibrinogen C domain containing 10.017
LOC286980putative pheromone receptor (Go-VN13B)0.016
Chrnb4cholinergic receptor, nicotinic, beta 40.016
Lrrc4bleucine rich repeat containing 4B0.016
Tax1bp3Tax1 (human T-cell leukemia virus type I) binding protein 30.016
Gabra4gamma-aminobutyric acid (GABA) A receptor, alpha 40.016
Sctsecretin0.016
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.016
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism