The network for 'cellular senescence' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular senescence

A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.

NameDescriptionProbabilityFunc Analog Organism
NSMCE1non-SMC element 1 homolog (S. cerevisiae)0.970
MAPK14mitogen-activated protein kinase 140.944
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.939
RB1retinoblastoma 10.897
CDK6cyclin-dependent kinase 60.892
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.845
CREBBPCREB binding protein0.820
PMLpromyelocytic leukemia0.816
NSMCE4Anon-SMC element 4 homolog A (S. cerevisiae)0.814
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.796
RUNX1runt-related transcription factor 10.793
SMC6structural maintenance of chromosomes 60.748
CALM1calmodulin 1 (phosphorylase kinase, delta)0.739
MDM2Mdm2 p53 binding protein homolog (mouse)0.722
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.654
CTAG1Bcancer/testis antigen 1B0.594
MAPK1mitogen-activated protein kinase 10.554
EP300E1A binding protein p3000.543
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.542
CCND1cyclin D10.433
NOXA1NADPH oxidase activator 10.414
SIN3ASIN3 homolog A, transcription regulator (yeast)0.413
NCF1neutrophil cytosolic factor 10.408
CCND3cyclin D30.382
EID2EP300 interacting inhibitor of differentiation 20.375
MAGEA3melanoma antigen family A, 30.365
HSPB1heat shock 27kDa protein 10.322
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.298
TP53tumor protein p530.294
HSF1heat shock transcription factor 10.277
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.263
TEKT4tektin 40.261
NAP1L5nucleosome assembly protein 1-like 50.259
DAXXdeath-domain associated protein0.253
BMP2bone morphogenetic protein 20.245
TAL1T-cell acute lymphocytic leukemia 10.243
MAP2K4mitogen-activated protein kinase kinase 40.233
KAT2BK(lysine) acetyltransferase 2B0.232
DUSP1dual specificity phosphatase 10.217
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.190
PKM2pyruvate kinase, muscle0.166
NCOR2nuclear receptor corepressor 20.158
UHRF2ubiquitin-like with PHD and ring finger domains 20.150
ATF2activating transcription factor 20.128
MAGEA1melanoma antigen family A, 1 (directs expression of antigen MZ2-E)0.126
GATA4GATA binding protein 40.122
CPNE6copine VI (neuronal)0.119
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.117
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.115
MYOD1myogenic differentiation 10.111
SETD8SET domain containing (lysine methyltransferase) 80.108
AKT1v-akt murine thymoma viral oncogene homolog 10.104
MKL1megakaryoblastic leukemia (translocation) 10.103
UBE3Aubiquitin protein ligase E3A0.101
CLOCKclock homolog (mouse)0.100
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.098
HIPK2homeodomain interacting protein kinase 20.094
MAP3K5mitogen-activated protein kinase kinase kinase 50.091
CDC37cell division cycle 37 homolog (S. cerevisiae)0.090
MAPKAPK3mitogen-activated protein kinase-activated protein kinase 30.089
TNIP1TNFAIP3 interacting protein 10.085
ARRB1arrestin, beta 10.083
PRKCZprotein kinase C, zeta0.079
DDX21DEAD (Asp-Glu-Ala-Asp) box polypeptide 210.079
MAP2K1mitogen-activated protein kinase kinase 10.076
PEBP4phosphatidylethanolamine-binding protein 40.076
JUNjun proto-oncogene0.073
SP1Sp1 transcription factor0.072
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.071
NCOR1nuclear receptor corepressor 10.070
RALBP1ralA binding protein 10.069
SMAD3SMAD family member 30.068
RHEBRas homolog enriched in brain0.067
SMAD7SMAD family member 70.067
WWOXWW domain containing oxidoreductase0.066
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.063
CNBPCCHC-type zinc finger, nucleic acid binding protein0.063
YAP1Yes-associated protein 10.062
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.061
DUSP9dual specificity phosphatase 90.061
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.058
SH3RF1SH3 domain containing ring finger 10.056
MAGEA5melanoma antigen family A, 50.055
SATB2SATB homeobox 20.055
P4HBprolyl 4-hydroxylase, beta polypeptide0.051
EID2BEP300 interacting inhibitor of differentiation 2B0.049
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.049
MAGEA12melanoma antigen family A, 120.049
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.048
SOS1son of sevenless homolog 1 (Drosophila)0.048
MAGEA2melanoma antigen family A, 20.047
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.046
ARRB2arrestin, beta 20.045
GATA2GATA binding protein 20.042
ARAFv-raf murine sarcoma 3611 viral oncogene homolog0.042
MAPK8mitogen-activated protein kinase 80.042
SMN1survival of motor neuron 1, telomeric0.041
NSMCE2non-SMC element 2, MMS21 homolog (S. cerevisiae)0.040
LNX1ligand of numb-protein X 10.039
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 531.000
Ptenphosphatase and tensin homolog1.000
Ighimmunoglobulin heavy chain complex0.961
Id1inhibitor of DNA binding 10.922
Id3inhibitor of DNA binding 30.898
Apcadenomatosis polyposis coli0.895
Clockcircadian locomotor output cycles kaput0.882
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.834
Cdkn1bcyclin-dependent kinase inhibitor 1B0.831
Ahraryl-hydrocarbon receptor0.820
Mdm2transformed mouse 3T3 cell double minute 20.789
Mapk14mitogen-activated protein kinase 140.713
Esr1estrogen receptor 1 (alpha)0.688
Nf1neurofibromatosis 10.638
Tcf3transcription factor 30.399
Ctnnb1catenin (cadherin associated protein), beta 10.396
Per2period homolog 2 (Drosophila)0.381
BrafBraf transforming gene0.364
Smad4MAD homolog 4 (Drosophila)0.364
Mdm4transformed mouse 3T3 cell double minute 40.350
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.347
Cdkn2acyclin-dependent kinase inhibitor 2A0.251
Ccnd2cyclin D20.217
Ccnd1cyclin D10.205
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.189
Tgfbr2transforming growth factor, beta receptor II0.185
Cry1cryptochrome 1 (photolyase-like)0.182
Smad6MAD homolog 6 (Drosophila)0.138
Bmpr1abone morphogenetic protein receptor, type 1A0.125
Ric8resistance to inhibitors of cholinesterase 8 homolog (C. elegans)0.124
Trp73transformation related protein 730.123
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.122
Runx1runt related transcription factor 10.120
Rb1retinoblastoma 10.103
Kiss1KiSS-1 metastasis-suppressor0.100
Raf1v-raf-leukemia viral oncogene 10.086
Cry2cryptochrome 2 (photolyase-like)0.081
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.079
Tgfbr1transforming growth factor, beta receptor I0.066
Shc1src homology 2 domain-containing transforming protein C10.066
Arntlaryl hydrocarbon receptor nuclear translocator-like0.064
Dok1docking protein 10.064
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.064
Ptch1patched homolog 10.062
Atf2activating transcription factor 20.061
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.061
Gnrh1gonadotropin releasing hormone 10.060
Arandrogen receptor0.057
Acvr1activin A receptor, type 10.056
Abl2v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)0.052
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.052
Ece1endothelin converting enzyme 10.050
Tcf4transcription factor 40.050
XiapX-linked inhibitor of apoptosis0.049
Cd40CD40 antigen0.048
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.043
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.043
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.042
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.041
Rc3h1RING CCCH (C3H) domains 10.041
Stk11serine/threonine kinase 110.039
Hes1hairy and enhancer of split 1 (Drosophila)0.039
Cdh5cadherin 50.038
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.037
Npas2neuronal PAS domain protein 20.037
Sox9SRY-box containing gene 90.037
DaxxFas death domain-associated protein0.033
Mapk11mitogen-activated protein kinase 110.032
Ikzf1IKAROS family zinc finger 10.031
Hsp90b1heat shock protein 90, beta (Grp94), member 10.031
Cdkn2dcyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)0.031
Psen1presenilin 10.030
Bcl6B-cell leukemia/lymphoma 60.030
Smad7MAD homolog 7 (Drosophila)0.028
Tgfb1transforming growth factor, beta 10.028
Srebf2sterol regulatory element binding factor 20.027
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.026
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.026
Hprthypoxanthine guanine phosphoribosyl transferase0.025
Yap1yes-associated protein 10.025
Cdk4cyclin-dependent kinase 40.025
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.025
Map3k7mitogen-activated protein kinase kinase kinase 70.024
En1engrailed 10.024
Foxp3forkhead box P30.023
Vegfavascular endothelial growth factor A0.023
Csf1colony stimulating factor 1 (macrophage)0.023
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.022
Sim1single-minded homolog 1 (Drosophila)0.022
Ghrgrowth hormone receptor0.022
Map2k2mitogen-activated protein kinase kinase 20.021
Thbs1thrombospondin 10.021
Cdc34cell division cycle 34 homolog (S. cerevisiae)0.020
Metmet proto-oncogene0.020
Foxc1forkhead box C10.020
Tbx4T-box 40.019
Rararetinoic acid receptor, alpha0.019
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
LOC100362824caveolin 2-like0.023
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism