The network for 'srp dependent cotranslational protein targeting to membrane' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

srp dependent cotranslational protein targeting to membrane

The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.

NameDescriptionProbabilityFunc Analog Organism
HSPA1Bheat shock 70kDa protein 1B0.967
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 10.932
HSPA1Aheat shock 70kDa protein 1A0.931
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.725
BAG3BCL2-associated athanogene 30.406
BAG1BCL2-associated athanogene0.269
DNAJB1DnaJ (Hsp40) homolog, subfamily B, member 10.229
STUB1STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase0.142
PPP5Cprotein phosphatase 5, catalytic subunit0.068
HSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)0.064
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.032
DNAJB9DnaJ (Hsp40) homolog, subfamily B, member 90.028
HSPH1heat shock 105kDa/110kDa protein 10.024
ST13suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)0.020
BAG2BCL2-associated athanogene 20.019
LDHBlactate dehydrogenase B0.018
ACTG1actin, gamma 10.017
SURF4surfeit 40.014
HSPA2heat shock 70kDa protein 20.012
CCDC117coiled-coil domain containing 1170.012
EIF4A1eukaryotic translation initiation factor 4A10.011
HSPA6heat shock 70kDa protein 6 (HSP70B')0.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hsp90b1heat shock protein 90, beta (Grp94), member 10.151
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.022
Dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.015
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.015
Iqcb1IQ calmodulin-binding motif containing 10.015
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.013
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
SEC63Sec63p0.998
KAR2Kar2p0.998
SBH1Sbh1p0.575
SRP54Srp54p0.554
SRP14Srp14p0.547
JEM1Jem1p0.540
SRP21Srp21p0.536
SEC62Sec62p0.499
SSS1Sss1p0.437
SSA2Ssa2p0.436
SSA4Ssa4p0.377
OST4Ost4p0.330
SSA3Ssa3p0.309
PMT1Pmt1p0.292
SIL1Sil1p0.261
ERO1Ero1p0.257
SRP72Srp72p0.216
WBP1Wbp1p0.198
STI1Sti1p0.198
SSA1Ssa1p0.071
SCJ1Scj1p0.067
SIS1Sis1p0.061
SRP68Srp68p0.059
RPS29BRps29bp0.044
YLR264C-Ahypothetical protein0.040
CUP1-1Cup1-1p0.036
MPD1Mpd1p0.034
SRD1Srd1p0.032
LEU2Leu2p0.031
SUB2Sub2p0.031
BTN2Btn2p0.030
SSE1Sse1p0.029
TDH1Tdh1p0.028
NMT1Nmt1p0.027
PRS2Prs2p0.026
YHB1Yhb1p0.025
SAR1Sar1p0.024
YOL038C-Ahypothetical protein0.024
YLR162Whypothetical protein0.023
ARP10Arp10p0.022
MER1Mer1p0.022
ENO1Eno1p0.021
URA3Ura3p0.021
GYL1Gyl1p0.020
YLR042Chypothetical protein0.020
YSY6Ysy6p0.020
NOP10Nop10p0.019
CRP1Crp1p0.019
YIR035Chypothetical protein0.019
HOHop0.018
YLR126Chypothetical protein0.018
SPL2Spl2p0.018
RPL15BRpl15bp0.018
HXT3Hxt3p0.018
YDL085C-Ahypothetical protein0.018
TYE7Tye7p0.017
YAR068Whypothetical protein0.017
SFB2Sfb2p0.017
RPL41ARpl41ap0.017
GLN1Gln1p0.017
YPR157Whypothetical protein0.017
YOL013W-Ahypothetical protein0.017
ZPS1Zps1p0.017
TSC3Tsc3p0.016
YMR130Whypothetical protein0.016
OYE2Oye2p0.016
ATP6Atp6p0.016
YBR013Chypothetical protein0.016
ARG8Arg8p0.016
SES1Ses1p0.015
SEC66Sec66p0.015
MF(ALPHA)2Mf(alpha)2p0.015
BSC1Bsc1p0.015
AUA1Aua1p0.015
ICS2Ics2p0.014
ALG12Alg12p0.014
TAD2Tad2p0.014
MCD4Mcd4p0.014
SWC7Swc7p0.014
CPD1Cpd1p0.014
HPF1Hpf1p0.014
SEC20Sec20p0.014
ALT2Alt2p0.014
TEF1Tef1p0.014
OPT2Opt2p0.013
YKR075Chypothetical protein0.013
PTR2Ptr2p0.013
YRB1Yrb1p0.012
FMT1Fmt1p0.012
REX2Rex2p0.012
DIC1Dic1p0.012
SRX1Srx1p0.012
ADH2Adh2p0.012
GTT2Gtt2p0.012
FAS2Fas2p0.011
CCT8Cct8p0.011
YLR040Chypothetical protein0.011
CUP1-2Cup1-2p0.011
CHA1Cha1p0.011
YMR122W-Ahypothetical protein0.011