The network for 'leukocyte mediated immunity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

leukocyte mediated immunity

Any process involved in the carrying out of an immune response by a leukocyte.

NameDescriptionProbabilityFunc Analog Organism
NCF1neutrophil cytosolic factor 10.982
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.936
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.882
BIRC3baculoviral IAP repeat containing 30.844
PTPN6protein tyrosine phosphatase, non-receptor type 60.826
CD80CD80 molecule0.810
HLA-Cmajor histocompatibility complex, class I, C0.789
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.784
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.772
IL4Rinterleukin 4 receptor0.764
HLA-Bmajor histocompatibility complex, class I, B0.760
CCL4chemokine (C-C motif) ligand 40.725
SLAMF1signaling lymphocytic activation molecule family member 10.711
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.701
IL8interleukin 80.674
CD40CD40 molecule, TNF receptor superfamily member 50.671
BTN3A2butyrophilin, subfamily 3, member A20.669
SYKspleen tyrosine kinase0.661
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.648
NOTCH1notch 10.632
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.582
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.571
SNAP23synaptosomal-associated protein, 23kDa0.559
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.555
HLA-Gmajor histocompatibility complex, class I, G0.548
BTN3A1butyrophilin, subfamily 3, member A10.542
IL2RGinterleukin 2 receptor, gamma0.519
CCR5chemokine (C-C motif) receptor 50.507
IL2RBinterleukin 2 receptor, beta0.493
NCF2neutrophil cytosolic factor 20.492
HLA-DRB5major histocompatibility complex, class II, DR beta 50.486
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.484
LTAlymphotoxin alpha (TNF superfamily, member 1)0.467
HLA-Fmajor histocompatibility complex, class I, F0.463
CARD11caspase recruitment domain family, member 110.461
HLA-DMBmajor histocompatibility complex, class II, DM beta0.460
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.438
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.436
APLFaprataxin and PNKP like factor0.435
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.431
C1QBcomplement component 1, q subcomponent, B chain0.428
CCR1chemokine (C-C motif) receptor 10.419
BTN3A3butyrophilin, subfamily 3, member A30.412
CCR7chemokine (C-C motif) receptor 70.393
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.390
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.382
TAPBPTAP binding protein (tapasin)0.374
TRAF6TNF receptor-associated factor 60.368
CD2CD2 molecule0.367
BRCA1breast cancer 1, early onset0.364
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.361
CTLA4cytotoxic T-lymphocyte-associated protein 40.358
HLA-Amajor histocompatibility complex, class I, A0.339
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.322
TLR2toll-like receptor 20.319
KLRK1killer cell lectin-like receptor subfamily K, member 10.319
CD84CD84 molecule0.316
HK3hexokinase 3 (white cell)0.315
TNFtumor necrosis factor0.314
SIGLEC7sialic acid binding Ig-like lectin 70.311
NCF4neutrophil cytosolic factor 4, 40kDa0.287
NOTCH3notch 30.287
PSMB8proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)0.282
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.282
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.279
SHC1SHC (Src homology 2 domain containing) transforming protein 10.277
TNFRSF13Btumor necrosis factor receptor superfamily, member 13B0.274
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.253
KLRD1killer cell lectin-like receptor subfamily D, member 10.242
JAK2Janus kinase 20.232
PCNAproliferating cell nuclear antigen0.228
PILRApaired immunoglobin-like type 2 receptor alpha0.228
PMS2PMS2 postmeiotic segregation increased 2 (S. cerevisiae)0.227
CCL2chemokine (C-C motif) ligand 20.219
BLNKB-cell linker0.219
C1QCcomplement component 1, q subcomponent, C chain0.219
H2AFXH2A histone family, member X0.218
CXCR6chemokine (C-X-C motif) receptor 60.214
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.210
TRAF3TNF receptor-associated factor 30.207
VEGFAvascular endothelial growth factor A0.205
FCN1ficolin (collagen/fibrinogen domain containing) 10.204
ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)0.204
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.202
CXCL2chemokine (C-X-C motif) ligand 20.196
HLA-Emajor histocompatibility complex, class I, E0.196
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.194
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.176
IL10interleukin 100.173
TYMPthymidine phosphorylase0.172
C19orf50chromosome 19 open reading frame 500.165
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.165
CASP8caspase 8, apoptosis-related cysteine peptidase0.156
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.156
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.155
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.155
CCL20chemokine (C-C motif) ligand 200.150
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
nod1nucleotide-binding oligomerization domain containing 10.180
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.093
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.072
dlg2discs, large (Drosophila) homolog 20.055
ptpn6protein tyrosine phosphatase, non-receptor type 60.051
tlr9toll-like receptor 90.048
wasbWiskott-Aldrich syndrome (eczema-thrombocytopenia) b0.043
LOC100000934hypothetical protein LOC1000009340.040
irak4interleukin-1 receptor-associated kinase 40.031
sult2st1sulfotransferase family 2, cytosolic sulfotransferase 10.030
lrrc33leucine rich repeat containing 330.025
sqstm1sequestosome 10.024
tlr3toll-like receptor 30.024
pcsk7proprotein convertase subtilisin/kexin type 70.024
grnagranulin a0.022
iqgap1IQ motif containing GTPase activating protein 10.022
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.022
ctsbacathepsin B, a0.021
rhogbras homolog gene family, member Gb0.020
kitlgakit ligand a0.020
ecrg4aesophageal cancer related gene 4a0.019
tbpTATA box binding protein0.018
lndc1ly6/neurotoxin domain containing 10.018
coro1acoronin, actin binding protein, 1A0.018
foxp3aforkhead box P3a0.016
nt5e5'-nucleotidase, ecto (CD73)0.016
ints6integrator complex subunit 60.016
mybl2myeloblastosis oncogene-like 20.015
chtf18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)0.015
cxcr3.2chemokine (C-X-C motif) receptor 3.20.014
c3bcomplement component c3b0.014
appl1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.014
nitr8novel immune-type receptor 80.013
ror2receptor tyrosine kinase-like orphan receptor 20.013
adipoql2adiponectin, C1Q and collagen domain containing, like 20.013
tlr21toll-like receptor 210.013
foxe3forkhead box E30.013
calcrlacalcitonin receptor-like a0.013
ptger4bprostaglandin E receptor 4 (subtype EP4) b0.013
tnfrsf18tumor necrosis factor receptor superfamily, member 180.013
phexphosphate regulating gene with homologues to endopeptidases on the X chromosome0.013
illr1immune-related, lectin-like receptor 10.012
bonbonnie and clyde0.012
c1qacomplement component 1, q subcomponent, A chain0.012
notch2notch homolog 20.012
st8sia1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 10.011
rorcaRAR-related orphan receptor C a0.011
g6pdglucose-6-phosphate dehydrogenase0.011
mxamyxovirus (influenza) resistance A0.011
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.011
c3ccomplement component c3c0.011
mtmr8myotubularin related protein 80.011
pou1f1POU domain, class 1, transcription factor 10.010
nitr5novel immune-type receptor 5 and immune-type receptor 5-like0.010
gpr126G protein-coupled receptor 1260.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor0.999
Cd19CD19 antigen0.997
Icosinducible T-cell co-stimulator0.997
Cd40CD40 antigen0.995
Batfbasic leucine zipper transcription factor, ATF-like0.992
Ighimmunoglobulin heavy chain complex0.992
FaslFas ligand (TNF superfamily, member 6)0.983
Prf1perforin 1 (pore forming protein)0.977
Ccl2chemokine (C-C motif) ligand 20.974
Klrk1killer cell lectin-like receptor subfamily K, member 10.974
Il2rginterleukin 2 receptor, gamma chain0.972
Il2rbinterleukin 2 receptor, beta chain0.972
Ccr1chemokine (C-C motif) receptor 10.959
Ifnginterferon gamma0.958
Ikzf1IKAROS family zinc finger 10.957
Il4interleukin 40.955
Itgalintegrin alpha L0.942
Inpp5dinositol polyphosphate-5-phosphatase D0.936
Il10interleukin 100.936
ItkIL2-inducible T-cell kinase0.934
Clec4dC-type lectin domain family 4, member d0.933
Pax2paired box gene 20.930
Lyz2lysozyme 20.920
Ccr2chemokine (C-C motif) receptor 20.920
Ltalymphotoxin A0.919
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.914
TyrobpTYRO protein tyrosine kinase binding protein0.911
Il10rainterleukin 10 receptor, alpha0.910
Il2interleukin 20.905
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.899
BtkBruton agammaglobulinemia tyrosine kinase0.897
Ccl22chemokine (C-C motif) ligand 220.887
Gpr132G protein-coupled receptor 1320.886
S1pr2sphingosine-1-phosphate receptor 20.882
Nos2nitric oxide synthase 2, inducible0.878
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.868
Cd22CD22 antigen0.868
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.864
H2-K1histocompatibility 2, K1, K region0.862
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.862
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.861
Ctswcathepsin W0.859
Acvrl1activin A receptor, type II-like 10.856
Cd44CD44 antigen0.855
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.855
Il6interleukin 60.844
Ccl4chemokine (C-C motif) ligand 40.844
Sh2d2aSH2 domain protein 2A0.842
Ifngr1interferon gamma receptor 10.833
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.831
Cd28CD28 antigen0.827
H2-DMb2histocompatibility 2, class II, locus Mb20.827
Zeb1zinc finger E-box binding homeobox 10.825
TapbpTAP binding protein0.814
Ccl8chemokine (C-C motif) ligand 80.802
Ptgirprostaglandin I receptor (IP)0.795
Klrd1killer cell lectin-like receptor, subfamily D, member 10.789
Leprleptin receptor0.788
Gzmkgranzyme K0.786
Cd160CD160 antigen0.780
H2-Ab1histocompatibility 2, class II antigen A, beta 10.771
H2-Aahistocompatibility 2, class II antigen A, alpha0.761
Cd7CD7 antigen0.758
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.755
Ptenphosphatase and tensin homolog0.754
Stat1signal transducer and activator of transcription 10.753
Apoeapolipoprotein E0.744
H2-Eb1histocompatibility 2, class II antigen E beta0.725
Ccr7chemokine (C-C motif) receptor 70.722
MefvMediterranean fever0.720
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.719
Latlinker for activation of T cells0.718
Klrg1killer cell lectin-like receptor subfamily G, member 10.717
Tlr2toll-like receptor 20.714
B2mbeta-2 microglobulin0.708
Sykbspleen tyrosine kinase0.700
Cxcr3chemokine (C-X-C motif) receptor 30.699
Csf1rcolony stimulating factor 1 receptor0.698
Slamf1signaling lymphocytic activation molecule family member 10.695
Il18rapinterleukin 18 receptor accessory protein0.680
Ncr1natural cytotoxicity triggering receptor 10.671
Il12rb1interleukin 12 receptor, beta 10.664
Casp8caspase 80.660
Chd7chromodomain helicase DNA binding protein 70.659
Socs1suppressor of cytokine signaling 10.653
Elaneelastase, neutrophil expressed0.647
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.646
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.643
Rab27aRAB27A, member RAS oncogene family0.642
Irf5interferon regulatory factor 50.642
Xcl1chemokine (C motif) ligand 10.640
Il1rninterleukin 1 receptor antagonist0.632
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.628
C3ar1complement component 3a receptor 10.626
Clec7aC-type lectin domain family 7, member a0.624
Cd180CD180 antigen0.622
Stat3signal transducer and activator of transcription 30.616
H2-D1histocompatibility 2, D region locus 10.615
Itgaxintegrin alpha X0.606
Cd4CD4 antigen0.604
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Icam1intercellular adhesion molecule 10.289
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.269
Il1binterleukin 1 beta0.266
RT1-EC2RT1 class Ib, locus EC20.257
Cd247Cd247 molecule0.254
Cd37CD37 molecule0.250
Ccr5chemokine (C-C motif) receptor 50.243
Csf1colony stimulating factor 1 (macrophage)0.241
C1qbcomplement component 1, q subcomponent, B chain0.205
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.194
Neurl3neuralized homolog 3 (Drosophila)0.161
Nkg7natural killer cell group 7 sequence0.156
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.156
Cfbcomplement factor B0.147
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.142
Oas1a2'-5' oligoadenylate synthetase 1A0.135
Klrb1akiller cell lectin-like receptor subfamily B, member 1A0.130
C3complement component 30.129
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.121
Inpp5dinositol polyphosphate-5-phosphatase D0.118
RT1-DaRT1 class II, locus Da0.115
Arl11ADP-ribosylation factor-like 110.114
Hsph1heat shock 105/110 protein 10.113
Fcgr2aFc fragment of IgG, low affinity IIa, receptor (CD32)0.113
Plcg2phospholipase C, gamma 20.113
Hspb1heat shock protein 10.109
Sellselectin L0.108
Gzmkgranzyme K0.106
Cxcl10chemokine (C-X-C motif) ligand 100.106
Fcgr3aFc fragment of IgG, low affinity IIIa, receptor0.102
Arhgap4Rho GTPase activating protein 40.102
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.100
Cd2Cd2 molecule0.098
Cd8aCD8a molecule0.094
Hckhemopoietic cell kinase0.093
Klrd1killer cell lectin-like receptor, subfamily D, member 10.093
P2ry14purinergic receptor P2Y, G-protein coupled, 140.092
Il2rbinterleukin 2 receptor, beta0.088
Cd14CD14 molecule0.083
Reg3bregenerating islet-derived 3 beta0.082
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.080
Fggfibrinogen gamma chain0.079
Xcl1chemokine (C motif) ligand 10.074
RT1-BaRT1 class II, locus Ba0.072
Serpind1serpin peptidase inhibitor, clade D (heparin cofactor), member 10.072
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.072
Dock8dedicator of cytokinesis 80.069
Apobapolipoprotein B0.069
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.068
Calm1calmodulin 10.066
Casp1caspase 10.066
Pgam1phosphoglycerate mutase 1 (brain)0.066
Cd53Cd53 molecule0.065
Gzmbgranzyme B0.064
Ptafrplatelet-activating factor receptor0.061
Ciitaclass II, major histocompatibility complex, transactivator0.060
Gbp2guanylate binding protein 20.059
Mmp12matrix metallopeptidase 120.057
Ptger2prostaglandin E receptor 2 (subtype EP2)0.056
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.055
Klrc2killer cell lectin-like receptor subfamily C, member 20.054
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.054
Pon1paraoxonase 10.053
Tuba1ctubulin, alpha 1C0.052
Cd4Cd4 molecule0.052
Bcl2a1dB-cell leukemia/lymphoma 2 related protein A1d0.051
Rhohras homolog gene family, member H0.051
Ccl7chemokine (C-C motif) ligand 70.051
UncxUNC homeobox0.050
Ccl5chemokine (C-C motif) ligand 50.050
Ccl4chemokine (C-C motif) ligand 40.049
Prf1perforin 1 (pore forming protein)0.049
Myo1fmyosin IF0.047
Hmox1heme oxygenase (decycling) 10.047
Prm2protamine 20.046
FaslgFas ligand (TNF superfamily, member 6)0.046
RGD1304644similar to RIKEN cDNA 2310046K010.045
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.045
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.045
Lcp1lymphocyte cytosolic protein 10.045
Ugt1a6UDP glucuronosyltransferase 1 family, polypeptide A60.045
Ppp2caprotein phosphatase 2, catalytic subunit, alpha isoform0.044
Fgf16fibroblast growth factor 160.044
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.043
Grprgastrin releasing peptide receptor0.043
Klhl6kelch-like 6 (Drosophila)0.043
Tlr7toll-like receptor 70.043
Dnase1l3deoxyribonuclease 1-like 30.042
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.042
Gckrglucokinase (hexokinase 4) regulator0.041
Il7rinterleukin 7 receptor0.041
Plauplasminogen activator, urokinase0.040
Bcl2l1Bcl2-like 10.040
Tfectranscription factor EC0.040
Pde3aphosphodiesterase 3A, cGMP inhibited0.039
Igsf6immunoglobulin superfamily, member 60.039
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.039
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism